LOCUS       NM_001362624            3489 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus fibroblast growth factor 11 (Fgf11), transcript
            variant 4, mRNA.
ACCESSION   NM_001362624 XM_017314258
VERSION     NM_001362624.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3489)
  AUTHORS   Cho JH, Kim K, Cho HC, Lee J and Kim EK.
  TITLE     Silencing of hypothalamic FGF11 prevents diet-induced obesity
  JOURNAL   Mol Brain 15 (1), 75 (2022)
   PUBMED   36064426
  REMARK    GeneRIF: Silencing of hypothalamic FGF11 prevents diet-induced
            obesity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3489)
  AUTHORS   Meuser M, Deuper L, Rudat C, Aydogdu N, Thiesler H, Zarnovican P,
            Hildebrandt H, Trowe MO and Kispert A.
  TITLE     FGFR2 signaling enhances the SHH-BMP4 signaling axis in early
            ureter development
  JOURNAL   Development 149 (1) (2022)
   PUBMED   35020897
REFERENCE   3  (bases 1 to 3489)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3489)
  AUTHORS   Tejedor G, Laplace-Builhe B, Luz-Crawford P, Assou S, Barthelaix A,
            Mathieu M, Kissa K, Jorgensen C, Collignon J, Chuchana P and Djouad
            F.
  TITLE     Whole embryo culture, transcriptomics and RNA interference identify
            TBX1 and FGF11 as novel regulators of limb development in the mouse
  JOURNAL   Sci Rep 10 (1), 3597 (2020)
   PUBMED   32107392
  REMARK    GeneRIF: Whole embryo culture, transcriptomics and RNA interference
            identify TBX1 and FGF11 as novel regulators of limb development in
            the mouse.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3489)
  AUTHORS   Lee KW, Jeong JY, An YJ, Lee JH and Yim HS.
  TITLE     FGF11 influences 3T3-L1 preadipocyte differentiation by modulating
            the expression of PPARgamma regulators
  JOURNAL   FEBS Open Bio 9 (4), 769-780 (2019)
   PUBMED   30984550
  REMARK    GeneRIF: FGF11 indirectly controls the expression of PPARgamma
            through modifying the expression of multiple PPARgamma regulators,
            thereby mediating adipogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3489)
  AUTHORS   Dichmann DS, Miller CP, Jensen J, Scott Heller R and Serup P.
  TITLE     Expression and misexpression of members of the FGF and TGFbeta
            families of growth factors in the developing mouse pancreas
  JOURNAL   Dev Dyn 226 (4), 663-674 (2003)
   PUBMED   12666204
REFERENCE   7  (bases 1 to 3489)
  AUTHORS   Hajihosseini MK and Heath JK.
  TITLE     Expression patterns of fibroblast growth factors-18 and -20 in
            mouse embryos is suggestive of novel roles in calvarial and limb
            development
  JOURNAL   Mech Dev 113 (1), 79-83 (2002)
   PUBMED   11900978
REFERENCE   8  (bases 1 to 3489)
  AUTHORS   Bachler M and Neubuser A.
  TITLE     Expression of members of the Fgf family and their receptors during
            midfacial development
  JOURNAL   Mech Dev 100 (2), 313-316 (2001)
   PUBMED   11165488
REFERENCE   9  (bases 1 to 3489)
  AUTHORS   Munoz-Sanjuan I, Smallwood PM and Nathans J.
  TITLE     Isoform diversity among fibroblast growth factor homologous factors
            is generated by alternative promoter usage and differential
            splicing
  JOURNAL   J Biol Chem 275 (4), 2589-2597 (2000)
   PUBMED   10644718
REFERENCE   10 (bases 1 to 3489)
  AUTHORS   Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert
            DJ, Copeland NG, Jenkins NA and Nathans J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603707.5.
            
            On Apr 21, 2018 this sequence version replaced XM_017314258.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.9592.1,
                                           SRR7652917.159427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-848               AL603707.5         180662-181509       c
            849-959             AL603707.5         178895-179005       c
            960-1063            AL603707.5         178581-178684       c
            1064-1284           AL603707.5         177771-177991       c
            1285-3489           AL603707.5         175297-177501       c
FEATURES             Location/Qualifiers
     source          1..3489
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.88 cM"
     gene            1..3489
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="fibroblast growth factor 11"
                     /db_xref="GeneID:14166"
                     /db_xref="MGI:MGI:109167"
     exon            1..848
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    581..583
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="upstream in-frame stop codon"
     CDS             656..1324
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="isoform 3 is encoded by transcript variant 4;
                     fibroblast growth factor homologous factor 3; fibroblast
                     growth factor 1d"
                     /codon_start=1
                     /product="fibroblast growth factor 11 isoform 3"
                     /protein_id="NP_001349553.1"
                     /db_xref="GeneID:14166"
                     /db_xref="MGI:MGI:109167"
                     /translation="

MAALASSLIRQKREVREPGGSRPVSAQRRVCPRGTKSLCQKQLLILLSKVRLCGGRPTRQDRGPEPQLKGIVTKLFCRQGFYLQANPDGSIQGTPEDTSSFTHFNLIPVGLRVVTIQSAKLGHYMAMNAEGLLYSSPHFTAECRFKECVFENYYVLYASALYRQRRSGRAWYLGLDKEGRVMKGNRVKKTKAAAHFVPKLLEGGYGLQKSGHVPGAFSPQCS"

     misc_feature    860..1252
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="Acidic and basic fibroblast growth factor family;
                     Region: FGF; smart00442"
                     /db_xref="CDD:214665"
     misc_feature    order(881..883,974..976,980..982,986..988,1070..1072,
                     1094..1096,1103..1120,1124..1126,1238..1240,1244..1246,
                     1250..1252)
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="receptor interaction site [active]"
                     /db_xref="CDD:238015"
     misc_feature    order(1181..1186,1199..1201,1211..1213,1229..1231)
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="heparin binding site (glycine box) [chemical
                     binding]; other site"
                     /db_xref="CDD:238015"
     exon            849..959
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1063
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1284
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..3489
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gggggtgacaatgagaaaaagcattatccagccagggggcctgggaaccccttttcactgaacctaaacagcctgaattttgagtcatatttgctggcagaggggggatttgaagaaagtgggagacccactccatttagagtatagaaaaggaaaaaagaaaacagagctgggctcctcttgacattgacagcagcctagggtgagctaatgtccacaaagcttaggacccacaccctgtgtaagagtaggctgggcaggagcggccccaaaatagggtagaaagaagcctcggggtattgagaacacatcttagaaatataggagggtcttgactgtgggatagaggaggtatcttctatctggtacagaggccagagaggagggaaggggaaagctttcattaggggacagaattcatgggtgaggtcagctgaggagtgcataggctgctggagccgctggagctagtcagggcccaagggtgggagccggtggtgttggggaacgtactggggtctggggtttctcttcagatcctgtgggtggggcggtgggttgggtcctgagcatgccctggtgagagggctcctcttggggagcccagggcgctccgggagcctgctggtttgggggtgtctcctcccggggcgcgatggcggcgttggccagtagcctgatccgacagaagcgggaggtccgcgagcccgggggcagccggcccgtgtcggcgcagcggcgcgtgtgtccccgcggtaccaagtcactttgccagaaacagctcctcatcctgctgtccaaggtgcgactgtgcggggggcgtcccacgcgacaggaccgcggcccagagcctcagctcaaaggcatcgtcaccaaactgttctgccgccagggtttctacctccaggcgaatcccgatgggagtatccagggcaccccagaggacaccagctccttcacccacttcaatctgattcctgtgggactccgtgtggtcaccatccagagtgccaagctgggtcactacatggccatgaacgctgaggggctattgtacagctcgccacatttcacagcagagtgtcgctttaaggagtgcgtctttgagaattactatgtcctgtatgcctctgctctctaccgtcagcgtcgttctggccgggcctggtacctaggcctggacaaggaaggccgggtcatgaagggaaaccgagtcaagaagaccaaggcagctgcccactttgtgcccaagctcctggagggtgggtatgggctccagaaaagtggccatgtaccgggagccttctctccacagtgttcctgagacctccccttccagtccccctgcccactgagatatagtccctggactggaggctccctgctcttccagtgagtcagccaccgccacatcctgtgtcctagccctgcgccgggccttgccgctctcacccctgttgccacacacatgccctgagcagtcaggtctcagcaggtgctgcaccctgtgggagcttcggggctgtcagggacctccggagttgctgagctcttagatcctggggcccaggagaggtcccaagatgggggtgcctgagatgaccctgcctgatcacttctcttttttccacactaattcctaccccttaagagaacacccattttttttcctaaaaggcaccggggttccaacactcaaggcaggaaggtaatactcttcaccctggctgagccagtctctgaagccatgtccttctttgcatcgtctcgaagccatagctttctaggtcggtccactggcactcagaatgcatctccttctctctctgctctaccttctgacttggtctggacaggttctgatagagctggtcaccccagccaggcagggccatccctatgttctgtgttggaacccaagtatgtatcctttccacgtctatccttgtcctagatggacacctcccacccctggctttaaaaaagaggccccctactgtagcaattggccttggtctgaattgggaccagtctcaggtcaccactgattaaaccttcttatcccagagacacccaattctagaacgtggtattctagacctttctggagccatacttcctcctgaatctcagttctaggacatagcccatgactctcagccctttcttcccggatggagctagggcctgtatagccatattattgtactagagtaagttctagacctacccttccactttctctagcaattaaaggatgagctatgggtagaactcagctatgattaattaaaaactgattggctctgagctgtgcttggtggcacacacctgtaattcagcacccgggaggctgaatcagacagatcctgagttggaggccatcctgggctacaatagcaaaaccctgtctcaaaagccaatacacacacacacatacacacacacacacacacacacacacagagagagagagagagaaagagagagagagagagagagagagagagaactaatcagtactgaacggatcaagaaccacttcttgcttttcctaaataattttctaaaaatagtccctccagaatactaaccttacttttacatggtttctagtttcagcattccaactagggttctgccagggagacaagagtctggggaaagatacaggaattctggaagaatatacctggctcctagaagggaagctgagagggagaaaatgccatggtatgattgaacctgtgtctgaacacttagctacctcagcaggaattccttccagatcccttttaaagctgaggactttcgttctgatatggtatgctgcatctgtgaggtaaaggagaggaggagaatcaggaaataaaaggctagcctgggctacctagtgaggtcagggccagcctaggctatgtgagaccctgtctcaaacaacaggaagctaaggtctacaatgagaataactctagaattaaaaaggacaaatagggacacagccttgactccccctcacagcagagagacccccaactcagcaataagttcaacttctccgagccctctacaggtcaggcttaggaaacgaggagcctcttgggctcccagacctcatatgtatccccagagcttctaactaaatagaatttactttactttacagcttttaaacctcaggtgggttctaagtacccaaaaaggacctgaaaaacggagaaagccatggggaacctctagtaaaataggaggtagattctgagtctagcagatgtaggtggaaacgtctattgaggtcctaagggaggggctagtgctcaaagacaggtcacttttcctcaggcccttttacttctggcttgttgcaagagatgcccccctccctcatacaaaccccgctcaggctccgcccatctcctggcactgctctcaggggacggggtctccacttcatgctttctgtaattaaagatgatttatacaaccgga

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