LOCUS       NM_001310602            2496 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus tripartite motif-containing 5 (Trim5), mRNA.
ACCESSION   NM_001310602 XM_011241954
VERSION     NM_001310602.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2496)
  AUTHORS   Schafer,A., Marzi,A., Furuyama,W., Catanzaro,N.J., Nguyen,C.,
            Haddock,E., Feldmann,F., Meade-White,K., Thomas,T., Hubbard,M.L.,
            Gully,K.L., Leist,S.R., Hock,P., Bell,T.A., De la Cruz,G.E.,
            Midkiff,B.R., Martinez,D.R., Shaw,G.D., Miller,D.R., Vernon,M.J.,
            Graham,R.L., Cowley,D.O., Montgomery,S.A., Schughart,K., de
            Villena,F.P.M., Wilkerson,G.K., Ferris,M.T., Feldmann,H. and
            Baric,R.S.
  TITLE     Mapping of susceptibility loci for Ebola virus pathogenesis in mice
  JOURNAL   Cell Rep 43 (5), 114127 (2024)
   PUBMED   38652660
REFERENCE   2  (bases 1 to 2496)
  AUTHORS   Fan,J., Campioli,E., Sottas,C., Zirkin,B. and Papadopoulos,V.
  TITLE     Amhr2-Cre-Mediated Global Tspo Knockout
  JOURNAL   J Endocr Soc 4 (2), bvaa001 (2020)
   PUBMED   32099945
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2496)
  AUTHORS   Boon,A.C., deBeauchamp,J., Hollmann,A., Luke,J., Kotb,M., Rowe,S.,
            Finkelstein,D., Neale,G., Lu,L., Williams,R.W. and Webby,R.J.
  TITLE     Host genetic variation affects resistance to infection with a
            highly pathogenic H5N1 influenza A virus in mice
  JOURNAL   J Virol 83 (20), 10417-10426 (2009)
   PUBMED   19706712
REFERENCE   4  (bases 1 to 2496)
  AUTHORS   Tareen,S.U., Sawyer,S.L., Malik,H.S. and Emerman,M.
  TITLE     An expanded clade of rodent Trim5 genes
  JOURNAL   Virology 385 (2), 473-483 (2009)
   PUBMED   19147168
REFERENCE   5  (bases 1 to 2496)
  AUTHORS   Johnson,W.E. and Sawyer,S.L.
  TITLE     Molecular evolution of the antiretroviral TRIM5 gene
  JOURNAL   Immunogenetics 61 (3), 163-176 (2009)
   PUBMED   19238338
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142110.4 and AC123830.5.
            
            On Jul 16, 2015 this sequence version replaced XM_011241954.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and paralogous data.
            
            CCDS Note: This gene lacks full-length transcript support.
            Therefore this CCDS representation has an inferred exon combination
            based on partial transcripts and paralogous transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849382
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC142110.4         37087-37112         c
            27-502              AC142110.4         28319-28794         c
            503-598             AC142110.4         27422-27517         c
            599-829             AC142110.4         25612-25842         c
            830-852             AC142110.4         23779-23801         c
            853-950             AC123830.5         3580-3677
            951-977             AC123830.5         3910-3936
            978-2496            AC123830.5         4181-5699
FEATURES             Location/Qualifiers
     source          1..2496
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.69 cM"
     gene            1..2496
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="tripartite motif-containing 5"
                     /db_xref="GeneID:667823"
                     /db_xref="MGI:MGI:3646853"
     exon            1..26
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     exon            27..502
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    32..34
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="upstream in-frame stop codon"
     CDS             83..1576
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /codon_start=1
                     /product="tripartite motif-containing 5"
                     /protein_id="NP_001297531.1"
                     /db_xref="CCDS:CCDS80770.1"
                     /db_xref="GeneID:667823"
                     /db_xref="MGI:MGI:3646853"
                     /translation="

MASQFMKNLKEEVTCPVCLNLMVKPVSADCGHTFCQGCITLYFESIKCDKEMFSCPVCRLSYQSSNLRPNLHVANIVERLKEFKPSPEEEQKVFNCARHGEKLQLFCRKDMMAICWLCERSQEHRGHKTALIEEVAREYKEQLQVVLQRLMADKKEFENWKDELQKDRTYWENQIQKDVENVQSEFKRMRDIIDSEEKNELQKLRQEKEDILNNLAESESEHAQQSKLLEDFISDVEHQLQCSDIEILQGVENIIKRSLTFSMKKPKTIAREQRKFRAPDLQGMLQVLQEVTEAQRYWVQVTLVQNNHPNIAITDDKRQVRYEDHQASNLIHECENSHEGVLGHPAIQSGKHYWEVDVSGKGAWVLGLSDGSYLFCPIFHSNAERNRLFCRGIKNDSHYQPKYGFWVIGLWKKSVYNAFEECPFTGKPSVLTLSLMVPPCRVGVFLDYAAGTLSFYNISNNGTLIYRFCTASFPDRVFPYFNPTGSSEPMTICWPDS"

     misc_feature    104..316
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; Region: RING_Ubox; cl17238"
                     /db_xref="CDD:473075"
     misc_feature    order(125..127,134..136,170..172,176..178,185..187,
                     194..196,245..247,254..256)
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="cross-brace motif; other site"
                     /db_xref="CDD:438253"
     misc_feature    368..481
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; Region: Bbox2_TRIM5-like;
                     cd19761"
                     /db_xref="CDD:380819"
     misc_feature    <431..>799
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    947..1561
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     5 (TRIM5), also known as RING finger protein 88 (RNF88);
                     Region: SPRY_PRY_TRIM5; cd15822"
                     /db_xref="CDD:293994"
     exon            503..598
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     exon            599..829
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     exon            830..852
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     exon            853..950
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     exon            951..977
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     exon            978..2496
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2313..2318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="hexamer: AAGAAA"
     polyA_site      2335
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="major polyA site"
     regulatory      2439..2444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="hexamer: AAGAAA"
     polyA_site      2464
                     /gene="Trim5"
                     /gene_synonym="EG667823; Gm8833"
                     /note="major polyA site"
ORIGIN      

cggaaataccttgaagttctggattggcacctgagcagaagtgcaaggagtccggacagtcatacacaggatcacagcaactatggcttcacaattcatgaagaatttaaaggaggaggtgacctgtcctgtctgtctgaacctgatggtgaaacctgtgagtgcagattgtggtcacaccttctgccaaggctgcatcacgttgtactttgaatccatcaaatgtgataaggaaatgttcagttgccctgtgtgccgacttagttaccagtctagcaatctgaggcctaatctacatgtggccaacatagtagagaggctcaaagagttcaagcccagcccagaagaggagcagaaagtgtttaactgtgcaagacatggagagaaactccagctcttctgtaggaaggacatgatggccatctgctggctttgtgagcgatctcaggagcaccggggccacaaaacagctctcattgaagaggtggcccgggagtacaaggagcagctgcaggtagttctgcaaaggctgatggcagataagaaagaatttgaaaactggaaagatgaacttcagaaggatagaacttactgggagaatcaaatacagaaagatgtggagaatgttcagtcagagtttaaacgaatgagggatatcatagactcagaggagaagaatgaattgcagaagctgaggcaagagaaggaagacattctcaacaacctggcagagtctgaaagtgagcatgctcagcagagcaagttgctagaagacttcatctcagatgtggaacatcagttacagtgctcagacatagaaatactacagggtgtggagaacatcataaaacggagtcttactttttcgatgaagaagcccaaaaccatcgccagggaacaaagaaagttccgagcccctgacctgcaaggcatgctgcaagtgctgcaagaggtcacagaggctcaacgctactgggttcaggtgaccctggttcaaaataaccatccaaacattgccattactgacgacaaaagacaagtacgatatgaagaccaccaagcaagtaatcttatacacgagtgtgaaaactctcatgaaggcgtcctgggacatccagctatccaatctggaaaacattactgggaagtagatgtgtctggaaaaggtgcttgggttctggggttaagtgatggaagctacctcttctgtccaatatttcattcaaatgctgaaagaaatcgtttattttgtagggggattaagaatgattcacattatcaaccaaaatatggcttctgggttatagggctgtggaaaaagtctgtgtataatgcttttgaggagtgtcctttcacaggcaagcccagtgtcttgaccctgtctctgatggtcccgccctgtcgtgttggtgttttccttgactatgcagctgggactctctcattttacaatatttccaacaatgggactcttatctacagattctgcacagcttcctttcctgatagggtttttccatattttaatcccacgggaagttcagagccgatgacaatttgctggccagactcttaacatttgcctgtttacttgcaaggtctctggctctgatatgtatatcatatgcctgagctcatcataccattttctctctcttttttttcctgactctagtctttctgtgtgaatgtctttcattggtaaaaaaggatatattcatttctctaggtcagattcttctcagtttctttcagttttgttttgttttagatgagaatattaaatcacttcccatttagtcaaggaaaagtgcctgagtgctcattgtgtaagataacactgctgcaaagttctcttattctttgcgccagaggtggaagccaaggccttgtgcatggtgaggaggtgctccacccctgaggaggtgctccaccactgagctaattacctcagctctgtcaggtctctataacttcatcctgcccatcaatgaaagaagattaaagaaagatcttcaacaacttgtccattcattctgaaaattataggtaggaatctgtggttaagaaatgcacccttagctataggccagttttaccaggatgcatcttcatcaaagaatgaaggagaagcatcacaatgaggcatactgtgttcttgctcaggcatcatatgtgcccaaagtagaatgatcagggaatgttaatatggcccctgctcatggatgacatgcgagtttatgaagcattccatatttttgaagagcattgatagtctaaatcatgttagagaggaggcagggggaaagaaaaagaaaggaaggaaggaaggaaggaaggaaggaaggaaggaaggaaggaagagtaaggaaggaaggaagggaaagaaagaaagaaagaaagaaagaaagaaagaaagaaagaaagaaagagaacaaaagaaagaacgaaagaaagaacgaaagaaagaaagaaagaaagaaagaaagaaagaaa

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