LOCUS       NM_001253848            3530 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus Casitas B-lineage lymphoma-like 1 (Cbll1), transcript
            variant 3, mRNA.
ACCESSION   NM_001253848
VERSION     NM_001253848.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3530)
  AUTHORS   Roca-Lema D, Quiroga M, Khare V, Diaz-Diaz A, Barreiro-Alonso A,
            Rodriguez-Alonso A, Concha A, Romay G, Cerdan ME, Gasche C and
            Figueroa A.
  TITLE     Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation
            and cancer bowel disease
  JOURNAL   Sci Rep 12 (1), 17571 (2022)
   PUBMED   36266428
  REMARK    GeneRIF: Role of the E3 ubiquitin-ligase Hakai in intestinal
            inflammation and cancer bowel disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3530)
  AUTHORS   Wen J, Lv R, Ma H, Shen H, He C, Wang J, Jiao F, Liu H, Yang P, Tan
            L, Lan F, Shi YG, He C, Shi Y and Diao J.
  TITLE     Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic
            Stem Cell Self-Renewal
  JOURNAL   Mol Cell 69 (6), 1028-1038 (2018)
   PUBMED   29547716
REFERENCE   3  (bases 1 to 3530)
  AUTHORS   Yue Y, Liu J, Cui X, Cao J, Luo G, Zhang Z, Cheng T, Gao M, Shu X,
            Ma H, Wang F, Wang X, Shen B, Wang Y, Feng X, He C and Liu J.
  TITLE     VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near
            stop codon and associates with alternative polyadenylation
  JOURNAL   Cell Discov 4, 10 (2018)
   PUBMED   29507755
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3530)
  AUTHORS   Harrow JL, Steward CA, Frankish A, Gilbert JG, Gonzalez JM,
            Loveland JE, Mudge J, Sheppard D, Thomas M, Trevanion S and Wilming
            LG.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   5  (bases 1 to 3530)
  AUTHORS   Mukherjee M, Chow SY, Yusoff P, Seetharaman J, Ng C, Sinniah S, Koh
            XW, Asgar NF, Li D, Yim D, Jackson RA, Yew J, Qian J, Iyu A, Lim
            YP, Zhou X, Sze SK, Guy GR and Sivaraman J.
  TITLE     Structure of a novel phosphotyrosine-binding domain in Hakai that
            targets E-cadherin
  JOURNAL   EMBO J 31 (5), 1308-1319 (2012)
   PUBMED   22252131
REFERENCE   6  (bases 1 to 3530)
  AUTHORS   Figueroa A, Kotani H, Toda Y, Mazan-Mamczarz K, Mueller EC, Otto A,
            Disch L, Norman M, Ramdasi RM, Keshtgar M, Gorospe M and Fujita Y.
  TITLE     Novel roles of hakai in cell proliferation and oncogenesis
  JOURNAL   Mol Biol Cell 20 (15), 3533-3542 (2009)
   PUBMED   19535458
  REMARK    GeneRIF: Results suggest that Hakai is an important regulator of
            cell proliferation and that Hakai may be an oncoprotein and a
            potential molecular target for cancer treatment.
REFERENCE   7  (bases 1 to 3530)
  AUTHORS   Kim TS, Nakagawa T, Endo T, Iguchi F, Murai N, Naito Y and Ito J.
  TITLE     Alteration of E-cadherin and beta-catenin in mouse vestibular
            epithelia during induction of apoptosis
  JOURNAL   Neurosci Lett 329 (2), 173-176 (2002)
   PUBMED   12165405
  REMARK    GeneRIF: E-cadherin distribution and expression is altered in
            utricle epithelia with induction of apoptosis.
REFERENCE   8  (bases 1 to 3530)
  AUTHORS   Fujita Y, Krause G, Scheffner M, Zechner D, Leddy HE, Behrens J,
            Sommer T and Birchmeier W.
  TITLE     Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis
            of the E-cadherin complex
  JOURNAL   Nat Cell Biol 4 (3), 222-231 (2002)
   PUBMED   11836526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974423.21.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site and lacks an segment in the coding region, compared to
            variant 1. This results in a shorter protein (isoform 2), compared
            to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166017.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849380,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                CR974423.21        23036-23129
            95-253              CR974423.21        27903-28061
            254-351             CR974423.21        30476-30573
            352-435             CR974423.21        31057-31140
            436-509             CR974423.21        32111-32184
            510-897             CR974423.21        34338-34725
            898-3530            CR974423.21        35191-37823
FEATURES             Location/Qualifiers
     source          1..3530
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.49 cM"
     gene            1..3530
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /note="Casitas B-lineage lymphoma-like 1"
                     /db_xref="GeneID:104836"
                     /db_xref="MGI:MGI:2144842"
     exon            1..94
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    46..48
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /note="upstream in-frame stop codon"
     CDS             82..1080
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3;
                     E-cadherin binding protein E7; E3 ubiquitin-protein ligase
                     Hakai; c-Cbl-like protein 1; casitas B-lineage
                     lymphoma-transforming sequence-like protein 1; RING-type
                     E3 ubiquitin transferase Hakai"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Hakai isoform 3"
                     /protein_id="NP_001240777.1"
                     /db_xref="CCDS:CCDS56835.1"
                     /db_xref="GeneID:104836"
                     /db_xref="MGI:MGI:2144842"
                     /translation="

MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQASKVKPAPRTQRTVSRMPAKAPQGFDYNEEQRYDCKGGELFGNQRRFPGHLFWDFKINILGEKDDTPVHFCDKCGLPIKVYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTDIPDRFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRMQGPPSQTPLPGPHHPDQTRYRPYYQ"

     misc_feature    388..552
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /note="RING finger, HC subclass, found in E3
                     ubiquitin-protein ligase Hakai, zinc finger protein 645
                     (ZNF645), and similar proteins; Region:
                     RING-HC_HAKAI-like; cd16508"
                     /db_xref="CDD:438171"
     misc_feature    order(430..432,442..453)
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438171"
     misc_feature    550..645
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /note="C2H2 Hakai zinc finger domain; Region: zf_Hakai;
                     pfam18408"
                     /db_xref="CDD:436477"
     misc_feature    <646..1059
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            95..253
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /inference="alignment:Splign:2.1.0"
     exon            254..351
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /inference="alignment:Splign:2.1.0"
     exon            352..435
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /inference="alignment:Splign:2.1.0"
     exon            436..509
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /inference="alignment:Splign:2.1.0"
     exon            510..897
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /inference="alignment:Splign:2.1.0"
     exon            898..3530
                     /gene="Cbll1"
                     /gene_synonym="c-Cbl-like; Hakai"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ctccggaaggtagggcgcaggcgcttactgcgactccggagcgactgacttccgttcccactgtgccccgcgagccgaatcatggatcacactgacaatgagttacaaggcactaatagttctggatccttgggtggtcttgatgttcgcagaagaatccctataaagctcatctccaaacaagccagcaaagttaagccggcacctcggactcaaaggactgtcagcaggatgcccgcaaaggccccgcaaggatttgattataacgaagaacagcgatatgactgtaaaggaggcgaactctttgggaatcagcgaagatttccaggacaccttttttgggatttcaagataaacatcttaggtgaaaaggacgatacaccagtacatttctgtgacaaatgtggactgcctattaaagtctatgggagaatgattccatgcaagcatgtcttttgctatgactgtgctattttacatgaaaaaaaaggagataagatgtgcccaggatgtagtgatcctgtgcagcggattgagcagtgcacacgaggttctctctttatgtgtagcattgttcaaggatgcaagagaacatatctgtctcagagagacttacaagctcatatcaaccatcgccatatgagagctggaaagcccgttacccgtgcttcacttgagaatgttcatcctcctattgcccccccaccaactgacatccccgatcggttcataatgccaccagacaagcatcatatgagccatattcctccaaagcagcacatcatgatgccaccgcctcctctgcagcatgtgccacatgagcactataatcagccacatgaggatattcgtgctcctccggcagaattgtccatggctccacctccacctcgttcgtttactgaagaccaaggaactctgagccctccatttacacaaccaggaggaatgagtcctggtatatggcctgcaccaagagggccacctcctcctccacgaatgcagggcccgccttctcaaaccccactacctggaccgcatcatccagatcaaacaagatacagaccgtattaccagtgatcatagtgttttgaactgaagatatgacaaggaaaaaaaagattagtcaatcttaattgacctttgactgtggaaggaaaactacctcttttgaggtagctattaacacaagtcttgtctctcaaaatggttttaatctgactaggattgctttcaagtactattctgtagtgcagataagtggcttggttgagcacaattctatcttaactgttactttgatgtgataaattttcccaaaacgaccatttgtaaaaaattgaaaaaaaattcactgttccactttgagaaatactgactttattaaacccaatgtttagttttcttgtgatgcattttgttaacctgtgtaaaagaattaaatttcaaaatggttgtaaaaatgctatttttatgtgaatttaagtgcagccatatcattttttaacccatattttaccactaattttccaaggttaaaatcctaaaagtaaaaatctactaaatcgttaccaggcagactgttaaatgtagggaattattcacactttaggcactgaaagttcaaagtgtagttctgtaatacggttcactcggatgccttttcacagcagctgcagatcatcagcgtttctgtaactgtgcttggctggcatgtctccaggtagtgtgtaattgggaaaccgacctgctctacaggctctaagctgccagtgagtgctgttctcattgacgctttttctgagtggctacaatcacataacttgtcacacttaaaggtcttaagttacattattttataggactgtttaaagttgttattggatgaaatgtgctctctgttcactgtcttaacctacatgtttggggctgactaggctttatttaaatctcctttttctcagtttgattctgtgttttagtgcatagtgtgttcttatttatggaattacacactgcagtttgaatgatgtggaggaatctgactaatgtattagcagacggtgttccttgtagtcacaagctagcatgtactcgggtttttgtggctgtggtgagtttttcctctaagttgaaattttaaaactatcatttcttttattggtaaaacagtcaaaaattggaacaatttactgtcgaatcaatagtaaggacaaccagataattttgaattggacagaagaaaagtcatggttagattgtgaatttcagtgccatgtaaggtgcctttagagtcagtgtttgcattataggggcttgttacagtccattggagatgaccactcagtttatacatatttctaagtcagcatccttaggatattatcgtatatcctttggattgactaaactcttgtgaagcttttcttcccctttaaaatggtgcataatataaacatggtgtgtagtgtgcagataacatttattagatagtttgtagtatataaatttagaacattggtttttgacaaggggtatactgattgctaattaaccattttattctgtcaggtacaggaaaacattctcatggtggatgatcagatacaaaatcatttctgaactttcagaagaaataatgtacatggccattcatccttggctggccagaaataactaatgcagttttttcttgagcaaataattttattttcacatgtagcattttgagaatctggtttgctcatgcactatttctagtgagaaattcttgttattagaagcatggacgtgaaatagtgtgacatgtggtgagtgtttctgtcattactgtaggtacttggactggtgcaaacttgattctttttcatgcccctgtttaggagctattaaatattactgttaaaatccaaataacccctttgtttcatgtagttagaaaatagccagattcatgtaagagctttttaactatttatgagaagctcttatattgagatttcctggggttaagtgtggtaagaaaccacttagcctgtattttggaccaaaaaaatcagtatcatgaaaaaaaaaaaatcccacattatgagaattcttgtaggctttaaaaaacaatgtaaaaaccattatgctgggaggcaggccagatgaatgttttgtaatagaattttaattgttagacttcagttcatcagttaattgtttgaatgagggtgggtgggtagacagataacaagattattattaagtgtttctgttcttaaggaaaaagatgtgaatcccagcacatttcagggaagccttcgaagctatctatgatggacataagtctaaatgtatgtatgtttcattaattgctcttaagactactgaggtggcagtttaattctttaaaacaataaaatggaagcataaatactattttgcctagatgagtctttaaacctaatgatgacatatttgggagactgcagaactttccatggttctaaagtaaaattagattcaccttttaaacacttataagc

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