LOCUS       NM_001168218            4587 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus lysine rich nucleolar protein 1 (Knop1), transcript
            variant 2, mRNA.
ACCESSION   NM_001168218
VERSION     NM_001168218.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4587)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   2  (bases 1 to 4587)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 4587)
  AUTHORS   Valerius MT and McMahon AP.
  TITLE     Transcriptional profiling of Wnt4 mutant mouse kidneys identifies
            genes expressed during nephron formation
  JOURNAL   Gene Expr Patterns 8 (5), 297-306 (2008)
   PUBMED   18346943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138717.2 and AC165086.4.
            
            On Jan 14, 2022 this sequence version replaced NM_001168218.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the middle portion of the coding region, compared to
            variant 1. This results in a shorter protein (isoform 2), compared
            to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3781686.1,
                                           SRR1660825.145315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC138717.2         105528-105589       c
            63-514              AC138717.2         102794-103245       c
            515-583             AC138717.2         100526-100594       c
            584-709             AC138717.2         98354-98479         c
            710-4587            AC165086.4         1524-5401
FEATURES             Location/Qualifiers
     source          1..4587
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 63.66 cM"
     gene            1..4587
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /note="lysine rich nucleolar protein 1"
                     /db_xref="GeneID:66356"
                     /db_xref="MGI:MGI:1913606"
     exon            1..62
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /inference="alignment:Splign:2.1.0"
     exon            63..514
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1021
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein C16orf88 homolog; testis-specific gene 118
                     protein"
                     /codon_start=1
                     /product="lysine-rich nucleolar protein 1 isoform 2"
                     /protein_id="NP_001161690.2"
                     /db_xref="CCDS:CCDS52377.1"
                     /db_xref="GeneID:66356"
                     /db_xref="MGI:MGI:1913606"
                     /translation="

MVSKTQKADLGPQLPEKKKKKKKKKRVVANVSEPETQYSVLNSNDYFIDASPPRATSPSNNVDEVQIPEISLSKRKKKKKSCSTHLEECLGAEPTRARQKKSPSPRRQALEQSAEGLIREKKKKRRKSLSKAASQGSGLKTSPDPKHAKEESDTDLEVVLEKKGNMDETCIDQVRRKALQEEIDRESGKTEASEPKKWTVGLSVKTEASEPKKWTGTQFGQWDTAGFENEEQKLKFLKLMGGFKHLSPSFSRPPSMTIRSNMALDKKSSEMLQQSLQQDYDRAMSWKYSHGAGLGFNSEARKVFYIDRNASKSIKLQD"

     misc_feature    215..217
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q1ED39; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2Q2.2); phosphorylation site"
     misc_feature    239..241
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q1ED39; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2Q2.2); phosphorylation site"
     misc_feature    488..490
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q1ED39; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2Q2.2); phosphorylation site"
     misc_feature    728..949
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /note="Small acidic protein family; Region: SMAP;
                     pfam15477"
                     /db_xref="CDD:434743"
     exon            515..583
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /inference="alignment:Splign:2.1.0"
     exon            584..709
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /inference="alignment:Splign:2.1.0"
     exon            710..4587
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gacttccggatcgcggctgcgcggctgctcacgcggggacgcttggcctgctagcgaaccagtaatggtcagcaagacccagaaagcagacctgggcccacaactcccagagaagaagaaaaagaagaagaagaaaaagagagtggttgcaaatgtctcagaaccagagactcaatactcagtcttaaacagtaatgattattttatagacgcttctcctccgagggccacgtccccttctaacaatgtggatgaggtgcagatccccgagatatcactgagcaagagaaagaagaaaaaaaagtcctgtagcactcacttggaggagtgcctgggggctgagcctacacgggcaaggcagaaaaagtcacctagccctagaaggcaggcccttgagcagtcagcagaaggcctcatcagagagaagaaaaagaagaggcggaagtccttatcaaaggctgcctcccaaggctcagggctgaagacctccccagaccccaagcatgccaaggaggagtcagacacagacttagaggtggtactggagaaaaaaggcaacatggatgagacctgcatagaccaggtgagacggaaggccttgcaagaagagattgatcgtgagtcgggcaagacagaggcttcagaacccaaaaagtggacagtgggtttgtcggtcaagacagaggcttcagaacccaaaaagtggacgggaacccagtttggccagtgggatactgccggctttgaaaatgaagaacagaagctaaaattcctgaagcttatgggtggctttaagcatctgtccccgtcattcagccgccctcccagcatgactatcaggtccaacatggccctggacaaaaagtcttcagaaatgctccagcagagtctgcagcaggactatgaccgggccatgagctggaagtacagccacggggctggcctgggctttaactctgaggcccgaaaggtcttctacattgaccggaatgcctccaagtctatcaagttgcaagattaaatattattgtcttgttcttcaaactgcatttcttgatcagttgcatccgtcaagttggcttgaaatagtcacctgcagttattgaggaccaataggaattgctaaagcctcctattttctatgttaaacattccacctccgggtgacagtattttaatagtagctagcagttgttggcacgtggagggtcctgactattttccttgcattgttacactaattatggaatgggtgctgttctcatctctatcaagttcagggataaataaagtaattaaacggcctagggtcaccttccgttaagtgccatcaagagtacatcacccagagtcactcaattatcagtgcagaaagcaagtgatatgccatgacttgcaagtttgttttccttctcccttatcaggaggcaggtgtggtgcagcaggcagacgtggccagtacctctgagctggcttctttccagccgtcctccttccatctgactgctgtgcttggatttgatgctgctgtattggctggatctcaaggcattttggacagtaggtaatcctgcgtatggacccatgacagattctcagcagcatgttttgtgtttgtgttcactagacagaagaccttggacacttgtgtgatgaaatcaaacatataaggggtggagaaaaagatactttgctgcaggcaccataccctcccacccctccctcccaaatcacagcaatcttcatggagctcctgatacagagacccatgtgacatgattttctctcccaccagctattggcagtctggtatcaaggttcagagaaggttactttcctgttttggcctgatttctcacaggcagaaacactgggtggggatggaggtgtttgatgctgcactcagccaggacattcattcatccttccagcaccgtcatcagtgttgatgccttcatgctgctaagaagatgagagacaattcccagcattccagagatgggagaaaaccctctctacaactaaagaaacttccggcagtccctcagggaacctgtgatggcgtcattcagctttgtagtttttcctgtatcagcccccttggtaaggagatgcccctcaggccagccagggagagggtgaggtgtgcagtactgccaaatgggcagcagaggtgttgctgtgccccctaccttgttcctgtcctgtgggcataggccatatgtatggcaaagacctgtttacaccactttcctggaatgaacttggcttctcatcaattcagcctcaagattcagaaaagaccacttccagtcacgtcaatggcagaattctgcatttgagtcaacttccagacaaatctccctcggccttggtgaactctgggaaccatctgcataactccaatagcttgtgttccccacaagtcacattccagcctaagtgtctcagctcatcaaaaacttgcacatggcaatcttacgggtggtagatggttttctatcttatgtcacatatgccttggaagctgtcatcaaagtgtgagagccagatctttttcttagctgttacacatacctcagtgctgaaagacttgattttgtagcttggtacctcagcgttgacttaggtgctccactagcccacctttctctaagaattgaagtctgtagtctatctccaaggcactggaggtagggtcagtgatctaacacaaccttgaacttgactgattctctcaggcatttcttaccagcttggtggcacttaagcaatatccttgtccaacagtcaccaaaatctcatgattcttaacacttgtgcttgagctgatttctgtgctatatctgcttgggcccatgaggccctgccctgaggctacatgtacaaccagactaacctgtgaaaaggctctctcagacacaggtgtccctgctcttagtactacttgggttatggtaggcaggacacacacatacccagcagaagggaaattaaagtcactaatcacatgctgctattattattgttgttgttgtttttttgagacagggtttctttgtgtagccctgaagaccataccatgctagccttaaaagtcacagcgattcacctgtctgcctcctggagtgctaggattaaaggtatacatcactgctgcctggcttccagccaccactggctatcagatagatttgaaatcagatccttgataacctgagcaggttcttttcttcacagttccctaactgatacgtagcagaagatttagtgtggaagacacttgggaaggaaaaggccacaagccaagatcacaggcaacgtacagaagccatgcagcatctctttccaccagagtacccacaaaagaacttagacatggggataccttgacctagcccagagaaaccagtgagttctgaccaacagcagtcaagacagtaaaaccacaggaagtcactgtgcttgtaatttcttaaaggaataagaaccaggaatcactcacagatggacatgaggcatcctgtttttcatttcctaaaagtctctttacatgtccttctcaggggaagtagatgctgtttgtggaggcgggcttcaaagactggactgtcagtaacacttctgcccaggtcagcagactgttgcaggagccccgtggtatgtgtacccagtgtgaggataagccgaggttaacacaagcagtgggaattccccaggccagtgtaagctgcttatgctgttatcctgggcagccttgaggcaggagagtaacgtacaaaggattatttatgaatttgccagttatttttgaaagaattagcatcacagtgaaagtgacataaaataattttagtagaaacagtttggtgaaataaaggccatttgggagtatttgaacagcaccatagtgcattctgggttctggcatgttcacagcaggaggaaaggcattttttagcatctggtttttgtttttgagactggggctcatatatcccagaccagcttcaaacatgtaactggggaccttgatcagatcttgatcctcctgtctctacctcctaactactgccgttctaggtctgcaccttggcactctgtcttatgtggggtcttgtgtctgccaggcaagcattccactgactgagccatatccttcgcctcatctgctcatttttggtttggtttttgttttaagaaattgtatcaattccttgggctggagggtattctcatcagattggccccaaatgtatatacaacagtaaccctgctctttgttgttgttgttttgttttgtttgttttttcgagacagggtttctctgtgtagccctgactgtcctggaactcactctgtagaccaacctgaccttgaactcagaaatccacctgcctctgcctctgcctcccaagtgctgggattaaaggcgtgcaccgccaccacctggctgtaactctgctcttaaactagtaaagacacaagctgtgtgtgtatgtgtgtgtgagacttaataacttctactttctgaggttagtcatgtatagtatttcagataaataaaatccatgcctaaagcacaaa

//