LOCUS       NM_001161457            2797 bp    mRNA    linear   ROD 23-JUN-2025
DEFINITION  Mus musculus core binding factor beta (Cbfb), transcript variant 3,
            mRNA.
ACCESSION   NM_001161457
VERSION     NM_001161457.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2797)
  AUTHORS   Chen,W., Lu,Y., Zhang,Y., Wu,J., McVicar,A., Chen,Y., Zhu,S.,
            Zhu,G., Lu,Y., Zhang,J., McConnell,M. and Li,Y.P.
  TITLE     Cbfbeta regulates Wnt/beta-catenin, Hippo/Yap, and Tgfbeta
            signaling pathways in articular cartilage homeostasis and protects
            from ACLT surgery-induced osteoarthritis
  JOURNAL   Elife 13, e95640 (2024)
   PUBMED   38805545
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2797)
  AUTHORS   Zhang,Y., Chen,H., Wu,J., McVicar,A., Chen,Y., Su,J., Li,Y.P. and
            Chen,W.
  TITLE     Deficiency of Cbfbeta in articular cartilage leads to
            osteoarthritis-like phenotype through Hippo/Yap, TGFbeta, and
            Wnt/beta-catenin signaling pathways
  JOURNAL   Int J Biol Sci 20 (6), 1965-1977 (2024)
   PUBMED   38617544
  REMARK    GeneRIF: Deficiency of Cbfbeta in articular cartilage leads to
            osteoarthritis-like phenotype through Hippo/Yap, TGFbeta, and
            Wnt/beta-catenin signaling pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2797)
  AUTHORS   Rahmawati,M., Stadler,K.M., Lopez-Biladeau,B., Hoisington,T.M. and
            Law,N.C.
  TITLE     Core binding factor subunit beta plays diverse and essential roles
            in the male germline
  JOURNAL   Front Cell Dev Biol 11, 1284184 (2023)
   PUBMED   38020932
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2797)
  AUTHORS   Wu,Y., Hu,S.S., Zhang,R., Goplen,N.P., Gao,X., Narasimhan,H.,
            Shi,A., Chen,Y., Li,Y., Zang,C., Dong,H., Braciale,T.J., Zhu,B. and
            Sun,J.
  TITLE     Single cell RNA sequencing unravels mechanisms underlying
            senescence-like phenotypes of alveolar macrophages
  JOURNAL   iScience 26 (7), 107197 (2023)
   PUBMED   37456831
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2797)
  AUTHORS   Cao,W., Sturmlechner,I., Zhang,H., Jin,J., Hu,B., Jadhav,R.R.,
            Fang,F., Weyand,C.M. and Goronzy,J.J.
  TITLE     TRIB2 safeguards naive T cell homeostasis during aging
  JOURNAL   Cell Rep 42 (3), 112195 (2023)
   PUBMED   36884349
REFERENCE   6  (bases 1 to 2797)
  AUTHORS   Hernandez-Munain,C. and Krangel,M.S.
  TITLE     c-Myb and core-binding factor/PEBP2 display functional synergy but
            bind independently to adjacent sites in the T-cell receptor delta
            enhancer
  JOURNAL   Mol Cell Biol 15 (6), 3090-3099 (1995)
   PUBMED   7760805
  REMARK    Erratum:[Mol Cell Biol 1995 Aug;15(8):4659]
REFERENCE   7  (bases 1 to 2797)
  AUTHORS   Satake,M., Nomura,S., Yamaguchi-Iwai,Y., Takahama,Y., Hashimoto,Y.,
            Niki,M., Kitamura,Y. and Ito,Y.
  TITLE     Expression of the Runt domain-encoding PEBP2 alpha genes in T cells
            during thymic development
  JOURNAL   Mol Cell Biol 15 (3), 1662-1670 (1995)
   PUBMED   7862157
REFERENCE   8  (bases 1 to 2797)
  AUTHORS   Bae,S.C., Ogawa,E., Maruyama,M., Oka,H., Satake,M., Shigesada,K.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Ito,Y.
  TITLE     PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess
            differential transactivation potentials
  JOURNAL   Mol Cell Biol 14 (5), 3242-3252 (1994)
   PUBMED   8164679
REFERENCE   9  (bases 1 to 2797)
  AUTHORS   Ogawa,E., Maruyama,M., Kagoshima,H., Inuzuka,M., Lu,J., Satake,M.,
            Shigesada,K. and Ito,Y.
  TITLE     PEBP2/PEA2 represents a family of transcription factors homologous
            to the products of the Drosophila runt gene and the human AML1 gene
  JOURNAL   Proc Natl Acad Sci U S A 90 (14), 6859-6863 (1993)
   PUBMED   8341710
REFERENCE   10 (bases 1 to 2797)
  AUTHORS   Ogawa,E., Inuzuka,M., Maruyama,M., Satake,M., Naito-Fujimoto,M.,
            Ito,Y. and Shigesada,K.
  TITLE     Molecular cloning and characterization of PEBP2 beta, the
            heterodimeric partner of a novel Drosophila runt-related DNA
            binding protein PEBP2 alpha
  JOURNAL   Virology 194 (1), 314-331 (1993)
   PUBMED   8386878
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164311.4, D14570.1 and BF661733.1.
            
            Transcript Variant: This variant (3) lacks an in-frame exon in the
            3' coding region, compared to variant 1. This results in a shorter
            protein (isoform 3), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D14570.1, SRR7345562.811902.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC164311.4         187196-187265
            71-2779             D14570.1           1-2709
            2780-2797           BF661733.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2797
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..2797
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /note="core binding factor beta"
                     /db_xref="GeneID:12400"
                     /db_xref="MGI:MGI:99851"
     exon            1..380
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    99..101
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /note="upstream in-frame stop codon"
     CDS             303..770
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     core-binding factor subunit beta; CBF-beta; PEA2-beta;
                     PEBP2-beta; SL3-3 enhancer factor 1 subunit beta; SL3/AKV
                     core-binding factor beta subunit; polyomavirus
                     enhancer-binding protein 2 beta subunit"
                     /codon_start=1
                     /product="core-binding factor subunit beta isoform 3"
                     /protein_id="NP_001154929.1"
                     /db_xref="CCDS:CCDS52655.1"
                     /db_xref="GeneID:12400"
                     /db_xref="MGI:MGI:99851"
                     /translation="

MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQTRFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLHRLDGMGCLEFDEERAQARRQQDPSPGSNLGGGDDLKLR"

     misc_feature    303..>701
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /note="Core binding factor beta subunit; Region: CBF_beta;
                     pfam02312"
                     /db_xref="CDD:396750"
     exon            381..467
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /inference="alignment:Splign:2.1.0"
     exon            468..584
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /inference="alignment:Splign:2.1.0"
     exon            585..701
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /inference="alignment:Splign:2.1.0"
     exon            702..2787
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2761..2766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /note="hexamer: ATTAAA"
     polyA_site      2787
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /note="major polyA site"
ORIGIN      

gagaggaagtggcggccgcagccgggggaggctggaagctgtgtctgcgcgggcgggcgggagggaggacggccggcaacggctgaggcgggcggcggtagcgtgggttgggctccaagcacacggccgcacctcagcctccctggagcgggaggccacgcgggcgggctcctgaaacaaagagaagcgggagtccgggtgccgcgggtgggcggtcaaggcggtcagcaccggagcccgccagcgggtgcccgcgcgagcctggggagcgcggccggccggcgcggcctgagggcgggaagatgccgcgcgtcgtcccggaccagaggagcaagttcgagaacgaggagttcttcaggaagctgagccgcgagtgcgagattaagtacacgggcttcagggaccggccccacgaggagcgccagacacgcttccagaacgcctgccgcgacggtcgctcggagatcgcttttgtggctacaggaaccaatctgtctctccagttttttccggccagctggcagggagaacagcgacaaacacctagccgggaatatgtcgacttagagagagaagcaggcaaggtatacttgaaggctcccatgattctgaatggagtgtgtgttatatggaagggctggattgatctccacagattggatggtatgggttgcctggagtttgatgaggagcgagcccaggcaagaagacagcaagaccctagtcctggttctaacttaggtggcggtgatgatctcaaacttcgttaagtggagcacagcttatgtgccccatctctacacacactgcttctagttggtataaataactcattgggcgaccagaaactgtgacaactggagggactgcagttggtttcatggcctgaggcagtgaagacgtcacccactgccatggttttgcactataatgcctgcatttctaatttttaaaatatgtagccagtaataatttgaaatttttttctatgcaagcttatcttgttggcattattttagttgtatcgaaagtatatactttcttcattttaacttaaaagctcatgtcatttagaaacaagataagaaattaaaatttgtatcagggttgcttaacattcttttatactttcagacgagttggttatacagctttcctccttagataagggttcttggtttttgtttgttttctctacatcatttcgtgtttttgtattctgcaccattttacaaatgaagatgtgtttgcagttattttttccagctataaacctagaatagagctgtctgccacagcctcctaaaacaaacgtttacagttgttaaagccacagtatcctttcaaatgctgatagtcaccctatcccctttagacaaaaattcacattagtattaaattttgtctcagaccctgtttcaaggtatatcttgtaatcatgagtttgggtagagatgctcttcacaggtgagaatgctctacagaaatgcccaaagaagccacagactggcttctgttttattcagggattttttttttaatcagtcagaaaaaggatactggaacttgttgtatgtaacagcatattaaactggaggcagtgataaatcagctacacaggtaaattgtgttaaaataatgtttaagatagctgctttcatgtgtattttgtattttgtattgcatgcttttgtagaaacaaaattgggtgatgaagatgagtcttagaaaatgttcatctgggcagaagatgcatttctcccattgattccgggcaaaacattcacagatatagatgatggtattttacaaaaggactattaatagtgccttttgagatgaatcaatgtaacgatatttttaaaacaggcttagtgtcaaattgcaattttttaaatataaaactggaaaaagtgctaagtcattggcacatgcttacaatactttccgtggtcgtattcattaaatgttactacatttctgaatttttgcaaaaatgtattttatcataaaatggcattattttagaaaattttaaaaactgacatggtcaattcagaaaagtctgaataaggtcattgcatttaaaaagcatataaagatacttgattgtggaagtgtgtctttcattgtatataggtcttataattcataaacaagtaccctgtatctcaaaataaaaatatttgttatatatttgaagtcgtgcatgataaggattgtgtttgaattattataaacaataatgtgttacagaagctgatgctgaccttgtgttactgagcactatgaatgaatttgcttggtatttggtgttgtacagctcacatgtttacactctcagtgccctgatgcctctcgggagttacctttttaaagtgatcctttcttttttaaaataacatctcggtggtacattttctctgttgcttctcgccaagagcttccagtccggcagtcagtaagatcacatggtgttaatgtggccgtccctctgtaaatagcaaatgttccttactggttctgcactgcttctgtctgtcttaatgctggcgttaagatcataaactccttttcttcggtagtgcaggctttgaaaattaagttattgatgcaatttcatatttttcataatctgtatttaaaatgacatcattgcatcattttttaaagattcatctccattaaaacttgccttaagcttccagattgctttgccgttagctttactgtatatttgtatgttttatttactttcacattaaaattctgtgtactgaaaacaaaaaaaaaaaaa

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