LOCUS       NM_001110323            1042 bp    mRNA    linear   ROD 23-JUN-2025
DEFINITION  Mus musculus killer cell lectin-like receptor, subfamily A, member
            7 (Klra7), transcript variant 1, mRNA.
ACCESSION   NM_001110323
VERSION     NM_001110323.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1042)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1042)
  AUTHORS   Parikh,B.A., Bern,M.D., Piersma,S.J., Yang,L., Beckman,D.L.,
            Poursine-Laurent,J., Plougastel-Douglas,B. and Yokoyama,W.M.
  TITLE     Control of Viral Infection by Natural Killer Cell Inhibitory
            Receptors
  JOURNAL   Cell Rep 32 (4), 107969 (2020)
   PUBMED   32726632
REFERENCE   3  (bases 1 to 1042)
  AUTHORS   Gays,F., Taha,S. and Brooks,C.G.
  TITLE     The distal upstream promoter in Ly49 genes, Pro1, is active in
            mature NK cells and T cells, does not require TATA boxes, and
            displays enhancer activity
  JOURNAL   J Immunol 194 (12), 6068-6081 (2015)
   PUBMED   25926675
REFERENCE   4  (bases 1 to 1042)
  AUTHORS   Ma,B.J., Craveiro Salvado,C.M. and Kane,K.P.
  TITLE     The activating Ly49W and inhibitory Ly49G NK cell receptors display
            similar affinities for identical MHC class I ligands
  JOURNAL   Immunogenetics 66 (7-8), 467-477 (2014)
   PUBMED   24797174
  REMARK    GeneRIF: The ectodomain of inhibitory Ly49G of the BALB/c mouse
            strain is highly similar to the Ly49W activating receptor in the
            nonobese diabetic (NOD) mouse.
REFERENCE   5  (bases 1 to 1042)
  AUTHORS   Yamanaka,T., Tosaki,A., Kurosawa,M., Akimoto,K., Hirose,T.,
            Ohno,S., Hattori,N. and Nukina,N.
  TITLE     Loss of aPKClambda in differentiated neurons disrupts the polarity
            complex but does not induce obvious neuronal loss or disorientation
            in mouse brains
  JOURNAL   PLoS One 8 (12), e84036 (2013)
   PUBMED   24391875
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1042)
  AUTHORS   Yokoyama,W.M.
  TITLE     Hybrid resistance and the Ly-49 family of natural killer cell
            receptors
  JOURNAL   J Exp Med 182 (2), 273-277 (1995)
   PUBMED   7629493
  REMARK    Review article
REFERENCE   7  (bases 1 to 1042)
  AUTHORS   Mason,L.H., Yagita,H. and Ortaldo,J.R.
  TITLE     LGL-1: a potential triggering molecule on murine NK cells
  JOURNAL   J Leukoc Biol 55 (3), 362-370 (1994)
   PUBMED   7509843
REFERENCE   8  (bases 1 to 1042)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   9  (bases 1 to 1042)
  AUTHORS   Wong,S., Freeman,J.D., Kelleher,C., Mager,D. and Takei,F.
  TITLE     Ly-49 multigene family. New members of a superfamily of type II
            membrane proteins with lectin-like domains
  JOURNAL   J Immunol 147 (4), 1417-1423 (1991)
   PUBMED   1869832
REFERENCE   10 (bases 1 to 1042)
  AUTHORS   Yokoyama,W.M., Kehn,P.J., Cohen,D.I. and Shevach,E.M.
  TITLE     Chromosomal location of the Ly-49 (A1, YE1/48) multigene family.
            Genetic association with the NK 1.1 antigen
  JOURNAL   J Immunol 145 (7), 2353-2358 (1990)
   PUBMED   1975828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U10093.1 and AC161448.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10093.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               U10093.1           1-559
            560-560             AC161448.4         104397-104397       c
            561-1042            U10093.1           561-1042
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..1042
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /note="killer cell lectin-like receptor, subfamily A,
                     member 7"
                     /db_xref="GeneID:16638"
                     /db_xref="MGI:MGI:101901"
     exon            1..75
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /inference="alignment:Splign:2.1.0"
     exon            76..242
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    101..103
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /note="upstream in-frame stop codon"
     CDS             131..973
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     killer cell lectin-like receptor 7; ly-49g; lymphocyte
                     antigen 49g; T-cell surface glycoprotein Ly-49G"
                     /codon_start=1
                     /product="killer cell lectin-like receptor 7 isoform 1"
                     /protein_id="NP_001103793.1"
                     /db_xref="CCDS:CCDS51928.1"
                     /db_xref="GeneID:16638"
                     /db_xref="MGI:MGI:101901"
                     /translation="

MSEQEVTYSTVRFHESSRLQKLVRTEEPQRPREACYREYSVPWKLIVIACGILCFLLLVTVALLAITIFQHSQQKHELQETLNCHDNCSPTQSDVNLKDELLRNKSIECRPGNDLLESLSRDQNRWYSETKTFSDSSQHTGVHKRPISKAEGKGRGFEKYWFCYGIKCYYFNMDRKTWSGCKQTCQISSLSLLKIDNEDELKFLQNLAPSDISWIGLSYDNKKKDWVWIDNGPSKLALNTTKYNIRDGLCMSLSKTRLDNGDCDKSYICICGKRLDKFPH"

     misc_feature    248..643
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /note="Ly49-like protein, N-terminal region; Region: Ly49;
                     pfam08391"
                     /db_xref="CDD:462461"
     misc_feature    263..328
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60654.1);
                     transmembrane region"
     misc_feature    440..442
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60654.1); glycosylation site"
     misc_feature    602..949
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); Region:
                     CLECT_NK_receptors_like; cd03593"
                     /db_xref="CDD:153063"
     misc_feature    order(764..766,845..847,899..901,905..910)
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153063"
     misc_feature    845..847
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60654.1); glycosylation site"
     exon            243..332
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /inference="alignment:Splign:2.1.0"
     exon            333..551
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..590
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /inference="alignment:Splign:2.1.0"
     exon            591..733
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /inference="alignment:Splign:2.1.0"
     exon            734..837
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1042
                     /gene="Klra7"
                     /gene_synonym="LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49g;
                     Ly49G.4; Ly49g1; Ly49g2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggagacacttaggggatatcaaccagaaaaagccaactttttctccacaggaatcacttctcagtagagacacagaaaccactcaaggcaccattttaactgagaacatacttcatacatcattcccaagatgagtgagcaggaggtcacttactcaactgtgagatttcatgagtcttcaaggttgcagaaactagtgaggactgaggagcctcaaaggcccagagaagcttgctacagagagtattcagtcccctggaagctcattgtgatagcttgtggaatcctctgtttccttctcctggtaactgttgcattgttggcaataacgatttttcagcatagtcaacaaaaacatgaactacaggaaactctaaattgccacgataactgcagccccacgcaaagtgacgtcaacttgaaggatgaactgctgagaaataagtctatagagtgtaggccaggcaatgatcttctggaatccctcagcagggatcagaacagatggtacagtgaaaccaagactttttcagattcctcacagcacacaggtgttcacaaaagacccatctccaaggcagaggggaagggtagaggttttgaaaaatattggttctgttatggtataaaatgttattatttcaacatggacagaaaaacgtggagtggatgtaaacagacctgccagatttccagcttatcccttctgaagatagacaatgaggatgaactgaagttccttcagaacctggctccttcagacatttcctggattggattgtcatatgacaataagaaaaaagattgggtatggattgacaatggcccatctaaacttgccttgaacacaacgaaatataatataagagatggattatgtatgtcgttatctaaaacaagactagacaatggggactgtgataaatcatacatctgtatttgtggtaagagactggataaatttcctcattgactctccaatgagtgtaaaaggtaaaaaaaatgaaatttttttactcacatttgtttcctgcaataattc

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