2024-04-29 05:20:57, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001081493 836 bp mRNA linear ROD 12-NOV-2023 DEFINITION Mus musculus CART prepropeptide (Cartpt), transcript variant 2, mRNA. ACCESSION NM_001081493 XM_989570 VERSION NM_001081493.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 836) AUTHORS Zhao M, Toma K, Kinde B, Li L, Patel AK, Wu KY, Lum MR, Tan C, Hooper JE, Kriegstein AR, La Torre A, Liao YJ, Welsbie DS, Hu Y, Han Y and Duan X. TITLE Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy JOURNAL Cell Rep 42 (9), 113038 (2023) PUBMED 37624696 REFERENCE 2 (bases 1 to 836) AUTHORS Priest MF, Freda SN, Rieth IJ, Badong D, Dumrongprechachan V and Kozorovitskiy Y. TITLE Peptidergic and functional delineation of the Edinger-Westphal nucleus JOURNAL Cell Rep 42 (8), 112992 (2023) PUBMED 37594894 REFERENCE 3 (bases 1 to 836) AUTHORS Vincent E, Chatterjee S, Cannon GH, Auer D, Ross H, Chakravarti A and Goff LA. TITLE Ret deficiency decreases neural crest progenitor proliferation and restricts fate potential during enteric nervous system development JOURNAL Proc Natl Acad Sci U S A 120 (34), e2211986120 (2023) PUBMED 37585461 REFERENCE 4 (bases 1 to 836) AUTHORS Lu C, Zhang J, Wang B, Gao Q, Ma K, Pei S, Li J and Cui S. TITLE Casein kinase 1alpha is required to maintain murine hypothalamic pro-opiomelanocortin expression JOURNAL iScience 26 (5), 106670 (2023) PUBMED 37168577 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 836) AUTHORS Stein J, Steiner DF and Dey A. TITLE Processing of cocaine- and amphetamine-regulated transcript (CART) precursor proteins by prohormone convertases (PCs) and its implications JOURNAL Peptides 27 (8), 1919-1925 (2006) PUBMED 16784796 REMARK Review article REFERENCE 6 (bases 1 to 836) AUTHORS Dey A, Xhu X, Carroll R, Turck CW, Stein J and Steiner DF. TITLE Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3 JOURNAL J Biol Chem 278 (17), 15007-15014 (2003) PUBMED 12584191 REMARK GeneRIF: Processing of pro-CART revealed that PC2 is more potent than PC1/3 in generating bioactive CART I; bioactive CART II is solely generated by PC2; and PC1/3 is predominantly active in liberating the two intermediate CART fragments, 33-102 and 10-89. REFERENCE 7 (bases 1 to 836) AUTHORS Tsuruta Y, Yoshimatsu H, Hidaka S, Kondou S, Okamoto K and Sakata T. TITLE Hyperleptinemia in A(y)/a mice upregulates arcuate cocaine- and amphetamine-regulated transcript expression JOURNAL Am J Physiol Endocrinol Metab 282 (4), E967-E973 (2002) PUBMED 11882520 REMARK GeneRIF: leptin modulates arcuate cocaine- and amphetamine-regulated transcript expression in obese A(y)/a mice REFERENCE 8 (bases 1 to 836) AUTHORS Asnicar MA, Smith DP, Yang DD, Heiman ML, Fox N, Chen YF, Hsiung HM and Koster A. TITLE Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet JOURNAL Endocrinology 142 (10), 4394-4400 (2001) PUBMED 11564703 REFERENCE 9 (bases 1 to 836) AUTHORS Adams LD, Gong W, Vechia SD, Hunter RG and Kuhar MJ. TITLE CART: from gene to function JOURNAL Brain Res 848 (1-2), 137-140 (1999) PUBMED 10612705 REFERENCE 10 (bases 1 to 836) AUTHORS Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ and Hastrup S. TITLE Hypothalamic CART is a new anorectic peptide regulated by leptin JOURNAL Nature 393 (6680), 72-76 (1998) PUBMED 9590691 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CO427341.1, AK134656.1 and AV341177.1. On Oct 4, 2012 this sequence version replaced NM_001081493.1. Summary: This gene encodes preproprotein isoforms that are processed into multiple biologically active peptides. Expression of this gene is regulated by cocaine and other drugs, and is associated with feeding/appetite and stress response. Mice lacking the encoded protein are predisposed to obesity. Deficiency of the encoded protein in mice results in pancreatic islet dysfunction, impaired insulin secretion and glucose intolerance. Alternative splicing results in multiple transcript variants encoding different isoforms, which are subsequently processed into mature peptides. [provided by RefSeq, Jul 2015]. Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK134656.1, CJ172339.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMN00849381, SAMN01164131 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-26 CO427341.1 369-394 27-830 AK134656.1 2-805 831-836 AV341177.1 251-256 FEATURES Location/Qualifiers source 1..836 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="13" /map="13 52.9 cM" gene 1..836 /gene="Cartpt" /gene_synonym="Cart" /note="CART prepropeptide" /db_xref="GeneID:27220" /db_xref="MGI:MGI:1351330" exon 1..208 /gene="Cartpt" /gene_synonym="Cart" /inference="alignment:Splign:2.1.0" misc_feature 2..4 /gene="Cartpt" /gene_synonym="Cart" /note="upstream in-frame stop codon" CDS 50..400 /gene="Cartpt" /gene_synonym="Cart" /note="isoform 2 preproprotein is encoded by transcript variant 2; cocaine- and amphetamine-regulated transcript protein" /codon_start=1 /product="cocaine- and amphetamine-regulated transcript protein isoform 2 preproprotein" /protein_id="NP_001074962.1" /db_xref="CCDS:CCDS88509.1" /db_xref="GeneID:27220" /db_xref="MGI:MGI:1351330" /translation="
MESSRLRLLPLLGAALLLLLPLLGARAQEDAELQPRALDIYSAVDDASHEKELIEALQEVLKKLKSKRIPIYEKKYGQVPMCDAGEQCAVRKGARIGKLCDCPRGTSCNSFLLKCL"
sig_peptide 50..130 /gene="Cartpt" /gene_synonym="Cart" /inference="COORDINATES: ab initio prediction:SignalP:4.0" proprotein 131..397 /gene="Cartpt" /gene_synonym="Cart" /product="cocaine- and amphetamine-regulated transcript proprotein" misc_feature 191..397 /gene="Cartpt" /gene_synonym="Cart" /note="Cocaine and amphetamine regulated transcript protein (CART); Region: CART; pfam06373" /db_xref="CDD:428907" mat_peptide 254..397 /gene="Cartpt" /gene_synonym="Cart" /product="CART(42-89)" /note="CART I" mat_peptide 275..397 /gene="Cartpt" /gene_synonym="Cart" /product="CART(49-89)" /exception="alternative processing" /note="CART II" exon 209..292 /gene="Cartpt" /gene_synonym="Cart" /inference="alignment:Splign:2.1.0" exon 293..836 /gene="Cartpt" /gene_synonym="Cart" /inference="alignment:Splign:2.1.0" regulatory 810..815 /regulatory_class="polyA_signal_sequence" /gene="Cartpt" /gene_synonym="Cart" polyA_site 836 /gene="Cartpt" /gene_synonym="Cart" ORIGIN
ataagaagccggagagcgcagtgcccgagcagcgaggaggtccagaaccatggagagctcccgcctgcggctgctacccctcctgggcgccgccctgctgctactgctacctttgctgggtgcccgtgcccaggaggacgccgagctgcagccccgagccctggacatctactctgccgtggatgatgcgtcccacgagaaggagctgatcgaagcgttgcaagaagtcctgaagaagctcaagagtaaacgcattccgatctacgagaagaagtacggccaagtccccatgtgtgacgctggagagcagtgcgcagtgaggaaaggggccaggatcgggaagctgtgtgactgtccccgaggaacttcctgcaattctttcctcttgaagtgcttgtgaagggacgacagccgccaccttcggttcccatattccctctttcccccaaaggagcgctccattatccctggagcctggctttagcaacaataaagtttgcgttcccctcagagagcggatgggctctttccctgttgcttcaaaataaaagatttgacatcattgtgtgaaggagaatgcctcgaatggtgttggtgtgtgtgcaaagatttcttttcttgttttatccatctgacacattcttgtgaatctttctgggaagaagaggaacttcgttttaaaactgtatttttgtatgtggtgtgtcacaatgagaattagatctagttaatttgggtagatgacatcacaacccggaaaataaattgccctaaagccacacaaattgaagcatgtacaaattacacataataaagcatttttaacaattgctcac
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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