LOCUS       NM_001013616            3827 bp    mRNA    linear   ROD 17-SEP-2023
DEFINITION  Mus musculus tripartite motif-containing 6 (Trim6), mRNA.
ACCESSION   NM_001013616 XM_133616
VERSION     NM_001013616.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3827)
  AUTHORS   Liu X, Zhao J, Dong P, Du X, Lu W, Feng Y and Wang L.
  TITLE     TRIM6 silencing for inhibiting growth and angiogenesis of gliomas
            by regulating VEGFA
  JOURNAL   J Chem Neuroanat 132, 102291 (2023)
   PUBMED   37236551
  REMARK    GeneRIF: TRIM6 silencing for inhibiting growth and angiogenesis of
            gliomas by regulating VEGFA.
REFERENCE   2  (bases 1 to 3827)
  AUTHORS   Zhang Y, Dong P, Liu N, Yang JY, Wang HM and Geng Q.
  TITLE     TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5
            in Lung Cancer
  JOURNAL   Oxid Med Cell Longev 2023, 9808100 (2023)
   PUBMED   36654781
  REMARK    GeneRIF: TRIM6 Reduces Ferroptosis and Chemosensitivity by
            Targeting SLC1A5 in Lung Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3827)
  AUTHORS   van Tol S, Kalveram B, Ilinykh PA, Ronk A, Huang K,
            Aguilera-Aguirre L, Bharaj P, Hage A, Atkins C, Giraldo MI,
            Wakamiya M, Gonzalez-Orozco M, Warren AN, Bukreyev A, Freiberg AN
            and Rajsbaum R.
  TITLE     Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral
            transcription and assembly
  JOURNAL   PLoS Pathog 18 (5), e1010532 (2022)
   PUBMED   35533195
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3827)
  AUTHORS   Zeng G, Lian C, Yang P, Zheng M, Ren H and Wang H.
  TITLE     E3-ubiquitin ligase TRIM6 aggravates myocardial
            ischemia/reperfusion injury via promoting STAT1-dependent
            cardiomyocyte apoptosis
  JOURNAL   Aging (Albany NY) 11 (11), 3536-3550 (2019)
   PUBMED   31171760
  REMARK    GeneRIF: these results suggest that TRIM6 aggravates MI/R injury
            through promoting IKKepsilon/STAT1 activation-dependent
            cardiomyocyte apoptosis
REFERENCE   5  (bases 1 to 3827)
  AUTHORS   Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva
            A, Martinez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L,
            Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever
            BR and Garcia-Sastre A.
  TITLE     Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin
            ligase TRIM6 stimulates the interferon-IKKepsilon kinase-mediated
            antiviral response
  JOURNAL   Immunity 40 (6), 880-895 (2014)
   PUBMED   24882218
REFERENCE   6  (bases 1 to 3827)
  AUTHORS   Sato T, Okumura F, Ariga T and Hatakeyama S.
  TITLE     TRIM6 interacts with Myc and maintains the pluripotency of mouse
            embryonic stem cells
  JOURNAL   J Cell Sci 125 (Pt 6), 1544-1555 (2012)
   PUBMED   22328504
  REMARK    GeneRIF: TRIM6 regulates the transcriptional activity of Myc during
            the maintenance of cell pluripotency, suggesting that TRIM6
            functions as a novel regulator for Myc-mediated transcription in
            embryonic stem cells.
REFERENCE   7  (bases 1 to 3827)
  AUTHORS   Tareen SU, Sawyer SL, Malik HS and Emerman M.
  TITLE     An expanded clade of rodent Trim5 genes
  JOURNAL   Virology 385 (2), 473-483 (2009)
   PUBMED   19147168
REFERENCE   8  (bases 1 to 3827)
  AUTHORS   Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L,
            Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci
            S, Pelicci PG and Ballabio A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB634731.1, AK049238.1 and AC123830.5.
            
            On Dec 19, 2006 this sequence version replaced NM_001013616.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049238.1, AK033396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BB634731.1         1-21
            22-1902             AK049238.1         2-1882
            1903-3653           AC123830.5         35168-36918         c
            3654-3827           AK049238.1         3635-3808
FEATURES             Location/Qualifiers
     source          1..3827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.55 cM"
     gene            1..3827
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /note="tripartite motif-containing 6"
                     /db_xref="GeneID:94088"
                     /db_xref="MGI:MGI:2137352"
     exon            1..89
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    21..23
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /note="upstream in-frame stop codon"
     exon            90..563
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1607
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif protein 6; RING-type E3 ubiquitin
                     transferase TRIM6"
                     /codon_start=1
                     /product="tripartite motif-containing protein 6"
                     /protein_id="NP_001013637.1"
                     /db_xref="CCDS:CCDS40065.1"
                     /db_xref="GeneID:94088"
                     /db_xref="MGI:MGI:2137352"
                     /translation="

MTSTVLVDIRDEVTCPICLELLTEPLSIDCGHSFCQVCIIGNSNNSVFGQGGRSSCPVCRTSYQPGNLRPNRHLAAIVKRLREVALCPGKQLEVIFCALHGEKLQLFCKEDGKLICWLCERSQEHRGHHTFLMEEVAQEYQDMFQESLKKLRREQQEAEKLKALIQEKRESWKSQVEPEKRRIQTEFKQLRSILDREEQRELKKLEVEERKGLSIIEKAEGDLIHQSQSLKDLISDLEHRCQGSTVELLQDVGDVTKRSEFWTLRKPQALPTKLKSLFRAPDLRKMLKVFRELTDVQSYWVDVTLNPQTANLNLVLSKNRRQVRFVGAQLSEPSSLEEHYDCSVLGSQHFSSGKYYWEVDVSKKTAWILGVCSTPVDPMFSFSQYSSKQGAYSRYQPQCGYWVIGLQCKHEYRAYEDSSPSLLLSMTVPPRRIGIFLDCEAGTVSFYNVTNHGLPIYTFSKYYFPSALCPYFNPCSCIVPMTLRRPTS"

     misc_feature    159..377
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; Region: RING-HC_TRIM5-like_C-IV;
                     cd16591"
                     /db_xref="CDD:438253"
     misc_feature    order(186..191,195..200,309..314,318..320)
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438253"
     misc_feature    429..542
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; Region: Bbox2_TRIM5-like;
                     cd19761"
                     /db_xref="CDD:380819"
     misc_feature    <576..>854
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /note="DNA double-strand break repair ATPase Rad50;
                     Region: PRK03918"
                     /db_xref="CDD:235175"
     misc_feature    1035..1598
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     6 (TRIM6), also known as RING finger protein 89 (RNF89);
                     Region: SPRY_PRY_TRIM6; cd15823"
                     /db_xref="CDD:293995"
     exon            564..659
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     exon            660..890
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     exon            891..913
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1014
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1041
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..3827
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3805..3810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /note="putative"
     polyA_site      3827
                     /gene="Trim6"
                     /gene_synonym="C430046K18Rik; D7Ertd684e"
                     /note="putative"
ORIGIN      

tttttcctggagtccggctttagtactggaaggagccgtctccttggctgcaagtcctcggcactgatccaggcacggattccagattggattctttttctaagcaagctgggaaggtaggagacgagagagtggctacaatgacttcaacagtcttggtggacatccgagatgaagtaacctgccctatctgcttggagctcctgacagaacccctgagcattgattgtggccatagcttctgccaggtctgcatcataggaaacagtaataattcagtgttcggccaaggagggaggagcagctgtcctgtgtgccggacctcctatcagcctgggaacctccgtcctaatcggcacctggccgccatagtgaagaggctcagagaggttgcgttgtgccctggaaaacaactcgaggtcattttttgtgcgcttcatggagagaaactccagctcttttgcaaggaggatgggaagttaatttgctggctttgtgaacgatctcaggagcaccgtggtcatcacacattcctcatggaggaggtggcccaggagtaccaggacatgttccaggagtctctgaagaaattgaggagggagcagcaggaagccgagaagctaaaagctcttatccaggagaagagggaatcctggaagagtcaggtggagcctgagaaacgccggatccagacagagtttaagcagctccgaagcatcctggacagggaggagcagcgggaactgaagaaactggaagtggaagagaggaaggggctgagcatcatagaaaaggccgagggtgacctgatccaccagagccagtcactgaaggacctcatctcagacctggagcaccggtgccaggggtccaccgtagaactgctgcaggatgtgggtgatgttacaaaaaggagtgagttctggaccctgaggaagccccaagctctccccaccaagctgaaaagtttgtttcgagcaccggatctgaggaagatgctaaaagtctttagagagctgacagatgtccaaagctattgggtggacgtgacactgaatccacagacggctaatttaaatcttgtcctgtcgaaaaatcggagacaggtgaggtttgtgggtgcccagctgtccgagccatccagtctggaagaacattatgactgtagtgtcctgggctctcagcacttctcctcaggaaaatactactgggaagtggacgtgagcaagaagacggcatggatcttgggtgtatgcagtaccccggtggatcccatgttctctttcagccagtactccagcaagcagggcgcctactccaggtatcagccacagtgtggatactgggtgattggcttgcagtgtaagcacgagtacagagcctatgaggattcctccccgtccctgctcctctccatgaccgtgccacctcgacgcatagggattttcttagactgtgaggctggcacggtctccttttataatgtcacaaaccacggcttgcccatctacaccttctcgaagtattactttccttctgccctttgtccctattttaatccctgcagctgtatagtcccgatgaccctgcggcggccaacttcctgaggtctgttacccctgcccacaactaagcagattccttcaaacacatgaatctccattctctgttctcctagtaggataccttccattgctaagagtgcgcacccttaagccatctcatggaaaagcatttagtgttttggggtttttgtatttttgcttttgggttgtttatttttgttttttgttttttatttttagagatagggtttctggaactctgtaggtcaaactggccttaaacttggagagatccgcttgcctctcctgagtgctgggacaccagtctagttgtgttttggttttgggttttttgtttgtttgtttgttttttgtttgtttgtatttttgaaacaggctggccttgaactctgtgattgagaaactaactgagaactgatccagagtcccgattacaagtggacatcaccatacctggctgtgaatttgttttagtgttgtttgagatagggtctccataaatagcccaaactggccacagactcagtccatttgcctcactcccaaatactgattatagatctacctcacagtgcctgactgagctcccaaatactgattatagctctacctcacagcacctgactgagctcccaaatactgattatagatctacctcacagtgcctgactgagctcccaaatactgattatagatctacctcacagcgcctgactgagctctcaaatactgattatagctctacctcacagcgcctgactgagcacatttgacgacttttttctttactaatgtctgtggtcaaatgtaaagaacctctgaattagataggaattttttaataaatattgaattcagtaattttttttctctagttactgagatacttgtgtatcctttctattctgctcctgggtcagcctcactgagttgtctcagttgttacgtttaccactgattcctgaagcaaaactgtcatgtgttacattcagcactttatgtttgctgactctaggtttggtttttgtctctttataaacaaactacctctaagtttgcattctttgttatctgtcaaggcatatcagaaagaaattatggggaagggcttatgtatgtgtatttaggatcacaataaatcctaagtatgtatatttaggattacagtaaaaataataaaatctttggatggtttcaagaagagattgtagctttggttttaacaataaatgctaccacaaccttcagccttcagcataaaattttaagagtggtaataaaaactagaaaatgctcttgaaagggagataaagtaagataaggagaagacttcaatcaaccagtatcagttattatttaggaggaggaagaaattcagttacccattctcacagtgagttattctggtccccccagcccctcttatttcttctgtagagctaggtactgaactcggctttttacttcaagcagagacattttagcaccaagcttaaccccatttttgtgttttgtattgttattattggggtttgtttgtttgtttgttttgttttgctgacacagggttttaacacatttcccaggctggccttgagcttgctatcaagtgcaggctgactttaagctttgcctcagcatcctgagtaactaggtgtttagggtaatactgacttttcatcttagcctggaccttctctttgtgctcatattcaaattgcaaatgagtgaaccgctttggctttgctggaaaggtgcaacaaactttcatattcaactgtgaaaaaagttatagctgtgaagatggaaatgagtgtcgggggaggtgcagctggacttctgacactgcagacaagggctactcgtggcttttggtactctccaatgtactgtaacagtgaaatactgaatttccataaaagcaatgtaaaataatctattatcttacaatgatggtattttggatatattttaaataaaatgttttatttcaggatggagtcttcttactctgtagcccaggctcgccatcaaattgtagtggtagcttcctgccttagcctttcaactgctggggttaaggcataagccaccacaggcagttttccctgtatgttttaaatgtgggtactaggaaattttcagttatacattaactggcttctgttacacttctactgtcaagatgaactttctattcttgggggaaccctagaataataaagacttggccagagaacc

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