LOCUS       XM_012439801           12568 bp    mRNA    linear   PRI 10-APR-2024
DEFINITION  PREDICTED: Aotus nancymaae argonaute RISC component 1 (AGO1),
            transcript variant X3, mRNA.
ACCESSION   XM_012439801
VERSION     XM_012439801.2
DBLINK      BioProject: PRJNA1095488
KEYWORDS    RefSeq.
SOURCE      Aotus nancymaae (Ma's night monkey)
  ORGANISM  Aotus nancymaae
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Platyrrhini; Aotidae; Aotus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_026988467) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 10, 2024 this sequence version replaced XM_012439801.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030222135.1-RS_2024_04
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 04/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12568
                     /organism="Aotus nancymaae"
                     /mol_type="mRNA"
                     /isolate="86718"
                     /db_xref="taxon:37293"
                     /chromosome="Unknown"
                     /sex="female"
                     /tissue_type="blood"
     gene            1..12568
                     /gene="AGO1"
                     /note="argonaute RISC component 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 4
                     Proteins"
                     /db_xref="GeneID:105708420"
     CDS             145..2310
                     /gene="AGO1"
                     /codon_start=1
                     /product="protein argonaute-1 isoform X3"
                     /protein_id="XP_012295224.1"
                     /db_xref="GeneID:105708420"
                     /translation="

MLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRVSRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA"

     misc_feature    247..399
                     /gene="AGO1"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    400..762
                     /gene="AGO1"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(556..558,601..603,643..645,655..657,709..711,
                     730..732,736..738)
                     /gene="AGO1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    895..2181
                     /gene="AGO1"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1315..1317,1327..1329,1363..1374,1381..1383,
                     1405..1407,1414..1416,1426..1428,1438..1440)
                     /gene="AGO1"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1519..1521,1525..1527,1735..1737,2149..2151)
                     /gene="AGO1"
                     /note="active site"
                     /db_xref="CDD:240015"
     polyA_site      12568
                     /gene="AGO1"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

cgtgtaccactacgaggtggacatcaagccggataagtgtccccgtagagtcaaccggtcgactttgaggtgacaatccctggggaagggaaggatcgaatctttaaggtctccatcaaatggctagccattgtgagctggcgaatgctgcatgaagccctggtcagtggccagatccctgttcccttggagtctgtgcaagccctggatgtggccatgaggcacctggcatccatgaggtacacccctgtgggccgctccttcttctcaccgcctgagggctactaccacccgctggggggtgggcgcgaggtctggttcggctttcaccagtctgtgcgccctgccatgtggaagatgatgctcaacattgatgtctcagccactgccttctataaggcacagccagtgattgagttcatgtgtgaggtgctggacatcaggaacatagatgagcagcccaagcccctcacggactctcagcgcgttcgcttcaccaaggagatcaagggcctgaaggtggaagtgacccactgtggacagatgaagaggaaataccgcgtgtgtaatgttacccgtcgccctgctagccatcagacattccccttacagctggagagtggacagactgtggagtgcacagtggcacagtatttcaagcagaaatataacctgcagctcaagtatccccatctgccctgcctacaagttggccaggaacaaaagcatacctaccttcccctagaggtctgtaacattgtggctgggcagcgctgcattaaaaagctgactgacaaccagacctcgaccatgataaaggccacagctagatccgctccagacagacaggaggagatcagtcgcctgatgaagaatgccagctacaacttagatccctacatccaggaatttgggatcaaagtgaaggatgacatgacggaggtgacggggcgagtgctgccggcgcccatcttgcagtacggcggccgggtgagcaggaaccgggccattgccacacccaatcagggtgtctgggacatgcgggggaaacagttctacaatgggattgagatcaaagtctgggccatcgcctgcttcgcaccccaaaaacagtgtcgagaagaggtgctcaagaacttcacagaccagctgcggaagatttccaaggatgcggggatgcctatccagggtcagccttgtttctgcaaatatgcacagggggcagacagcgtggagcctatgttccggcatctcaagaacacctactcagggctgcagctcattatcgtcatcctgccaggaaagacgccagtgtatgctgaggtgaaacgtgttggagatacgctcttgggaatggctacccagtgtgtgcaggtgaagaacgtggtcaagacctcacctcagactttgtccaacctctgcctcaagatcaatgtcaaacttggtggcattaacaacatcttagtcccacaccagcgctctgccgtttttcaacagccagtgatattcctgggagcagatgttacacaccccccagcaggggatgggaaaaagccttctattacagcagtggtaggcagtatggatgcccaccccagccgatactgtgctactgtgcgggtgcagcgaccacggcaagagattattgaagacttgtcctacatggtgcgtgagctcctcatccaattctacaagtccacccgcttcaagcctacccgcatcatcttctaccgggatggggtccctgaaggccagctaccccagatcctccactatgagctactggccattcgtgatgcctgcatcaaactggaaaaggactatcagcctgggatcacttatattgtggtgcagaaacgccatcacacccgccttttttgcgctgataagaatgagcgaatcgggaagagtggtaacatcccagctgggaccacagtggacaccaacatcacccacccatttgagtttgacttctatctgtgcagccacgcaggcatccagggcaccagccgaccatcccattactatgtcctttgggatgacaaccgtttcacagcagatgagctccagatcctgacgtaccagctgtgccacacttatgtacgatgcacacgctctgtctctatcccagcacctgcctactatgcccgcctggtggctttccgggcacgataccacctggtggacaaggagcatgacagtggagaggggagccacatatcggggcagagcaatgggcgggacccccaggctctggccaaagccgtgcaggttcaccaggatactctgcgcaccatgtacttcgcttgaaggcagaacgctgttacctcactggatagaagaaagctttccaagccccaggaactgtgccacccaaatccagaggaagcaaggaggagggaggtggggtagggaagagtgtaggaggccttgtttccctctatagaggtggtataagagtggggaacagggccagcaagacagaccaccagccagaaatctctgatatcaacctcatgtcccccacccctcaccccatcttgtcacatctggccctgaccccactggaccaaaaggggcagcactggtgcccaccatacacacaggtgtctcatgtgactcacagtgctaaagactcatgcttgacagcttggtaaggtcgactctgtagccctgcagacaaaagctggttaggtttgggtttgatactttagatgggaaagtgaggggcttgataaagtgggtgggaggagggaaggattttttaggagccttaatcagaaaaggactagatttgtttaagaagaaaaatgaaaccagacccagatcaatattttaggatactagatgttttaatgggttcagaatccagtttgtaggaggattttttaatggttttggttgctcctcccccagctgccaccccctttccccttattcctttctgtccacgttttctaccccaccttacttctcctccctgacagacatccagcccctaataatacttaaggcactatggcacttagctttgaagtgacacgaccctgtcttccttccgcccgctggtgggtaaccagtgccttccctgtaacggtaatgctgcagaactgcaaccttttgtacctttctttggggaatggggtgggggtgggagaggaggtagatggggaagaaataccccagacccaacaaacctccagccagaaagccagctattttgcatttgaaggaactgacttcctcattcattgagctttttaaaagatcacaacctcaagatggttaaaatccattgacatttgcactttcaaacatgacaagtctcggagctgctgagatgactggcccctggcctttccacttatgcctccttttctccttgttcctcctacctcccaccccgcccaggtctggagttactttcatagcatttttcactgttggctttttttctcccctgatggtcaagtctcttatgtttcaatatttcttaactggggtgtcttataacaaaaaactcttaggtctaaaatgagaaaaaagagagaaaacaaaatgttatttttataccataacttgagtctattgccaaaatttggaaatccttcccatgcctgatgaatttatatcccggaaacattgagccatcagaaggaactgtgtacctgatttgttctctgacctggctaggtagggggtggttattgccccaggatggggtccaggctccattcttcctttgtgcagataataccttttcttgctatagcctccctcctctgcactgtcctgcactcttacttgcaagtgcatctttttccttcctctggactgtcctctgaccttttggcccatcctagattccagtgtgtcttgtggacaggctggggaattttgctgctccctattgcttctgtttacacaaatgaatttttcctggtttcccactagggcatgtgagtgggtggcatgggctttttttttttttgtcttgagacatggggtttggctgtcttgcaggactggagaagaaggtggttctagcttggtctctgctggccttgaagcaagccccctctccccacctttttccttgactgttcattttttttcctgccccactgcttgggatggggagttgcaccttcagtgtggaatttcctctttttgaggagcctgggcttggatctatcttgatctggtgatgaagccatgattactttagacctagcccaggcttggaggccagctggaggaagcaggatctaaatcctggcctatagagttagaactaccgtttcctctcctcagcggcccttctatgacccagatttgctatgcaaaacaatctatcccaggttctgttctggttggctacattgttcagcaactcaaaaaacgtagcacaaacattcattatggagaaagcatcaggactgttgagtaactcctcctttacttttttcctgctggctacagcacggggtgccctatgggcacaagcccagctgaagaacagaatggagggctctgggaggagacaactcactggagagcctacattccttacacaagtgcctaaagagagtgatgctaacactccatctgccctgtccattgccttcatatacagtctacttcatgttctgtcaccctttgaagaggggagctctcctgggacaatgggctctgcatgttctctacttgggtacattttggggctaggatcagggcactgttcctggagggtccagtcattcaccagcatttgcaaatgtccacagggagcaggtagcagcctctactcccagcaacaagtttgtgttctctccttttctctctttgcctcactctctccagttggttttcagctggggcttgaaatgcatttttagccctttggcattgaatatgccattcaagaaataaaaagcaagagaagcagctttgggcaatgacaagaaaacgacttcttactctgatttttaaaaaattttttgagacttgaaaagtacccctaaccttgaggattattcttgtttgaaaggtggtgcatgcagatggagaagtggtgttggcagcaagctttggattgtggatttggtttaagtggtgcttacccagtcttcaaggaagtgcttgggggacccccagcctcatcctcttagacaagtgtcttgctccctttgtaccttcctcccttttccttgtctctctttccctgactttctttccctttttgctattcactctgcttgcttgctggctggcctgcctgcctgcctgcctgcctgcctgcctacctatgtgatgatgaaatctctgcatggctgccatgactccactgttagctggcaaggtcaggcttagctccttgactgcacaagaccaagactctgttccccaagcccagagatatccacctgggctggactgccctcaagcttatgctagagcagagcaactggcctgcccaacttgtgtgaaatcaggaggttctggcattttccacacctgtccactccctggagctgatttctctcattgctttttctagatctggttctttttctctacctgagcctaccttttctgagattgtcttagggttgagctagttgggtatcctgggtttgagttttaggggatggacataagggaaaaagagaatgatgagaagagaatggagagaatttgaataaaaggtgggaaaggagagcactgttctttgactgtttatccactccagcctgatccattagggattgaggtgctactgcaggcctccaggaataagcctggggctattgttgctgggaacttaggcttagcacaaagctgaagaaaaaggtacctagaagtttgaaacttgcctaaaaagctcctaatgcccatctgctagatagcttctctgtggcctcctatttagctaagcagcaatgttcttggatacttttctttttctgttcagaattttgtgaataaggccagcactcaagacgggcagccaatggcatactgactgttagcaggcccataggatacctgtacggctggtgggacagtttcggacctggaatcatgtgtaacaaacaaggatggatgtttgttccccttcagggtagaaaagtcatctcaaactagccaaaaggcagttttggaaactgcatcgggggaagttatttttatttatatatggggcctaggccaatccaggatggtagctggaataccttccttcttaaaatctgatcatggcagggatatgtagggcactttttactatttggccttctaagcagattgggaaggaggtattttctggttttctctttcccctgacttacaggtcttgccttctccctgggcagggagagaggctgggttggtgctctccccttactctactcaaccgtctggctgctgtttgggcgtccaagaaagggaggggaaggaatgagctaaaaacaaaatagaatgaggtgggaaagggagatttccttctctacagaggaaaataggaaaccctccaagaattgtgcaagtaaagacagtttgtcgaatgcactgagtcccttggtgtagtagcaataaggaaaaatgaaattactttcctgtgcacacagtccagcctgattggtatgtgatgttgcacttagcagccatgtggtgggcatgtgtgacgactatgggtttcactttagtttctaaactttttatccctctcaagtccagcatggatggggaaatgtctctggatccccacagctgtgtacttgtttgcatttgtttccctttgagactgtgtttgtgtcctgctttgagctgtaccttgtccagtccattgtgaaattatcccagcagctgtaatgtacagttccttctgaagcaagcaacagcagcagcagcagcacaattctgtgttttataaagacaacagtggcttctatttctaaagtgcggtctttctcttttttttcctaccagcaaaacaaacttttgggactgattacatctctgataggttttaggtgagaataatactgtagactgttatgcaggaatacttcacagagcctttattcttcattcaacaaacatgcaaagcactgtgccagcagtattatggggagggcaggcacaattcaaaataaggaaaatagtgtctgtctcattaagggaattaagtttggtaggagatatgattagccaaatagtctcctgacatagaataaagaaaatgagggactggaatcaggctacagcaactaatacagagaggaagggacagatttgagagacaggagacagaattaataggactcgatggctggtgggagtgagaagacaggagtagaggttagctcccaggtttctccttgagcataggggtgtgttgggacattctgctagtcaagatggagatggcagggggagactatagaatgaaggtggggagttttttgaagaaagaacgtatagactgggttttgaggtttttgtgggcaataagggtaaggtttccaataaacaggttggtgctcaggtaagactgtaaaactgcagttatagatatgggagtcatatagatggtagttaaagccataggcatgaacgaggtagcttttaaaaagagaagagaaacatagtatacaacctcctaagaaactcaatttaaaggatgtggtgaggaagcatatctttaggtgacagatcactggtaggcagcttgtgggttttttgtttctttgtttaaccagtttattgaggtaggagaagaaatcagagtagaagaaggtgcatgaagggagtgattaacaacatgaactgcttcagagagggacttcttttttgactatgtgttttaccttcctactccctatctttttgggatcttataactatgacttacttaggttattctccagtatttctagaaaatgagcattggaaaaacccaattttaaaaaggctaagactaggactttcaagttcaccacaactaccaccatttaggagataactgtaaaagaataaacaaaatctaattttgttcttagccaatattataaaccatgctccagtatactagataacacttagtagcatactgtatttatttccataacttgtcttctttagagcctgtgcacgcctaggagcagaagctatattctcttcatttttgtcatctcagggtcatggcatataccaacggatcagtatttgtgaatagaattgaaatagcctagtagtctgtggtttatgagtataggctgggtgggcagtggatcaagaagtggtaatgaatatacaggatgaactcagcattcctgaattttcaggtaagcggatacttaatcagattatcattgttttttcccactcacaccaagttggaggttctatggttttatactttaagctgctggtataattgtcaagcatgtaaattctggcattcttcctagtacggctagagcattgttatttctgtgcacgggggtaagaaggctcagagaaagattctggcagaggacccagtgagaaatcatcagtagcagccactgtgtacatagatggacctagcattcatctggaggcccagtgttgtgaattggcctgtggctatcacctggcagattcccttgggaaagagccagccagccccatgcttcttttcagcagcaagggttagggaggttggttgaacttgaagaacagattggacatggagcagattttgcccagttgaaataagatataaatttatgaccctgagtgaagcagaaataaagtacttagcagggggaatgagaggatgatgattatggcagattttgctataaactttagttttagaaaagattgatattgaaaagccttcaggatttgcctgctggttgctactcaagataaaaagactgggagcccagggcctgcattgtctggtcctagagcacaaggttttcagtgaaggcttgtcctagcacttctgggccttccttttcggtattggttgagtacccttccttctgctctgtcagttggcaaaatatgctggagcacattctgaacctgcaggtgccttgggtatttgttgggtatctcttggcttagcagaccccagaatctcatggcaattaggatttggtggctaaaagaaagaattatagtgcaaagaaaagacttgttggaagttctgagtctgggcagtctttaagctgctatctactgcttgaatgggaagtaatgttgaactggaaaatttgctcaccttttttgttactagctttgcagacatttattcttctgattataggctgagaaatgcctaggcaggcttagaaggcacacagagcatgacagaagtactccttcaaagcagctgtgtcaagaaggaaggctggaaaagtggatttgctggggaattaggtgcatttagaagttttccacttatgcacaactgccttccccagcatatcatatcaaggttttttaggcctttgtggcttaccctacaggaacatactgtcctcttgttctggactgtaccaccttcaccaaaatcctcttggcaatagttttttttatttgggtttttttttgacaaagtataataacattgagagatctttctagggagcctttggtccctcgtccccgttttccaaaggcagggaactttaatcttaaaagagagggtgggaacttttagccaggtttttggaaaaggcccgtcagctattaatgagagtgagctgcaaaaggaggaagagtttgtttgggtactttggagtacttagctaggtgttttgtacagtatcttatataattgcatattatggcatcttacagcatctttacatgtgaaatagttcatcaattatcttcaattgcatattataaaattccgattaaatttttcttaaataagaagactatcatttcacatgacaagaaatcctaatttattatgactccaaggttgactaattcagtggctcagtgataacagcaaagaatcagtttcttgaaatctttttactctgccatcctccatattgtttatcctcacactagttcaactcatggtcccaatatggctactgtaatcccaggaaggaaatactgacagaacaatgtctagtgaaagagagacaattttttccgtgtccttctaaagcaaggaagtctttccctgaaagctccagcagatccagcctcgtggctttgctagaaatgggtcatctcactcctgtcattggcaaagcaagtatcatccgtcatgagtggcttagattaatgagttatccttttgagtcaggtagactagaaagttcagtcgtgtctactagcaagaaaggagataaaggctattggataggcagcatctactctcaaaggtactttgacttttacagttgagaaacatgaatctgagtgactttcccaggctcacagcaagtaagagagagccttccgtgttagctgtgtctgtccctaaagcccatgttttatattgtatcttgctagagtatagagtaacttactttctaccttgtagaaactgatggtctaggaaaagagatttgaactcaggggccatgttgactctaatcttggcccatgtgagcagattctatccagttgctctcatccagtgatgtttcttgtctaacacaagaagcctaggagtagaaagccctaagtggagtagaataacagtggtagtagggaggaagacgtatactgtgtgtccctgagcctgacttactgggcagggacttaccagcgcttaaagtgagcaactggccaccctgtctttcctgcatgcactgagtatttggtagctcattatgcctttccttagtgatcagtgatactcatcaccttttcatatgcttatttactatccccatatcctttgtaagttgttcacatcttttacccattttatttgttgttgtttttgagacagttgtctcactgtcactggagtacagtggcacgatcacggctcactgcagtttctgcctcttgggctcaaccaatcctcccacctcagcgtcctgagtagctggacttacaggcacacaccaccatgcccagctaattaaaaaaaaaaatttttttttttgtagtggttgggtctcattaactattgcccaggctggtctctctcagcctcaagctatcctctcaccttggccccttaaagtgctggaattacaggtacaagccactgggcccagcctcttttacctgttttaaaattgagttttattgagttgtaagagttctttattaattttagatacaggtcttatgttagatatatgttttacatctatttttcccagtctgtgtcttgccttttcattttgaagagcgaaagtttaaaattttgctaatttattaaagctccatttgttgcttcatttctagtttatgcttttgtatcacattttaggaaattttgcactgggtatttggtggctcctgaggaggctcgactttcagagggtactgatttctgtgcacctgagattttgtactatttccatttctttttgtttttcccccaagacagagtcttgctctgtcgcccagtctggagtgcagtggagggatctcagctcactgcaatctccacctcccgagttcaagcgattttcctgcctcagcctcctgagtagctgagattacaggcatgcgccaccactcctggctaatttttatattattagtagagacggagttttaccatgttggccaggttggtctccaagtcctgaccttgtgatccacccgccttggcctcccagaatgctgggattacaggtgtgagccaccgtacctggccatatttctgtatttctttcttctgagaacaaccagtgttaccagggatgaaggcagagtgttagcttgttttctgagccccattcttgaagcccatttattcattcatctgtccaccaatccaacaaatatactaaatgttgctatgtgccaggcactgacactgttctgggtactggggcaatggcagttaagataatacccaatgaccctgctctgtacccttaagagcagactcagttgggaatgaattttccaaaaataggatgtacatgtagtcaggagagagcctcatacagctttgcctttggcagaatccttcaaacctttgtcttcccacttcttgatattacaattcatgagcctttcacatgcgttcactgtaaagatgtgggttcctggatagcagaagtagataggaaggcattgttgacatttactgaggtggattgaatcagagggtataaattctgctccgttaatgtcgagcccacctcaagggttcatcactgtcaccatgtctaatgtctattctggaagaaggtgaagaagcctgcctttgtttagggaaccagttccagaattgggggttgaggatataaaagacccttgcacaagagttggtatttaccctgtcagatgctgctaccaagatttggattgtgtatagtcgaggattaaaaatgacttttaagatgca

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