LOCUS       NM_001100275            1739 bp    mRNA    linear   VRT 22-DEC-2019
DEFINITION  Xenopus tropicalis SIX homeobox 2 (six2), mRNA.
ACCESSION   NM_001100275
VERSION     NM_001100275.1
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
REFERENCE   1  (bases 1 to 1739)
  AUTHORS   Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW and
            Richardson P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev. Dyn. 225 (4), 384-391 (2002)
   PUBMED   12454917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC135532.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC135532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00028293, SAMD00028296
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1739
                     /organism="Xenopus tropicalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8364"
                     /chromosome="5"
                     /map="5"
     gene            1..1739
                     /gene="six2"
                     /note="SIX homeobox 2"
                     /db_xref="GeneID:100101784"
                     /db_xref="Xenbase:XB-GENE-481504"
     misc_feature    115..117
                     /gene="six2"
                     /note="upstream in-frame stop codon"
     CDS             256..1125
                     /gene="six2"
                     /note="sine oculis homeobox homolog 2"
                     /codon_start=1
                     /product="homeobox protein SIX2"
                     /protein_id="NP_001093745.1"
                     /db_xref="GeneID:100101784"
                     /db_xref="Xenbase:XB-GENE-481504"
                     /translation="

MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKILEGHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERYEENNENSNSNSHNPLSTSMNGGKTVLGSSDDDKTPSGTPDHTSSSPALLLSGNPGLQALHGMSHPQGPSAIPVSAADPMHHHTLQDSILNPMSSNLVDLGS"

     misc_feature    280..609
                     /gene="six2"
                     /note="Transcriptional regulator, SIX1, N-terminal SD
                     domain; Region: SIX1_SD; pfam16878"
                     /db_xref="CDD:465293"
     misc_feature    640..795
                     /gene="six2"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(643..645,763..765,772..777,784..786)
                     /gene="six2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
ORIGIN      

gacttttactggcctattatccgccgcaccgctgcgaagtccctgcggcgcccacaagagaagtcggcggagcggagtcgagcaggaacggcgcggagggcaaaagcgaaactttaacgtcggagaaaagtttctgcgaaaaggagaaagtttccccggtcccatggcttgtggattggtctgagggggcagattccttcggaactggatgattatagctgtaggggggagcagcagggggccccagccaggatcatgtcgatgcttccgacttttggcttcacccaggagcaagtggcgtgtgtgtgcgaggtgctccagcagggcggcaatatagagaggctggggcgcttcctctggtccctgccggcctgcgagcacctccataagaacgaaagtgtgctgaaggccaaggccgtggtggcgttccacaggggcaatttcagggagctgtataagattctggaggggcaccagttctccccgcacaatcaccccaagttgcagcagttgtggctgaaggcgcattacattgaggcggagaagctccgggggcgccccctgggggcagtgggcaagtacagggtacgcagaaagttccccttaccccggtccatttgggacggggaagagaccagttactgcttcaaggagaagagccggagcgtactgagagaatggtatgcccacaacccctacccctcgcccagggaaaagagggaattggccgaggccaccggactcaccacgactcaggtcagcaactggttcaaaaacaggaggcagagggacagagcggccgaggccaaggaaaggtacgaggaaaataatgaaaactccaactccaacagccacaacccattgtccacttcgatgaatggagggaaaacagttcttgggagctcagatgatgacaaaactccatcgggaacgccagaccacacttcgtccagcccggccttactcctcagtgggaaccccggcctgcaggctcttcatgggatgagccacccccaaggacctagcgccatcccagtgtcagcagcggaccccatgcaccaccacacactgcaggactcaatcctcaaccccatgtcatccaacttggtagaccttggctcttaaaacttcatcctcaggaactcactggccaccccaagtaatactggctagcctggatactgagccaacctctctgtggatggaactgcttatggtactatgtgccccagacaggtctacatgggcaatcagatcgatggatctaaccattatcccaaatgcttgttatcgcttttaacagcaacctgctacaaagtcgcttctccaggaaagtcgctggtgatgttggcaccaggcaggatggagtgaaaccgaaggggcttatgtgcccaaagagataagtcgctcatatgcacaaagtgtattctgcatttacagagccacatagtcagagtatacccacaaggatatgtaggcaggcaatgttatttatcgatactatccatggacaagcccaatccaatagcactttcagcaacactcaagcaccagagttgaaggacccccccaattccctatactattatacattttatccaaatttgcattcagcaggtcaagctgccctttttcctttttatttttcctttttattatgtgaataaactacatggaaatatccctgcttctattttataataaaacaggaatcatacagtcaaaaaaaaaaaaaaaaa

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