2024-11-01 08:02:56, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_133514 1714 bp mRNA linear ROD 29-MAR-2024 DEFINITION Rattus norvegicus matrix metallopeptidase 10 (Mmp10), mRNA. ACCESSION NM_133514 VERSION NM_133514.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1714) AUTHORS Faraj Shaglouf,L.H., Ranjpour,M., Wajid,S. and Jain,S.K. TITLE Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression JOURNAL Protoplasma 257 (1), 157-167 (2020) PUBMED 31428857 REMARK GeneRIF: Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression. REFERENCE 2 (bases 1 to 1714) AUTHORS Takamura,Y., Matsumoto,T., Tomomatsu,T., Matsumura,T., Takihara,Y. and Inatani,M. TITLE Aldose reductase inhibitor counteracts the enhanced expression of matrix metalloproteinase-10 and improves corneal wound healing in galactose-fed rats JOURNAL Mol Vis 19, 2477-2486 (2013) PUBMED 24339723 REMARK GeneRIF: MMP-10 modulates corneal epithelial wound healing. Publication Status: Online-Only REFERENCE 3 (bases 1 to 1714) AUTHORS Thibert,K.A., Raymond,G.V., Nascene,D.R., Miller,W.P., Tolar,J., Orchard,P.J. and Lund,T.C. TITLE Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction JOURNAL PLoS One 7 (11), e50430 (2012) PUBMED 23185624 REFERENCE 4 (bases 1 to 1714) AUTHORS Friese,R.S., Rao,F., Khandrika,S., Thomas,B., Ziegler,M.G., Schmid-Schonbein,G.W. and O'Connor,D.T. TITLE Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease JOURNAL Clin Exp Hypertens 31 (7), 521-533 (2009) PUBMED 19886850 REFERENCE 5 (bases 1 to 1714) AUTHORS Nishino,K., Yamanouchi,K., Naito,K. and Tojo,H. TITLE Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry JOURNAL Dev Growth Differ 44 (1), 35-43 (2002) PUBMED 11869290 REFERENCE 6 (bases 1 to 1714) AUTHORS Saghizadeh,M., Brown,D.J., Castellon,R., Chwa,M., Huang,G.H., Ljubimova,J.Y., Rosenberg,S., Spirin,K.S., Stolitenko,R.B., Adachi,W., Kinoshita,S., Murphy,G., Windsor,L.J., Kenney,M.C. and Ljubimov,A.V. TITLE Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations JOURNAL Am J Pathol 158 (2), 723-734 (2001) PUBMED 11159210 REFERENCE 7 (bases 1 to 1714) AUTHORS Chan,J.C., Scanlon,M., Zhang,H.Z., Jia,L.B., Yu,D.H., Hung,M.C., French,M. and Eastman,E.M. TITLE Molecular cloning and characterization of v-mos-activated transformation-associated proteins JOURNAL J Biol Chem 267 (2), 1099-1103 (1992) PUBMED 1370458 REFERENCE 8 (bases 1 to 1714) AUTHORS De Vouge,M.W. and Mukherjee,B.B. TITLE Transformation of normal rat kidney cells by v-K-ras enhances expression of transin 2 and an S-100-related calcium-binding protein JOURNAL Oncogene 7 (1), 109-119 (1992) PUBMED 1741158 REFERENCE 9 (bases 1 to 1714) AUTHORS Breathnach,R., Matrisian,L.M., Gesnel,M.C., Staub,A. and Leroy,P. TITLE Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene JOURNAL Nucleic Acids Res 15 (3), 1139-1151 (1987) PUBMED 3547333 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAXUCZ010000008.1. On Nov 24, 2020 this sequence version replaced NM_133514.1. ##Evidence-Data-START## Transcript exon combination :: X05083.1, M65253.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA5760476, SAMN06621351 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-139 JAXUCZ010000008.1 12974707-12974845 140-384 JAXUCZ010000008.1 12975482-12975726 385-533 JAXUCZ010000008.1 12975818-12975966 534-659 JAXUCZ010000008.1 12976407-12976532 660-824 JAXUCZ010000008.1 12977667-12977831 825-966 JAXUCZ010000008.1 12978377-12978518 967-1100 JAXUCZ010000008.1 12979318-12979451 1101-1260 JAXUCZ010000008.1 12980124-12980283 1261-1364 JAXUCZ010000008.1 12980956-12981059 1365-1714 JAXUCZ010000008.1 12982264-12982613 FEATURES Location/Qualifiers source 1..1714 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="8" /map="8q11" gene 1..1714 /gene="Mmp10" /gene_synonym="SL-2" /note="matrix metallopeptidase 10" /db_xref="GeneID:117061" /db_xref="RGD:620192" exon 1..139 /gene="Mmp10" /gene_synonym="SL-2" /inference="alignment:Splign:2.1.0" misc_feature 5..7 /gene="Mmp10" /gene_synonym="SL-2" /note="upstream in-frame stop codon" CDS 35..1465 /gene="Mmp10" /gene_synonym="SL-2" /EC_number="3.4.24.22" /note="stromelysin-2; transin-2; matrix metalloproteinase-10; transformation-associated protein 34A" /codon_start=1 /product="stromelysin-2 precursor" /protein_id="NP_598198.2" /db_xref="GeneID:117061" /db_xref="RGD:620192" /translation="
MEPLAILVLLCFPICSAYPLHGAVRQDHSTMDLAQQYLEKYYNFRKNEKQFFKRKDSSPVVKKIEEMQKFLGLEMTGKLDSNTVEMMHKPRCGVPDVGGFSTFPGSPKWRKNHISYRIVNYTLDLPRESVDSAIERALKVWEEVTPLTFSRISEGEADIMISFAVGEHGDFYPFDGVGQSLAHAYPPGPGFYGDAHFDDDEKWSLGPSGTNLFLVAAHELGHSLGLFHSNNKESLMYPVYRFSTSQANIRLSQDDIEGIQSLYGARPSSDATVVPVPSVSPKPETPVKCDPALSFDAVTMLRGEFLFFKDRHFWRRTQWNPEPEFHLISAFWPSLPSGLDAAYEANNKDRVLIFKGSQFWAVRGNEVQAGYPKRIHTLGFPPTVKKIDAAVFEKEKKKTYFFVGDKYWRFDETRQLMDKGFPRLITDDFPGIEPQVDAVLHAFGFFYFFRGSSQFEFDPNARTVTHTLKSNSWLLC"
sig_peptide 35..85 /gene="Mmp10" /gene_synonym="SL-2" /inference="COORDINATES: ab initio prediction:SignalP:6.0" misc_feature 131..295 /gene="Mmp10" /gene_synonym="SL-2" /note="Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471" /db_xref="CDD:460223" misc_feature 302..325 /gene="Mmp10" /gene_synonym="SL-2" /note="propagated from UniProtKB/Swiss-Prot (P07152.1); Region: Cysteine switch. /evidence=ECO:0000250" mat_peptide 332..1462 /gene="Mmp10" /gene_synonym="SL-2" /product="Stromelysin-2. /id=PRO_0000028769" /note="propagated from UniProtKB/Swiss-Prot (P07152.1)" misc_feature 356..826 /gene="Mmp10" /gene_synonym="SL-2" /note="Matrixin; Region: Peptidase_M10; pfam00413" /db_xref="CDD:425668" misc_feature 890..1462 /gene="Mmp10" /gene_synonym="SL-2" /note="Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of...; Region: HX; cd00094" /db_xref="CDD:238046" misc_feature 890..1039 /gene="Mmp10" /gene_synonym="SL-2" /note="propagated from UniProtKB/Swiss-Prot (P07152.1); Region: Hemopexin 1" misc_feature order(920..922,926..928,1052..1054,1058..1060,1196..1198, 1202..1204,1343..1345,1349..1351) /gene="Mmp10" /gene_synonym="SL-2" /note="Metal binding sites [ion binding]; metal-binding site" /db_xref="CDD:238046" misc_feature 1040..1180 /gene="Mmp10" /gene_synonym="SL-2" /note="propagated from UniProtKB/Swiss-Prot (P07152.1); Region: Hemopexin 2" misc_feature 1184..1330 /gene="Mmp10" /gene_synonym="SL-2" /note="propagated from UniProtKB/Swiss-Prot (P07152.1); Region: Hemopexin 3" misc_feature 1331..1462 /gene="Mmp10" /gene_synonym="SL-2" /note="propagated from UniProtKB/Swiss-Prot (P07152.1); Region: Hemopexin 4" exon 140..384 /gene="Mmp10" /gene_synonym="SL-2" /inference="alignment:Splign:2.1.0" exon 385..533 /gene="Mmp10" /gene_synonym="SL-2" /inference="alignment:Splign:2.1.0" exon 534..659 /gene="Mmp10" /gene_synonym="SL-2" /inference="alignment:Splign:2.1.0" exon 660..824 /gene="Mmp10" /gene_synonym="SL-2" /inference="alignment:Splign:2.1.0" exon 825..966 /gene="Mmp10" /gene_synonym="SL-2" /inference="alignment:Splign:2.1.0" exon 967..1100 /gene="Mmp10" /gene_synonym="SL-2" /inference="alignment:Splign:2.1.0" exon 1101..1260 /gene="Mmp10" /gene_synonym="SL-2" /inference="alignment:Splign:2.1.0" exon 1261..1364 /gene="Mmp10" /gene_synonym="SL-2" /inference="alignment:Splign:2.1.0" exon 1365..1714 /gene="Mmp10" /gene_synonym="SL-2" /inference="alignment:Splign:2.1.0" ORIGIN
aagttaggtgctacagaaggtaaaggctgtctctatggagccactggccatcctggtgctgctgtgctttccgatctgctcagcatatcctctgcatggggcagtgagacaagaccactcaaccatggatcttgctcagcaatacctagaaaaatactacaactttagaaaaaatgagaaacaatttttcaaaagaaaggacagtagtcctgttgtcaaaaaaattgaagaaatgcagaagttccttgggctggagatgacagggaagctggactcgaacactgtggagatgatgcacaagccccggtgtggtgttcccgacgtcggtggcttcagtacctttccaggttcacccaaatggaggaaaaaccacatctcctacaggattgtgaattatacactggatttaccaagagagagtgtggattctgccattgagagagctttgaaggtctgggaggaggtgaccccactcacattctccaggatctctgaaggagaggctgacataatgatctcctttgcagttggagaacatggagacttttacccttttgatggagtgggacagagcttggctcatgcctacccacctggccctggattttatggagatgctcacttcgatgatgatgagaaatggtcactgggaccctcagggaccaatttattcctggttgctgcgcatgaacttggtcactccctgggtctctttcactcaaacaacaaagaatctctgatgtacccagtctacaggttctccacgagccaagccaacattcgcctttctcaggatgatatagagggcattcaatccctgtatggagcccgcccctcctctgatgccacagtggttcctgtgccctctgtctctccaaaacctgagaccccagtcaaatgtgatcctgctttgtcctttgatgcagtcaccatgctgagaggggaattcctattctttaaagacaggcacttctggcgtagaacccagtggaatcccgagcctgaattccatttgatttcagcattttggccctctcttccttcaggcttagatgctgcctatgaggcaaataacaaggacagagttctgatttttaaaggaagtcagttctgggcagtccgaggaaatgaagtccaagcaggttacccaaagaggatccacactcttggctttcctcccaccgtgaagaagattgatgcagctgtttttgaaaaggagaagaagaagacgtatttctttgtaggtgacaaatactggagatttgatgagacaagacagcttatggataaaggcttcccgagactgataacagatgacttcccaggaattgagccacaagttgatgctgtgttacatgcatttgggtttttttatttcttccgtggatcatcacagttcgagtttgaccccaatgccaggacggtgacacacacactgaagagcaacagctggctgttgtgctgattatcatgatgacaagacatatacaacactgtaaaatagtatttctcgcctaatttattatgtgtcataatgatgaattgttcctgcatgtgctgtggctcgagatgagcccagcagatagatgtctttcttaatgaaccacagagcatcacctgagcacagaagtgaaagcttctcggtacactaggtgagaggatgcatccccatgggtactttattgtttaataaagaactttatttttgaaccat
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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