2024-11-01 08:39:57, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_023985 1972 bp mRNA linear ROD 06-OCT-2023 DEFINITION Rattus norvegicus tribbles pseudokinase 1 (Trib1), mRNA. ACCESSION NM_023985 XM_001065461 XM_343250 VERSION NM_023985.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1972) AUTHORS Ram R, Wakil SM, Muiya NP, Andres E, Mazhar N, Hagos S, Alshahid M, Meyer BF, Morahan G and Dzimiri N. TITLE A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia JOURNAL Clin Genet 91 (3), 371-378 (2017) PUBMED 27599772 REFERENCE 2 (bases 1 to 1972) AUTHORS Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O and Akira S. TITLE Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages JOURNAL Nature 495 (7442), 524-528 (2013) PUBMED 23515163 REFERENCE 3 (bases 1 to 1972) AUTHORS Dedhia PH, Keeshan K, Uljon S, Xu L, Vega ME, Shestova O, Zaks-Zilberman M, Romany C, Blacklow SC and Pear WS. TITLE Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia JOURNAL Blood 116 (8), 1321-1328 (2010) PUBMED 20410507 REFERENCE 4 (bases 1 to 1972) AUTHORS Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T and Akira S. TITLE Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency JOURNAL J Exp Med 204 (9), 2233-2239 (2007) PUBMED 17724128 REFERENCE 5 (bases 1 to 1972) AUTHORS Sung HY, Guan H, Czibula A, King AR, Eder K, Heath E, Suvarna SK, Dower SK, Wilson AG, Francis SE, Crossman DC and Kiss-Toth E. TITLE Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways JOURNAL J Biol Chem 282 (25), 18379-18387 (2007) PUBMED 17452330 REFERENCE 6 (bases 1 to 1972) AUTHORS Kiss-Toth E, Bagstaff SM, Sung HY, Jozsa V, Dempsey C, Caunt JC, Oxley KM, Wyllie DH, Polgar T, Harte M, O'neill LA, Qwarnstrom EE and Dower SK. TITLE Human tribbles, a protein family controlling mitogen-activated protein kinase cascades JOURNAL J Biol Chem 279 (41), 42703-42708 (2004) PUBMED 15299019 REFERENCE 7 (bases 1 to 1972) AUTHORS Volpe CM, Koo J, Miloro SM, Driscoll DL, Nava HR and Douglass HO Jr. TITLE The effect of extended lymphadenectomy on survival in patients with gastric adenocarcinoma JOURNAL J Am Coll Surg 181 (1), 56-64 (1995) PUBMED 7599772 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI601976.1, AW530250.1, BE096693.1, AF205438.1 and AA964141.1. On or before Jan 20, 2007 this sequence version replaced XM_343250.3, XM_001065461.1. ##Evidence-Data-START## Transcript exon combination :: AF205438.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00132261, SAMD00132262 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-317 AI601976.1 1-317 c 318-354 AW530250.1 7-43 c 355-625 BE096693.1 1-271 626-639 AF205438.1 2-15 640-819 BE096693.1 286-465 820-1713 AF205438.1 196-1089 1714-1972 AA964141.1 10-268 FEATURES Location/Qualifiers source 1..1972 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="Sprague-Dawley" /db_xref="taxon:10116" /chromosome="7" /map="7q33" gene 1..1972 /gene="Trib1" /gene_synonym="Gig2" /note="tribbles pseudokinase 1" /db_xref="GeneID:78969" /db_xref="RGD:621596" exon 1..964 /gene="Trib1" /gene_synonym="Gig2" /inference="alignment:Splign:2.1.0" misc_feature 227..229 /gene="Trib1" /gene_synonym="Gig2" /note="upstream in-frame stop codon" CDS 605..1723 /gene="Trib1" /gene_synonym="Gig2" /note="G-protein-coupled receptor induced protein GIG2" /codon_start=1 /product="tribbles homolog 1" /protein_id="NP_076475.1" /db_xref="GeneID:78969" /db_xref="RGD:621596" /translation="
MRVGPVRFALSGASQPRGPALLFPAARGTPAKRLLDTDDAAAVAAKCPRLSECSNPPDYLSPPGSPCSPQPPPSAQGTGGSCVSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYTQLPSHRNITGIVEVILGESKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHMIKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHVSPKARCLIRSLLRREPSERLTAPEILLHPWFEYVLEPGYVDSEVGTSDQIVPEYQDDNDVSSFFC"
misc_feature 893..1618 /gene="Trib1" /gene_synonym="Gig2" /note="Pseudokinase domain of Tribbles Homolog 1; Region: PK_TRB1; cd14023" /db_xref="CDD:270925" exon 965..1257 /gene="Trib1" /gene_synonym="Gig2" /inference="alignment:Splign:2.1.0" exon 1258..1972 /gene="Trib1" /gene_synonym="Gig2" /inference="alignment:Splign:2.1.0" ORIGIN
acacagcccgggctgtgagtgtgtgtgtgtgtatacagcgtgagtcaccgggaggcggaggaggtggaggaaaaggagaaggagtgcactggccgggatcagtgcggcacacactcatattcagtcactctctctaagcgcgtctcgctcgctcacacgcctggagcccaggagcgcgcaggatcccgagcggcgcggaaaagttgcaccggcttttactcaagactaattgctttgggaagtgcgtttgctcggtgaagccaacgagcctgcggaatctgtcctccaggctcagcacccgggaactcgggcggcctccacgtcccgggctatccacggtctcggcaacaatagcggccgccaccgccagcgaggcgtccagacctggtgcctgccggggtctggggaccttagccggcctcccacccttggacgcgtggccagtgtggttctcgtgtacaacatcagcgtcctggaactgctctcgttttgctccttttggggaccgatccaagctctatctgcagactccatcccgcggactggaagtcgtagcgcggatccagggatttacaaagccggggccgctccggccagggccgcgatgcgggtcggtcccgtgcgttttgccctgagcggcgcctcgcagccccgcggaccggctctactgttcccggctgcccggggcaccccggccaaacgcctgctggacacggacgacgcggcggccgtggcggccaagtgtccgcgcctctctgagtgctcgaatccccctgactacctcagtccccccggctcgccctgcagtcctcagcctccaccctcggcgcaggggaccggcggcagctgtgtgagcgcacccgggcccagccgaatcgccgactacctgctgctacccctagctgagcgcgagcatgtgtcccgggcactgtgcatccacaccggccgcgagctgcgctgcaaggtgtttcccattaaacactaccaagacaaaatcaggccttacacccagctgccgtcccatagaaacattactggcatcgtggaagtgatcctcggggagagcaaggcctacgttttctttgagaaggactttggagacatgcactcctatgtacgaagccggaaaaggcttcgggaagaggaggccgctcggctcttcaagcaaattgtttccgccgttgcccactgccaccagtcagccattgtgctgggggacctgaagcttaggaaattcgtcttctccacagaggagaggacccagcttagactggaaagcctagaagatacgcacatgataaagggtgaagatgacgcattgtcagataaacatggctgcccggcctatgtgagccctgagatcctcaacactactgggacctactccggaaaggcagcggatgtttggagccttggggtgatgctctacacccttttggtcggacgatacccctttcatgactcagacccgagcgcccttttctccaaaatccgtcggggacagttttgcattcccgagcatgtttcccccaaagccaggtgcctcatccgcagcctcctgagacgagaaccttctgagagactcacagctcctgagatcttactccatccctggtttgaatacgtcttggaaccggggtatgttgactcagaagtaggaacttctgaccagattgttcccgagtaccaggacgacaatgacgttagttcctttttctgctaatcccccccccccaaaaaaaaacctcagaaacctcataattctcacacatggcatttctaatgatgggcaggccctcttacacggtgccagccagctatggggacggagcaccattgtccctgtggggctcagtgtggtgccacctctcgggccgagtgacttgatttgaccagcatgcactcagattagctgcttgacaaaggtgtccccttttcgatgaccatcgtgactgtcccggtgtcggaggca
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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