LOCUS       NM_012826               1212 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus alpha-2-glycoprotein 1, zinc-binding (Azgp1),
            mRNA.
ACCESSION   NM_012826
VERSION     NM_012826.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1212)
  AUTHORS   Jain,A., Kotimoole,C.N., Ghoshal,S., Bakshi,J., Chatterjee,A.,
            Prasad,T.S.K. and Pal,A.
  TITLE     Identification of potential salivary biomarker panels for oral
            squamous cell carcinoma
  JOURNAL   Sci Rep 11 (1), 3365 (2021)
   PUBMED   33564003
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1212)
  AUTHORS   Tan,C., Liu,X., Peng,W., Wang,H., Zhou,W., Jiang,J., Wei,X., Mo,L.,
            Chen,Y. and Chen,L.
  TITLE     Seizure-induced impairment in neuronal ketogenesis: Role of
            zinc-alpha2-glycoprotein in mitochondria
  JOURNAL   J Cell Mol Med 24 (12), 6833-6845 (2020)
   PUBMED   32340079
  REMARK    GeneRIF: Seizure-induced impairment in neuronal ketogenesis: Role
            of zinc-alpha2-glycoprotein in mitochondria.
REFERENCE   3  (bases 1 to 1212)
  AUTHORS   Yu,W., Ling,J., Yu,H., Du,J. and Liu,T.
  TITLE     AZGP1 suppresses the process of colorectal cancer after
            upregulating FASN expression via mTOR signal pathway
  JOURNAL   Gen Physiol Biophys 39 (3), 239-248 (2020)
   PUBMED   32525817
REFERENCE   4  (bases 1 to 1212)
  AUTHORS   Wei,X., Liu,X., Tan,C., Mo,L., Wang,H., Peng,W., Zhou,W., Jiang,J.,
            Deng,F. and Chen,L.
  TITLE     Insulin attenuates epileptiform discharge-induced oxidative stress
            by increasing zinc-alpha2-glycoprotein in primary cultured cortical
            neurons
  JOURNAL   Neuroreport 30 (8), 580-585 (2019)
   PUBMED   30950934
  REMARK    GeneRIF: Insulin attenuates epileptiform discharge-induced
            oxidative stress by increasing zinc-alpha2-glycoprotein in primary
            cultured cortical neurons.
REFERENCE   5  (bases 1 to 1212)
  AUTHORS   Zhu,H., Liu,M., Zhang,N., Pan,H., Lin,G., Li,N., Wang,L., Yang,H.,
            Yan,K. and Gong,F.
  TITLE     Circulating and Adipose Tissue mRNA Levels of
            Zinc-alpha2-Glycoprotein, Leptin, High-Molecular-Weight
            Adiponectin, and Tumor Necrosis Factor-Alpha in Colorectal Cancer
            Patients With or Without Obesity
  JOURNAL   Front Endocrinol (Lausanne) 9, 190 (2018)
   PUBMED   29755407
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1212)
  AUTHORS   Hale,L.P., Price,D.T., Sanchez,L.M., Demark-Wahnefried,W. and
            Madden,J.F.
  TITLE     Zinc alpha-2-glycoprotein is expressed by malignant prostatic
            epithelium and may serve as a potential serum marker for prostate
            cancer
  JOURNAL   Clin Cancer Res 7 (4), 846-853 (2001)
   PUBMED   11309332
REFERENCE   7  (bases 1 to 1212)
  AUTHORS   Ogikubo,O., Maeda,T., Yamane,T., Ohtsuka,T., Ohkubo,I.,
            Takahashi,S., Ohnishi,S. and Matsui,N.
  TITLE     Regulation of Zn-alpha2-glycoprotein-mediated cell adhesion by
            kininogens and their derivatives
  JOURNAL   Biochem Biophys Res Commun 252 (1), 257-262 (1998)
   PUBMED   9813179
REFERENCE   8  (bases 1 to 1212)
  AUTHORS   Uria,J.A., Fueyo,A., Balbin,M., Velasco,G., Pendas,A.M. and
            Lopez-Otin,C.
  TITLE     Alternative splicing gives rise to two novel long isoforms of
            Zn-alpha 2-glycoprotein, a member of the immunoglobulin superfamily
  JOURNAL   Gene 169 (2), 233-236 (1996)
   PUBMED   8647453
REFERENCE   9  (bases 1 to 1212)
  AUTHORS   Ueyama,H., Naitoh,H. and Ohkubo,I.
  TITLE     Structure and expression of rat and mouse mRNAs for Zn-alpha
            2-glycoprotein
  JOURNAL   J Biochem 116 (3), 677-681 (1994)
   PUBMED   7852290
REFERENCE   10 (bases 1 to 1212)
  AUTHORS   Fueyo,A., Uria,J.A., Freije,J.M. and Lopez-Otin,C.
  TITLE     Cloning and expression analysis of the cDNA encoding rat Zn-alpha
            2-glycoprotein
  JOURNAL   Gene 145 (2), 245-249 (1994)
   PUBMED   8056339
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105822.1.
            
            On Aug 18, 2012 this sequence version replaced NM_012826.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105822.1, FQ219362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1212
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1212
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="alpha-2-glycoprotein 1, zinc-binding"
                     /db_xref="GeneID:25294"
                     /db_xref="RGD:2187"
     exon            1..79
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..909
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="zinc-alpha-2-glycoprotein; zn-alpha-2-GP;
                     zn-alpha-2-glycoprotein; alpha-2 - glycoprotein 1, zinc;
                     Zn - alpha2 - glycoprotein; alpha-2-glycoprotein 1, zinc"
                     /codon_start=1
                     /product="zinc-alpha-2-glycoprotein precursor"
                     /protein_id="NP_036958.2"
                     /db_xref="GeneID:25294"
                     /db_xref="RGD:2187"
                     /translation="

MVPVLLSLPLLLGPAVLQETGSYSLIFLYTGLSRPSKGLLRFQATAFLNDQAFFHYNSNSGKAEPVEPWSHVEGMEDWEKESQLQRAREEIFLVTLKDIMDYYEDSTGSHTFQGMFGCEITNNRSSGAVWRYAYDGEDFIEFNKEIPAWIPLDPAAANTKLKWEAEKVYVQRAKAYLEEECPTMLKKYLTYSRSHLDRTDPPTVKITSRVAPGRNRIFRCLAYDFYPQRISLHWNQASKKLASEPERGVFPNGNGTYLSWMEVEVPPQNRDPFVCHIEHKGLSQSLSVQWDEKSKV"

     sig_peptide     19..69
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q63678.1)"
     mat_peptide     70..906
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /product="Zinc-alpha-2-glycoprotein. /id=PRO_0000019014"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63678.1)"
     misc_feature    70..72
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="Pyrrolidone carboxylic acid.
                     /evidence=ECO:0000250|UniProtKB:P25311; propagated from
                     UniProtKB/Swiss-Prot (Q63678.1);
                     pyrrolidone-carboxylic-acid site"
     misc_feature    79..606
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    385..387
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q63678.1); glycosylation site"
     misc_feature    610..888
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    664..678
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    709..723
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    778..780
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q63678.1); glycosylation site"
     misc_feature    799..813
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    832..849
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    877..888
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     exon            80..340
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /inference="alignment:Splign:2.1.0"
     exon            341..616
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /inference="alignment:Splign:2.1.0"
     exon            617..1185
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ctgggcactacagtagcaatggtgcctgtcctgttgtccctgcctctccttctgggtcctgcagtccttcaggagactgggtcttattctctgatcttcctctacaccgggttgtccaggcccagcaaaggccttctgaggtttcaagccaccgcatttctcaacgatcaggccttcttccactacaacagcaacagtgggaaggcagagcccgtggaaccctggagccatgtggaaggaatggaggactgggagaaggaaagccagcttcagagagccagggaggagatcttcctcgtgaccctgaaagacatcatggactattacgaggacagtacagggtctcacacctttcagggaatgtttggttgtgagatcacaaataacagaagtagtggagcagtctggaggtatgcctacgatggagaagatttcatcgaattcaacaaggaaatcccagcctggatccccttagacccagcagccgcaaacaccaagctgaagtgggaggcagaaaaggtctatgtgcagcgagccaaggcatacctagaggaggagtgtcctacaatgctgaagaagtacctgacctacagtagatctcacctggaccgaacagatcctcccactgtgaaaatcaccagccgtgtggccccaggaagaaacagaatattcagatgtctggcctatgacttctacccacaaagaattagtctgcactggaaccaggccagcaagaagctggcatctgaaccagaaagaggtgtttttcccaatggaaatggcacttacctctcctggatggaggtggaagtccccccacagaacagagacccctttgtctgccacatagaacacaaggggctatcccaatctctctcagtgcagtgggatgagaaaagtaaagtctgaaaacagtgctgtatctcagcctcagaaaggttaccctctctgccggatatgagagagttgaacttcagaagtcactgtcaccagcaagcccgcaagtctccaaggaatgggtgtgggcccagaagatttgaataccaagcaccgagttcactctcaaagtcaaatcaatcaccttgccttgtaaaactcctcctcaattaatctgtaagcccttgcaattaccttcacgcccagcacagcacagaaaggcattttaaactctgagatgctacagaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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