2024-11-01 08:00:05, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_012826 1212 bp mRNA linear ROD 03-APR-2024 DEFINITION Rattus norvegicus alpha-2-glycoprotein 1, zinc-binding (Azgp1), mRNA. ACCESSION NM_012826 VERSION NM_012826.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1212) AUTHORS Jain,A., Kotimoole,C.N., Ghoshal,S., Bakshi,J., Chatterjee,A., Prasad,T.S.K. and Pal,A. TITLE Identification of potential salivary biomarker panels for oral squamous cell carcinoma JOURNAL Sci Rep 11 (1), 3365 (2021) PUBMED 33564003 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 1212) AUTHORS Tan,C., Liu,X., Peng,W., Wang,H., Zhou,W., Jiang,J., Wei,X., Mo,L., Chen,Y. and Chen,L. TITLE Seizure-induced impairment in neuronal ketogenesis: Role of zinc-alpha2-glycoprotein in mitochondria JOURNAL J Cell Mol Med 24 (12), 6833-6845 (2020) PUBMED 32340079 REMARK GeneRIF: Seizure-induced impairment in neuronal ketogenesis: Role of zinc-alpha2-glycoprotein in mitochondria. REFERENCE 3 (bases 1 to 1212) AUTHORS Yu,W., Ling,J., Yu,H., Du,J. and Liu,T. TITLE AZGP1 suppresses the process of colorectal cancer after upregulating FASN expression via mTOR signal pathway JOURNAL Gen Physiol Biophys 39 (3), 239-248 (2020) PUBMED 32525817 REFERENCE 4 (bases 1 to 1212) AUTHORS Wei,X., Liu,X., Tan,C., Mo,L., Wang,H., Peng,W., Zhou,W., Jiang,J., Deng,F. and Chen,L. TITLE Insulin attenuates epileptiform discharge-induced oxidative stress by increasing zinc-alpha2-glycoprotein in primary cultured cortical neurons JOURNAL Neuroreport 30 (8), 580-585 (2019) PUBMED 30950934 REMARK GeneRIF: Insulin attenuates epileptiform discharge-induced oxidative stress by increasing zinc-alpha2-glycoprotein in primary cultured cortical neurons. REFERENCE 5 (bases 1 to 1212) AUTHORS Zhu,H., Liu,M., Zhang,N., Pan,H., Lin,G., Li,N., Wang,L., Yang,H., Yan,K. and Gong,F. TITLE Circulating and Adipose Tissue mRNA Levels of Zinc-alpha2-Glycoprotein, Leptin, High-Molecular-Weight Adiponectin, and Tumor Necrosis Factor-Alpha in Colorectal Cancer Patients With or Without Obesity JOURNAL Front Endocrinol (Lausanne) 9, 190 (2018) PUBMED 29755407 REMARK Publication Status: Online-Only REFERENCE 6 (bases 1 to 1212) AUTHORS Hale,L.P., Price,D.T., Sanchez,L.M., Demark-Wahnefried,W. and Madden,J.F. TITLE Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer JOURNAL Clin Cancer Res 7 (4), 846-853 (2001) PUBMED 11309332 REFERENCE 7 (bases 1 to 1212) AUTHORS Ogikubo,O., Maeda,T., Yamane,T., Ohtsuka,T., Ohkubo,I., Takahashi,S., Ohnishi,S. and Matsui,N. TITLE Regulation of Zn-alpha2-glycoprotein-mediated cell adhesion by kininogens and their derivatives JOURNAL Biochem Biophys Res Commun 252 (1), 257-262 (1998) PUBMED 9813179 REFERENCE 8 (bases 1 to 1212) AUTHORS Uria,J.A., Fueyo,A., Balbin,M., Velasco,G., Pendas,A.M. and Lopez-Otin,C. TITLE Alternative splicing gives rise to two novel long isoforms of Zn-alpha 2-glycoprotein, a member of the immunoglobulin superfamily JOURNAL Gene 169 (2), 233-236 (1996) PUBMED 8647453 REFERENCE 9 (bases 1 to 1212) AUTHORS Ueyama,H., Naitoh,H. and Ohkubo,I. TITLE Structure and expression of rat and mouse mRNAs for Zn-alpha 2-glycoprotein JOURNAL J Biochem 116 (3), 677-681 (1994) PUBMED 7852290 REFERENCE 10 (bases 1 to 1212) AUTHORS Fueyo,A., Uria,J.A., Freije,J.M. and Lopez-Otin,C. TITLE Cloning and expression analysis of the cDNA encoding rat Zn-alpha 2-glycoprotein JOURNAL Gene 145 (2), 245-249 (1994) PUBMED 8056339 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC105822.1. On Aug 18, 2012 this sequence version replaced NM_012826.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC105822.1, FQ219362.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA5756307, SAMEA5760396 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..1212 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="12" /map="12q11" gene 1..1212 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /note="alpha-2-glycoprotein 1, zinc-binding" /db_xref="GeneID:25294" /db_xref="RGD:2187" exon 1..79 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /inference="alignment:Splign:2.1.0" CDS 19..909 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /note="zinc-alpha-2-glycoprotein; zn-alpha-2-GP; zn-alpha-2-glycoprotein; alpha-2 - glycoprotein 1, zinc; Zn - alpha2 - glycoprotein; alpha-2-glycoprotein 1, zinc" /codon_start=1 /product="zinc-alpha-2-glycoprotein precursor" /protein_id="NP_036958.2" /db_xref="GeneID:25294" /db_xref="RGD:2187" /translation="
MVPVLLSLPLLLGPAVLQETGSYSLIFLYTGLSRPSKGLLRFQATAFLNDQAFFHYNSNSGKAEPVEPWSHVEGMEDWEKESQLQRAREEIFLVTLKDIMDYYEDSTGSHTFQGMFGCEITNNRSSGAVWRYAYDGEDFIEFNKEIPAWIPLDPAAANTKLKWEAEKVYVQRAKAYLEEECPTMLKKYLTYSRSHLDRTDPPTVKITSRVAPGRNRIFRCLAYDFYPQRISLHWNQASKKLASEPERGVFPNGNGTYLSWMEVEVPPQNRDPFVCHIEHKGLSQSLSVQWDEKSKV"
sig_peptide 19..69 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /note="/evidence=ECO:0000250; propagated from UniProtKB/Swiss-Prot (Q63678.1)" mat_peptide 70..906 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /product="Zinc-alpha-2-glycoprotein. /id=PRO_0000019014" /note="propagated from UniProtKB/Swiss-Prot (Q63678.1)" misc_feature 70..72 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /note="Pyrrolidone carboxylic acid. /evidence=ECO:0000250|UniProtKB:P25311; propagated from UniProtKB/Swiss-Prot (Q63678.1); pyrrolidone-carboxylic-acid site" misc_feature 79..606 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /note="Class I Histocompatibility antigen, domains alpha 1 and 2; Region: MHC_I; cl08246" /db_xref="CDD:471794" misc_feature 385..387 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q63678.1); glycosylation site" misc_feature 610..888 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 664..678 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 709..723 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 778..780 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q63678.1); glycosylation site" misc_feature 799..813 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 832..849 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 877..888 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" exon 80..340 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /inference="alignment:Splign:2.1.0" exon 341..616 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /inference="alignment:Splign:2.1.0" exon 617..1185 /gene="Azgp1" /gene_synonym="ZA2GA; Zna2gp" /inference="alignment:Splign:2.1.0" ORIGIN
ctgggcactacagtagcaatggtgcctgtcctgttgtccctgcctctccttctgggtcctgcagtccttcaggagactgggtcttattctctgatcttcctctacaccgggttgtccaggcccagcaaaggccttctgaggtttcaagccaccgcatttctcaacgatcaggccttcttccactacaacagcaacagtgggaaggcagagcccgtggaaccctggagccatgtggaaggaatggaggactgggagaaggaaagccagcttcagagagccagggaggagatcttcctcgtgaccctgaaagacatcatggactattacgaggacagtacagggtctcacacctttcagggaatgtttggttgtgagatcacaaataacagaagtagtggagcagtctggaggtatgcctacgatggagaagatttcatcgaattcaacaaggaaatcccagcctggatccccttagacccagcagccgcaaacaccaagctgaagtgggaggcagaaaaggtctatgtgcagcgagccaaggcatacctagaggaggagtgtcctacaatgctgaagaagtacctgacctacagtagatctcacctggaccgaacagatcctcccactgtgaaaatcaccagccgtgtggccccaggaagaaacagaatattcagatgtctggcctatgacttctacccacaaagaattagtctgcactggaaccaggccagcaagaagctggcatctgaaccagaaagaggtgtttttcccaatggaaatggcacttacctctcctggatggaggtggaagtccccccacagaacagagacccctttgtctgccacatagaacacaaggggctatcccaatctctctcagtgcagtgggatgagaaaagtaaagtctgaaaacagtgctgtatctcagcctcagaaaggttaccctctctgccggatatgagagagttgaacttcagaagtcactgtcaccagcaagcccgcaagtctccaaggaatgggtgtgggcccagaagatttgaataccaagcaccgagttcactctcaaagtcaaatcaatcaccttgccttgtaaaactcctcctcaattaatctgtaagcccttgcaattaccttcacgcccagcacagcacagaaaggcattttaaactctgagatgctacagaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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