2024-11-01 08:30:13, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_012671 4222 bp mRNA linear ROD 29-MAR-2024 DEFINITION Rattus norvegicus transforming growth factor alpha (Tgfa), mRNA. ACCESSION NM_012671 VERSION NM_012671.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 4222) AUTHORS Yu,Y., Chen,E., Weiss,R.M., Felder,R.B. and Wei,S.G. TITLE Transforming Growth Factor-alpha Acts in Hypothalamic Paraventricular Nucleus to Upregulate ERK1/2 Signaling and Expression of Sympathoexcitatory Mediators in Heart Failure Rats JOURNAL Neuroscience 483, 13-23 (2022) PUBMED 34968668 REMARK GeneRIF: Transforming Growth Factor-alpha Acts in Hypothalamic Paraventricular Nucleus to Upregulate ERK1/2 Signaling and Expression of Sympathoexcitatory Mediators in Heart Failure Rats. REFERENCE 2 (bases 1 to 4222) AUTHORS Naito,K., Moteki,H., Kimura,M., Natsume,H. and Ogihara,M. TITLE Serotonin 5-HT2B Receptor-Stimulated DNA Synthesis and Proliferation Are Mediated by Autocrine Secretion of Transforming Growth Factor-alpha in Primary Cultures of Adult Rat Hepatocytes JOURNAL Biol Pharm Bull 39 (4), 570-577 (2016) PUBMED 26804134 REMARK GeneRIF: 5-HT stimulates DNA synthesis and proliferation in primary cultures of adult rat hepatocytes by acting via autocrine secretion of TGF-alpha induced by the serotonin 5-HT2B receptor/Gq/PLC/Ca2+ pathway. REFERENCE 3 (bases 1 to 4222) AUTHORS Ni,W., Lin,N., He,H., Zhu,J. and Zhang,Y. TITLE Lipopolysaccharide induces up-regulation of TGF-alpha through HDAC2 in a rat model of bronchopulmonary dysplasia JOURNAL PLoS One 9 (3), e91083 (2014) PUBMED 24595367 REMARK GeneRIF: Lipopolysaccharide exposure led to a suppression of both HDAC1 and HDAC2 expression and activity, induced TGFa expression, and disrupted alveolar morphology. Publication Status: Online-Only REFERENCE 4 (bases 1 to 4222) AUTHORS Wong,H.H. and Lemoine,N.R. TITLE Pancreatic cancer: molecular pathogenesis and new therapeutic targets JOURNAL Nat Rev Gastroenterol Hepatol 6 (7), 412-422 (2009) PUBMED 19506583 REMARK Review article REFERENCE 5 (bases 1 to 4222) AUTHORS Kimura,M., Okamoto,H., Natsume,H. and Ogihara,M. TITLE IP receptor agonist-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of endogenous transforming growth factor-alpha JOURNAL J Pharmacol Sci 109 (4), 618-629 (2009) PUBMED 19346670 REFERENCE 6 (bases 1 to 4222) AUTHORS Korc,M., Chandrasekar,B., Yamanaka,Y., Friess,H., Buchier,M. and Beger,H.G. TITLE Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha JOURNAL J Clin Invest 90 (4), 1352-1360 (1992) PUBMED 1401070 REFERENCE 7 (bases 1 to 4222) AUTHORS Luetteke,N.C. and Lee,D.C. TITLE Transforming growth factor alpha: expression, regulation and biological action of its integral membrane precursor JOURNAL Semin Cancer Biol 1 (4), 265-275 (1990) PUBMED 2103501 REMARK Review article REFERENCE 8 (bases 1 to 4222) AUTHORS Blasband,A.J., Rogers,K.T., Chen,X.R., Azizkhan,J.C. and Lee,D.C. TITLE Characterization of the rat transforming growth factor alpha gene and identification of promoter sequences JOURNAL Mol Cell Biol 10 (5), 2111-2121 (1990) PUBMED 2325647 REFERENCE 9 (bases 1 to 4222) AUTHORS Gentry,L.E., Twardzik,D.R., Lim,G.J., Ranchalis,J.E. and Lee,D.C. TITLE Expression and characterization of transforming growth factor alpha precursor protein in transfected mammalian cells JOURNAL Mol Cell Biol 7 (5), 1585-1591 (1987) PUBMED 3299049 REFERENCE 10 (bases 1 to 4222) AUTHORS Lee,D.C., Rose,T.M., Webb,N.R. and Todaro,G.J. TITLE Cloning and sequence analysis of a cDNA for rat transforming growth factor-alpha JOURNAL Nature 313 (6002), 489-491 (1985) PUBMED 3855503 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M31076.1 and JAXUCZ010000004.1. On Jun 13, 2010 this sequence version replaced NM_012671.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M31076.1, SRR26643288.19572.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA5760383, SAMEA5760389 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-804 M31076.1 1-804 805-4222 JAXUCZ010000004.1 120254920-120258337 FEATURES Location/Qualifiers source 1..4222 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="4" /map="4q34" gene 1..4222 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /note="transforming growth factor alpha" /db_xref="GeneID:24827" /db_xref="RGD:3849" exon 1..184 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /inference="alignment:Splign:2.1.0" CDS 145..624 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /note="protransforming growth factor alpha" /codon_start=1 /product="protransforming growth factor alpha preproprotein" /protein_id="NP_036803.1" /db_xref="GeneID:24827" /db_xref="RGD:3849" /translation="
MVPAAGQLALLALGILVAVCQALENSTSPLSDSPVAAAVVSHFNKCPDSHTQYCFHGTCRFLVQEEKPACVCHSGYVGVRCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALVCRHEKPSALLKGRTACCHSETVV"
sig_peptide 145..213 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /note="/evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (P01134.2)" proprotein 211..621 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /product="transforming growth factor alpha proprotein" misc_feature 217..219 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (P01134.2); glycosylation site" mat_peptide 259..408 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /product="transforming growth factor alpha" misc_feature <271..390 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /note="EGF-like protein; Provisional; Region: PHA02887" /db_xref="CDD:165214" misc_feature <280..504 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /note="epidermal growth factor-like protein (EGF-like protein); Provisional; Region: PHA03099" /db_xref="CDD:165381" misc_feature 436..513 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /note="propagated from UniProtKB/Swiss-Prot (P01134.2); transmembrane region" exon 185..238 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /inference="alignment:Splign:2.1.0" exon 239..356 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /inference="alignment:Splign:2.1.0" exon 357..506 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /inference="alignment:Splign:2.1.0" exon 507..616 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /inference="alignment:Splign:2.1.0" exon 617..4222 /gene="Tgfa" /gene_synonym="RATTGFAA; TGFAA" /inference="alignment:Splign:2.1.0" ORIGIN
ccgggaggcgcggtcgtccctccgcccgcgcgccgggggccggccctgtcgcctgcgcctttttcccccgcgcacaccgcggcggcgcgcggccactcgccaaccgcaaagagcgcggtggctgcagcgccctgcgctcggaagatggtccccgcggccggacagctcgctctgctagcgctgggtatcctggtagctgtgtgtcaggctctggagaacagcacgtcccccctgagtgactcacccgtggcggctgcagtggtgtctcacttcaacaagtgcccagattcccacactcagtattgtttccatgggacctgcaggtttttggtgcaggaagagaagccagcatgtgtctgccactctgggtacgtgggtgttcgctgtgagcatgcagatctcctggcagtggtggctgccagccagaagaagcaggccatcactgccctggtggtagtctccattgtggccctggctgtcctcattatcacctgtgtgctgatccactgctgtcaggtccgcaagcactgtgagtggtgccgtgccctcgtctgcagacacgagaagcccagcgccctcctgaaaggaaggactgcctgctgccactctgagacagtggtctgaagatcccagaggaggaatttggccaggtggccgatgacagcccaaccaaggaaaggtgtctcaggacaacaccaccagcagtgcccaggccccgggacatgctgggagaccttccccctcaatgtacaaccacctgggcagctctctgtcctttacgagcttcaaaactgtgtgataaagctgcccgctgggcaccctagagaagaggccagtagacaacatttgaacgacaagttgaacaagaacctcaaagggctggccttcttgctaacccacaccaagaaggctgtccgtggactccaaactgtttcttctccatgggccgtctaaccccccacagagactccacgcttggtgtacaaaatggacaaggggaaacatctattgtcctttgaagacaccatggccccggcatgagccctgacatctcctcaaacggttgccaggatgatgtgtcttatgtattaggtggatgacgcggttttgtttgtattctctttatgtcagtatcgggcatccatgttaatgatccacgagcggctggctgtgaagttacaccaaatagaaatgttcagccactttgataaagtaaggctgtggggatgggagcctcccaggggctgtagagacagaactcaaaagtgcattctgctgggaaccaaactgctaccaggaggttgtgcccactaagacaggaaagtccctggatatatgctgtggcaaagttagcaagggcaagaggacaagagagcctgtgtgggcactgagggaggacgcacattccatcactcgattaagttggattagcctcctcgtgagcccagctccagcatcagccatgagccgtgggccaaatccgtgaaggtgaccccctctttattggtttctgctcatttttagaaggagaaatttacctttcctatttattttcaagcattaagagaaatagcccccctgtcttgttttgttttgtttcccctttcagaatgttggcattactaatgaaatcgctaccaagcctctccactcccctccggggaaggagctatgttccctgagcactggagggcgctctgacccattgagcccacctcctccctgtgctgctcaggactgtcaggagacagtaaatacatccagctgcttgtggaggaggccattctccaactcagaacttaaagggccctccaccctccagagcctttaacgtaacgtcaggaaaaggggtgtttgacataccaaattctcagcaagttctgcctgttcctcattcttctccattccacctttctctgtgaatgttttcttttctcatatgacctagatatcaatctgcccaggtcttaaccctggctccctttgttaacaatgcctcaagctccacaagaagaaagtgggttggttcagtgctgacctctaactactcagtcgacgtggctccaggcggaaatcgtcacttgtgttgttattattattattattttggtttgatgttttatcttgttttgtgagacaaggtcttgctgtgtagcccaggttggccttgaagttaagatcctcctgcttcagcatcctgagagctgggcttactggtgtacagcaccgcacccagcagagtctttacggttattaaagaagacaggttaagtttgctttccttgggtcgtgcatgtgggtcaaggccaagtgtagcctgctgctcagacacccatcgacctcactggacgttggccctctattgggcccccaatgcagaccctgtatgaagtactagctcaccagggccaacacaaagggaggggcttgttttaatttagttcacaccgttagcttccgatgataagtctttcctggtctgttggaagctcctgggtgtctgacttcttttaaagagtttgaactgatatcaaaatatcattgggaatttcttcacctagtgtcccatcctgaagatattaccatgcaagactcagcagaggtgggaaaagttagtacaaacctttaatggtggaggcagaggatcttgggaggacctcagctttagtgtctgaacattccggttctcaggtccagccagtcacagcagccagtaccatcccagtacccatacacagatgcagccggctcaaacgtctcccagaagtgccttccccaccagtcataccctctgaagagtcagaagctgagactaagttgaggcaaatctggttggacatcgtccctgccctgacataagacagccctgcttctttggtgactctgattcttggaagtcagacaaatgctgacagcacaaatctcacagcacagttagacctgggtagctgtcccagcacctcctgtcaggtcacactggccctcttgatactcagtgcagctactgagtcaggagcactcgtcagcagacacacaggtcagtggacagtgactcagaggactgtgaacattcccattaaatggattgaaattaattctggagtcattaagagagctcagttaagaatggcacttaccaatatccctgagaacatgagttcaatcccctgggacccatctggtggaaggagagaaccaacttgcccaggatgtcttctgaattctacatacacaacacacacacacacacacacacacacacacacacacacacacccctctagctgtaactttaaacacatgatgggacatgttctctccatgcaaaactacaatggggactcagtctgaaagatagattctaggtggacatacgcagacccaaaccataagtcagtttgtcatgtgcccagaaaaaggtggtaacaatagtcccaatgtcctttttctcctaaaaaggttgtggggaggcatggttggtacccacccacccacactggtgagggaagtgactgtgtccctgagtcttagatggtgatgttgttccctgcaagtccccaggccaggtttcctagtgcctgtgagccactaggtggaccggcaacacgctgacactgcctacaggccccagtcccatggtgaatagtaaggttacctctctcaaaggccaaggggaggccacatgagacaacacgtttttcacacagggtttcactgtatagcccaggccagcctcaaacccatgattcccctgcctcagcctactgggttacaggtgtgcactgccatacctggctcacgtttgttttttaatgttctggtgtaacatgtattccctgaagccattgatctatctcaaagacacagtgttgtacgcatacatgtgcgcacgtacacacaccaaactggaaagcgacccctctccatagtgtgataagtttattataagtttattataaggaccctatgctgtttttagaactcatctttctgacttctgtatatgatgcactgaaggttaatatgtaatattttaatttattttatgtggtaagttaattttggttttctgtaatgtattaatgtgattagaagcttttttccttaatatctgaattatacttaaagagtagtgaggaatataagatactgttgtgtattgttactcagttgtattgtaccttgtttggaaggatgaaggaatgaaccctttttttttttc
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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