2024-11-01 08:30:39, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001398656 1314 bp mRNA linear ROD 31-MAR-2024 DEFINITION Rattus norvegicus cyclin-dependent kinase 7 (Cdk7), transcript variant 1, mRNA. ACCESSION NM_001398656 XM_039103488 VERSION NM_001398656.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1314) AUTHORS Jeronimo,C., Bataille,A.R. and Robert,F. TITLE The writers, readers, and functions of the RNA polymerase II C-terminal domain code JOURNAL Chem Rev 113 (11), 8491-8522 (2013) PUBMED 23837720 REMARK Review article REFERENCE 2 (bases 1 to 1314) AUTHORS Wang,Y., Liu,F., Mao,F., Hang,Q., Huang,X., He,S., Wang,Y., Cheng,C., Wang,H., Xu,G., Zhang,T. and Shen,A. TITLE Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration JOURNAL J Biol Chem 288 (13), 9028-9034 (2013) PUBMED 23393140 REFERENCE 3 (bases 1 to 1314) AUTHORS Egloff,S., Dienstbier,M. and Murphy,S. TITLE Updating the RNA polymerase CTD code: adding gene-specific layers JOURNAL Trends Genet 28 (7), 333-341 (2012) PUBMED 22622228 REMARK Review article REFERENCE 4 (bases 1 to 1314) AUTHORS Fujii,W., Nishimura,T., Kano,K., Sugiura,K. and Naito,K. TITLE CDK7 and CCNH are components of CDK-activating kinase and are required for meiotic progression of pig oocytes JOURNAL Biol Reprod 85 (6), 1124-1132 (2011) PUBMED 21778139 REFERENCE 5 (bases 1 to 1314) AUTHORS Egly,J.M. and Coin,F. TITLE A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor JOURNAL DNA Repair (Amst) 10 (7), 714-721 (2011) PUBMED 21592869 REMARK Review article REFERENCE 6 (bases 1 to 1314) AUTHORS Kershnar,E., Wu,S.Y. and Chiang,C.M. TITLE Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes JOURNAL J Biol Chem 273 (51), 34444-34453 (1998) PUBMED 9852112 REFERENCE 7 (bases 1 to 1314) AUTHORS Reardon,J.T., Ge,H., Gibbs,E., Sancar,A., Hurwitz,J. and Pan,Z.Q. TITLE Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH JOURNAL Proc Natl Acad Sci U S A 93 (13), 6482-6487 (1996) PUBMED 8692841 REMARK Erratum:[Proc Natl Acad Sci U S A 1996 Sep 17;93(19):10538] REFERENCE 8 (bases 1 to 1314) AUTHORS Weiler,M.C., Smith,J.L. and Masters,J.N. TITLE CR16, a novel proline-rich protein expressed in rat brain neurons, binds to SH3 domains and is a MAP kinase substrate JOURNAL J Mol Neurosci 7 (3), 203-215 (1996) PUBMED 8906616 REFERENCE 9 (bases 1 to 1314) AUTHORS Ossipow,V., Tassan,J.P., Nigg,E.A. and Schibler,U. TITLE A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation JOURNAL Cell 83 (1), 137-146 (1995) PUBMED 7553866 REFERENCE 10 (bases 1 to 1314) AUTHORS Serizawa,H., Makela,T.P., Conaway,J.W., Conaway,R.C., Weinberg,R.A. and Young,R.A. TITLE Association of Cdk-activating kinase subunits with transcription factor TFIIH JOURNAL Nature 374 (6519), 280-282 (1995) PUBMED 7885450 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAXUCZ010000002.1. On Dec 21, 2021 this sequence version replaced XM_039103488.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR26643298.9380.1, SRR26360176.2117034.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-172 JAXUCZ010000002.1 33599314-33599485 c 173-232 JAXUCZ010000002.1 33598993-33599052 c 233-266 JAXUCZ010000002.1 33593218-33593251 c 267-334 JAXUCZ010000002.1 33591851-33591918 c 335-403 JAXUCZ010000002.1 33589803-33589871 c 404-514 JAXUCZ010000002.1 33586594-33586704 c 515-633 JAXUCZ010000002.1 33585525-33585643 c 634-733 JAXUCZ010000002.1 33582765-33582864 c 734-820 JAXUCZ010000002.1 33581125-33581211 c 821-970 JAXUCZ010000002.1 33577478-33577627 c 971-1118 JAXUCZ010000002.1 33575715-33575862 c 1119-1314 JAXUCZ010000002.1 33574623-33574818 c FEATURES Location/Qualifiers source 1..1314 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="2" /map="2q12" gene 1..1314 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /note="cyclin-dependent kinase 7" /db_xref="GeneID:171150" /db_xref="RGD:621124" exon 1..172 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /inference="alignment:Splign:2.1.0" misc_feature 23..25 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /note="upstream in-frame stop codon" CDS 107..1147 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /EC_number="2.7.11.23" /EC_number="2.7.11.22" /note="isoform 1 is encoded by transcript variant 1; cell division protein kinase 7; 39 protein kinase; CDK-activating kinase 1; TFIIH basal transcription factor complex kinase subunit; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)" /codon_start=1 /product="cyclin-dependent kinase 7 isoform 1" /protein_id="NP_001385585.1" /db_xref="GeneID:171150" /db_xref="RGD:621124" /translation="
MAVDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLQHIFIAAGDDLLELIQGLFLFNPCTRITASQALRTKYFSNRPGPTPGCQLPRPNCPVEALKEQSNPAMATKRKRAEALEQGILPKKLIF"
misc_feature 137..1030 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /note="Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; Region: STKc_CDK7; cd07841" /db_xref="CDD:270833" misc_feature order(158..169,173..178,182..184,221..223,227..229, 287..289,329..331,377..388,395..397,401..406,515..517, 521..523,527..532,536..538,569..571,578..580,584..586, 614..616,620..631,635..637,749..754) /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /note="active site" /db_xref="CDD:270833" misc_feature order(158..160,164..178,182..184,221..223,227..229, 329..331,377..388,527..532,584..586) /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:270833" misc_feature order(263..271,275..277,284..289,293..298,305..310, 344..346,350..352,365..367,482..484,491..502,584..586, 590..601,611..616,947..949,959..967) /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /note="CDK/cyclin interface [polypeptide binding]; other site" /db_xref="CDD:270833" misc_feature order(287..289,401..403,515..517,521..523,578..580, 614..616,620..631,635..637,749..754) /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270833" misc_feature order(566..601,605..637) /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /note="activation loop (A-loop); other site" /db_xref="CDD:270833" exon 173..232 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /inference="alignment:Splign:2.1.0" exon 233..266 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /inference="alignment:Splign:2.1.0" exon 267..334 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /inference="alignment:Splign:2.1.0" exon 335..403 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /inference="alignment:Splign:2.1.0" exon 404..514 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /inference="alignment:Splign:2.1.0" exon 515..633 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /inference="alignment:Splign:2.1.0" exon 634..733 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /inference="alignment:Splign:2.1.0" exon 734..820 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /inference="alignment:Splign:2.1.0" exon 821..970 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /inference="alignment:Splign:2.1.0" exon 971..1118 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /inference="alignment:Splign:2.1.0" exon 1119..1314 /gene="Cdk7" /gene_synonym="CAK; P39 Mo15" /inference="alignment:Splign:2.1.0" ORIGIN
atgcgcgtccagtgaacggaagtagctgttggaaactttcagacgctttaaattcctgcggggtggagggcttagtttagctgctggacgctggcttctcactcgtatggctgtggacgtgaaatctcgagcgaagcgctatgagaaactggacttcctcggagagggacagtttgctactgtctataaggccagagataagaacaccaaccagatcgtcgccattaagaaaatcaaacttggacacaggtcagaagctaaagatggtataaatagaacagccttaagggagataaagctcttgcaggaactaagtcatccaaatataattggtctccttgatgcatttggacataaatcgaacattagccttgtctttgattttatggagactgacctagaggttatcataaaggataacagtctcgtgttgaccccatcccacattaaagcctacatgctgatgactcttcagggcttggaatatttacatcagcactggattctacacagggatctgaaaccaaacaacttgttgttagatgagaatggagttctgaaactggcagattttggcctggccaaatcatttgggagccccaatagggcttacacacatcaagttgtgaccaggtggtaccgggcccccgagttactgtttggagctaggatgtacggtgtgggagtggacatgtgggctgtcggttgtatcttagcagaattgcttctaagggttccttttttgcctggagattcagaccttgatcagctaacaagaatatttgaaactctgggtacaccaaccgaagaacagtggcctgacatgtgtagtcttccagattacgtgacgttcaagagtttccctggcatccccctgcagcacatcttcattgcagctggagacgacctgcttgagctcatacaaggcttgttcttattcaacccatgtactagaattacagcttcacaggcgttgaggaccaagtacttcagtaatcgtccagggccaacacctggatgccagcttccaagaccaaactgtccagtggaagcattaaaggaacagtcaaatccagccatggcgacaaaacggaaaagagcggaggccttagaacaaggaatattgcccaagaagctaattttttagttgcagcgaacaatggacagtttcactgctgaaagaaatgatccaaaggcaaataacggaaaaaaaatagggaatattaaatactatataagaacttgtaaatactctacagatgtaaaatatgtaaagctatgggttatttttattaaatgtattttaaaataaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]