2024-11-01 08:31:32, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001270587 3119 bp mRNA linear ROD 28-MAR-2024 DEFINITION Rattus norvegicus solute carrier organic anion transporter family member 1B2 (Slco1b2), transcript variant 3, mRNA. ACCESSION NM_001270587 VERSION NM_001270587.1 KEYWORDS RefSeq. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 3119) AUTHORS Chen,S., Li,K., Jiang,J., Wang,X., Chai,Y., Zhang,C., Deng,Q., Shuai,L., Feng,K., Ma,K. and Zhang,L. TITLE Low expression of organic anion-transporting polypeptide 1B3 predicts a poor prognosis in hepatocellular carcinoma JOURNAL World J Surg Oncol 18 (1), 127 (2020) PUBMED 32534581 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 3119) AUTHORS Ma,X., Shang,X., Qin,X., Lu,J., Liu,M. and Wang,X. TITLE Characterization of organic anion transporting polypeptide 1b2 knockout rats generated by CRISPR/Cas9: a novel model for drug transport and hyperbilirubinemia disease JOURNAL Acta Pharm Sin B 10 (5), 850-860 (2020) PUBMED 32528832 REFERENCE 3 (bases 1 to 3119) AUTHORS Alam,K., Farasyn,T., Ding,K. and Yue,W. TITLE Characterization of Liver- and Cancer-type-Organic Anion Transporting Polypeptide (OATP) 1B3 Messenger RNA Expression in Normal and Cancerous Human Tissues JOURNAL Drug Metab Lett 12 (1), 24-32 (2018) PUBMED 29577869 REFERENCE 4 (bases 1 to 3119) AUTHORS Verboom,M.C., Kloth,J.S.L., Swen,J.J., van der Straaten,T., Bovee,J.V.M.G., Sleijfer,S., Reyners,A.K.L., Mathijssen,R.H.J., Guchelaar,H.J., Steeghs,N. and Gelderblom,H. TITLE Genetic polymorphisms in angiogenesis-related genes are associated with worse progression-free survival of patients with advanced gastrointestinal stromal tumours treated with imatinib JOURNAL Eur J Cancer 86, 226-232 (2017) PUBMED 29054076 REFERENCE 5 (bases 1 to 3119) AUTHORS Sun,B., Chen,Y., Xiang,T., Zhang,L., Chen,Z., Zhang,S., Zhou,H. and Chen,S. TITLE The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea JOURNAL Biomed Res Int 2015, 752850 (2015) PUBMED 26665149 REFERENCE 6 (bases 1 to 3119) AUTHORS Cattori,V., van Montfoort,J.E., Stieger,B., Landmann,L., Meijer,D.K., Winterhalter,K.H., Meier,P.J. and Hagenbuch,B. TITLE Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3 JOURNAL Pflugers Arch 443 (2), 188-195 (2001) PUBMED 11713643 REFERENCE 7 (bases 1 to 3119) AUTHORS Ismair,M.G., Stieger,B., Cattori,V., Hagenbuch,B., Fried,M., Meier,P.J. and Kullak-Ublick,G.A. TITLE Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver JOURNAL Gastroenterology 121 (5), 1185-1190 (2001) PUBMED 11677211 REFERENCE 8 (bases 1 to 3119) AUTHORS Choudhuri,S., Ogura,K. and Klaassen,C.D. TITLE Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat lst-1 gene JOURNAL Biochem Biophys Res Commun 274 (1), 79-86 (2000) PUBMED 10903899 REFERENCE 9 (bases 1 to 3119) AUTHORS Cattori,V., Hagenbuch,B., Hagenbuch,N., Stieger,B., Ha,R., Winterhalter,K.E. and Meier,P.J. TITLE Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver JOURNAL FEBS Lett 474 (2-3), 242-245 (2000) PUBMED 10838093 REFERENCE 10 (bases 1 to 3119) AUTHORS Kakyo,M., Unno,M., Tokui,T., Nakagomi,R., Nishio,T., Iwasashi,H., Nakai,D., Seki,M., Suzuki,M., Naitoh,T., Matsuno,S., Yawo,H. and Abe,T. TITLE Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1 JOURNAL Gastroenterology 117 (4), 770-775 (1999) PUBMED 10500057 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF217450.2 and JAXUCZ010000004.1. Transcript Variant: This variant (3, also known as rlst-1c) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF217450.2, SRR26643286.15360.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA5760400, SAMEA5760476 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2398 AF217450.2 1-2398 2399-3119 JAXUCZ010000004.1 176350370-176351090 FEATURES Location/Qualifiers source 1..3119 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="4" /map="4q44" gene 1..3119 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /note="solute carrier organic anion transporter family member 1B2" /db_xref="GeneID:58978" /db_xref="RGD:69300" exon 1..40 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /inference="alignment:Splign:2.1.0" exon 41..198 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /inference="alignment:Splign:2.1.0" misc_feature 43..45 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /note="upstream in-frame stop codon" CDS 115..2079 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /note="isoform 3 is encoded by transcript variant 3; solute carrier family 21 member 10; sodium-independent organic anion-transporting polypeptide 4; solute carrier organic anion transporter family, member 1b3; solute carrier family 21 (organic anion transporter) member 10; solute carrier family (organic anion transporter) member 10; organic anion transporting polypeptide 4; liver-specific transporter-1; liver-specific organic anion transporter 1" /codon_start=1 /product="solute carrier organic anion transporter family member 1B2 isoform 3" /protein_id="NP_001257516.1" /db_xref="GeneID:58978" /db_xref="RGD:69300" /translation="
MDHTQQSRKAAEAQPSRSKQTRFCDGFKLFLAALSFSYICKALGGVVMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGSILTALPHFFMGYYKYAKENDIGSLGNSTLTCFINQMTSPTGPSPEIVEKGCEKGLKSHMWIYVLMGNMLRGIGETPIVPLGISYLDDFAKEGHTSMHLDSVRITPNDARWVGAWWLSFIVNGLLCITSSIPFFFLPKIPKRSQEERKNSVSLHAPKTDEEKKHMTNLTKQEEQDPSNMTGFLRSLRSILTNEIYVIFLILTLLQVSGFIGSFTYLFKFIEQQFGRTASQANFLLGIITIPTMATAMFLGGYIVKKFKLTSVGIAKFVFFTSSVAYAFQFLYFPLLCENKPFAGLTLTYDGMNPVDSHIDVPLSYCNSDCSCDKNQWEPICGENGVTYISPCLAGCKSFRGDKKPNNTEFYDCSCISNSGNNSAHLGECPRYKCKTNYYFYIILQVTVSFFTAMGSPSLILILMKSVQPELKSLAMGFHSLIIRALGGILAPIYYGAFIDRTCIKWSVTSCGKRGACRLYNSRLFGFSYLGLNLALKTPPLFLYVVLIYFTKRKYKRNDNKTLENGRQFTDEGNPDSVNKNGYYCVPYDEQSNETPL"
misc_feature 199..1860 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /note="Organic Anion Transporter Polypeptide (OATP) family; Region: OATP; pfam03137" /db_xref="CDD:460821" exon 199..340 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /inference="alignment:Splign:2.1.0" exon 341..473 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /inference="alignment:Splign:2.1.0" exon 474..586 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /inference="alignment:Splign:2.1.0" exon 587..733 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /inference="alignment:Splign:2.1.0" exon 734..976 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /inference="alignment:Splign:2.1.0" exon 977..1141 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /inference="alignment:Splign:2.1.0" exon 1142..1337 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /inference="alignment:Splign:2.1.0" exon 1338..1509 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /inference="alignment:Splign:2.1.0" exon 1510..1679 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /inference="alignment:Splign:2.1.0" exon 1680..1744 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /inference="alignment:Splign:2.1.0" exon 1745..1862 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /inference="alignment:Splign:2.1.0" exon 1863..3119 /gene="Slco1b2" /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3" /inference="alignment:Splign:2.1.0" ORIGIN
ggttagacatgccacgcttgctctagaagcctgagctcagggtagacgaccatttcaaaagaaatatttatcaacagtgattgcagacgttcccatcacaaccactgttcagtcatggaccacactcagcagtcaaggaaagctgcagaggcccaaccttcacgatcaaagcaaacaaggttctgcgatggattcaagctatttttggcagccctctccttcagctacatatgcaaagcactaggtggagttgttatgaagagttccatcacccaaatcgaaagaagattcgacataccatcttccatttctggtttgattgatggaggctttgaaattgggaatttattagttattgtatttgtgagttactttggatccaaactacacaggccaaagctgattggaattggctgcttcatcatgggcattgggagcattttgacagcgttgccacatttcttcatgggatattacaagtatgcaaaagaaaacgacattggctctctaggcaactctacattgacctgtttcatcaatcaaatgacatcacccactggaccttcacctgagatagtggagaaaggttgtgaaaaggggttaaagtcacacatgtggatttatgtcttgatggggaacatgcttcgtgggataggggaaacaccaatagtgcccctgggaatttcctaccttgatgactttgcaaaagaagggcacacttccatgcacctagacagtgtccgaataactcctaatgatgctcgttgggttggtgcctggtggctcagcttcattgtgaatggactattatgcattacttcttccatacccttcttttttctgcccaaaattccaaagaggtcacaggaggaaaggaaaaattcagtatctcttcatgcacccaaaacagatgaggagaagaaacacatgactaatttaacaaagcaagaggaacaagatccttccaacatgactggttttctaaggtctctgagaagcatccttaccaatgaaatatatgttatattcttgatactgacgttactacaagtcagcggcttcattggctcctttacttacctgttcaagttcatagagcagcagttcggccggacagcatctcaggccaacttcttgttaggaattataaccatacctactatggcaactgcaatgtttttaggaggatatattgttaaaaaattcaaattgacatcggttggaatcgccaagtttgtatttttcacctcctcagtggcctatgcgtttcagttcttatattttcctctactctgtgaaaacaagccatttgctggcctaaccttgacctacgatggaatgaacccagtggactctcacatagatgtaccactttcttattgtaactcggactgcagttgtgataaaaatcaatgggaacccatctgtggggaaaatggagtcacttacatttcaccttgtctggcaggatgcaaatcttttcgtggtgataagaagccgaataacacagagttctatgactgcagttgtatcagcaactctggaaacaactcagcacatttgggtgaatgcccaagatacaaatgcaaaaccaactattacttttatataattcttcaagtcactgtgtcctttttcactgcaatgggaagcccatctttaatcttgattctgatgaagagcgtccaacctgaattgaaatcacttgcaatgggtttccattcactgattattcgagcactaggagggattctagctccaatctattatggggcattcattgacagaacgtgtattaagtggtctgtcaccagctgtggaaaacgtggtgcatgtaggctatataactccagattatttggattctcctacttgggtttgaacttagctttaaaaactccaccactttttttatatgttgtattaatttatttcacaaagagaaaatataaaagaaatgataacaagacattggaaaatggaagacagttcacagatgaaggaaacccagattctgtaaataaaaatggatactattgtgtaccttatgatgaacaaagcaatgaaacacctctttaaggaaagagaaagatacatctgttgctgtgttttcaaatacccccggggttctttcactgaaatttttcatactttatatgtaatagagaatttataaccctatgcatttataattaaacaaattgcaaatcaaaagaaataagagaacccttgttagggtatagctgtgcatttgtagctaaagatttggagatatataaacaggtattcgcttaagcatttataactcaataaaatagagaatggggcaaggatggacaaaggggaaagggactgtgaaaaattgttgtctttaaaaatcaaaatttgaatcgtactattcatgccagaagcttctgtgataggtgacttcatgatgtggcatattctggtatccccggtaagtcaaatatatatatatatatatatatatatatatatatatatatatatatatatatatttttttttttttttttggagctggggaccgaacccagagccttgcgcttgctaggcaagtgctctaccactgagttaaatccccaaccctaagtcatatatttttaattattaattttaaattgtgtttaatgacatatccatcttctttgtacatactgtacagaatattgagaataaaacagagacgtttaggatgtgagatatctctgtctatctctatctctacccctagcttcacctccttctctgtctccatctccctatctatctatctatctatctatctatctatctatctatcatctatctatccatctatgtatctgtctatctattatctatctatctatctatctatctatctatctatctatctatctatctatctacaatctccccaaatatctaaaattaagatagagtgaatgagacagatatctgtagacactgtattttcttgtgtgatcagatctagtgtggtggatgatagaagttgaacttgctttattgctatgtgttaaaatattttgtttgcattaaaatggcctattgaaatgcttttctgttcctataataaaataacctgatgaaaaagt
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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