2024-03-28 22:19:00, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_177931 2560 bp mRNA linear ROD 22-MAR-2023 DEFINITION Rattus norvegicus origin recognition complex, subunit 1 (Orc1), mRNA. ACCESSION NM_177931 VERSION NM_177931.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 2560) AUTHORS Grolimund L, Aeby E, Hamelin R, Armand F, Chiappe D, Moniatte M and Lingner J. TITLE A quantitative telomeric chromatin isolation protocol identifies different telomeric states JOURNAL Nat Commun 4, 2848 (2013) PUBMED 24270157 REFERENCE 2 (bases 1 to 2560) AUTHORS Patel DJ and Wang Z. TITLE Readout of epigenetic modifications JOURNAL Annu Rev Biochem 82, 81-118 (2013) PUBMED 23642229 REMARK Review article REFERENCE 3 (bases 1 to 2560) AUTHORS Bartke T, Vermeulen M, Xhemalce B, Robson SC, Mann M and Kouzarides T. TITLE Nucleosome-interacting proteins regulated by DNA and histone methylation JOURNAL Cell 143 (3), 470-484 (2010) PUBMED 21029866 REFERENCE 4 (bases 1 to 2560) AUTHORS Shen Z, Sathyan KM, Geng Y, Zheng R, Chakraborty A, Freeman B, Wang F, Prasanth KV and Prasanth SG. TITLE A WD-repeat protein stabilizes ORC binding to chromatin JOURNAL Mol Cell 40 (1), 99-111 (2010) PUBMED 20932478 REFERENCE 5 (bases 1 to 2560) AUTHORS Shu MQ, Qin YL and Jiang MH. TITLE RNA interference targeting ORC1 gene suppresses the proliferation of vascular smooth muscle cells in rats JOURNAL Exp Mol Pathol 84 (3), 206-212 (2008) PUBMED 18499104 REMARK GeneRIF: ORC1 gene silencing causes rat VSMCs to enter a reversible G(0) quiescent, growth arrested state; thus, ORC1 gene may be an important new target for suppressing VSMCs proliferation. REFERENCE 6 (bases 1 to 2560) AUTHORS Siddiqui K and Stillman B. TITLE ATP-dependent assembly of the human origin recognition complex JOURNAL J Biol Chem 282 (44), 32370-32383 (2007) PUBMED 17716973 REFERENCE 7 (bases 1 to 2560) AUTHORS Minami H, Takahashi J, Suto A, Saitoh Y and Tsutsumi K. TITLE Binding of AlF-C, an Orc1-binding transcriptional regulator, enhances replicator activity of the rat aldolase B origin JOURNAL Mol Cell Biol 26 (23), 8770-8780 (2006) PUBMED 16982680 REFERENCE 8 (bases 1 to 2560) AUTHORS Miyake Y, Mizuno T, Yanagi K and Hanaoka F. TITLE Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation JOURNAL J Biol Chem 280 (13), 12643-12652 (2005) PUBMED 15634681 REFERENCE 9 (bases 1 to 2560) AUTHORS Natale DA, Li CJ, Sun WH and DePamphilis ML. TITLE Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals JOURNAL EMBO J 19 (11), 2728-2738 (2000) PUBMED 10835370 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB105378.1. On Jun 3, 2003 this sequence version replaced NM_177931.1. ##Evidence-Data-START## Transcript exon combination :: AB105378.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00132296, SAMD00132297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..2560 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="5" /map="5q34" gene 1..2560 /gene="Orc1" /gene_synonym="Orc1l" /note="origin recognition complex, subunit 1" /db_xref="GeneID:313479" /db_xref="RGD:631435" CDS 1..2547 /gene="Orc1" /gene_synonym="Orc1l" /codon_start=1 /product="origin recognition complex subunit 1" /protein_id="NP_808792.1" /db_xref="GeneID:313479" /db_xref="RGD:631435" /translation="
MPSYVTRQKTRQTFSWVGRPLPNRKQFYQMYKEICMKINGCSEIHIKVGQFVLIQGEDNQKPYVAKLIELFENGSEVPPKKYARVQWFVRFCEIPIPKRHLLGRRPSAQEIFWYDCSDCDNDIHVETIIGPVQVVALAPEDEIPVNQKSEETLFVKLSWNKKNFAPLPPEELAALRRLECQKPLEAKTKSVKSPSWSTAEQEVKRIESSHSTSRSYQDPAHTVTPNAMKSLECGGFTRKPNMRLSRKILCDSLDSQKTCKRRAAFSETTSPPKKPQPGEIKTSSALETLGKNGHTQPFFAKSSMVLRTRGTAVKTTKLTVESALSPVRSRSRYSVAPSVGLTPQYIGRKAKEQETHKEPIHTSLRARRRSSLLTLKRIKQQLWLLDDDKSDQEEEESISSVEVSDSSSEEEDESVPSPPTGKPVGQSRTRRTASKPSSQTPSKSPKKTFRPRPPLHATPQIRDRNLAVQEPASVLEEARLRLHVSAVPDSLPCREQEFQDIYSFVESKLLDGTGGCMYISGVPGTGKTATVHEVIRCLQQAAQTNDVPPFEYVEVNGMKLTEPHQVYVQILQKLTGQKATANHAAELLAKQFCSRGSQKETTVLLVDELDLLWTHKQDVLYNLFDWPTHKGARLVVLTIANTMDLPERIMMNRVASRLGLTRMSFQPYSHSQLKQILVSRLKHLKAFEDDAVQLVARKVAALSGDARRCLDICRRATEICEVSHQRGDSQCLVTVAHLMEAIDEMFSSSYITAIKNSSVLEQSFLRAIIAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSRLGSCRILLVEPSRNDLLLRVRLNVSQNDVLYALKEE"
misc_feature 127..507 /gene="Orc1" /gene_synonym="Orc1l" /note="BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC...; Region: BAH_Orc1p_animal; cd04719" /db_xref="CDD:240070" misc_feature 277..279 /gene="Orc1" /gene_synonym="Orc1l" /note="Histone H4K20me2 binding. /evidence=ECO:0000250|UniProtKB:Q9Z1N2; propagated from UniProtKB/Swiss-Prot (Q80Z32.1); other site" misc_feature 565..681 /gene="Orc1" /gene_synonym="Orc1l" /note="propagated from UniProtKB/Swiss-Prot (Q80Z32.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 577..579 /gene="Orc1" /gene_synonym="Orc1l" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q13415; propagated from UniProtKB/Swiss-Prot (Q80Z32.1); phosphorylation site" misc_feature 754..756 /gene="Orc1" /gene_synonym="Orc1l" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q9Z1N2; propagated from UniProtKB/Swiss-Prot (Q80Z32.1); phosphorylation site" misc_feature 781..840 /gene="Orc1" /gene_synonym="Orc1l" /note="propagated from UniProtKB/Swiss-Prot (Q80Z32.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 808..810 /gene="Orc1" /gene_synonym="Orc1l" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q13415; propagated from UniProtKB/Swiss-Prot (Q80Z32.1); phosphorylation site" misc_feature 850..852 /gene="Orc1" /gene_synonym="Orc1l" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q13415; propagated from UniProtKB/Swiss-Prot (Q80Z32.1); phosphorylation site" misc_feature 940..942 /gene="Orc1" /gene_synonym="Orc1l" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:Q13415; propagated from UniProtKB/Swiss-Prot (Q80Z32.1); acetylation site" misc_feature 973..975 /gene="Orc1" /gene_synonym="Orc1l" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q9Z1N2; propagated from UniProtKB/Swiss-Prot (Q80Z32.1); phosphorylation site" misc_feature 1030..1095 /gene="Orc1" /gene_synonym="Orc1l" /note="propagated from UniProtKB/Swiss-Prot (Q80Z32.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1162..1398 /gene="Orc1" /gene_synonym="Orc1l" /note="propagated from UniProtKB/Swiss-Prot (Q80Z32.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1210..1212 /gene="Orc1" /gene_synonym="Orc1l" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q13415; propagated from UniProtKB/Swiss-Prot (Q80Z32.1); phosphorylation site" misc_feature 1219..1221 /gene="Orc1" /gene_synonym="Orc1l" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q13415; propagated from UniProtKB/Swiss-Prot (Q80Z32.1); phosphorylation site" misc_feature <1444..2319 /gene="Orc1" /gene_synonym="Orc1l" /note="origin recognition complex 1 protein; Provisional; Region: PTZ00112" /db_xref="CDD:240274" misc_feature 1462..2544 /gene="Orc1" /gene_synonym="Orc1l" /note="propagated from UniProtKB/Swiss-Prot (Q80Z32.1); Region: Necessary and sufficient for ORC complex assembly. /evidence=ECO:0000250" misc_feature 2293..2532 /gene="Orc1" /gene_synonym="Orc1l" /note="CDC6, C terminal winged helix domain; Region: Cdc6_C; pfam09079" /db_xref="CDD:430397" misc_feature order(2347..2349,2410..2415,2467..2469,2473..2475, 2485..2493) /gene="Orc1" /gene_synonym="Orc1l" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:176573" exon 1..95 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 96..220 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 221..399 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 400..703 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 704..1043 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 1044..1148 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 1149..1344 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 1345..1442 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 1443..1544 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 1545..1716 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 1717..1824 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 1825..1974 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 1975..2094 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 2095..2264 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 2265..2352 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" exon 2353..2560 /gene="Orc1" /gene_synonym="Orc1l" /inference="alignment:Splign:2.1.0" ORIGIN
atgccgtcctatgtcacaaggcagaagaccagacaaactttctcatgggttggcaggccattgccgaatcgaaaacagttctaccaaatgtacaaagaaatttgtatgaaaatcaatggttgttctgagattcacatcaaggttggacagtttgtattgattcaaggggaagataatcaaaagccctatgttgctaaactgattgaattatttgaaaatgggtctgaagttcctcccaagaaatatgcgcgagtacaatggtttgtccgattctgtgagattcctatccctaaaaggcatttgttaggacggagaccttctgcacaggagatattctggtatgactgttctgactgtgataacgacattcatgtggagaccatcattggccctgttcaggtagtggcattagccccagaagacgagatccctgtgaatcagaaaagtgaggagacactgtttgtgaagctgtcctggaataaaaagaactttgcgccactgccaccagaagaacttgcagcattgaggagactggagtgccaaaaacctttagaagccaagactaagagtgttaaaagcccttcctggagcacagcagaacaagaggtcaaaaggattgaatcaagtcattccacttccagatcttaccaggatcctgctcatactgtcactcccaacgcaatgaagtctctggaatgtggtggttttaccaggaagcctaacatgaggctgtcacggaagatcttgtgtgattccttggattctcaaaaaacatgtaaacgaagagcagccttctctgagaccacctcaccacctaaaaagcctcaacctggtgaaatcaagacctcctcagctttggaaactctaggaaaaaatgggcatactcaacccttttttgccaaaagtagcatggttctgagaacccggggcacagctgtgaagaccacaaagcttactgtggagagtgcacttagccctgtcaggagcaggtcgaggtactcagtggcaccctctgtgggtctgacacctcaatacattgggaggaaggcaaaagaacaagaaactcacaaagaacccatccatacttctcttcgtgcccgtagaaggagttctctcttgactttgaagcggattaagcaacagctttggcttctagatgatgataaaagtgaccaagaagaggaagagtccatatcctctgtggaagtgtcagactccagtagtgaggaggaagatgagtctgttccctcccctccaacaggaaaacccgtggggcagtccaggacccggagaactgcctctaagccatcatcacagaccccctccaagtcaccaaagaaaacttttagacctagaccacctcttcatgctactcctcagatccgagacagaaacttggctgtccaagagccagctagtgtgcttgaagaggcccggctcaggctgcatgtttctgccgtgcctgactctcttccctgtcgagagcaggagttccaagacatctacagctttgtggaaagtaaacttcttgatggaaccggagggtgtatgtacatttctggggtccctgggacagggaagacagccactgtgcatgaagtcatacgctgtctgcagcaggcagcacaaacaaatgatgttcctccctttgaatacgttgaggttaatgggatgaagctgacagaaccccaccaggtctatgtgcagattttacagaaactgacaggccagaaggcaacagctaatcatgcagcagaactgctggcaaagcaattctgcagccgagggtcccagaaggaaaccactgtgctgcttgtggatgagcttgaccttctttggactcacaaacaagatgtgttgtacaacctctttgattggcctactcacaaaggagcccggttggtcgtgttgactattgccaataccatggaccttccagagaggatcatgatgaaccgtgtggctagccgcctgggcctcaccaggatgtctttccaaccctactctcacagccaactgaaacaaatcttagtgtcccgactgaagcatttaaaggcctttgaggatgatgccgtccagttggtagccagaaaggtagcagccctttctggagatgcccggcgctgcctggacatctgcaggcgtgccacagagatctgcgaggtttcccatcagcgtggtgactctcagtgcctggtgactgtggcccacttaatggaagctatagatgaaatgttttcctcatcctatattactgccatcaaaaactcttctgtcctggaacagagcttcctgagagccatcattgcggaattccgtcgatcaggactggaggaagctacatttcaacagatatacagtcagcatgtggctctgtgcagaatggagggactgccttacccaaccatgtcagagaccatggccgtgtgctcgcgtctgggttcttgccgcattcttctggtggagcctagcaggaatgacctactccttcgagtgagactcaatgttagccagaatgatgtgctgtatgctctcaaagaagagtgaaggacttaacaaa
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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