2024-04-25 20:52:35, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_133620 4530 bp mRNA linear ROD 23-MAR-2023 DEFINITION Rattus norvegicus zinc fingers and homeoboxes 1 (Zhx1), mRNA. ACCESSION NM_133620 VERSION NM_133620.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 4530) AUTHORS Clement LC, Liu G, Perez-Torres I, Kanwar YS, Avila-Casado C and Chugh SS. TITLE Early changes in gene expression that influence the course of primary glomerular disease JOURNAL Kidney Int 72 (3), 337-347 (2007) PUBMED 17457373 REMARK GeneRIF: Upregulation of B7.1 with the downregulation of GLEPP1, Wilms' tumor gene (WT1), megalin, and vascular endothelial growth factor started early and persisted through the course of primary glomerular disease. REFERENCE 2 (bases 1 to 4530) AUTHORS Kim SH, Park J, Choi MC, Kim HP, Park JH, Jung Y, Lee JH, Oh DY, Im SA, Bang YJ and Kim TY. TITLE Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression JOURNAL Biochem Biophys Res Commun 355 (2), 318-323 (2007) PUBMED 17303076 REFERENCE 3 (bases 1 to 4530) AUTHORS Liu G, Clement LC, Kanwar YS, Avila-Casado C and Chugh SS. TITLE ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome JOURNAL J Biol Chem 281 (51), 39681-39692 (2006) PUBMED 17056598 REMARK GeneRIF: ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140] REFERENCE 4 (bases 1 to 4530) AUTHORS Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T and Miyamoto K. TITLE Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor JOURNAL Biochem J 373 (Pt 3), 747-757 (2003) PUBMED 12741956 REFERENCE 5 (bases 1 to 4530) AUTHORS Yamada K, Kawata H, Shou Z, Hirano S, Mizutani T, Yazawa T, Sekiguchi T, Yoshino M, Kajitani T and Miyamoto K. TITLE Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3 JOURNAL Biochem J 373 (Pt 1), 167-178 (2003) PUBMED 12659632 REFERENCE 6 (bases 1 to 4530) AUTHORS Yamada K, Kawata H, Matsuura K, Shou Z, Hirano S, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T and Miyamoto K. TITLE Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1) JOURNAL Biochem Biophys Res Commun 297 (2), 368-374 (2002) PUBMED 12237128 REFERENCE 7 (bases 1 to 4530) AUTHORS Hirano S, Yamada K, Kawata H, Shou Z, Mizutani T, Yazawa T, Kajitani T, Sekiguchi T, Yoshino M, Shigematsu Y, Mayumi M and Miyamoto K. TITLE Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer JOURNAL Gene 290 (1-2), 107-114 (2002) PUBMED 12062805 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JACYVU010000185.1. On Nov 26, 2020 this sequence version replaced NM_133620.1. ##Evidence-Data-START## Transcript exon combination :: AB072439.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA5760434, SAMEA5760494 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-54 JACYVU010000185.1 72241268-72241321 c 55-165 JACYVU010000185.1 72234512-72234622 c 166-3017 JACYVU010000185.1 72218017-72220868 c 3018-4530 JACYVU010000185.1 72213043-72214555 c FEATURES Location/Qualifiers source 1..4530 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="7" /map="7q33" gene 1..4530 /gene="Zhx1" /note="zinc fingers and homeoboxes 1" /db_xref="GeneID:171159" /db_xref="RGD:620010" exon 1..54 /gene="Zhx1" /inference="alignment:Splign:2.1.0" exon 55..165 /gene="Zhx1" /inference="alignment:Splign:2.1.0" exon 166..3017 /gene="Zhx1" /inference="alignment:Splign:2.1.0" misc_feature 354..356 /gene="Zhx1" /note="upstream in-frame stop codon" CDS 393..3014 /gene="Zhx1" /note="zinc finger and homeodomain protein 1" /codon_start=1 /product="zinc fingers and homeoboxes protein 1" /protein_id="NP_598304.2" /db_xref="GeneID:171159" /db_xref="RGD:620010" /translation="
MASRRKSTTPCMVLASEQDPDLELISDLEEGPPVLTPVENARAESVSSDEEVHESVDSDNQQNKKVEGGYECKYCTFQTPDLNMFTFHVDSEHPNVVLNSSYVCVECNFLTKRYDALSEHNLKYHPGEENFKLTMVKRNNQTIFEQTINDLTFDGSFVKEENTEQGESIDVSSSGISISKTPIMKMMKNKVENKRITVHHNSAEGTSEEKENGVKASREENAENTSSSASESNTSTSTVNRVHPSPAGTVVTPTAVLPGLAQVITAVSAQQNSNLVPKVLIPVNSIPTYNAALDNNPLLLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLKHGVSWTPEEVEEARRKQFNGTVHTVPQTITVIPTHISTGSNGLPSILQTCQIVGQPGLVLTQVAGANTLPVTAPIALTVAGVPNQTNVQKSQVPAAQPAAETKPATAAVPSSPSVRPEAALVNPDSFGIRAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQRNSKSNQCLHLNNDSSATIIIDSSDETPEPPAAAASQPKQSWNPFPDFAPQKFKEKTAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWFTEKNKTKALKDEKVEVDESNVGSSKEEPGENSPGDEAVAPKSAGTGKICKKTPEQLHMLKSAFVRTQWPSPEEYDKLAEESGLARTDIVSWFGDTRYAWKNGNLKWYYYYQSSNSSSLNGLSSLRKRGRGRPKGRGRGRPRGRPRGGKRMNTWDRVPSLIKFKTGTAILKDYYLKHKFLNEQDLDELVNRSHMGYEQVREWFAERQRRSELGIELFEENEEEDEVIDDQEEDEEETDDSDTWEPPRHVKRKLSKSDD"
misc_feature 393..581 /gene="Zhx1" /note="propagated from UniProtKB/Swiss-Prot (Q8R515.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 498..500 /gene="Zhx1" /note="Phosphothreonine. /evidence=ECO:0000250|UniProtKB:Q9UKY1; propagated from UniProtKB/Swiss-Prot (Q8R515.1); phosphorylation site" misc_feature 525..527 /gene="Zhx1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q9UKY1; propagated from UniProtKB/Swiss-Prot (Q8R515.1); phosphorylation site" misc_feature 531..533 /gene="Zhx1" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q8R515.1); phosphorylation site" misc_feature 534..536 /gene="Zhx1" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q8R515.1); phosphorylation site" misc_feature 684..842 /gene="Zhx1" /note="Zinc-fingers and homeoboxes C2H2 finger domain; Region: zf_C2H2_ZHX; pfam18387" /db_xref="CDD:436457" misc_feature 984..1133 /gene="Zhx1" /note="propagated from UniProtKB/Swiss-Prot (Q8R515.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 996..998 /gene="Zhx1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q9UKY1; propagated from UniProtKB/Swiss-Prot (Q8R515.1); phosphorylation site" misc_feature 1206..2084 /gene="Zhx1" /note="propagated from UniProtKB/Swiss-Prot (Q8R515.1); Region: Required for interaction with NFYA. /evidence=ECO:0000250" misc_feature 1206..1688 /gene="Zhx1" /note="propagated from UniProtKB/Swiss-Prot (Q8R515.1); Region: Required for dimerization. /evidence=ECO:0000250" misc_feature <1287..1421 /gene="Zhx1" /note="Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; Region: homeodomain; cd00086" /db_xref="CDD:238039" misc_feature 1680..1757 /gene="Zhx1" /note="propagated from UniProtKB/Swiss-Prot (Q8R515.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1794..1961 /gene="Zhx1" /note="Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; Region: homeodomain; cd00086" /db_xref="CDD:238039" misc_feature order(1794..1799,1803..1805,1854..1856,1872..1874, 1911..1913,1917..1922,1929..1934,1938..1946,1950..1955) /gene="Zhx1" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238039" misc_feature order(1800..1802,1920..1922,1929..1934,1941..1943) /gene="Zhx1" /note="specific DNA base contacts [nucleotide binding]; other site" /db_xref="CDD:238039" misc_feature 2010..2096 /gene="Zhx1" /note="propagated from UniProtKB/Swiss-Prot (Q8R515.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 2118..2240 /gene="Zhx1" /note="Homeodomain; Region: HOX; smart00389" /db_xref="CDD:197696" misc_feature 2271..2384 /gene="Zhx1" /note="propagated from UniProtKB/Swiss-Prot (Q8R515.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 2334..2336 /gene="Zhx1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q9UKY1; propagated from UniProtKB/Swiss-Prot (Q8R515.1); phosphorylation site" misc_feature 2385..2540 /gene="Zhx1" /note="Homeodomain; Region: HOX; smart00389" /db_xref="CDD:197696" misc_feature order(2388..2390,2508..2510,2517..2522,2529..2531) /gene="Zhx1" /note="specific DNA base contacts [nucleotide binding]; other site" /db_xref="CDD:238039" misc_feature 2583..2693 /gene="Zhx1" /note="propagated from UniProtKB/Swiss-Prot (Q8R515.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 2592..2696 /gene="Zhx1" /note="propagated from UniProtKB/Swiss-Prot (Q8R515.1); Region: Required for nuclear localization. /evidence=ECO:0000250" misc_feature 2712..2714 /gene="Zhx1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q9UKY1; propagated from UniProtKB/Swiss-Prot (Q8R515.1); phosphorylation site" misc_feature <2745..2855 /gene="Zhx1" /note="Homeodomain leucine-zipper encoding, Homez; Region: Homez; pfam11569" /db_xref="CDD:431938" misc_feature 2877..3011 /gene="Zhx1" /note="propagated from UniProtKB/Swiss-Prot (Q8R515.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 2883..3011 /gene="Zhx1" /note="propagated from UniProtKB/Swiss-Prot (Q8R515.1); Region: Required for repressor activity. /evidence=ECO:0000250" exon 3018..4530 /gene="Zhx1" /inference="alignment:Splign:2.1.0" ORIGIN
ctctgaaatgcaagatggcggcggcgaggcgctgaggcgaggcggcccctgcagaagactgctagctactttgggacaatttgcaatgatggcctgagccaagtacctcatttgaagggataaccttccgctttaaggaacataatgctgaagaagctatggcaggtgattggagttgtgcttcatacatttcagcagttcagcagtgttttatctgccaactaagctttttacttgagtgcaccatggagacgctactaatgagacttgttgagcacaaaagtggacttgaagagccagaagccactgttttccaatgaaggattccaaacagttttaagcctcagtgcttttaaatcaccagagattccctccctgcccctaaaatcaaaatggcaagcagacgaaaatcaacaacaccttgcatggtccttgccagtgagcaggatccagatcttgagttgatatcggatttggaagaaggccctcccgtccttacacccgtagaaaatgctagagcagagagtgtctccagcgatgaagaagttcacgaatctgtggattctgacaatcagcaaaataagaaagtggaagggggctatgaatgtaaatactgtacttttcaaactccagatctaaatatgtttactttccatgtagattcagaacatcccaatgttgtgctgaattcatcctatgtttgtgttgaatgcaattttcttaccaaaaggtatgatgcactttctgagcataatctgaaataccacccaggagaagaaaatttcaaactgactatggtgaagcggaataaccagacaatctttgaacagacaataaatgatctgacttttgatggcagttttgttaaagaggagaatacagaacaaggagaatccatagatgtttcttcttcgggaatctccattagtaaaactcccattatgaaaatgatgaaaaataaggtagaaaacaaacggattacagttcaccataactcagctgagggcacttctgaagagaaagagaatggagtaaaagcaagccgggaagaaaatgcagaaaatacgagttcttcagcttcagaatctaacacaagtacttccactgtcaaccgagtgcatcccagtcctgcaggcacagtggtgacccccacagctgttcttcctgggctagcacaggtgataactgcagtctccgctcaacagaactcaaacttggtccctaaggtcttaatccctgttaatagcattccaacctacaatgctgcattggataacaatcctcttctacttaacacctacaacaaattcccttatcctacaatgtcagaaattacagttctttctgctcaagcaaaatatacagaggaacagatcaagatctggttttcagcccaacgtttaaagcatggggttagttggactcctgaagaagtagaggaggcaagaagaaaacaattcaatggaacagtgcatactgtacctcagaccataactgttattcctacacacatttccacaggaagtaatgggttaccatctattttacaaacatgccaaatagttggtcagccaggtctggtccttactcaagtagctggagcaaacaccttgccagtaacggctcccattgctctgacagtggcaggggttccaaatcaaacaaatgtacaaaagagtcaagtgcctgctgctcagcctgctgcagaaacaaagccagccacagcagcagttccatcatcgccaagtgtcaggcctgaagctgcactagtgaacccagattcatttggtattcgggccaaaaagactaaggaacagctggcagaactgaaagttagctaccttaaaaaccagtttccccacgactcagagatcatcaggcttatgaaaataacaggccttaccaaaggcgagattaaaaaatggtttagtgatacaaggtacaaccagagaaattcaaagagtaaccagtgcttacatctcaataacgactcctctgccactatcatcatagactccagtgatgaaaccccagaacccccagctgcagctgcgtcacagccgaaacagtcctggaatccctttcctgactttgctccccagaagtttaaagagaaaactgcagagcaacttcgtgtccttcaggcaagttttctcaacagttctgtacttacagatgaagaattaaataggttaagagcgcaaaccaaacttactagaagagaaattgatgcttggtttacagagaaaaataaaacaaaagctttaaaggatgagaaagtagaagtagatgaaagtaatgtaggtagttccaaagaagaacctggagaaaattctcctggagacgaagccgttgcacctaagtcagcagggacaggcaagatatgtaagaagacaccagagcaactgcacatgcttaaaagtgcatttgtccgaacacagtggccgtcaccagaagagtatgacaagctggctgaagaaagtgggcttgccagaacagacatagttagttggtttggagatacccgttatgcttggaagaatgggaacttgaaatggtactactactatcaaagctccaattcaagtagtttgaatggtctgtcctcccttaggaaaagagggagaggcagacccaaaggacgaggcagaggcagaccacgtgggcggcccagaggaggaaaaagaatgaacacctgggacagggtaccgtcgctcataaagtttaaaactggaacagcaatacttaaagattattacctgaagcacaaatttcttaatgagcaagaccttgatgaacttgtcaacagatcacacatgggttacgagcaggtcagagagtggtttgcagaaagacaaagaagatctgagttaggtatagaattatttgaggaaaatgaggaggaagatgaggttattgatgatcaggaagaagatgaagaagaaacagatgatagtgacacttgggaacccccacgacatgtgaagcggaagctttctaaatcggatgactgaaatctacttaaaattctgaaggagaataagttcttcaattcaagatgtctgaattactgtgaatgggcccaaccaatccttgatgacactgagaatgctttggggcatacatactttcaaaacagaatccaatatccaaaagaaatggagctccatgttgtgccaaagtcaaactgctgcagtcgggggcggttctgcaatgtaaatagagcgctaattaaaacaaacagactgtaaaagtgaaattttattctgacaggatgcaaaccttgtgaatctttgactttctaaggggttaatgaccactagagcttgtcctcacctcgactccagcatacagctctgtaagacaggctgtattacctgtattctttgacatgtgattaagcttacagctttgagtgaccaaacattttacagagtaaaagttgttagaaatgggagaggagaaccaaaccctactttctgtgtcttatttttcaggccctcaccaaattaaaagttgtacatgggcttacacagtttgcagtgtaaaagcagcctgtgcctgttatgttaggacagaaagacctgtggcttgctggcctttatgacgagaccctccactgaacactcatataaaccagtttctacttgtgcacttgtggggcttctctttgtcagaatccgatttgctttttactaagctgaagatactaccccagcaggagaaggaactcagtagggaacactctaaacatgttccaaacatgtgagagtccatagtgaaatacatgtggtgtgttctcaccggcgtgggactcaggaaggccagacagtctcaggttggattttgcaggaattaccttttcatgaagttgtaccttatgtaacaatttcagtgaacagaggggaaaaaaaattggaacctagcaagttaaaaatttccttttgatgtaagaatcagggcgtgttagcggtaactgtgctgcagcagaagacagagttcctactgacttgtaacagactggtgctgacgttcgtgctgggaaggaccctttctgttgtgatcataggaccacttttcaaactgtgctttcctcacagaacaaaatttttagttttattagatttggatttaaaatttttttgaatgatcacacatagtgggtttggccagttcatctttttctaacttaatgaataataaatactaagctcttggtttaatgtttgtcagctaatgagagatgttatgaaaaagccttgaatatgcatgctgctttcatttttataaactttttattttttaactatagctttattagcaattcccaaatgctgcaatttgctgatttcttcactcagacagctggctttgtgggcggctttttcatactactgttaactttttgaaaacgaagtgatgtaaagactgtaacaattgaatgcactaagctgtttttcttttacacatttaaaaacttcttaaagtactctgtattataatgattaaattgctccctttttaaaacca
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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