2024-04-24 10:58:56, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_053457 1848 bp mRNA linear ROD 20-MAR-2023 DEFINITION Rattus norvegicus claudin 11 (Cldn11), mRNA. ACCESSION NM_053457 VERSION NM_053457.3 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1848) AUTHORS Kato T, Mizuno K, Nishio H, Moritoki Y, Kamisawa H, Kurokawa S, Nakane A, Maruyama T, Ando R, Hayashi Y and Yasui T. TITLE Disorganization of claudin-11 and dysfunction of the blood-testis barrier during puberty in a cryptorchid rat model JOURNAL Andrology 8 (5), 1398-1408 (2020) PUBMED 32196966 REMARK GeneRIF: Disorganization of claudin-11 and dysfunction of the blood-testis barrier during puberty in a cryptorchid rat model. REFERENCE 2 (bases 1 to 1848) AUTHORS Berndt P, Winkler L, Cording J, Breitkreuz-Korff O, Rex A, Dithmer S, Rausch V, Blasig R, Richter M, Sporbert A, Wolburg H, Blasig IE and Haseloff RF. TITLE Tight junction proteins at the blood-brain barrier: far more than claudin-5 JOURNAL Cell Mol Life Sci 76 (10), 1987-2002 (2019) PUBMED 30734065 REFERENCE 3 (bases 1 to 1848) AUTHORS Oh YS, Jo NH, Park JK and Gye MC. TITLE Changes in Inflammatory Cytokines Accompany Deregulation of Claudin-11, Resulting in Inter-Sertoli Tight Junctions in Varicocele Rat Testes JOURNAL J Urol 196 (4), 1303-1312 (2016) PUBMED 27164517 REMARK GeneRIF: An increase in proinflammatory cytokines might be responsible for deregulation of Cldn11 in the Sertoli cells in varicocele testes, leading to alterations in the permeability of the blood-testis barrier and immunological barriers to normal spermatogenesis. REFERENCE 4 (bases 1 to 1848) AUTHORS McCabe MJ, Foo CF, Dinger ME, Smooker PM and Stanton PG. TITLE Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro JOURNAL Asian J Androl 18 (4), 620-626 (2016) PUBMED 26585695 REMARK GeneRIF: We provide quantitative evidence that claudin-11 contributes significantly to Sertoli cell tight junction function in vitro. Interestingly, occludin, which is hormonally regulated but not implicated in infertility until late adulthood, is also a significant contributor to barrier function. REFERENCE 5 (bases 1 to 1848) AUTHORS Uetsuka S, Ogata G, Nagamori S, Isozumi N, Nin F, Yoshida T, Komune S, Kitahara T, Kikkawa Y, Inohara H, Kanai Y and Hibino H. TITLE Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea JOURNAL Eur J Neurosci 42 (3), 1984-2002 (2015) PUBMED 26060893 REFERENCE 6 (bases 1 to 1848) AUTHORS Krause G, Winkler L, Mueller SL, Haseloff RF, Piontek J and Blasig IE. TITLE Structure and function of claudins JOURNAL Biochim Biophys Acta 1778 (3), 631-645 (2008) PUBMED 18036336 REMARK Review article REFERENCE 7 (bases 1 to 1848) AUTHORS Werner HB, Kuhlmann K, Shen S, Uecker M, Schardt A, Dimova K, Orfaniotou F, Dhaunchak A, Brinkmann BG, Mobius W, Guarente L, Casaccia-Bonnefil P, Jahn O and Nave KA. TITLE Proteolipid protein is required for transport of sirtuin 2 into CNS myelin JOURNAL J Neurosci 27 (29), 7717-7730 (2007) PUBMED 17634366 REFERENCE 8 (bases 1 to 1848) AUTHORS Florin A, Maire M, Bozec A, Hellani A, Chater S, Bars R, Chuzel F and Benahmed M. TITLE Androgens and postmeiotic germ cells regulate claudin-11 expression in rat Sertoli cells JOURNAL Endocrinology 146 (3), 1532-1540 (2005) PUBMED 15591150 REMARK GeneRIF: claudin-11 expression in rat Sertoli cells is regulated by androgens and postmeiotic germ cells REFERENCE 9 (bases 1 to 1848) AUTHORS Lui WY, Lee WM and Cheng CY. TITLE Transforming growth factor-beta3 perturbs the inter-Sertoli tight junction permeability barrier in vitro possibly mediated via its effects on occludin, zonula occludens-1, and claudin-11 JOURNAL Endocrinology 142 (5), 1865-1877 (2001) PUBMED 11316752 REFERENCE 10 (bases 1 to 1848) AUTHORS Gow A, Southwood CM, Li JS, Pariali M, Riordan GP, Brodie SE, Danias J, Bronstein JM, Kachar B and Lazzarini RA. TITLE CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice JOURNAL Cell 99 (6), 649-659 (1999) PUBMED 10612400 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JACYVU010000067.1. On Nov 27, 2020 this sequence version replaced NM_053457.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070927.1, CB582493.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA5760383, SAMEA5760389 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-421 JACYVU010000067.1 27288252-27288672 c 422-586 JACYVU010000067.1 27284586-27284750 c 587-1848 JACYVU010000067.1 27275367-27276628 c FEATURES Location/Qualifiers source 1..1848 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="2" /map="2q24" gene 1..1848 /gene="Cldn11" /note="claudin 11" /db_xref="GeneID:84588" /db_xref="RGD:71081" exon 1..421 /gene="Cldn11" /inference="alignment:Splign:2.1.0" misc_feature 118..120 /gene="Cldn11" /note="upstream in-frame stop codon" CDS 196..819 /gene="Cldn11" /codon_start=1 /product="claudin-11" /protein_id="NP_445909.2" /db_xref="GeneID:84588" /db_xref="RGD:71081" /translation="
MVATCLQVVGFVTSFVGWIGIIVTTSTNDWVVTCSYTIPTCRKMDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGHEPGVAKYRRAQLAGVLLILLALCAIVATIWFPVCAHREITIVSFGYSLYAGWIGAVMCLVGGCVIVCCSGDAQSFGENRFYYSSGSSSPTHAKSAHV"
misc_feature 199..261 /gene="Cldn11" /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1); transmembrane region" misc_feature 211..711 /gene="Cldn11" /note="PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl21598" /db_xref="CDD:451326" misc_feature 442..504 /gene="Cldn11" /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1); transmembrane region" misc_feature 562..624 /gene="Cldn11" /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1); transmembrane region" misc_feature 667..729 /gene="Cldn11" /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1); transmembrane region" misc_feature 772..774 /gene="Cldn11" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site" misc_feature 775..777 /gene="Cldn11" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site" misc_feature 784..786 /gene="Cldn11" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site" misc_feature 787..789 /gene="Cldn11" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site" exon 422..586 /gene="Cldn11" /inference="alignment:Splign:2.1.0" exon 587..1848 /gene="Cldn11" /inference="alignment:Splign:2.1.0" ORIGIN
gtccccgccaggcgcacctgtccccgctgcacgccgtcgcagcagcgctcgcagcctctcctctccactcggagtatcccggagccagcggcttgcgagggcgggagagagcaagcctagggaaggctctgtccaggccggcgcagggggcacagtccgtgtgggtcgagctgcgtggacgtcgctgcggccaccatggtagccacttgcctgcaggtggtgggcttcgtcactagcttcgtgggttggattggcatcatcgtcacaacgtccaccaatgactgggtggtgacctgcagctacaccatccccacctgccgcaaaatggacgaactgggctccaaggggctgtgggccgactgcgtcatggccactggtctctaccactgcaagcccctggtggacatcctcatcctccctggttacgtgcaggcttgtagagccctcatgattgctgcctcagttctgggcctgccggccatcttgctgctgttaacagttctcccctgtatccgaatgggccacgagcctggagtggccaagtacaggcgagcccagctggctggggtgctccttattctgctggctctctgcgccattgtcgccaccatctggtttcctgtatgcgcccaccgcgagatcaccatcgtgagctttggctactcgctgtatgcgggctggatcggtgctgtgatgtgcctggtgggtggctgtgtcatcgtctgctgctccggggatgcacagtcgtttggagaaaaccgtttctattactcttctggctccagctcaccaacgcacgccaagagtgcccatgtctaagagggctgctccactgcccaccgaggtgctgtaaatgctgggcctgggccctgggtttgcttgccacagtggggagaagcccacttccctgccaggcactaaagccaaagttctagaaagtatcctgcctggcattttgcagtcataacaccccacccatccacccacccacccacccaccacctcttggttgccttaaaagaaatctccagctcagataatgcccacatagttttctcctggagttgcaggctgttcgctcctttcctcgggcgttccattgttgttgattaaaaaaatattgtgtttctctcttaaatccaaatgtcttgggaacattgctgacttgggtgtgggttgggagagaaataaaagatgcttttcaaagggttaccagcgacaatggaagcctcgtagagacagcgctcttctctctttcggcttagtttcaaggtcacttacatataagagatagaaacggatagacttggaacacgggtgggaggggaactcggggcattccctccgtgggaaagaagcttctcttttataagttgaggggttgggtctctctctctcttttttttttttagtttgtgattttacatttttctgtatatactttttcaagatcgatcgtttttataaccacgggtttcctgaaattctcaattcaccaatatgaaggaaatgaaccaagcagacgttaatatgcaataagtaatagtacggagattataactttaactgaccacccccagtttccaggtttgtatgctgtagtttttaattctacggttgcgtatgctttgaattaacacatttaaaaaccctttctccccttctatctctgtctccattctgttagcgatcttgaagcagtgctgtttagcataagttgtactgttgaatttggcttcatgggtgtaaacaccgatggtctgtcagtgtctaagattctgggcactgcaagctcggctcggtgcatttgtttcaggtaaaatctgtgcaataaaataacaaactgtc
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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