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Previous release (v1)
2024-04-26 06:36:59, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_053376 4255 bp mRNA linear ROD 20-MAR-2023
DEFINITION Rattus norvegicus kinesin family member 2A (Kif2a), mRNA.
ACCESSION NM_053376 XM_001065116 XM_001065173 XM_003753516 XM_345150
VERSION NM_053376.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 4255)
AUTHORS Wang J, Chen J, Chen J, Liu X, Yang H, Liu J, He A, Gao X and Xin
Y.
TITLE KIF2 mediates the neuroprotection in cerebral ischaemia injury by
affecting NF-kappaB pathway
JOURNAL Clin Exp Pharmacol Physiol 47 (2), 274-280 (2020)
PUBMED 31514228
REMARK GeneRIF: KIF2 mediates the neuroprotection in cerebral ischaemia
injury by affecting NF-kappaB pathway.
REFERENCE 2 (bases 1 to 4255)
AUTHORS Seira O, Liu J, Assinck P, Ramer M and Tetzlaff W.
TITLE KIF2A characterization after spinal cord injury
JOURNAL Cell Mol Life Sci 76 (21), 4355-4368 (2019)
PUBMED 31041455
REMARK GeneRIF: KIF2A at the injured axonal tips may contribute to neurite
outgrowth inhibition after injury, and that its increased
expression in inhibitory spinal neurons adjacent to the injury site
might contribute to an intrinsic wiring-control mechanism
associated with neuropathic pain. Further studies will determine
whether KIF2A may be a potential target for the development of
regeneration-promoting or pain-preventing therapies.
REFERENCE 3 (bases 1 to 4255)
AUTHORS Watanabe T, Kakeno M, Matsui T, Sugiyama I, Arimura N, Matsuzawa K,
Shirahige A, Ishidate F, Nishioka T, Taya S, Hoshino M and Kaibuchi
K.
TITLE TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells
through KIF2A phosphorylation
JOURNAL J Cell Biol 210 (5), 737-751 (2015)
PUBMED 26323690
REFERENCE 4 (bases 1 to 4255)
AUTHORS Krahling AM, Alvarez L, Debowski K, Van Q, Gunkel M, Irsen S,
Al-Amoudi A, Strunker T, Kremmer E, Krause E, Voigt I, Wortge S,
Waisman A, Weyand I, Seifert R, Kaupp UB and Wachten D.
TITLE CRIS-a novel cAMP-binding protein controlling spermiogenesis and
the development of flagellar bending
JOURNAL PLoS Genet 9 (12), e1003960 (2013)
PUBMED 24339785
REFERENCE 5 (bases 1 to 4255)
AUTHORS Sonnen KF, Schermelleh L, Leonhardt H and Nigg EA.
TITLE 3D-structured illumination microscopy provides novel insight into
architecture of human centrosomes
JOURNAL Biol Open 1 (10), 965-976 (2012)
PUBMED 23213374
REFERENCE 6 (bases 1 to 4255)
AUTHORS Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I,
Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA
and Andersen JS.
TITLE Novel asymmetrically localizing components of human centrosomes
identified by complementary proteomics methods
JOURNAL EMBO J 30 (8), 1520-1535 (2011)
PUBMED 21399614
REFERENCE 7 (bases 1 to 4255)
AUTHORS Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
TITLE Defining the membrane proteome of NK cells
JOURNAL J Mass Spectrom 45 (1), 1-25 (2010)
PUBMED 19946888
REFERENCE 8 (bases 1 to 4255)
AUTHORS Jang CY, Wong J, Coppinger JA, Seki A, Yates JR 3rd and Fang G.
TITLE DDA3 recruits microtubule depolymerase Kif2a to spindle poles and
controls spindle dynamics and mitotic chromosome movement
JOURNAL J Cell Biol 181 (2), 255-267 (2008)
PUBMED 18411309
REFERENCE 9 (bases 1 to 4255)
AUTHORS Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan JB,
Abraham RT and Jiang W.
TITLE Functional analysis of human microtubule-based motor proteins, the
kinesins and dyneins, in mitosis/cytokinesis using RNA interference
JOURNAL Mol Biol Cell 16 (7), 3187-3199 (2005)
PUBMED 15843429
REFERENCE 10 (bases 1 to 4255)
AUTHORS Debernardi S, Fontanella E, De Gregorio L, Pierotti MA and Delia D.
TITLE Identification of a novel human kinesin-related gene (HK2) by the
cDNA differential display technique
JOURNAL Genomics 42 (1), 67-73 (1997)
PUBMED 9177777
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JACYVU010000065.1 and FM092220.1.
On or before Sep 8, 2012 this sequence version replaced
XM_001065173.3, XM_001065116.3, XM_003753516.1, XM_345150.5.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support SAMD00132261,
SAMD00132262 [ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-110 JACYVU010000065.1 30936398-30936507 c
111-205 JACYVU010000065.1 30903434-30903528 c
206-322 JACYVU010000065.1 30902738-30902854 c
323-377 JACYVU010000065.1 30899446-30899500 c
378-500 JACYVU010000065.1 30897151-30897273 c
501-601 JACYVU010000065.1 30896480-30896580 c
602-697 JACYVU010000065.1 30894234-30894329 c
698-752 JACYVU010000065.1 30892776-30892830 c
753-905 JACYVU010000065.1 30892284-30892436 c
906-1162 FM092220.1 1-257
1163-1305 JACYVU010000065.1 30888634-30888776 c
1306-1510 JACYVU010000065.1 30888298-30888502 c
1511-1621 JACYVU010000065.1 30887170-30887280 c
1622-1689 JACYVU010000065.1 30886284-30886351 c
1690-1840 JACYVU010000065.1 30880415-30880565 c
1841-1942 JACYVU010000065.1 30878171-30878272 c
1943-2078 JACYVU010000065.1 30877427-30877562 c
2079-4255 JACYVU010000065.1 30873268-30875444 c
FEATURES Location/Qualifiers
source 1..4255
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="2"
/map="2q13"
gene 1..4255
/gene="Kif2a"
/gene_synonym="Kif2"
/note="kinesin family member 2A"
/db_xref="GeneID:84391"
/db_xref="RGD:70974"
exon 1..110
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
CDS 47..2164
/gene="Kif2a"
/gene_synonym="Kif2"
/note="kinesin heavy chain member 2; kinesin-2; kinesin
heavy chain family, member 2; kinesin heavy chain member
2A"
/codon_start=1
/product="kinesin-like protein KIF2A"
/protein_id="NP_445828.1"
/db_xref="GeneID:84391"
/db_xref="RGD:70974"
/translation="
MATANFGKIQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLESIFSLNPDLVPDEDIEPSPEIPPPSSSSKVNKIVKNRRTVASIKNDPPPRDNRVVGSARARPSQLPEQSSSAQQNGSVSDISPVQAAKKEFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKRAQDVDATNPNYEIMCMIRDFRGSLDYRPLTTADPIDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKGKLHGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKELTVDPTAAGDVRPIMHHPPSQIDDLETQWGVGSSPQRDDLKLLCEQNEEEVSPQLFTFHEAVSQMVEMEEQVVEDHRAVFQESIRWIEDEKALLEMTEEVDYDVDSYATQLEAILEQKIDILTELRDKVKSFRAALQEEEQASKQINPKRPRAL"
misc_feature 239..601
/gene="Kif2a"
/gene_synonym="Kif2"
/note="propagated from UniProtKB/Swiss-Prot (Q9WV63.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 269..271
/gene="Kif2a"
/gene_synonym="Kif2"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q9WV63.2); phosphorylation site"
misc_feature 332..334
/gene="Kif2a"
/gene_synonym="Kif2"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:O00139; propagated from
UniProtKB/Swiss-Prot (Q9WV63.2); phosphorylation site"
misc_feature 341..343
/gene="Kif2a"
/gene_synonym="Kif2"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:O00139; propagated from
UniProtKB/Swiss-Prot (Q9WV63.2); phosphorylation site"
misc_feature 347..349
/gene="Kif2a"
/gene_synonym="Kif2"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P28740; propagated from
UniProtKB/Swiss-Prot (Q9WV63.2); acetylation site"
misc_feature 446..448
/gene="Kif2a"
/gene_synonym="Kif2"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:O00139; propagated from
UniProtKB/Swiss-Prot (Q9WV63.2); phosphorylation site"
misc_feature 461..463
/gene="Kif2a"
/gene_synonym="Kif2"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:O00139; propagated from
UniProtKB/Swiss-Prot (Q9WV63.2); phosphorylation site"
misc_feature 710..1696
/gene="Kif2a"
/gene_synonym="Kif2"
/note="Kinesin motor domain, KIF2-like group; Region:
KISc_KIF2_like; cd01367"
/db_xref="CDD:276818"
misc_feature order(734..736,980..982,989..991,995..1006,1412..1414)
/gene="Kif2a"
/gene_synonym="Kif2"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:276818"
misc_feature order(1556..1558,1565..1567,1574..1576)
/gene="Kif2a"
/gene_synonym="Kif2"
/note="microtubule interaction site [polypeptide binding];
other site"
/db_xref="CDD:276818"
misc_feature 1760..1762
/gene="Kif2a"
/gene_synonym="Kif2"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q9WV63.2); phosphorylation site"
exon 111..205
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 206..322
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 323..377
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 378..500
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 501..601
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 602..697
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 698..752
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 753..915
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 916..1006
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 1007..1070
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 1071..1162
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 1163..1305
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 1306..1510
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 1511..1621
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 1622..1689
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 1690..1840
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 1841..1942
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 1943..2078
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
exon 2079..4255
/gene="Kif2a"
/gene_synonym="Kif2"
/inference="alignment:Splign:2.1.0"
ORIGIN
tccccgtctgtttcgcccgcccgccgccgccgctccggatgaggtgatggcaacggctaacttcggcaagatccagatcgggatttacgtggaaatcaagcgcagcgatggccgaatacaccaggcaatggtgacatcattaaatgaagataatgaaagtgtcacagtcgagtggatagaaaatggagacacaaaaggaaaagagattgacttggaaagcatcttttcacttaaccctgaccttgtacctgatgaagacattgagccaagtccagaaatacctccaccctcctcatcctcaaaagtaaacaaaattgtaaagaaccgacggactgtggcatctattaagaacgaccctccccccagagataatagagtggttggttcagcacgcgcacggcctagtcaacttcctgagcagtcatcttctgcacaacagaatggtagcgtttcagatatatctccagttcaagctgcaaaaaaggagtttggacctccttcacgtagaaaatctaattgtgtgaaagaagtagaaaaattgcaagaaaaacgagaaaaaagaagattgcaacagcaagaacttagagaaaaaagagcccaggatgtcgatgccacaaatccaaattacgagattatgtgtatgatcagagacttcagagggagcttggactatagacccctcacaacagctgatcctattgatgaacataggatatgtgtttgtgtaagaaaacgaccactcaataaaaaagaaactcagatgaaagatcttgatgtcatcacaatccctagtaaagatgttgtgatggttcatgaacccaaacagaaagtagacttaacaaggtacttagaaaaccagacatttcgttttgattatgcctttgatgactcagctcctaatgaaatggtttacagatttactgccaggccactggtggaaacaatatttgaaaggggcatggctacctgctttgcttatgggcagactggaagtgggaaaactcacactatgggtggtgacttttcaggaaagaaccaggattgctctaagggaatttatgcattagcagctcgagatgtgtttttaatgctgaagaagccaaactataagaaactagaactccaagtatatgcaacattttttgaaatttatagtggaaaggtgtttgacttactaaataggaaaacaaagttaagagtcctagaggatggaaagcagcaggtgcaagtggtagggctgcaggaacgggaggtcaagtgtgtggaagacgtgctgaagctcatcgacatcggcaacagctgcagaacatctggtcagacatctgcaaatgcacactcatctcggagccatgcagtgtttcagatcattcttaggaggaaggggaaactacatggtaaattttctctcatcgacctggctgggaacgaaagaggagctgatacgtccagtgcagacaggcaaaccaggcttgaaggtgctgaaattaataaaagccttttagcactcaaggagtgcatccgagccttaggtagaaataaaccccacactcctttccgagcaagtaaactcactcaggtgttgagagattccttcataggtgagaattctcgcacttgcatgattgccacgatctctccaggaatggcatcctgtgaaaacactcttaatacattaagatatgcaaatagggtgaaagaactgactgtggatccaactgctgctggtgatgtccgtccaataatgcaccatccaccaagccagattgacgacctagagacacagtggggggtggggagttcccctcagagagatgatctgaaacttctttgtgaacaaaatgaagaagaagtttctccacagttgtttactttccacgaagccgtctcccagatggtagagatggaggaacaggttgtggaagaccacagggcagtgttccaggaatccattcgctggatagaagatgaaaaggctctcctagagatgactgaagaagtagactatgatgtagactcatatgctacacagcttgaagctattcttgagcaaaaaatagacattttaactgagttacgagataaagtgaaatcttttcgtgcagcgctacaagaagaagaacaagccagcaagcagattaaccccaagagaccccgagccctctaagttggtatttgctactaaaggatcgctggaatccccaatactgtaacacatggtggtccaactgtaaaggccacttgaacgtttttgaaatcttaagtgtgtggaaaatatcttgtccttcatctgaatgacatttcaattttgtgaaacactcctttgtctacaaaatgcttctagtccaagaggcacaagtaacaattgggattagtgaagtattttgtttcatttacccacatagtgattgcttttcgatatccttgccaattttatttaaaggttgtggaagtaatccagaagtggaaaataggggaaaccacagaatttcctttaactcacatcaattttggtagcaagactgagcagttttgagtcctctgcgtgcatgcatacctcatcagtgatgtacatacttcgcctactcctagggccagttgtggttactcatcctcctgtgccttccctaaggctagcgactgcaggcttctgaaacacagccacgagaagtacattccttgtttgtaactgtaagttcctttattgcgtgtgcattttactgtattgaggcgcgtgtgtgtgtgtgtgactagtcactttggcaggatgagccgtatcagttgaacgggactgcggcctgacagtgggcaagctgctggaccacttcgtcttacgtgtaaagaaatctggaattatgattttaataccatgacatgcgattataactttcttaccactttctctgtaaaaactaaaatataaactagttggtgtataataaaaagtaaagaaattctgagaggacttttatcttaggataatacatatatacatgcagtgtgtgtgcagtggtgttaacaagactcatagtggaatctggtccttagcgatgccgttattgaagttgaagtgtttattagctcaccaaaacgtaacgtactgttaaaggagactggtttctgatgcatgaacatttgtatgtacactgaaagtagtccatagcataagttagatagccaagcatagagtatgtaaccaaccccgggatgtgttgacgacttacaaggcaggtctttccaagctccatctaatacctgggatgtgatggttatttggtgagaatcatatttcacctatagattggtggtaaaataggctactctttaaatggcagcactcatttttatagctgctcgtctaaaaaagaaaactggccaattttcatgtaaatattgtttaaagatatatatatatatgtatatctctaggagttttcccttggttccccctacatagtccagtaggtgaaccaaagaacctcccatggatctcgtgattaactctagggaacctgctgattcagtaggtgaaccaaggggaaatctatgaatagagtcaatgagccagattctttattctcattcacttgtcataaatgagagggtagctgtgaggaatcctaacaccatggtcaaaaagctctgtaaacatgaaatctaaatcaaatgtagattttttcacaatatgcttattaataaatgaaatttatgaaacaaatttagaaataatgtacttcaatataatcacctttgttttggaaggaactcaggttttcttgcagttttatgatatattctatttgtgtttgtttcaaagacaagctgtttaagaaggtaatttttgctgagtacatgcctttaatcccagcaattggaagcaaaggcaggtggatttctgagttcagggccagcctggtgtacatactaagttccaggacggccagctctatgtaccttgtccccagttttgagggtggctgttaatgtagtgggcaataaaggcacaaaattgcttataacttgcaaaatagtttaatgttattggcattggacaggcattgtctttgaaggtcctaatagggatatgttgccttattggctccgtcctgatctgtagtcagtaaacattctgggaggtaagatgagcctcagctttacagagggaagctttagtcagcagaaaactagctgagaaagcctggccaagcagaaacgtctccctaaggtagaagtggtaagagctaactctgcaaagctg
//
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@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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