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Previous release (v1)
2024-11-01 10:23:42, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_019195 1952 bp mRNA linear ROD 04-JUN-2024
DEFINITION Rattus norvegicus Cd47 molecule (Cd47), mRNA.
ACCESSION NM_019195
VERSION NM_019195.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 1952)
AUTHORS Zhang,Y. and Hao,J.
TITLE Anti-tumor effect of PTEN and its effect on inhibition of the bone
tumor through the CD47-SIRPalpha signaling pathway
JOURNAL Cell Mol Biol (Noisy-le-grand) 69 (14), 40-44 (2023)
PUBMED 38279488
REMARK GeneRIF: Anti-tumor effect of PTEN and its effect on inhibition of
the bone tumor through the CD47-SIRPalpha signaling pathway.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 1952)
AUTHORS Takayasu,H.
TITLE Upregulated TSP1 and CD47 expression in the lung in
nitrofen-induced congenital diaphragmatic hernia
JOURNAL Pediatr Int 65 (1), e15447 (2023)
PUBMED 36528876
REMARK GeneRIF: Upregulated TSP1 and CD47 expression in the lung in
nitrofen-induced congenital diaphragmatic hernia.
REFERENCE 3 (bases 1 to 1952)
AUTHORS Ye,F., Hua,Y., Keep,R.F., Xi,G. and Garton,H.J.L.
TITLE CD47 blocking antibody accelerates hematoma clearance and
alleviates hydrocephalus after experimental intraventricular
hemorrhage
JOURNAL Neurobiol Dis 155, 105384 (2021)
PUBMED 33945877
REMARK GeneRIF: CD47 blocking antibody accelerates hematoma clearance and
alleviates hydrocephalus after experimental intraventricular
hemorrhage.
REFERENCE 4 (bases 1 to 1952)
AUTHORS Gao,Y., Zhang,D., Yang,C., Duan,X., Li,X. and Zhong,D.
TITLE Two validated liquid chromatography-mass spectrometry methods with
different pretreatments for the quantification of an anti-CD47
monoclonal antibody in rat and cynomolgus monkey serum compared
with an electrochemiluminescence method
JOURNAL J Pharm Biomed Anal 175, 112792 (2019)
PUBMED 31377653
REMARK GeneRIF: For the quantification of an anti-CD47 monoclonal
antibody.
REFERENCE 5 (bases 1 to 1952)
AUTHORS Li,Y., Zhao,K., Zong,P., Fu,H., Zheng,Y., Bao,D., Yin,Y., Chen,Q.,
Lu,L., Dai,Y., Hou,D. and Kong,X.
TITLE CD47 deficiency protects cardiomyocytes against
hypoxia/reoxygenation injury by rescuing autophagic clearance
JOURNAL Mol Med Rep 19 (6), 5453-5463 (2019)
PUBMED 31059044
REMARK GeneRIF: The CD47 antibody or SiCD47 can protect cardiomyocytes
against H/R injury through increasing autophagic flux and
autophagic clearance. CD47 deficiency may offer a potential
therapeutic approach for preventing myocardial I/R injury.
REFERENCE 6 (bases 1 to 1952)
AUTHORS de Vries,H.E., Hendriks,J.J., Honing,H., De Lavalette,C.R., van der
Pol,S.M., Hooijberg,E., Dijkstra,C.D. and van den Berg,T.K.
TITLE Signal-regulatory protein alpha-CD47 interactions are required for
the transmigration of monocytes across cerebral endothelium
JOURNAL J Immunol 168 (11), 5832-5839 (2002)
PUBMED 12023387
REFERENCE 7 (bases 1 to 1952)
AUTHORS Latour,S., Tanaka,H., Demeure,C., Mateo,V., Rubio,M., Brown,E.J.,
Maliszewski,C., Lindberg,F.P., Oldenborg,A., Ullrich,A.,
Delespesse,G. and Sarfati,M.
TITLE Bidirectional negative regulation of human T and dendritic cells by
CD47 and its cognate receptor signal-regulator protein-alpha:
down-regulation of IL-12 responsiveness and inhibition of dendritic
cell activation
JOURNAL J Immunol 167 (5), 2547-2554 (2001)
PUBMED 11509594
REFERENCE 8 (bases 1 to 1952)
AUTHORS Verdrengh,M., Lindberg,F.P., Ryden,C. and Tarkowski,A.
TITLE Integrin-associated protein (IAP)-deficient mice are less
susceptible to developing Staphylococcus aureus-induced arthritis
JOURNAL Microbes Infect 1 (10), 745-751 (1999)
PUBMED 10816079
REFERENCE 9 (bases 1 to 1952)
AUTHORS Huang,A.M., Wang,H.L., Tang,Y.P. and Lee,E.H.
TITLE Expression of integrin-associated protein gene associated with
memory formation in rats
JOURNAL J Neurosci 18 (11), 4305-4313 (1998)
PUBMED 9592107
REFERENCE 10 (bases 1 to 1952)
AUTHORS Nishiyama,Y., Tanaka,T., Naitoh,H., Mori,C., Fukumoto,M., Hiai,H.
and Toyokuni,S.
TITLE Overexpression of integrin-associated protein (CD47) in rat kidney
treated with a renal carcinogen, ferric nitrilotriacetate
JOURNAL Jpn J Cancer Res 88 (2), 120-128 (1997)
PUBMED 9119739
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC085740.1.
On Nov 15, 2004 this sequence version replaced NM_019195.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC085740.1, D87659.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760400, SAMEA5760476
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..1952
/organism="Rattus norvegicus"
/mol_type="mRNA"
/db_xref="taxon:10116"
/chromosome="11"
/map="11q21"
gene 1..1952
/gene="Cd47"
/gene_synonym="Itgp"
/note="Cd47 molecule"
/db_xref="GeneID:29364"
/db_xref="RGD:2308"
exon 1..161
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
CDS 116..1027
/gene="Cd47"
/gene_synonym="Itgp"
/note="leukocyte surface antigen CD47; IAP;
integrin-associated protein; CD47 antigen (Rh-related
antigen, integrin-associated signal transducer)"
/codon_start=1
/product="leukocyte surface antigen CD47 precursor"
/protein_id="NP_062068.1"
/db_xref="GeneID:29364"
/db_xref="RGD:2308"
/translation="
MWPLAAALLLGSCCCGSAQLLLSKVKSVEFTSCNDTVVIPCKVLNVEAQSTDEMFVKWKLNKSYIFIYDGNKNSTTREQNFTSAKISVSDLLKGIASLTMDTHEAVVGNYTCEVTELSREGKTVIELKNRPVSWFSTNEKILIVIFPILAILLFWGKFGILTLKYKSSHTNKRIILLLVAGLALTLIVVVGAILFIPGEKPVKNASGLGLIVISTGILILLQYNVFMTAFGMTSFTIAILITQVLGYVLAVVGMCLCIMACEPVHGPLLISGLGIIALAELLGLVYMKFVASNQRTIQPPRNN"
sig_peptide 116..169
/gene="Cd47"
/gene_synonym="Itgp"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
mat_peptide 170..1024
/gene="Cd47"
/gene_synonym="Itgp"
/product="Leukocyte surface antigen CD47.
/id=PRO_0000042209"
/note="propagated from UniProtKB/Swiss-Prot (P97829.1)"
misc_feature 170..172
/gene="Cd47"
/gene_synonym="Itgp"
/note="Pyrrolidone carboxylic acid.
/evidence=ECO:0000250|UniProtKB:Q08722, ECO:0000305;
propagated from UniProtKB/Swiss-Prot (P97829.1);
pyrrolidone-carboxylic-acid site"
misc_feature 173..505
/gene="Cd47"
/gene_synonym="Itgp"
/note="Immunoglobulin variable region (IgV) in Cluster of
Differentiation (CD) 47; Region: IgV_CD47; cd16090"
/db_xref="CDD:409511"
misc_feature 173..247
/gene="Cd47"
/gene_synonym="Itgp"
/note="FR1 [structural motif]; Region: FR1"
/db_xref="CDD:409511"
misc_feature 173..184
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand A [structural motif]; Region: Ig strand
A"
/db_xref="CDD:409511"
misc_feature 191..205
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand A' [structural motif]; Region: Ig strand
A'"
/db_xref="CDD:409511"
misc_feature 215..217
/gene="Cd47"
/gene_synonym="Itgp"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P97829.1); glycosylation site"
misc_feature 224..247
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand B [structural motif]; Region: Ig strand
B"
/db_xref="CDD:409511"
misc_feature 248..274
/gene="Cd47"
/gene_synonym="Itgp"
/note="CDR1 [structural motif]; Region: CDR1"
/db_xref="CDD:409511"
misc_feature 275..301
/gene="Cd47"
/gene_synonym="Itgp"
/note="FR2 [structural motif]; Region: FR2"
/db_xref="CDD:409511"
misc_feature order(278..280,284..286,290..292,452..454,479..481)
/gene="Cd47"
/gene_synonym="Itgp"
/note="SIRP-CD47 complex [polypeptide binding]; other
site"
/db_xref="CDD:409511"
misc_feature 278..295
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand C [structural motif]; Region: Ig strand
C"
/db_xref="CDD:409511"
misc_feature 296..298
/gene="Cd47"
/gene_synonym="Itgp"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P97829.1); glycosylation site"
misc_feature 302..346
/gene="Cd47"
/gene_synonym="Itgp"
/note="CDR2 [structural motif]; Region: CDR2"
/db_xref="CDD:409511"
misc_feature 302..325
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand C' [structural motif]; Region: Ig strand
C'"
/db_xref="CDD:409511"
misc_feature 332..346
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand C' [structural motif]; Region: Ig strand
C'"
/db_xref="CDD:409511"
misc_feature 332..334
/gene="Cd47"
/gene_synonym="Itgp"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P97829.1); glycosylation site"
misc_feature 350..460
/gene="Cd47"
/gene_synonym="Itgp"
/note="FR3 [structural motif]; Region: FR3"
/db_xref="CDD:409511"
misc_feature 353..355
/gene="Cd47"
/gene_synonym="Itgp"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0007744|PubMed:24090084; propagated from
UniProtKB/Swiss-Prot (P97829.1); glycosylation site"
misc_feature 362..373
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand D [structural motif]; Region: Ig strand
D"
/db_xref="CDD:409511"
misc_feature 374..376
/gene="Cd47"
/gene_synonym="Itgp"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P97829.1); phosphorylation site"
misc_feature 380..382
/gene="Cd47"
/gene_synonym="Itgp"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P97829.1); phosphorylation site"
misc_feature 395..415
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand E [structural motif]; Region: Ig strand
E"
/db_xref="CDD:409511"
misc_feature 440..463
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand F [structural motif]; Region: Ig strand
F"
/db_xref="CDD:409511"
misc_feature 440..442
/gene="Cd47"
/gene_synonym="Itgp"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0007744|PubMed:24090084; propagated from
UniProtKB/Swiss-Prot (P97829.1); glycosylation site"
misc_feature 461..472
/gene="Cd47"
/gene_synonym="Itgp"
/note="CDR3 [structural motif]; Region: CDR3"
/db_xref="CDD:409511"
misc_feature 470..502
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand G [structural motif]; Region: Ig strand
G"
/db_xref="CDD:409511"
misc_feature 473..505
/gene="Cd47"
/gene_synonym="Itgp"
/note="FR4 [structural motif]; Region: FR4"
/db_xref="CDD:409511"
misc_feature 536..598
/gene="Cd47"
/gene_synonym="Itgp"
/note="propagated from UniProtKB/Swiss-Prot (P97829.1);
transmembrane region"
misc_feature 539..985
/gene="Cd47"
/gene_synonym="Itgp"
/note="CD47 transmembrane region; Region: CD47; pfam04549"
/db_xref="CDD:367985"
misc_feature 635..697
/gene="Cd47"
/gene_synonym="Itgp"
/note="propagated from UniProtKB/Swiss-Prot (P97829.1);
transmembrane region"
misc_feature 725..727
/gene="Cd47"
/gene_synonym="Itgp"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P97829.1); glycosylation site"
misc_feature 734..796
/gene="Cd47"
/gene_synonym="Itgp"
/note="propagated from UniProtKB/Swiss-Prot (P97829.1);
transmembrane region"
misc_feature 830..892
/gene="Cd47"
/gene_synonym="Itgp"
/note="propagated from UniProtKB/Swiss-Prot (P97829.1);
transmembrane region"
misc_feature 914..976
/gene="Cd47"
/gene_synonym="Itgp"
/note="propagated from UniProtKB/Swiss-Prot (P97829.1);
transmembrane region"
exon 162..509
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
exon 510..599
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
exon 600..707
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
exon 708..800
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
exon 801..893
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
exon 894..986
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
exon 987..1018
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
exon 1019..1942
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
ORIGIN
ctgggcggccgttcctgcctatcacggctgcggcgctgctggtcgttctcttgaaggcagcggaggcggcggctgctccagacacctgcggcggcgaccccccggcggcgcggagatgtggcccttggcggcggcgctgttgctgggctcctgctgctgcggttcagctcaactcctgcttagtaaagtcaaatctgtagagttcacgtcatgcaatgacactgtggtcatcccttgcaaagtccttaatgtggaagcccaaagcaccgatgaaatgtttgtgaagtggaagttgaacaaatcgtatattttcatctatgatggaaataaaaatagcactactagagaacaaaactttaccagtgcaaaaatctcggtctcagacttgctcaaaggcattgcctctttgacaatggatacccatgaggctgtggtgggaaactacacctgtgaagtgactgagctttccagagaaggcaaaacagttatagagctgaaaaaccgcccagtttcgtggttttctacaaatgaaaagatcctcattgttattttcccaattttggctatactcctgttctggggaaagtttggtatattaacactcaaatacaagtccagccatacgaataagagaatcattctgctgctggttgccgggctggcgctcacactcatcgtggttgttggcgccatccttttcatcccgggagagaagcccgtgaagaacgcttctggtcttggcctcattgtaatctccacaggaatattaatactgcttcagtacaatgtgtttatgacagcttttggaatgacctctttcaccattgccatattgatcactcaagtgctgggctatgtccttgctgtggtcgggatgtgtctctgcatcatggcttgtgaaccagtgcacggcccccttttgatttcaggtttgggaatcatagctctagcagaattacttggactagtttatatgaagtttgtcgcttccaaccagcggactatacaacctcctaggaataactgaagggaagtgatggactgtaacttgaaagtcagaagtggaagaattcagttgtctgagcaccatggccttcacaactcacagctggaaggaacacacaacagtgactgactttcatctctgaaaaaagtcattgaaccataaatgaatattacagttaagtttatattaaagcagctgtaatttacgtaataaaaaatatatgatgtgctgtgtaaccaatcgaaatccatttttctattgtttctactcaactaggggcaaaagtttcaggggcaacttccaagaatgatgcttgttagatccttgagtctctgaacactgagtttaaatcgattcccagagagactcgccaagcactaaccttcgggttagttacctagagatacctacgagaaacaggggtatccagcaagccttagtaaactcaggttcccagcagctttgccactcatgctgctagctgaataacaagactgccacttctgggtcttagtgacagagactgaagtacaaaaatgaatgtggttgggcaaaccccgtgtggcccctctgtgtgctatgatgttgatggccctgttgtcttcattcttgggcgttgccatcgttcacacacaccccctttgacatacagcgcacccaggttttgaatacttttttttttacagatgtggttttcctttttgcacacaaccctttgcaccctgtcccgtcctgctactttgatttgtgtttcaagatacagtacctttcctcccctttaaacatgatcctgtgacacaattttgtcagttgcagaaaggagccagacttattctcaaagcactgtgctcaaactcttcaaaaaaaaaataaaatagctatggttgtaacatatgtattccagacctctggtttaaaggcaaaaaaaaaaaaaaaaaaaaaaaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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