LOCUS       NM_012546               3426 bp    mRNA    linear   ROD 15-OCT-2023
DEFINITION  Rattus norvegicus dopamine receptor D1 (Drd1), mRNA.
ACCESSION   NM_012546
VERSION     NM_012546.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3426)
  AUTHORS   Andreska T, Luningschror P, Wolf D, McFleder RL, Ayon-Olivas M,
            Rattka M, Drechsler C, Perschin V, Blum R, Aufmkolk S, Granado N,
            Moratalla R, Sauer M, Monoranu C, Volkmann J, Ip CW, Stigloher C
            and Sendtner M.
  TITLE     DRD1 signaling modulates TrkB turnover and BDNF sensitivity in
            direct pathway striatal medium spiny neurons
  JOURNAL   Cell Rep 42 (6), 112575 (2023)
   PUBMED   37252844
  REMARK    GeneRIF: DRD1 signaling modulates TrkB turnover and BDNF
            sensitivity in direct pathway striatal medium spiny neurons.
REFERENCE   2  (bases 1 to 3426)
  AUTHORS   Witt KM, Harper DN and Ellenbroek BA.
  TITLE     Dopamine D1 receptor and effort-based decision making in rats: The
            moderating effect of sex
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 120, 110651 (2023)
   PUBMED   36191805
  REMARK    GeneRIF: Dopamine D1 receptor and effort-based decision making in
            rats: The moderating effect of sex.
REFERENCE   3  (bases 1 to 3426)
  AUTHORS   Babushkina N and Manahan-Vaughan D.
  TITLE     Frequency-dependency of the involvement of dopamine D1/D5 and
            beta-adrenergic receptors in hippocampal LTD triggered by locus
            coeruleus stimulation
  JOURNAL   Hippocampus 32 (6), 449-465 (2022)
   PUBMED   35478421
  REMARK    GeneRIF: Frequency-dependency of the involvement of dopamine D1/D5
            and beta-adrenergic receptors in hippocampal LTD triggered by locus
            coeruleus stimulation.
REFERENCE   4  (bases 1 to 3426)
  AUTHORS   Mesgar S, Jameie SB, Aliaghaei A, Parvardeh S, Torabi A and
            Haghparast A.
  TITLE     Dopamine D1 Receptor-Mediated Regulation of Per1, Per2, CLOCK, and
            BMAL1 Expression in the Suprachiasmatic Nucleus in Adult Male Rats
  JOURNAL   J Mol Neurosci 72 (3), 618-625 (2022)
   PUBMED   34751875
  REMARK    GeneRIF: Dopamine D1 Receptor-Mediated Regulation of Per1, Per2,
            CLOCK, and BMAL1 Expression in the Suprachiasmatic Nucleus in Adult
            Male Rats.
REFERENCE   5  (bases 1 to 3426)
  AUTHORS   Ramires Lima K, de Souza da Rosa AC, Severo Picua S, Souza E Silva
            S, Marks Soares N and Billig Mello-Carpes P.
  TITLE     One single physical exercise session improves memory persistence by
            hippocampal activation of D1 dopamine receptors and PKA signaling
            in rats
  JOURNAL   Brain Res 1762, 147439 (2021)
   PUBMED   33753064
  REMARK    GeneRIF: One single physical exercise session improves memory
            persistence by hippocampal activation of D1 dopamine receptors and
            PKA signaling in rats.
REFERENCE   6  (bases 1 to 3426)
  AUTHORS   Zhou QY, Li C and Civelli O.
  TITLE     Characterization of gene organization and promoter region of the
            rat dopamine D1 receptor gene
  JOURNAL   J Neurochem 59 (5), 1875-1883 (1992)
   PUBMED   1402930
REFERENCE   7  (bases 1 to 3426)
  AUTHORS   Liu YF, Civelli O, Zhou QY and Albert PR.
  TITLE     Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and
            calcium signals of the human dopamine-D1 receptor: selective
            potentiation by protein kinase A
  JOURNAL   Mol Endocrinol 6 (11), 1815-1824 (1992)
   PUBMED   1282671
REFERENCE   8  (bases 1 to 3426)
  AUTHORS   Salkovic M and Lackovic Z.
  TITLE     Brain D1 dopamine receptor in alloxan-induced diabetes
  JOURNAL   Diabetes 41 (9), 1119-1121 (1992)
   PUBMED   1386820
REFERENCE   9  (bases 1 to 3426)
  AUTHORS   Tiberi M, Jarvie KR, Silvia C, Falardeau P, Gingrich JA, Godinot N,
            Bertrand L, Yang-Feng TL, Fremeau RT Jr and Caron MG.
  TITLE     Cloning, molecular characterization, and chromosomal assignment of
            a gene encoding a second D1 dopamine receptor subtype: differential
            expression pattern in rat brain compared with the D1A receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7491-7495 (1991)
   PUBMED   1831904
REFERENCE   10 (bases 1 to 3426)
  AUTHORS   O'Dowd BF, Nguyen T, Tirpak A, Jarvie KR, Israel Y, Seeman P and
            Niznik HB.
  TITLE     Cloning of two additional catecholamine receptors from rat brain
  JOURNAL   FEBS Lett 262 (1), 8-12 (1990)
   PUBMED   2138567
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000284.1.
            
            On Feb 3, 2015 this sequence version replaced NM_012546.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M35077.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3426              JACYVU010000284.1  10541546-10544971
FEATURES             Location/Qualifiers
     source          1..3426
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..3426
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="dopamine receptor D1"
                     /db_xref="GeneID:24316"
                     /db_xref="RGD:2518"
     exon            1..3426
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    316..318
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="upstream in-frame stop codon"
     CDS             439..1779
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="Dopamine-1A receptor; dopamine receptor D1A"
                     /codon_start=1
                     /product="D(1A) dopamine receptor"
                     /protein_id="NP_036678.3"
                     /db_xref="GeneID:24316"
                     /db_xref="RGD:2518"
                     /translation="

MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST"

     misc_feature    448..450
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P18901.2); glycosylation site"
     misc_feature    502..1461
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:452889"
     misc_feature    505..582
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P18901.2);
                     transmembrane region"
     misc_feature    511..585
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    613..681
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    616..696
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P18901.2);
                     transmembrane region"
     misc_feature    724..792
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    724..792
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P18901.2);
                     transmembrane region"
     misc_feature    850..924
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P18901.2);
                     transmembrane region"
     misc_feature    859..909
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    1012..1083
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    1015..1092
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P18901.2);
                     transmembrane region"
     misc_feature    1249..1317
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    1255..1335
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P18901.2);
                     transmembrane region"
     misc_feature    1366..1443
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    1375..1449
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P18901.2);
                     transmembrane region"
ORIGIN      

ggcatttggagagatgcggtgccaggggcttggaggagaaatgcatgtattttaggccgtgtctcagaaaaagaggcagcatccctgaaaagtgactagaattgacctggaagaggccatggactcagagtgtgcttaaaagccaatgctctccttggggaatgtagggaccagccgatgtcacagggacacactgtcacagggacagtgacctggagcaccaagcccagaagacagatgggaagcaggagagtctttaccccggcatggcttggattgctacggggaagctcctgatggaaccctaccatcctttagtccaggcagcaactggggctgaacaagaaggggctgggtggtgagtggttgggggaagtctggctaagcctggtcaagaacttgaggggcaagtccccggaagtgtgttccttctggaagatggctcctaacacttctaccatggatgaggccgggctgccagcggagagggatttctcctttcgcatcctcacggcctgtttcctgtcactgctcatcctgtccactctcctgggcaatacccttgtctgtgcggccgtcatccggtttcgacacctgaggtccaaggtgaccaacttctttgtcatctctttagctgtgtcagatctcttggtggctgtcctggtcatgccctggaaagctgtggccgagattgctggcttttggccctttgggtccttttgtaacatctgggtagcctttgacatcatgtgctctacggcgtccattctgaacctctgcgtgatcagcgtggacaggtactgggctatctccagccctttccagtatgagaggaagatgacccccaaagcagccttcatcctgattagcgtagcatggactctgtctgtccttatatccttcatcccagtacagctaagctggcacaaggcaaagcccacatggcccttggatggcaattttacctccctggaggacaccgaggatgacaactgtgacacaaggttgagcaggacgtatgccatttcatcgtccctcatcagcttttacatccccgtagccattatgatcgtcacctacaccagtatctacaggattgcccagaagcaaatccggcgcatctcagccttggagagggcagcagtccatgccaagaattgccagaccaccgcaggtaacgggaaccccgtcgaatgcgcccagtctgaaagttcctttaagatgtccttcaagagggagacgaaagttctaaagacgctgtctgtgatcatgggggtgtttgtgtgctgctggctccctttcttcatctcgaactgtatggtgcccttctgtggctctgaggagacccagccattctgcatcgattccatcaccttcgatgtgtttgtgtggtttgggtgggcgaattcttccctgaaccccattatttatgcttttaatgctgacttccagaaggcgttctcaaccctcttaggatgctacagactctgccctactacgaataatgccatagagacggtgagcattaacaacaatggggctgtggtgttttccagccaccatgagccccgaggctccatctccaaggactgtaatctggtttacctgatccctcatgccgtgggctcctctgaggacctgaagaaggaagaggctggtggaatagctaagccactggagaagctgtccccagccttatcggtcatattggactatgacaccgatgtctctctagaaaagatccaacctgtcacacacagtggacagcattccacttgaatattgggtcctcatctctgaggccacgagttcccttgggcttgctgttaaggaattaacaggagatccctctgctgcttttggacaattacgaagcttctcaaactcactgattccagtgtattctctagcttcaagggaaatgacttcggctctgaaatcagtttgggagtattatcttaggacattataaaacaacaacaaacaaacaaacaaacaaacaaatagggccaagagtcaactgtaaacagcttcacttaaaaatcgaactttccagaaaggaagggtaggagttgagtttgctgtccaaacaggtgctaaaactgtccgagcagttttcagattggaaaggtaggtgcatgcctttgttaattaacttctccaataataattgagccttacagcaggagtgggattcctttttctcagaattgacagatgcattgttgatgacggttttatttatttatttattgtactatatgaatattttaaatttatcatagtgaatctatatttaacatatttaacagagcaaaccaatgtgttatctgagactgacctctccatttgtactagcactttatgagccaatgaaacatacgcgtagactctgagattctgaattgtgagttacttctgggaacacagcaaagactgatgtggtggctccttaactcgacaaggacacaaagaaacgcaagaggagaagtgactaatgccaccaatgctccccctaaaaagattttgaaaagattagttttttttttttttaaaagaagctactattgtgttctgaatgttttaaatggcagaggctttccccggggcgaatttgcacttctgtaaatatctatgtaagaaccagctcaagaggaatacaactttatatttccgcttttggatggcgaggaagagcatatgccactttgtatttatgtaaaataattggccctccttgtcatttctcatttcatgcttgaaatagctttctgaaacaaacaaatgactgtccaggctggagatctgcagggtggagaatgagttgtaaattcacaggtcacagcagcccctccgatagctgggctcatcattggtcctttatctgcccaggtctaaccaagtcggctgcttaaggggctacttttgtagtgctttaatccgaatttagtatcctctctttaaaaaaaaaaagctctttaatgttagtggtaaactagctaatgaacggtacctcatcgctgcataatacacttctgttggtgggggcgtagacgagccccttcccggtgcgagcaccacaaagccatctgcatagctagtcacaaatgctgtttttctttctctgtgggtttgaatctagtttccttgttatcatagcctggactgcaaaaagaaccatcgagtcccctcttgtgggggcattgcaacagtgtttctttttgtttttgttttgtttttgaaatgtttacaaggtgttctttggaagcagttgcaacacgtggatggaactgaagaaaaggctgactggcttgctaacggtatctcctgcagggggtttgtactgcggactttgaatgttttctcagctctaaggcttgtatgctttcttacatacaataaacttattttgtgaattcaaatcaa

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