LOCUS       NM_001439479            2768 bp    mRNA    linear   ROD 07-MAY-2025
DEFINITION  Rattus norvegicus claudin 6 (Cldn6), transcript variant 2, mRNA.
ACCESSION   NM_001439479 XM_008767511
VERSION     NM_001439479.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2768)
  AUTHORS   Harris,H.J., Davis,C., Mullins,J.G., Hu,K., Goodall,M.,
            Farquhar,M.J., Mee,C.J., McCaffrey,K., Young,S., Drummer,H.,
            Balfe,P. and McKeating,J.A.
  TITLE     Claudin association with CD81 defines hepatitis C virus entry
  JOURNAL   J Biol Chem 285 (27), 21092-21102 (2010)
   PUBMED   20375010
REFERENCE   2  (bases 1 to 2768)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   3  (bases 1 to 2768)
  AUTHORS   Nunes,F.D., Lopez,L.N., Lin,H.W., Davies,C., Azevedo,R.B., Gow,A.
            and Kachar,B.
  TITLE     Distinct subdomain organization and molecular composition of a
            tight junction with adherens junction features
  JOURNAL   J Cell Sci 119 (Pt 23), 4819-4827 (2006)
   PUBMED   17130295
REFERENCE   4  (bases 1 to 2768)
  AUTHORS   Morita,K., Furuse,M., Yoshida,Y., Itoh,M., Sasaki,H., Tsukita,S.
            and Miyachi,Y.
  TITLE     Molecular architecture of tight junctions of periderm differs from
            that of the maculae occludentes of epidermis
  JOURNAL   J Invest Dermatol 118 (6), 1073-1079 (2002)
   PUBMED   12060405
REFERENCE   5  (bases 1 to 2768)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On May 5, 2025 this sequence version replaced XM_008767511.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.3307179.1,
                                           SRR26360190.1292669.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676809, SAMN17050745
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1080              JAXUCZ010000010.1  13214069-13215148
            1081-1269           JAXUCZ010000010.1  13215312-13215500
            1270-1333           JAXUCZ010000010.1  13215859-13215922
            1334-2768           JAXUCZ010000010.1  13217148-13218582
FEATURES             Location/Qualifiers
     source          1..2768
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2768
                     /gene="Cldn6"
                     /note="claudin 6"
                     /db_xref="GeneID:287098"
                     /db_xref="RGD:1308837"
     exon            1..1080
                     /gene="Cldn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1269
                     /gene="Cldn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1333
                     /gene="Cldn6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1320..1322
                     /gene="Cldn6"
                     /note="upstream in-frame stop codon"
     exon            1334..2768
                     /gene="Cldn6"
                     /inference="alignment:Splign:2.1.0"
     CDS             1350..2009
                     /gene="Cldn6"
                     /codon_start=1
                     /product="claudin-6"
                     /protein_id="NP_001426408.1"
                     /db_xref="GeneID:287098"
                     /db_xref="RGD:1308837"
                     /translation="

MASTGLQILGIVLTLLGWVNALVSCALPMWKVTAFIGNSIVVAQMVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVITLLIVLLGLLLYLAGAKCTTCVEDKNSKSRLVLISGVIFVISGVLTLIPICWTAHAIIQDFYNPLVADAQKRELGASLYLGWAASGLLLIGGGLLCCACSSGGTQGPSHYVARYSSPVPHSRGPSEYPSKNYV"

ORIGIN      

ttcttttttttttttttttttttggttttttttttttttttttttttttccggagctggggaccgaacccagggccttgcgcttcctaggcaagcgctctaccactgagctaaatccccaacccccagacttggttttcttgagacaagatctcacactctatcctagggtagcctctaattcgaaacactcagcctcccaagtgctaggactgcaggcagacgccaccacacccagattttctttggtttggtttgggttttttggagacagaatcttgctgtatagcttaggctggtcttgatcttggtatactccagtacacagtaccactagcatatatattatatgctactttctttttggagagatatattttatttgtgtgtgtgtgtgtgtgccacgtatatgagtgtctctggagtccagaagagggcaacggatcttctggaaatggaatctcaggtagttataagatgagggcaaaaacctggaaaagcagaaaggctcataacccatgaaccatctttccagaaacacgtgccacttttttctttttggttgtgtggttggttttttgtgacaaggtttctctgtgccctgactatcctggaattcaagaagtaaaccaggctgacctggaactgacagagatctgcctgcctctctgccttcccaggccggtgattaaaggcatgtgtcaccatctccggtcacaaatgttgctttctttctttctttctttctttctttctttcttttttttttaaagatttatttattatttataagtacactgtcgctgtcttcagacacaccagaagagggcatcagatctcattacagatggttgtgagccaccatgtggttgctgggaattgaacttgggacctctggaagagcagccatttctccagcccctttatgttgctttcttaagggcctcgggaatacaacaacaacaacgtaacggcacgagatgactcagtggatacgagtgtctgctgccaagcctggcaacctgagttcgatccctggggtccacagagtggaagaggagaaccaactctctgaccctagcaggtcccgcccttggagtggccggtgactaaagggaaccttgggaaacacgctcaggtggctatcgcggccggggtctctgctcctcccagagagaggtggtcccgtgacgtcattgagactttaagaccccttgcctccgccctcattccactttcgacctgggaatcttagcggtctcttttgcaggcttggatatcgtgggtggccgaaccggacaggacgccctcggacaaagctgactgagcatttgccccctcaacctcatcatggcctctactggtctgcaaatcttggggattgtcctgaccctgcttggctgggtcaacgccctggtgtcctgtgccctgccgatgtggaaggtgaccgccttcatcggcaacagcatcgttgtggcccagatggtgtgggaggggctatggatgtcctgtgtggtccagagcactggtcagatgcagtgcaaggtgtacgactcgctgctggcgctgccccaggacctgcaggctgccagagccctctgtgtcatcaccctcctcattgtcctgcttggcctactcctgtaccttgccggagccaagtgcactacctgtgtggaagacaagaattccaagtctcgtctggtgctcatctctggtgtcatcttcgtcatctccggggtcctgaccctcattcccatctgctggactgcccacgccatcatccaggacttctacaaccccttggtcgcagacgctcaaaagcgagagctaggggcctccctctacctgggttgggccgcctcaggccttttgctgataggtggagggctgctatgctgcgcctgctcttctggagggacccagggacccagccattatgtggcccgctattcttcgcctgtcccacattctcggggaccctccgaatacccctccaagaattatgtctgatgcccactggggagtgaggctctactggccagagaacctgagctgagccgtgagaaatgatgtggggtagtttttggggtttgtcttgttccttgttttccttttgcaatgctgggtatgaaacctggggccccgcatatttggtaggcaagcactccacagtgagctgtgtggtaccctgccccctagggttggttccacctgtttttgagacaggctctccctaatggcgctctgactgacctccagctctcgttttttttttttttttgtttgtttgtttttttttcctgtctcaccctgagtccgaactccgcctatcgctccgttactggcatttctcgcttttacctactgtagctggagggatttgaccctgagttcctgtgtctttattcattctggggatctactgtgcaaagtgttttaaggctgcctgtgaatctggcctttgcgattctcaaaatggcttgtcccgagagttcctgctgtggctggaggtaactcacaggacagacacacccgctcctggtcaaactcttcccagtcctggaagggcaggtgataatttacctaagaattttcaactcagtcttccaacctttggcccctgaatcccatcaccaaggttactgtgtactctccccacatacggtcccagctgtgctgtagaccctcctcccccttacctctaaccttgcacatttccctgcccacacaatgttttacttaataaaacatgattttttttttttatat

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