LOCUS       NM_001429714            1942 bp    mRNA    linear   ROD 28-APR-2024
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase IG
            (Camk1g), transcript variant 2, mRNA.
ACCESSION   NM_001429714 XM_006250470
VERSION     NM_001429714.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1942)
  AUTHORS   Davare,M.A., Fortin,D.A., Saneyoshi,T., Nygaard,S., Kaech,S.,
            Banker,G., Soderling,T.R. and Wayman,G.A.
  TITLE     Transient receptor potential canonical 5 channels activate
            Ca2+/calmodulin kinase Igamma to promote axon formation in
            hippocampal neurons
  JOURNAL   J Neurosci 29 (31), 9794-9808 (2009)
   PUBMED   19657032
  REMARK    GeneRIF: These results are consistent with a model in which highly
            localized calcium influx through the TRPC5 channels activates CaMKK
            and CaMKI, which subsequently promote axon formation.
REFERENCE   2  (bases 1 to 1942)
  AUTHORS   Nishimura,H., Sakagami,H., Uezu,A., Fukunaga,K., Watanabe,M. and
            Kondo,H.
  TITLE     Cloning, characterization and expression of two alternatively
            splicing isoforms of Ca2+/calmodulin-dependent protein kinase I
            gamma in the rat brain
  JOURNAL   J Neurochem 85 (5), 1216-1227 (2003)
   PUBMED   12753081
  REMARK    GeneRIF: findings suggest that both alternatively splicing isoforms
            of CaMKI gamma may be involved in Ca2+ signal transduction in the
            cytoplasmic compartment of certain neuronal population
REFERENCE   3  (bases 1 to 1942)
  AUTHORS   Takemoto-Kimura,S., Terai,H., Takamoto,M., Ohmae,S., Kikumura,S.,
            Segi,E., Arakawa,Y., Furuyashiki,T., Narumiya,S. and Bito,H.
  TITLE     Molecular cloning and characterization of CLICK-III/CaMKIgamma, a
            novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein
            kinase (CaMK)
  JOURNAL   J Biol Chem 278 (20), 18597-18605 (2003)
   PUBMED   12637513
REFERENCE   4  (bases 1 to 1942)
  AUTHORS   Yokokura,H., Terada,O., Naito,Y. and Hidaka,H.
  TITLE     Isolation and comparison of rat cDNAs encoding
            Ca2+/calmodulin-dependent protein kinase I isoforms
  JOURNAL   Biochim Biophys Acta 1338 (1), 8-12 (1997)
   PUBMED   9074610
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Apr 25, 2024 this sequence version replaced XM_006250470.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB101232.1, SRR26643298.53180.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000013.1  107430180-107430230 c
            52-172              JAXUCZ010000013.1  107421916-107422036 c
            173-301             JAXUCZ010000013.1  107419897-107420025 c
            302-376             JAXUCZ010000013.1  107416378-107416452 c
            377-515             JAXUCZ010000013.1  107414819-107414957 c
            516-639             JAXUCZ010000013.1  107414195-107414318 c
            640-715             JAXUCZ010000013.1  107412962-107413037 c
            716-828             JAXUCZ010000013.1  107411225-107411337 c
            829-907             JAXUCZ010000013.1  107410449-107410527 c
            908-995             JAXUCZ010000013.1  107408894-107408981 c
            996-1112            JAXUCZ010000013.1  107407549-107407665 c
            1113-1942           JAXUCZ010000013.1  107406592-107407421 c
FEATURES             Location/Qualifiers
     source          1..1942
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..1942
                     /gene="Camk1g"
                     /note="calcium/calmodulin-dependent protein kinase IG"
                     /db_xref="GeneID:171358"
                     /db_xref="RGD:621800"
     exon            1..51
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            52..172
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1214
                     /gene="Camk1g"
                     /EC_number="2.7.11.17"
                     /note="isoform 2 is encoded by transcript variant 2;
                     calcium/calmodulin-dependent protein kinase type 1G;
                     caMKIG; CLICK III; caM-KI gamma; caM kinase IG; caMKI
                     gamma; caM kinase I gamma; caMK-like CREB kinase III;
                     calcium/calmodulin-dependent protein kinase I gamma"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     1G isoform 2"
                     /protein_id="NP_001416643.1"
                     /db_xref="GeneID:171358"
                     /db_xref="RGD:621800"
                     /translation="

MGRKEEEDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRVTGKLFALKCIKKSPAFRDSSLENEIAVLKRIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALRHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWRELQVRGHGTSESRWQHPLPGWADWGVSHNVIPGARVVFQETRLALLCLSKLASALRKGSSKAGIAEAAGLRQ"

     exon            173..301
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            302..376
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            377..515
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            516..639
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            640..715
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            716..828
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            829..907
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            908..995
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1112
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1942
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggctcgctggccaagatcacagactggagcacctttcttgtgagcccctggcttcccaggcagcttcaactctggaggacatggggcgaaaggaggaggaggactgtagctcctggaagaaacagaccaccaacatcaggaaaaccttcatcttcatggaagtgctcggatcaggagcgttctcagaggtgttcctggtgaagcaaagagtgactgggaaactctttgctctgaagtgcatcaagaagtcaccagccttccgggacagtagcctagagaatgagattgctgtgttgaaaaggatcaagcatgaaaacattgtgaccctggaggatatctatgagagcaccacccactactacctggtcatgcagcttgtttctggaggtgagctttttgaccgaatcctagagcgtggtgtctacacagaaaaggatgccagtctggtcatccagcaggtcttgtctgccgtgaaataccttcatgagaatggcatcgttcacagagatctaaagcctgaaaacctgctgtacctcacccctgaggagaactccaagataatgatcactgattttggcctatccaagatggagcagaatggagtcatgtccacagcttgtgggaccccaggctatgtggctccagaagtgctggcccagaagccctacagtaaggctgtggactgctggtccattggtgtcatcacatacatactgctgtgtgggtatccccctttctatgaagaaacagaatcaaagctttttgagaagatcaaagagggttactacgagtttgagtctccattctgggatgacatttctgagtcagccaaggactttatttgccatctgcttgagaaggacccaaatgaacgatacacctgcgagaaagccctcagacacccttggattgacgggaacacagccctgcaccgggacatctacccatctgtcagcctccagattcagaagaactttgccaagagcaagtggagggaacttcaagtcagaggtcatggtaccagtgaaagcaggtggcagcacccactgccgggctgggcagactggggtgtgtctcataatgtgatcccaggagcccgtgtggtttttcaggagacacgtctagctcttctctgcctctctaagctggcgtctgctctgaggaaagggagcagcaaagcagggatagccgaagcggctggtctgaggcagtaggggtgttgctgcctgggcagacactcgcaggaagtccagaggagctccaatcctggacgttctctgaggccacaagcaggatgtgtggtctgcctccagcatcccagcctccaggtctccagacctgcccattcccttccccacatcctatgtgcagtggctctgtgcagtgtccatagatagtgctcatctgggtccgtattgtttgttgtgaaaagctttatgggctggccaggctgtgccactttcttcaagcaaagccatatggagtctaactcagactccctgctctgcatactcactccggcctctctggcctcatggccagattgaacccgttatcatagtacctgcctatccgcatgaatgccagcctgcttcaggggcctgggagcactcacagctctagtcctcccctccaggattagcttcccactgcactgagacccaggccacttcaaagctctccctgcctccgcctaacagcagtgcccccattctccatggtggaacgagaaagctgagactatggactgtgagccttctctcccagccacacacctcacatatccctaactaaggattcggggactatttccatgtcggccaggtctcctctggctccttccattcccctgaaggtcaggtgcattgttctgtctctctgtgttcttaccctcataccctcaagcttcgtgctgtgttgtgctcaaataaaatggacatat

//