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Previous release (v1)
2026-10-05 18:47:06, GGRNA.v2 : RefSeq release 233 (Jan, 2026)
LOCUS NM_001395152 2672 bp mRNA linear ROD 31-MAR-2024
DEFINITION Rattus norvegicus protection of telomeres 1 (Pot1), mRNA.
ACCESSION NM_001395152 XM_006236160
VERSION NM_001395152.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 2672)
AUTHORS Yin,H., Hardikar,S., Lindstroem,S., Hsu,L., Anderson,K.E.,
Banbury,B.L., Berndt,S.I., Chan,A.T., Giovanucci,E.L.,
Harrison,T.A., Joshi,A.D., Nan,H., Potter,J.D., Sakoda,L.C.,
Slattery,M.L., Schoen,R.E., White,E., Peters,U. and Newcomb,P.A.
TITLE Telomere Maintenance Variants and Survival after Colorectal Cancer:
Smoking- and Sex-Specific Associations
JOURNAL Cancer Epidemiol Biomarkers Prev 29 (9), 1817-1824 (2020)
PUBMED 32586834
REFERENCE 2 (bases 1 to 2672)
AUTHORS Ishigaki,K., Akiyama,M., Kanai,M., Takahashi,A., Kawakami,E.,
Sugishita,H., Sakaue,S., Matoba,N., Low,S.K., Okada,Y., Terao,C.,
Amariuta,T., Gazal,S., Kochi,Y., Horikoshi,M., Suzuki,K., Ito,K.,
Koyama,S., Ozaki,K., Niida,S., Sakata,Y., Sakata,Y., Kohno,T.,
Shiraishi,K., Momozawa,Y., Hirata,M., Matsuda,K., Ikeda,M.,
Iwata,N., Ikegawa,S., Kou,I., Tanaka,T., Nakagawa,H., Suzuki,A.,
Hirota,T., Tamari,M., Chayama,K., Miki,D., Mori,M., Nagayama,S.,
Daigo,Y., Miki,Y., Katagiri,T., Ogawa,O., Obara,W., Ito,H.,
Yoshida,T., Imoto,I., Takahashi,T., Tanikawa,C., Suzuki,T.,
Sinozaki,N., Minami,S., Yamaguchi,H., Asai,S., Takahashi,Y.,
Yamaji,K., Takahashi,K., Fujioka,T., Takata,R., Yanai,H.,
Masumoto,A., Koretsune,Y., Kutsumi,H., Higashiyama,M., Murayama,S.,
Minegishi,N., Suzuki,K., Tanno,K., Shimizu,A., Yamaji,T.,
Iwasaki,M., Sawada,N., Uemura,H., Tanaka,K., Naito,M., Sasaki,M.,
Wakai,K., Tsugane,S., Yamamoto,M., Yamamoto,K., Murakami,Y.,
Nakamura,Y., Raychaudhuri,S., Inazawa,J., Yamauchi,T., Kadowaki,T.,
Kubo,M. and Kamatani,Y.
TITLE Large-scale genome-wide association study in a Japanese population
identifies novel susceptibility loci across different diseases
JOURNAL Nat Genet 52 (7), 669-679 (2020)
PUBMED 32514122
REFERENCE 3 (bases 1 to 2672)
AUTHORS Yu,Y., Tan,R., Ren,Q., Gao,B., Sheng,Z., Zhang,J., Zheng,X.,
Jiang,Y., Lan,L. and Mao,Z.
TITLE POT1 inhibits the efficiency but promotes the fidelity of
nonhomologous end joining at non-telomeric DNA regions
JOURNAL Aging (Albany NY) 9 (12), 2529-2543 (2017)
PUBMED 29227966
REFERENCE 4 (bases 1 to 2672)
AUTHORS Poojary,S.S., Mishra,G., Singh,T.D., Gupta,S., Shrivastav,B.R. and
Tiwari,P.K.
TITLE Telomere length variation and expression analysis of shelterin
complex genes during gallbladder carcinogenesis
JOURNAL J Cancer Res Ther 13 (2), 235-239 (2017)
PUBMED 28643740
REFERENCE 5 (bases 1 to 2672)
AUTHORS Karami,S., Han,Y., Pande,M., Cheng,I., Rudd,J., Pierce,B.L.,
Nutter,E.L., Schumacher,F.R., Kote-Jarai,Z., Lindstrom,S.,
Witte,J.S., Fang,S., Han,J., Kraft,P., Hunter,D.J., Song,F.,
Hung,R.J., McKay,J., Gruber,S.B., Chanock,S.J., Risch,A., Shen,H.,
Haiman,C.A., Boardman,L., Ulrich,C.M., Casey,G., Peters,U., Amin Al
Olama,A., Berchuck,A., Berndt,S.I., Bezieau,S., Brennan,P.,
Brenner,H., Brinton,L., Caporaso,N., Chan,A.T., Chang-Claude,J.,
Christiani,D.C., Cunningham,J.M., Easton,D., Eeles,R.A., Eisen,T.,
Gala,M., Gallinger,S.J., Gayther,S.A., Goode,E.L., Gronberg,H.,
Henderson,B.E., Houlston,R., Joshi,A.D., Kury,S., Landi,M.T., Le
Marchand,L., Muir,K., Newcomb,P.A., Permuth-Wey,J., Pharoah,P.,
Phelan,C., Potter,J.D., Ramus,S.J., Risch,H., Schildkraut,J.,
Slattery,M.L., Song,H., Wentzensen,N., White,E., Wiklund,F.,
Zanke,B.W., Sellers,T.A., Zheng,W., Chatterjee,N., Amos,C.I. and
Doherty,J.A.
CONSRTM GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and
TRICL
TITLE Telomere structure and maintenance gene variants and risk of five
cancer types
JOURNAL Int J Cancer 139 (12), 2655-2670 (2016)
PUBMED 27459707
REFERENCE 6 (bases 1 to 2672)
AUTHORS Kelleher,C., Kurth,I. and Lingner,J.
TITLE Human protection of telomeres 1 (POT1) is a negative regulator of
telomerase activity in vitro
JOURNAL Mol Cell Biol 25 (2), 808-818 (2005)
PUBMED 15632080
REFERENCE 7 (bases 1 to 2672)
AUTHORS Liu,D., O'Connor,M.S., Qin,J. and Songyang,Z.
TITLE Telosome, a mammalian telomere-associated complex formed by
multiple telomeric proteins
JOURNAL J Biol Chem 279 (49), 51338-51342 (2004)
PUBMED 15383534
REFERENCE 8 (bases 1 to 2672)
AUTHORS Liu,D., Safari,A., O'Connor,M.S., Chan,D.W., Laegeler,A., Qin,J.
and Songyang,Z.
TITLE PTOP interacts with POT1 and regulates its localization to
telomeres
JOURNAL Nat Cell Biol 6 (7), 673-680 (2004)
PUBMED 15181449
REFERENCE 9 (bases 1 to 2672)
AUTHORS Loayza,D. and De Lange,T.
TITLE POT1 as a terminal transducer of TRF1 telomere length control
JOURNAL Nature 423 (6943), 1013-1018 (2003)
PUBMED 12768206
REFERENCE 10 (bases 1 to 2672)
AUTHORS Colgin,L.M., Baran,K., Baumann,P., Cech,T.R. and Reddel,R.R.
TITLE Human POT1 facilitates telomere elongation by telomerase
JOURNAL Curr Biol 13 (11), 942-946 (2003)
PUBMED 12781132
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000004.1.
On Jun 4, 2021 this sequence version replaced XM_006236160.3.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR26643291.11953.1,
SRR26360186.1455042.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5760383,
SAMEA5760386 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-43 JAXUCZ010000004.1 55228501-55228543 c
44-109 JAXUCZ010000004.1 55225282-55225347 c
110-156 JAXUCZ010000004.1 55217874-55217920 c
157-271 JAXUCZ010000004.1 55212898-55213012 c
272-402 JAXUCZ010000004.1 55199614-55199744 c
403-693 JAXUCZ010000004.1 55196339-55196629 c
694-849 JAXUCZ010000004.1 55192964-55193119 c
850-1019 JAXUCZ010000004.1 55187448-55187617 c
1020-1105 JAXUCZ010000004.1 55184334-55184419 c
1106-1168 JAXUCZ010000004.1 55183125-55183187 c
1169-1325 JAXUCZ010000004.1 55180469-55180625 c
1326-1531 JAXUCZ010000004.1 55178709-55178914 c
1532-1667 JAXUCZ010000004.1 55177899-55178034 c
1668-1756 JAXUCZ010000004.1 55175863-55175951 c
1757-1848 JAXUCZ010000004.1 55174201-55174292 c
1849-1954 JAXUCZ010000004.1 55172488-55172593 c
1955-2672 JAXUCZ010000004.1 55170821-55171538 c
FEATURES Location/Qualifiers
source 1..2672
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="4"
/map="4q22"
gene 1..2672
/gene="Pot1"
/gene_synonym="Pot1a"
/note="protection of telomeres 1"
/db_xref="GeneID:500054"
/db_xref="RGD:1562696"
exon 1..43
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 44..109
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 110..156
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
misc_feature 118..120
/gene="Pot1"
/gene_synonym="Pot1a"
/note="upstream in-frame stop codon"
CDS 148..2064
/gene="Pot1"
/gene_synonym="Pot1a"
/note="protection of telomeres 1A; protection of telomeres
1 homolog"
/codon_start=1
/product="protection of telomeres protein 1"
/protein_id="NP_001382081.1"
/db_xref="GeneID:500054"
/db_xref="RGD:1562696"
/translation="
MSLVPVTPYTYTPLNLLKEGAVANVYGVVKFFKPPYLSKGTDYCSVVTIVDPTNVKLTCMLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINSSGFASLTFEGTLGTPVTARTSSKVFSFTSQDQKMVEALRVWASKHIAASSSLVQLCDAQPLQYYDLTCQLLGKAEVDGTAFLLKVWDGTRTMFPSWRVSIQNLTFEGDLSHIQRLQSLVIDILVYDNHVQVAKSLKIGSFIRIYSLHTKLQSVDSETSKSLLRLEFHLHGGTSYGRGIRVLPDESSCVDQLKKDLECADSAVTQPSNGICQSKNEDSFVLSSSASGSVSLYEEERCQQVSSTILTDHQHLEKTPLCAVLKQKAPQQYRVRAKLRSYLPRRLPQSVKLICPQCHSLQEVPHEDSLDKLLQDAATKAPDIRLQGTSLYESKIWTTEGQGGRQVAVHFVKKDGVLPLSSECLILIEGGRLCEVSKLSSKFHSVIPVRSGPEDLELLDISAPFLIQGKLHHYGCKQCSSLKPIQNLNSLLNKGPWIPSSVAKVLGIVPLQYVFVMTFTLDDGTGVLDTYLKDSENFFKIPASEVLTDDNLQRNLEAIMDMICPPGIKVDAYPWLECLIKSYNVTIGTEQRICYQIFDTTVAEDV"
misc_feature 178..570
/gene="Pot1"
/gene_synonym="Pot1a"
/note="Telomeric single stranded DNA binding POT1/CDC13;
Region: Telo_bind; smart00976"
/db_xref="CDD:214949"
misc_feature order(217..219,379..381,385..387,391..393,457..459)
/gene="Pot1"
/gene_synonym="Pot1a"
/note="generic binding surface II [active]"
/db_xref="CDD:239943"
misc_feature order(238..249,253..255,289..291,355..357,361..363,
367..372,472..474)
/gene="Pot1"
/gene_synonym="Pot1a"
/note="OB1/OB2 interface [polypeptide binding]; other
site"
/db_xref="CDD:239943"
misc_feature order(244..246,253..255,259..261,271..273,289..291,
325..327,331..333,337..339,406..408,412..414,427..429)
/gene="Pot1"
/gene_synonym="Pot1a"
/note="ssDNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:239943"
misc_feature 628..984
/gene="Pot1"
/gene_synonym="Pot1a"
/note="A subfamily of OB folds similar to the second OB
fold (OB2) of human protection of telomeres 1 protein
(hPOT1). POT1 proteins bind to the single-stranded (ss)
3-prime ends of the telomere. hPOT1 binds specifically to
ss telomeric DNA repeats ending with...; Region:
hPOT1_OB2; cd04498"
/db_xref="CDD:239944"
misc_feature order(628..630,814..819,874..876,880..882,946..951,
958..963,967..969)
/gene="Pot1"
/gene_synonym="Pot1a"
/note="ssDNA binding [nucleotide binding]; other site"
/db_xref="CDD:239944"
misc_feature order(865..867,871..873,955..957,964..966,976..978)
/gene="Pot1"
/gene_synonym="Pot1a"
/note="binding surface II [active]"
/db_xref="CDD:239944"
misc_feature 1189..2049
/gene="Pot1"
/gene_synonym="Pot1a"
/note="Protection Of Telomeres Protein 1 (POT1) C-terminal
region; Region: Pot1C; cd20374"
/db_xref="CDD:380669"
misc_feature order(1189..1191,1252..1254,1273..1275,1504..1506,
1585..1587,1591..1593,1756..1758,1765..1767,1876..1878,
1921..1923,1933..1935,2029..2031)
/gene="Pot1"
/gene_synonym="Pot1a"
/note="disease mutation sites; other site"
/db_xref="CDD:380669"
misc_feature order(1273..1275,1279..1290,1297..1299,1318..1320,
1324..1326,1330..1335,1339..1341,1420..1422,1426..1428,
1432..1440,1456..1458,1474..1476,1501..1509,1546..1548,
1555..1560,1567..1572,1789..1797,1843..1845,1879..1884,
1891..1893,1900..1902,1984..1986,1990..1992,1996..1998,
2017..2019,2023..2025,2029..2031)
/gene="Pot1"
/gene_synonym="Pot1a"
/note="heterodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:380669"
exon 157..271
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 272..402
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 403..693
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 694..849
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 850..1019
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1020..1105
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1106..1168
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1169..1325
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1326..1531
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1532..1667
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1668..1756
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1757..1848
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1849..1954
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1955..2672
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
ORIGIN
tgggcgcgtcaatgcagaccttagttgtccgcgggtcttgctgggaaaactcagttgttcttaatgccttgcggaagtaaaacagctgttttgaagattagactttgaggtttgtgataaatctatgagaggatttcccatcaaacaatgtctttggttccggtaactccctatacatatacacccctgaatctacttaaggaaggtgcagttgccaatgtctatggtgttgtgaaattctttaagcctccatatctcagcaaaggaactgattattgctcagttgtaacaattgtggacccaacaaatgtgaagttaacgtgcatgctctttagtggaaactatgaagcccttccgatcatttacaaagttggagacattgttcgcttccataggctgaagatccaagtatataaaaatgagcttcagggaatcaacagctctgggttcgcgtctttgacatttgaaggaacattagggacacctgtcacagcacgtacttcaagcaaagtttttagcttcacttctcaggaccaaaaaatggtagaagctttgcgagtttgggcatccaagcacattgcagcttcttcaagtttagtgcagctgtgtgacgctcagcccctgcaatattatgacctgacctgtcagcttctgggtaaagcagaagtggatggaacagcctttcttctaaaggtatgggacggaaccaggactatgtttccctcttggagagtctccatacaaaatcttacctttgaaggtgacttgagtcacattcagcggctacagagtctggtgatagacattctagtctatgacaatcatgttcaagtggcaaaatccctcaagattggaagctttattcgaatctatagcctccataccaaacttcagtctgttgattcagaaaccagcaagtcattgttaaggctggagtttcatctccatggagggaccagttatggtcgggggattagggttttgccagatgaaagctcgtgtgtggatcagctgaaaaaagatttagaatgtgcagattcggcagtcactcaaccctcaaatggtatctgtcaatcaaaaaatgaggatagctttgtactttcaagctctgcatcaggctcagtatccctgtatgaggaagaacgatgtcagcaagtctcttctacaatactcacagatcaccagcacttagagaaaactccattgtgtgccgttttgaagcaaaaggctccgcagcaatatcgggtccgtgccaagctgaggtcgtatttgcccaggagacttccccagtctgttaaactgatctgtccgcagtgccattcactacaagaagttccacatgaggacagtttggataaacttttgcaagatgctgcaactaaagcgccagacatcaggctgcaaggtacatctttgtatgaatcaaagatctggaccaccgaaggccagggaggacggcaggtcgctgttcactttgtgaagaaggatggtgttctcccactttcaagtgaatgtctaattttgatagaaggaggaagactctgtgaagtgtccaagctgtccagcaagttccacagtgtgatccctgtgaggtccggccctgaggatctggagctcctcgacatttcagccccattcctcatacagggaaagctgcatcactatggatgtaaacagtgttcaagcttgaaacctatacaaaacctaaattcccttcttaataaaggaccatggattccttcctccgtggcaaaagtcctgggcattgtgcctctgcagtatgtgtttgttatgacgttcactctggatgatggaacaggagtgttggacacttacctcaaggattctgaaaactttttcaagatcccagcatctgaagtcctcactgatgacaaccttcagaggaatctggaagcgatcatggatatgatatgccctcctggaataaaagttgatgcatacccgtggcttgagtgcctcatcaagtcctacaatgtcaccattggaacagaacaacgaatttgctaccagatttttgacaccacggttgcagaagatgtctagtgctgccattcagtgcagtgtgtatggattttacaattttagaaaaggtcatgactctgagattctcagaagacacttggctattgtcaaaagtattgtatccattttcactgtagttcttttgtacagaaaactattttgttatttatgccatcttgtgaacatgtcagaaatcccttgctgctcatcatgtcccagggagtataaaatgagacagcactggttggggagaatgcccactctcatttttaaaacactggtagcaacttctccttctgtgctgtttgattctttttttttttttttttttgtacagaagaatctgcttagcaacttctgaaagaattctccctctacttccacacatgagtatcaggttaactgagtgcttgttgaacagatgccgtctcaccaagcggggatatactaaaaggagggtttcctttcagaagacatggctttgtttgggtgctcttgatgcccatttcaggataaatgtatctctttgaaccaaatagtatgcgtgactttctgcttctctctggaatactagaagctatttaatttcataccaactaataaagtgataggatttatattttcatgaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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