LOCUS       NM_001113740            2462 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus septin 7 (Septin7), transcript variant 2, mRNA.
ACCESSION   NM_001113740
VERSION     NM_001113740.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2462)
  AUTHORS   Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame
            AL, Jan LY and Jan YN.
  TITLE     TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine
            Maturation through Septin7 Phosphorylation
  JOURNAL   Neuron 93 (2), 379-393 (2017)
   PUBMED   28065648
REFERENCE   2  (bases 1 to 2462)
  AUTHORS   Kuo YC, Shen YR, Chen HI, Lin YH, Wang YY, Chen YR, Wang CY and Kuo
            PL.
  TITLE     SEPT12 orchestrates the formation of mammalian sperm annulus by
            organizing core octameric complexes with other SEPT proteins
  JOURNAL   J Cell Sci 128 (5), 923-934 (2015)
   PUBMED   25588830
REFERENCE   3  (bases 1 to 2462)
  AUTHORS   Ewers H, Tada T, Petersen JD, Racz B, Sheng M and Choquet D.
  TITLE     A Septin-Dependent Diffusion Barrier at Dendritic Spine Necks
  JOURNAL   PLoS One 9 (12), e113916 (2014)
   PUBMED   25494357
  REMARK    GeneRIF: show that diffusion of receptors and bulk membrane, but
            not cytoplasmic proteins, is slower in spines bearing Sept7 at
            their neck. Finally, when Sept7 expression was suppressed by RNA
            interference, membrane molecules explored larger membrane areas.
            Our findings indicate that Sept7 regulates membrane protein access
            to spines
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2462)
  AUTHORS   Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2462)
  AUTHORS   Menon MB, Sawada A, Chaturvedi A, Mishra P, Schuster-Gossler K,
            Galla M, Schambach A, Gossler A, Forster R, Heuser M, Kotlyarov A,
            Kinoshita M and Gaestel M.
  TITLE     Genetic deletion of SEPT7 reveals a cell type-specific role of
            septins in microtubule destabilization for the completion of
            cytokinesis
  JOURNAL   PLoS Genet 10 (8), e1004558 (2014)
   PUBMED   25122120
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2462)
  AUTHORS   Nagata K, Asano T, Nozawa Y and Inagaki M.
  TITLE     Biochemical and cell biological analyses of a mammalian septin
            complex, Sept7/9b/11
  JOURNAL   J Biol Chem 279 (53), 55895-55904 (2004)
   PUBMED   15485874
  REMARK    GeneRIF: Sept7/9b/11 form a complex that has effects on filament
            elongation, bundling, or disruption.
REFERENCE   7  (bases 1 to 2462)
  AUTHORS   Peng XR, Jia Z, Zhang Y, Ware J and Trimble WS.
  TITLE     The septin CDCrel-1 is dispensable for normal development and
            neurotransmitter release
  JOURNAL   Mol Cell Biol 22 (1), 378-387 (2002)
   PUBMED   11739749
REFERENCE   8  (bases 1 to 2462)
  AUTHORS   Kinoshita A, Noda M and Kinoshita M.
  TITLE     Differential localization of septins in the mouse brain
  JOURNAL   J Comp Neurol 428 (2), 223-239 (2000)
   PUBMED   11064363
REFERENCE   9  (bases 1 to 2462)
  AUTHORS   Walikonis RS, Jensen ON, Mann M, Provance DW Jr, Mercer JA and
            Kennedy MB.
  TITLE     Identification of proteins in the postsynaptic density fraction by
            mass spectrometry
  JOURNAL   J Neurosci 20 (11), 4069-4080 (2000)
   PUBMED   10818142
REFERENCE   10 (bases 1 to 2462)
  AUTHORS   Nakatsuru S, Sudo K and Nakamura Y.
  TITLE     Molecular cloning of a novel human cDNA homologous to CDC10 in
            Saccharomyces cerevisiae
  JOURNAL   Biochem Biophys Res Commun 202 (1), 82-87 (1994)
   PUBMED   8037772
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA512303.1, EV764168.1 and BC128738.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128738.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                CA512303.1         1-59
            60-102              EV764168.1         32-74
            103-1688            BC128738.1         1-1586
            1689-2462           BC128738.1         1588-2361
FEATURES             Location/Qualifiers
     source          1..2462
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2462
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="septin 7"
                     /db_xref="GeneID:64551"
                     /db_xref="RGD:620469"
     exon            1..186
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1439
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="isoform b is encoded by transcript variant 2; CDC10
                     protein homolog; CDC10 (cell division cycle 10,
                     S.cerevisiae, homolog)"
                     /codon_start=1
                     /product="septin-7 isoform b"
                     /protein_id="NP_001107212.1"
                     /db_xref="GeneID:64551"
                     /db_xref="RGD:620469"
                     /translation="

MSVSARSAAAEERSVNCSTMVAQPKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQEHKIKIYEFPETDDEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNGVDNNKNKGQLTKSPLAQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEAQHKELEEKRRQFEEEKANWEAQQRILEQQNSSRTLEKNKKKGKIF"

     misc_feature    129..131
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:Q16181; propagated from
                     UniProtKB/Swiss-Prot (Q9WVC0.1); acetylation site"
     misc_feature    213..215
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:O55131; propagated from
                     UniProtKB/Swiss-Prot (Q9WVC0.1); phosphorylation site"
     misc_feature    264..1076
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="CDC/Septin GTPase family; Region: CDC_Septin;
                     cd01850"
                     /db_xref="CDD:206649"
     misc_feature    264..1076
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVC0.1);
                     Region: Interaction with SEPTIN12.
                     /evidence=ECO:0000250|UniProtKB:Q16181"
     misc_feature    294..317
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVC0.1);
                     Region: G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
     misc_feature    294..317
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="G1 box; other site"
                     /db_xref="CDD:206649"
     misc_feature    order(300..320,462..464,471..473,705..710,714..716,
                     873..878)
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206649"
     misc_feature    354..356
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9WVC0.1); phosphorylation site"
     misc_feature    387..413
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206649"
     misc_feature    393..395
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="G2 box; other site"
                     /db_xref="CDD:206649"
     misc_feature    462..473
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVC0.1);
                     Region: G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
     misc_feature    462..473
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="G3 box; other site"
                     /db_xref="CDD:206649"
     misc_feature    order(468..575,576..605)
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206649"
     misc_feature    705..716
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVC0.1);
                     Region: G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
     misc_feature    705..716
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="G4 box; other site"
                     /db_xref="CDD:206649"
     misc_feature    807..809
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9WVC0.1); phosphorylation site"
     misc_feature    873..881
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="G5 box; other site"
                     /db_xref="CDD:206649"
     misc_feature    1125..1127
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9WVC0.1); phosphorylation site"
     misc_feature    1134..>1424
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="phosphodiesterase; Provisional; Region: PRK12704"
                     /db_xref="CDD:237177"
     misc_feature    1242..1244
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O55131; propagated from
                     UniProtKB/Swiss-Prot (Q9WVC0.1); acetylation site"
     misc_feature    1257..1436
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVC0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1395..1397
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q16181; propagated from
                     UniProtKB/Swiss-Prot (Q9WVC0.1); phosphorylation site"
     misc_feature    1401..1403
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q16181; propagated from
                     UniProtKB/Swiss-Prot (Q9WVC0.1); phosphorylation site"
     exon            187..191
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            192..294
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            295..401
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            402..502
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            503..637
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            638..755
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            756..848
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            849..945
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            946..997
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1123
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1259
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1399
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..2462
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ccgcctgctgccgtgtgcgtaagtggggcagtgacgctgggcggctacgctgcggaatcggcgtaggaggttttggagaatccgccggctgcgacgcgccggggctggtcgcggagggggaggggatgtcggtcagtgcgagatccgctgctgctgaggagaggagcgtcaactgcagcaccatggtagctcaaccgaagaaccttgagggctatgtgggatttgccaacctcccaaatcaagtgtacagaaaatcggtgaaaagaggatttgaattcactcttatggtagtaggtgaatctggactgggaaagtcgacattaatcaactcattattcctcacagatttgtattctccagagtatccaggaccttctcatagaatcaaaaagactgttcaggtggagcaatccaaagttttaatcaaagaaggtggcgttcagttgctgctgacgatagttgatactccgggatttggagatgcagtggataatagtaattgctggcagcctgttatcgactacattgatagtaaatttgaagattacttaaatgcagaatctcgagtgaacagacgacagatgcctgataacagggtgcagtgttgtttatacttcattgctccttcaggacatggacttaaaccattggatattgagtttatgaaacgtttgcatgaaaaagtgaatatcattcctttaattgccaaagcagacacacttacaccagaggaatgccaacagtttaaaaagcagataatgaaagaaatccaagaacataaaattaaaatatatgaatttccagaaacggatgatgaagaagagaataagctggttaagaagataaaggaccgtttacctcttgctgtggtgggtagtaatactatcattgaagttaatggcaaaagagtcagaggaaggcagtatccttggggtgtggctgaagttgaaaatggtgagcattgtgattttacaattctaagaaatatgttgatacgaacacacatgcaggacttgaaagatgttaccaataacgtacactatgagaactacagaagcagaaaactagcagcagtgacctacaatggagtagataacaacaagaacaaagggcaacttaccaagagccctctggcgcagatggaggaggagagaagggagcacgtggccaagatgaagaagatggagatggagatggagcaggtgtttgagatgaaggtcaaggaaaaagttcaaaagctgaaggactctgaagccgagctccagcggcgccatgagcaaatgaaaaagaatttagaagcacagcacaaagaattagaggaaaaacgtcgtcagtttgaagaagaaaaagcaaactgggaagctcaacaacgtattttagagcaacagaattcttcaagaaccttggaaaagaacaagaagaaaggcaagatcttttaaactctattgaccaccagttatgtattagttgccaatacgccagcttggacatcagtgtttgttggatccgtttgaccaatttgcaccaattttatccataatgatggatttaacagcatgacaaaaattatttttttgttgttgttctcgaaggagattaagatgccttgaattgtctaggatattgtgtacttagaaattaacagctctaagtacctttctacattttttctttttttttttttttttaaattaaaaagatgtcttcagtttaatgcaagaaaacattttactgttgtacaatcatgttctggtggtttgattgtttacagaatattctaaaataaaaggactctggaaggttttcattgaggataaattgccataatatgatgcaaactatgctactctatgataattataatacagaggttccattcgatgcagcctatacaataatgtatttagtctaacacagtggaccctattttttgacacttccattgtttaaaagtacacatggaaaaaacctatatgcttacagtgcacctagagctttttataacagccttttttgttgtttgttttggattctttaaatatatatatatatatattattctcgtttagtacccctttagccagaatctcattactgcttcatttttgtaataacatttaatttagatattttccatgtattggccctgctaaaatagaagatagcatctttcatatggtagaaaccaacgaggaaactttactttaactccctttttacattttatggtaagtagcaggaggaaaaatgcatttgtagatcatttctaggcaaattgtgaagtttacgaccagcctgtttctacctatactcagtcttgttttactagaaatgggaatcatggcctcttgaagagaaaaaaagtcaccattctgcatttagctgtatctatatattgcatacctgtattttttgtttgtattgtaaaaaaaattcacataataaacaatgttgtgacgtaa

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