2024-04-25 17:02:46, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001033894 2410 bp mRNA linear ROD 22-DEC-2022 DEFINITION Rattus norvegicus janus kinase and microtubule interacting protein 1 (Jakmip1), transcript variant 6, mRNA. ACCESSION NM_001033894 XM_223515 VERSION NM_001033894.1 KEYWORDS RefSeq. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 2410) AUTHORS Berg JM, Lee C, Chen L, Galvan L, Cepeda C, Chen JY, Penagarikano O, Stein JL, Li A, Oguro-Ando A, Miller JA, Vashisht AA, Starks ME, Kite EP, Tam E, Gdalyahu A, Al-Sharif NB, Burkett ZD, White SA, Fears SC, Levine MS, Wohlschlegel JA and Geschwind DH. TITLE JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse JOURNAL Neuron 88 (6), 1173-1191 (2015) PUBMED 26627310 REFERENCE 2 (bases 1 to 2410) AUTHORS Vidal RL, Fuentes P, Valenzuela JI, Alvarado-Diaz CP, Ramirez OA, Kukuljan M and Couve A. TITLE RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons JOURNAL Mol Cell Neurosci 51 (1-2), 1-11 (2012) PUBMED 22828129 REMARK GeneRIF: RNA interference of Marlin-1 in vivo results in abnormal migration and abnormal morphology of newborn pyramidal neurons during the formation of the cortex. REFERENCE 3 (bases 1 to 2410) AUTHORS Vidal RL, Valenzuela JI, Lujan R and Couve A. TITLE Cellular and subcellular localization of Marlin-1 in the brain JOURNAL BMC Neurosci 10, 37 (2009) PUBMED 19386132 REMARK GeneRIF: Marlin-1 is enriched in restricted areas of the brain including olfactory bulb, cerebral cortex, hippocampus and cerebellum; it is abundant in dendrites and axons of hippocampal neurons, associated with microtubules at the ultrastructural level. Publication Status: Online-Only REFERENCE 4 (bases 1 to 2410) AUTHORS Vidal RL, Ramirez A, Castro M, Concha II and Couve A. TITLE Marlin-1 is expressed in testis and associates to the cytoskeleton and GABAB receptors JOURNAL J Cell Biochem 103 (3), 886-895 (2008) PUBMED 17668444 REMARK GeneRIF: Our findings demonstrate that Marlin-1 associates with a microtubule fraction and with GABA(B) receptors in testis suggesting that the set of protein interactions of Marlin-1 are conserved in different tissues. REFERENCE 5 (bases 1 to 2410) AUTHORS Nishimura Y, Martin CL, Vazquez-Lopez A, Spence SJ, Alvarez-Retuerto AI, Sigman M, Steindler C, Pellegrini S, Schanen NC, Warren ST and Geschwind DH. TITLE Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways JOURNAL Hum Mol Genet 16 (14), 1682-1698 (2007) PUBMED 17519220 REFERENCE 6 (bases 1 to 2410) AUTHORS Vidal RL, Ramirez OA, Sandoval L, Koenig-Robert R, Hartel S and Couve A. TITLE Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport JOURNAL Mol Cell Neurosci 35 (3), 501-512 (2007) PUBMED 17532644 REFERENCE 7 (bases 1 to 2410) AUTHORS Couve A, Restituito S, Brandon JM, Charles KJ, Bawagan H, Freeman KB, Pangalos MN, Calver AR and Moss SJ. TITLE Marlin-1, a novel RNA-binding protein associates with GABA receptors JOURNAL J Biol Chem 279 (14), 13934-13943 (2004) PUBMED 14718537 REMARK GeneRIF: Marlin-1 functions to regulate the cellular levels of GABA(B) R2 subunits, which may have significant effects on the production of functional GABA(B) receptor heterodimers. COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC104677.1. On Sep 30, 2005 this sequence version replaced XM_223515.3. ##Evidence-Data-START## Transcript exon combination :: BC104677.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00132261, SAMD00132263 [ECO:0000350] ##Evidence-Data-END## FEATURES Location/Qualifiers source 1..2410 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="14" /map="14q21" gene 1..2410 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /note="janus kinase and microtubule interacting protein 1" /db_xref="GeneID:305434" /db_xref="RGD:1562401" exon 1..69 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /inference="alignment:Splign:2.1.0" exon 70..332 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /inference="alignment:Splign:2.1.0" misc_feature 165..167 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /note="upstream in-frame stop codon" CDS 204..2084 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /note="isoform 5 is encoded by transcript variant 6; multiple alpha helices and RNA-linker protein 1; multiple coiled-coil GABABR1-binding protein" /codon_start=1 /product="janus kinase and microtubule-interacting protein 1 isoform 5" /protein_id="NP_001029066.1" /db_xref="GeneID:305434" /db_xref="RGD:1562401" /translation="
MSKKGRSKGEKPETETDSVQMANEELRAKLTNIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREALIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLADAREEARRTFDGERQRLQQEILELKAARKQAEEALSNCMQADKAKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKERVILALEKELGVQAGQTQRLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMAELMGGQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLHSIQRMEEKLKSLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDETTTREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDAAWVEEKQVLMRTNQDLLEKIYRLEMEENQLKSEMQDAKDQNELLEFRVLELEVRDSICCKLSNGADILFEPKLKFV"
misc_feature 204..1298 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /note="propagated from UniProtKB/Swiss-Prot (Q3SWS9.1); Region: Mediates association with microtubules. /evidence=ECO:0000250" misc_feature 204..278 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /note="propagated from UniProtKB/Swiss-Prot (Q3SWS9.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature <219..1292 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /note="chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169" /db_xref="CDD:274009" misc_feature 1296..2081 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /note="propagated from UniProtKB/Swiss-Prot (Q3SWS9.1); Region: Mediates interaction with TYK2 and GABBR1. /evidence=ECO:0000250" misc_feature 1347..1349 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q96N16; propagated from UniProtKB/Swiss-Prot (Q3SWS9.1); phosphorylation site" misc_feature 1446..2015 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /note="JAKMIP CC3 domain; Region: JAKMIP_CC3; pfam16034" /db_xref="CDD:435088" misc_feature 1557..1646 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /note="propagated from UniProtKB/Swiss-Prot (Q3SWS9.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1611..1613 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /note="Phosphothreonine. /evidence=ECO:0000250|UniProtKB:Q96N16; propagated from UniProtKB/Swiss-Prot (Q3SWS9.1); phosphorylation site" exon 333..827 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /inference="alignment:Splign:2.1.0" exon 828..1037 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /inference="alignment:Splign:2.1.0" exon 1038..1157 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /inference="alignment:Splign:2.1.0" exon 1158..1304 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /inference="alignment:Splign:2.1.0" exon 1305..1445 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /inference="alignment:Splign:2.1.0" exon 1446..1505 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /inference="alignment:Splign:2.1.0" exon 1506..1634 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /inference="alignment:Splign:2.1.0" exon 1635..1763 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /inference="alignment:Splign:2.1.0" exon 1764..1847 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /inference="alignment:Splign:2.1.0" exon 1848..1910 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /inference="alignment:Splign:2.1.0" exon 1911..2319 /gene="Jakmip1" /gene_synonym="Marlin-1; Marlin1" /inference="alignment:Splign:2.1.0" ORIGIN
cagccatcctgcagggcagatggagggactcccagacgaggctggaattggttcggggaggtggtagagactctccagtgatggtgtgcacagaggacgagcggaggcctgcacgactgcttagcacagctgagctggtagctgtgcttgccggtgggcaggcgtgaacctcaggacctcagcgtctcactccaagaggaaacatgtctaaaaagggccgcagcaagggtgagaagcccgagacagagacagactctgtacagatggccaatgaagagctacgggccaagctgacgaacatccagatcgagttccagcaggagaagagcaaggtggggaagctgcgggagcgtctgcaggaggccaagctggaacgggagcaggagcagcgtcgccacacggcctacatctcagaactcaaggccaagctgcacgaagagaagacgaaggaactgcaggcgctgcgcgaggcgctcatccggcagcacgagcaggaggcagcgcggaccgccaagatcaaggaaggcgagctgcagcgactgcaggccacgctgaatgtgctgcgcgatggcgccgcggacaaagtcaagactgcattgctggccgacgcgcgcgaggaggcgcgcaggacctttgatggcgagcgccagaggctgcagcaggagattctggaactgaaggctgcgcgcaaacaggcagaagaggcactcagcaactgcatgcaggcagacaaggccaaagccgcggacctgcgcgctgcgtaccaggcgcaccaggatgaggtgcaccgcatcaagcgggagtgtgaacgtgacatccgcagactgatggacgagatcaaaggaaaggaacgcgtgatcctggccctggagaaggagcttggtgtgcaggccgggcagacccagcggctgctattacagaaggaggctctggatgagcagctggtccaggtcaaggaggccgaacgccaccacagcagcccaaagagggagcttcctccaggcattggtgacatggctgagcttatgggtggccaggatcagcatatggacgagcgagatgtgaggcgatttcagctgaagattgccgaactgaattcagtgattcggaagctggaggacaggaacaccctgctggctgatgagaggaacgaactgctgaagcgctctcgggagacggaggtgcagctgaagccgctggtggagaagaacaaacgcatgaataaaaagaacgaggatctgctgcacagcatccaaaggatggaggagaaactcaagagcctcacgagggaaaacgtggagatgaaagaaaagctgtctgcccaggcctcactaaagcgacacacatccctgaatgacctcagtctgaccagggacgagcaggagatagagttcctgaggctgcaggtgctggaacagcagcatgtcattgatgacctctctctggaaagagaacgcctgctgcgctccaagaggcatcgagggaagagcctgaaaccccccaagaagcatgttgtggagacattttttggatttgatgaggagtctgtggactctgaaacattgtcagagacgtcctacaacacagacaggacagaccggaccccagccacgcctgaagaggacttagatgagaccacaaccagagaagaggctgacctgaggttctgccagctgaccagggagtaccaggctctgcagagggcttatgccctgcttcaggagcaggttggggggacgctggatgctgagagggaggctcggactcgggagcaacttcaggctgacctgctgagatgccaggccaaaattgaggacttagagaagctgctggttgagaagggacaggatgctgcgtgggtagaggagaagcaggtactcatgaggacaaaccaggacctgctggagaagatttacaggctggagatggaggagaaccagctaaagagtgaaatgcaagacgccaaggaccagaacgagctgttagaattcagagtgctagaactcgaagtaagagactctatctgttgtaagctctcaaatggagcagacattctctttgagcccaaactgaaattcgtgtaaagctctctgctatttccaagcatgcgtgaagggacgcgcgttaccgtttctctccttccttcctccgttcttttcctcttcgtctttttaaaaagatctgtatgttcggggtaacttcactgccttaacatgtcctggggaggatgctcgcgacgcctgtggacctgtaccagagcaatcgacttattgcctaccgcttgttttgcacttaataaaataagttgtttttgcaataaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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