LOCUS       NR_015388               4266 bp    RNA     linear   ROD 02-MAY-2024
DEFINITION  Mus musculus distal-less homeobox 6, opposite strand 1 (Dlx6os1),
            transcript variant 1, long non-coding RNA.
ACCESSION   NR_015388
VERSION     NR_015388.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4266)
  AUTHORS   Guo,J., Zheng,W., Liu,Y., Zhou,M., Shi,Y., Lei,M., Zhang,C. and
            Liu,Z.
  TITLE     Long non-coding RNA DLX6-AS1 is the key mediator of glomerular
            podocyte injury and albuminuria in diabetic nephropathy by
            targeting the miR-346/GSK-3beta signaling pathway
  JOURNAL   Cell Death Dis 14 (2), 172 (2023)
   PUBMED   36854759
  REMARK    GeneRIF: Long non-coding RNA DLX6-AS1 is the key mediator of
            glomerular podocyte injury and albuminuria in diabetic nephropathy
            by targeting the miR-346/GSK-3beta signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4266)
  AUTHORS   Liu,L., Zhou,T., Li,T., Liang,Z. and Luo,X.
  TITLE     LncRNA DLX6-AS1 promotes microglial inflammatory response in
            Parkinson's disease by regulating the miR-223-3p/NRP1 axis
  JOURNAL   Behav Brain Res 431, 113923 (2022)
   PUBMED   35550840
  REMARK    GeneRIF: LncRNA DLX6-AS1 promotes microglial inflammatory response
            in Parkinson's disease by regulating the miR-223-3p/NRP1 axis.
REFERENCE   3  (bases 1 to 4266)
  AUTHORS   Zheng,W., Guo,J., Lu,X., Qiao,Y., Liu,D., Pan,S., Liang,L., Liu,C.,
            Zhu,H., Liu,Z. and Liu,Z.
  TITLE     cAMP-response element binding protein mediates podocyte injury in
            diabetic nephropathy by targeting lncRNA DLX6-AS1
  JOURNAL   Metabolism 129, 155155 (2022)
   PUBMED   35093327
REFERENCE   4  (bases 1 to 4266)
  AUTHORS   Chen,Y.X., Zhu,S.Y., Huang,C., Xu,C.Y., Fang,X.D. and Tu,W.P.
  TITLE     LncRNA Dlx6os1 Accelerates Diabetic Nephropathy Progression by
            Epigenetically Repressing SOX6 via Recruiting EZH2
  JOURNAL   Kidney Blood Press Res 47 (3), 177-184 (2022)
   PUBMED   35038705
  REMARK    GeneRIF: LncRNA Dlx6os1 Accelerates Diabetic Nephropathy
            Progression by Epigenetically Repressing SOX6 via Recruiting EZH2.
REFERENCE   5  (bases 1 to 4266)
  AUTHORS   Fazel Darbandi,S., Esau,C., Lesage-Pelletier,C., Monis,S.,
            Poitras,L., Yu,M., Perin,S., Hatch,G. and Ekker,M.
  TITLE     Increased Sociability in Mice Lacking Intergenic Dlx Enhancers
  JOURNAL   Front Neurosci 15, 718948 (2021)
   PUBMED   34671237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4266)
  AUTHORS   Lo Iacono,N., Mantero,S., Chiarelli,A., Garcia,E., Mills,A.A.,
            Morasso,M.I., Costanzo,A., Levi,G., Guerrini,L. and Merlo,G.R.
  TITLE     Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in
            EEC and SHFM congenital limb defects
  JOURNAL   Development 135 (7), 1377-1388 (2008)
   PUBMED   18326838
REFERENCE   7  (bases 1 to 4266)
  AUTHORS   Mercer,T.R., Dinger,M.E., Sunkin,S.M., Mehler,M.F. and Mattick,J.S.
  TITLE     Specific expression of long noncoding RNAs in the mouse brain
  JOURNAL   Proc Natl Acad Sci U S A 105 (2), 716-721 (2008)
   PUBMED   18184812
REFERENCE   8  (bases 1 to 4266)
  AUTHORS   Feng,J., Bi,C., Clark,B.S., Mady,R., Shah,P. and Kohtz,J.D.
  TITLE     The Evf-2 noncoding RNA is transcribed from the Dlx-5/6
            ultraconserved region and functions as a Dlx-2 transcriptional
            coactivator
  JOURNAL   Genes Dev 20 (11), 1470-1484 (2006)
   PUBMED   16705037
REFERENCE   9  (bases 1 to 4266)
  AUTHORS   Faedo,A., Quinn,J.C., Stoney,P., Long,J.E., Dye,C., Zollo,M.,
            Rubenstein,J.L., Price,D.J. and Bulfone,A.
  TITLE     Identification and characterization of a novel transcript
            down-regulated in Dlx1/Dlx2 and up-regulated in Pax6 mutant
            telencephalon
  JOURNAL   Dev Dyn 231 (3), 614-620 (2004)
   PUBMED   15376329
REFERENCE   10 (bases 1 to 4266)
  AUTHORS   Kohtz,J.D. and Fishell,G.
  TITLE     Developmental regulation of EVF-1, a novel non-coding RNA
            transcribed upstream of the mouse Dlx6 gene
  JOURNAL   Gene Expr Patterns 4 (4), 407-412 (2004)
   PUBMED   15183307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK032537.1 and BE989474.1.
            
            On Apr 10, 2018 this sequence version replaced NR_015388.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032537.1, CA318216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4247              AK032537.1         1-4247
            4248-4266           BE989474.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..4266
                     /organism="Mus musculus"
                     /mol_type="transcribed RNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 2.68 cM"
     gene            1..4266
                     /gene="Dlx6os1"
                     /gene_synonym="A230055N17Rik; Dlx6as1; Evf-1; Evf-2; Evf1;
                     Evf1/2; Evf2; Shhrs"
                     /note="distal-less homeobox 6, opposite strand 1"
                     /db_xref="GeneID:320038"
                     /db_xref="MGI:MGI:2443217"
     ncRNA           1..4266
                     /ncRNA_class="lncRNA"
                     /gene="Dlx6os1"
                     /gene_synonym="A230055N17Rik; Dlx6as1; Evf-1; Evf-2; Evf1;
                     Evf1/2; Evf2; Shhrs"
                     /product="distal-less homeobox 6, opposite strand 1,
                     transcript variant 1"
                     /db_xref="GeneID:320038"
                     /db_xref="MGI:MGI:2443217"
     exon            1..225
                     /gene="Dlx6os1"
                     /gene_synonym="A230055N17Rik; Dlx6as1; Evf-1; Evf-2; Evf1;
                     Evf1/2; Evf2; Shhrs"
                     /inference="alignment:Splign:2.1.0"
     exon            226..4250
                     /gene="Dlx6os1"
                     /gene_synonym="A230055N17Rik; Dlx6as1; Evf-1; Evf-2; Evf1;
                     Evf1/2; Evf2; Shhrs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcttcaaattggatggcactgcagctggaggctttgttcagaattgatcctggggagctacgaacccaaagtttcacagtaggaagggggaaaaaagaaaagaaaacatttttcctaatgtaacaatgcgaatgctagaaaatgacaagactgatcggttttaaaccattctgaagactgactgagcgtggaagttgctcaacaaaaaagggaacggggatattgaaccagagagaaacctacgcccagaagaacatgtccctggattgctttcccactgctgtggagtgtcttgaacactggtccctggacaccaacttcaagaagacttcatggatggctgtccagtcttatgagccacagtttcccctctacattttcttcactccagcgaggctcttatcagggtcagatcagagatgaaccagctggacgacagattggagcgctgacctcttagagtgctaacagtgaacagtgtggggtcagatctatagaaagataataataagaaaacaccctatatgcaagggagagggatggttcataatttcttaaagattgaaatcaaggaacaatcaaaatatagaagaatgtggacgtgttttgctgcaggacttctgttttgtccccattggaatatgtattatggtattcctgttggatcaggactcaggggcaaggctaagcattccagtggtcctcctacttagctcttgtcctttcgtaagaaacaccaactcattagtctctatattacttctctgtactgtagatctgcattcttgatctgagagatattggcaatgacactcttgtatgataaagctcaatgataagagtacttcaaacccccttgaactttttgtttatacatcaagtggtgacattgtgtattgagctaattagatcaatggagtcacagggtgatactgaactcttttaaaatatttggctgaaacatgacattgtagttatttgtagaagagaacattatggaatatgaaaaacatcacagaacacagaactagcagcagaaactagcagcaggtagacatttttccttttccatagagctttcaaccaaatgtctctgtagaaaatagtggctatcgtgtatatatatagccacatagatgtccttgagtgtaccctgtagtcagtgggagagttcctactgccacagtcatggccatggctatgttctctaagcctacattttataaacactctgtgaatcttgactacttttctttagcaagcattgcaaagtcctgggatgtcagagaagtgcctggggttggcagggtttctagagaggaaattgttaaatgatttgaaccagaaaacaaacaggggatggggttcagaaccaacaattacctctattctatgtaggaaaccacaacatgaaatatgctgggcatggaaactttgataccttggtttttcattctttttaaaaattaatactaaagagctatgcgactgtaggcaagccatttcccatcccctgtgaatatctcccagatgactttaaatcccttctagttctgaaaggcttttaacatcagggcccaggctccagtggccagtttcaaaataccctcccttttgatgttaggttacataaacattgttcttttttagggagggtctcttttatcaacttttaaaaacacacatcaggttctctggtattaaaaagatgccatctctgagtcccctactatctgtgctgcctgcctttcctcctgttctttccttattcccatccctattgaacttgtgctatgcagtatgcatcaggtatgtgttagctttggggatacatgatagataaactggacacacagggtcttcccattctcttctggaattttctttggagggagcctcttgtatctagacagaccgtgctgtggtaccccagaggtaaccacctacaggcttcactctgcctaagcaattttgctgtgcactaagatacacattcaagtaactttagattaccacaataactttctccaggtatgaggaaaagagataatttacttctgagatgtgtataggatagccctccatcctgggaagaacagtgactactccctgcatcccgaccttgcccagggaaagctaatgtttctctgtgttatccctgtgacttgccacttctttaaaaaggaatgggcaaacaataaacagacaaaaatgttgtctgacctcattggaaatccttttaagaattaatcctttctatctccttcattatcaacaaatctattgaatacttatctctgagtccagggcatattttataatacataaaacaatggaatttcaaaattggagcactgacatacaatattggttttgagtatttttattatagggaatgactttagacattgcaatttatgacttaactgataaaatggatgactcttgactttcaattttcattttcagttcagtcgaggaatagcttcctccaggtaatgtctatactttcctatgactaagggctctaactatctctgttgcttttctttatgtaggcatatgttagtatttattttctatatgacaaatgtattaaagaaagcatgaaattaatgagataaacttttcagataggagtttagaaaatcaaggggccaagataaataaatgaaaaatcaacttaaataattaacatattccagatatattggaataaatgtttattgtacccttttggttttgtcttgggttatttttttcttatctcactgatttttttttctttcctttttagcttttttgtcttttttgatttttgttgttgcgtttctcctttttttttttcttgttgatgttgtttgtttgtttgtttgtttgttttttgagaaagaacagaaggttggttggatagggaggtggggaagatctatctggatggagttgggaggagggaaaatacacgatcaaaatatattttgtgatgggcagggcatagtggtacatgtctttaatctcagcactctggaggcagaggcaggtggatctctatgagatggaggctagcctgatatacaaagtgagaccagaacatagggctgcctcaaaaactttatatatatattaaaaatgtttgctttttgagacagtcacagataaccaaaactgatcttgtaatgatgtaaacatgtccagctaattttcaaatattgtagggcagcatttctccctttgtgcacacgtggagtcagcaaatccatataattctaaccattctggtgaaaaggagaacactcggccaagcatctcacacttccaagtgtgaagccttgtttgaaagctccgagtatctaaatagtagccctgtgaaaggtaaatttatgaatggtctggtgtgttcttattccagccattgaccttaaagcaacttatatatgttttctttatccttcaagagaaaagaaaaatcatatttttccaagcaattaaaattcttctgcttcaggtaggaagaaggaattaggagttatgtctccttgtatataattgcaagtttcatttttcttgttttaatgattgacagaaaactgataaactgagacatctccttattagggttgaatgtactctcttggtggccccattgctaatttgtttgactattttccatgatttcttactctgtaatggaaaggtttattaaatatgagggttgcaaagctttctgaatactaatgaacttatttgccaaaatttaaatgttcttcttgtcagtgaatgcctgtctcacttaacaggcaccaaattgaataatgaagaaaattagactctatcgtaccctcaagagaaatcgcgtgtgaattgtaatagaaaattgagggagaaaagggtcatattgtagcaataacactagataatttggattattttaaaaaaggatgaacttagggaagctcaggtcttttcaaagaaacacacatttggttaattcatgcaaaacgctggtttcccctcaacccaggtggtctatacctatcgccagtttacagaaaaaggaagccaggtggatggaaaacgtgtgccaagtttctgtgcttacaatccactaaactcattctcatatgaggactttatatacctgtgatggagtgggaaaatcaataacctggaaaaaatgagtaccattttccaaagaagttcaataaagagatggaatttgggaaactgctgcagttcttcctataagcataaaaaaaaaaaaaaaaa

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