LOCUS       NM_207533               2271 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus developing brain homeobox 2 (Dbx2), mRNA.
ACCESSION   NM_207533 XM_356793
VERSION     NM_207533.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2271)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2271)
  AUTHORS   Giuliani,A., Licursi,V., Nisi,P.S., Fiore,M., D'Angelo,S.,
            Biagioni,S., Negri,R., Rugg-Gunn,P.J., Cacci,E. and Lupo,G.
  TITLE     Dbx2, an Aging-Related Homeobox Gene, Inhibits the Proliferation of
            Adult Neural Progenitors
  JOURNAL   Stem Cell Rev Rep 19 (8), 2837-2851 (2023)
   PUBMED   37605090
  REMARK    GeneRIF: Dbx2, an Aging-Related Homeobox Gene, Inhibits the
            Proliferation of Adult Neural Progenitors.
REFERENCE   3  (bases 1 to 2271)
  AUTHORS   Beccari,L., Jaquier,G., Lopez-Delisle,L., Rodriguez-Carballo,E.,
            Mascrez,B., Gitto,S., Woltering,J. and Duboule,D.
  TITLE     Dbx2 regulation in limbs suggests interTAD sharing of enhancers
  JOURNAL   Dev Dyn 250 (9), 1280-1299 (2021)
   PUBMED   33497014
REFERENCE   4  (bases 1 to 2271)
  AUTHORS   Gao,Y., Duque-Wilckens,N., Aljazi,M.B., Wu,Y., Moeser,A.J.,
            Mias,G.I., Robison,A.J. and He,J.
  TITLE     Loss of histone methyltransferase ASH1L in the developing mouse
            brain causes autistic-like behaviors
  JOURNAL   Commun Biol 4 (1), 756 (2021)
   PUBMED   34145365
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2271)
  AUTHORS   Ma,P., Song,N.N., Cheng,X., Zhu,L., Zhang,Q., Zhang,L.L., Yang,X.,
            Wang,H., Kong,Q., Shi,D., Ding,Y.Q. and Mao,B.
  TITLE     ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through
            modulating Shh/Gli signaling
  JOURNAL   J Mol Cell Biol 12 (5), 337-344 (2020)
   PUBMED   31336385
REFERENCE   6  (bases 1 to 2271)
  AUTHORS   Muller,T., Brohmann,H., Pierani,A., Heppenstall,P.A., Lewin,G.R.,
            Jessell,T.M. and Birchmeier,C.
  TITLE     The homeodomain factor lbx1 distinguishes two major programs of
            neuronal differentiation in the dorsal spinal cord
  JOURNAL   Neuron 34 (4), 551-562 (2002)
   PUBMED   12062039
REFERENCE   7  (bases 1 to 2271)
  AUTHORS   Vallstedt,A., Muhr,J., Pattyn,A., Pierani,A., Mendelsohn,M.,
            Sander,M., Jessell,T.M. and Ericson,J.
  TITLE     Different levels of repressor activity assign redundant and
            specific roles to Nkx6 genes in motor neuron and interneuron
            specification
  JOURNAL   Neuron 31 (5), 743-755 (2001)
   PUBMED   11567614
REFERENCE   8  (bases 1 to 2271)
  AUTHORS   Pierani,A., Moran-Rivard,L., Sunshine,M.J., Littman,D.R.,
            Goulding,M. and Jessell,T.M.
  TITLE     Control of interneuron fate in the developing spinal cord by the
            progenitor homeodomain protein Dbx1
  JOURNAL   Neuron 29 (2), 367-384 (2001)
   PUBMED   11239429
REFERENCE   9  (bases 1 to 2271)
  AUTHORS   Pierani,A., Brenner-Morton,S., Chiang,C. and Jessell,T.M.
  TITLE     A sonic hedgehog-independent, retinoid-activated pathway of
            neurogenesis in the ventral spinal cord
  JOURNAL   Cell 97 (7), 903-915 (1999)
   PUBMED   10399918
REFERENCE   10 (bases 1 to 2271)
  AUTHORS   Shoji,H., Ito,T., Wakamatsu,Y., Hayasaka,N., Ohsaki,K., Oyanagi,M.,
            Kominami,R., Kondoh,H. and Takahashi,N.
  TITLE     Regionalized expression of the Dbx family homeobox genes in the
            embryonic CNS of the mouse
  JOURNAL   Mech Dev 56 (1-2), 25-39 (1996)
   PUBMED   8798145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX214447.1, CX214957.1 and AK035803.1.
            
            On Sep 16, 2006 this sequence version replaced NM_207533.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035803.1, SRR1660811.164293.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               CX214447.1         1-317
            318-404             CX214957.1         235-321
            405-2271            AK035803.1         2-1868
FEATURES             Location/Qualifiers
     source          1..2271
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 50.47 cM"
     gene            1..2271
                     /gene="Dbx2"
                     /gene_synonym="9430056A22Rik; 9630005K15; Gm1229"
                     /note="developing brain homeobox 2"
                     /db_xref="GeneID:223843"
                     /db_xref="MGI:MGI:107445"
     exon            1..532
                     /gene="Dbx2"
                     /gene_synonym="9430056A22Rik; 9630005K15; Gm1229"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    7..9
                     /gene="Dbx2"
                     /gene_synonym="9430056A22Rik; 9630005K15; Gm1229"
                     /note="upstream in-frame stop codon"
     CDS             10..1143
                     /gene="Dbx2"
                     /gene_synonym="9430056A22Rik; 9630005K15; Gm1229"
                     /codon_start=1
                     /product="homeobox protein DBX2"
                     /protein_id="NP_997416.2"
                     /db_xref="CCDS:CCDS37183.1"
                     /db_xref="GeneID:223843"
                     /db_xref="MGI:MGI:107445"
                     /translation="

MDGPDTPSIPVLKTLSGSADRSRTLPEEPLRAKDSPLSPDPVRALSLSLRTRSPRLPGQRARTMLPSAVAAQAGAYWDVVASSALFGLPAPGFGSLGKSFLIENLLRAGAGPTHAPPPPRPAPGPECPQLRPLPASPVPLKLCPAGPFGVRWAFQMPPGRAPGERDSAFQPSAPVPSKPFLLSAPPFYSACCGGSCRRPASPTAFSREEHGLPLLTQDSNSKARRGILRRAVFSEEQRKALEKMFQKQKYISKTDRRKLAVSLGLKESQVKIWFQNRRMKWRNSKEKEVLSSRCLQEVSLQEDRLARPAVGCPPQCPSIWEVSQPHSSPSWREETPESAERLTQENSGVLEADSLRGTLYLCPEKGPRDKHGLQSTI"

     misc_feature    <658..1011
                     /gene="Dbx2"
                     /gene_synonym="9430056A22Rik; 9630005K15; Gm1229"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]; Region: COG5576"
                     /db_xref="CDD:227863"
     misc_feature    694..858
                     /gene="Dbx2"
                     /gene_synonym="9430056A22Rik; 9630005K15; Gm1229"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            533..628
                     /gene="Dbx2"
                     /gene_synonym="9430056A22Rik; 9630005K15; Gm1229"
                     /inference="alignment:Splign:2.1.0"
     exon            629..816
                     /gene="Dbx2"
                     /gene_synonym="9430056A22Rik; 9630005K15; Gm1229"
                     /inference="alignment:Splign:2.1.0"
     exon            817..2271
                     /gene="Dbx2"
                     /gene_synonym="9430056A22Rik; 9630005K15; Gm1229"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1444..1449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dbx2"
                     /gene_synonym="9430056A22Rik; 9630005K15; Gm1229"
                     /note="hexamer: ATTAAA"
     polyA_site      1466
                     /gene="Dbx2"
                     /gene_synonym="9430056A22Rik; 9630005K15; Gm1229"
                     /note="major polyA site"
ORIGIN      

atgacatgaatggatgggccggacacaccttccatcccagtcctgaaaaccctgtccggatctgcagaccgttcccggacgctgccagaggagccgctgagggccaaggactcacccctcagccccgatcctgtccgcgccctgtccctgtcccttcgcactcgctctccacggctccccgggcagcgggcgcgcaccatgctgcccagcgctgtggccgcccaggccggagcctactgggatgtggtggcgtcctcagcactcttcggccttcctgcgcccggctttggcagtctgggcaagagtttcctgatcgagaacttgctgcgcgcaggggccgggcccacgcacgcacccccgcccccacgcccagcgcccggtcctgagtgtccgcagctgcggccactgcctgccagcccagtgccgctcaagctgtgcccggccggaccctttggtgtgcgctgggccttccagatgccccctggccgggctccgggggagcgggacagtgccttccagccctcagccccagtgccttccaaaccctttcttctgagcgccccgccattctactctgcatgctgcggtgggtcctgcaggcgcccagcatcccccacagctttttcaagagaagaacacgggctgcctttgctgacccaggactcaaattccaaagctcgcagggggattttacgaagagctgtgttctcagaggagcagagaaaggctctggagaaaatgtttcagaagcagaaatacatcagcaaaacagaccgaaggaaactcgcggtcagcttgggactgaaggagtcacaggtgaagatttggttccagaaccgaaggatgaaatggcggaattccaaagaaaaggaagtactctccagtaggtgtctccaagaagtgagccttcaggaagacaggctggcacggcctgccgtgggctgtcctccgcagtgcccgtcaatatgggaagtctcccagccacactcaagtccaagctggagggaggagactccagaatctgcagaaagactgacccaggagaattcaggggtcctggaagcagattcactccgaggtaccttgtatctgtgtcctgagaagggacctagagacaagcatggactccagagcaccatttgacgggaacatactccgtgtacatctaaaagaacccttagccagtaacacttggattaaagccagttagattgtgcctcaaaactgccttaaactaataccttggcatgatgcctgagctgttgcctaaggagagccactctactgtttcttatttagccctagcctaaggctcaatgtatatatggaatagaaccttccacaaagtgtgataagactgaaagaagagccaggatcagccccagagcctgttctgaatatgtgtacatattcgtgtgtctgtgtgtttgtatgtatatgctcattaaatacatcatcagaaattagttctctccaagttttatatggaacaaattcatttcattttgtatgaagtaaaaaaaaaaaaaaccaacgagcaaatattcattttctaatagtgtaaaatctgggcttttgtgctgcacaattaattatgccggtataaattctctgcttctggcctctttggtgtccactgtcaatgagttttagcaagcttagcaaccctagtcgagttagctgtggttagacacacactgaagagagacaagaggaactcaacaggaaactactacttttgaatatagttattagtacctctagcccccagttctgaggcagctggggccatcagtgaagaaggtctacactgaggcgttgatcgtcttctggtctcttgtctggctgggtttcctaggccagagtcttctaaacacaataaatgcctgagtggaaggaagggcttgtcaggcaactgtttgatcgtctgcaccaacgagtttataatcagcgaccaagatgaagtcaagacccagggtcactgttctcaaacagtctacaacagggctaaaaatcccagggctgaagggctctgtggtcaatgctgattgcacactacataccatctgaatttcccacctagctcgctcacactacatatgttatgtggttttatatattaacagacaccacccagatgttttatgattaccttgtaatagtctttgtgtaaaatcacatttctggtaacaattttcttagttaatccaaatatattaattctaagcccacaaaacaaaacaaaatgttttactttgcaggaaatgaagc

//