LOCUS       NM_145707               1603 bp    mRNA    linear   ROD 27-APR-2025
DEFINITION  Mus musculus oocyte specific homeobox 3 (Obox3), mRNA.
ACCESSION   NM_145707 XM_908582
VERSION     NM_145707.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1603)
  AUTHORS   Sakamoto,M., Ito,A., Wakayama,S., Sasaki,H., Wakayama,T. and
            Ishiuchi,T.
  TITLE     Detection of newly synthesized RNA reveals transcriptional
            reprogramming during ZGA and a role of Obox3 in totipotency
            acquisition
  JOURNAL   Cell Rep 43 (4), 114118 (2024)
   PUBMED   38619966
  REMARK    GeneRIF: Detection of newly synthesized RNA reveals transcriptional
            reprogramming during ZGA and a role of Obox3 in totipotency
            acquisition.
REFERENCE   2  (bases 1 to 1603)
  AUTHORS   Ji,S., Chen,F., Stein,P., Wang,J., Zhou,Z., Wang,L., Zhao,Q.,
            Lin,Z., Liu,B., Xu,K., Lai,F., Xiong,Z., Hu,X., Kong,T., Kong,F.,
            Huang,B., Wang,Q., Xu,Q., Fan,Q., Liu,L., Williams,C.J.,
            Schultz,R.M. and Xie,W.
  TITLE     OBOX regulates mouse zygotic genome activation and early
            development
  JOURNAL   Nature 620 (7976), 1047-1053 (2023)
   PUBMED   37459895
REFERENCE   3  (bases 1 to 1603)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 1603)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   5  (bases 1 to 1603)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 1603)
  AUTHORS   Cheng,W.C., Hsieh-Li,H.M., Yeh,Y.J. and Li,H.
  TITLE     Mice lacking the Obox6 homeobox gene undergo normal early embryonic
            development and are fertile
  JOURNAL   Dev Dyn 236 (9), 2636-2642 (2007)
   PUBMED   17676645
REFERENCE   7  (bases 1 to 1603)
  AUTHORS   Yeh,Y.J., Choo,K.B., Cheng,W.T. and Li,H.
  TITLE     Ohx is a homeobox-encoding gene preferentially expressed in mature
            oocytes
  JOURNAL   Mech Dev 117 (1-2), 259-263 (2002)
   PUBMED   12204267
REFERENCE   8  (bases 1 to 1603)
  AUTHORS   Rajkovic,A., Yan,C., Yan,W., Klysik,M. and Matzuk,M.M.
  TITLE     Obox, a family of homeobox genes preferentially expressed in germ
            cells
  JOURNAL   Genomics 79 (5), 711-717 (2002)
   PUBMED   11991721
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139750.1.
            
            On May 17, 2008 this sequence version replaced NM_145707.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139750.1, BY725694.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1603              AK139750.1         2-1604
FEATURES             Location/Qualifiers
     source          1..1603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 8.53 cM"
     gene            1..1603
                     /gene="Obox3"
                     /gene_synonym="Ohx"
                     /note="oocyte specific homeobox 3"
                     /db_xref="GeneID:246791"
                     /db_xref="MGI:MGI:2149032"
     exon            1..48
                     /gene="Obox3"
                     /gene_synonym="Ohx"
                     /inference="alignment:Splign:2.1.0"
     exon            49..121
                     /gene="Obox3"
                     /gene_synonym="Ohx"
                     /inference="alignment:Splign:2.1.0"
     exon            122..383
                     /gene="Obox3"
                     /gene_synonym="Ohx"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    149..151
                     /gene="Obox3"
                     /gene_synonym="Ohx"
                     /note="upstream in-frame stop codon"
     CDS             167..1174
                     /gene="Obox3"
                     /gene_synonym="Ohx"
                     /note="oocyte-specific homeobox"
                     /codon_start=1
                     /product="oocyte-specific homeobox protein 3"
                     /protein_id="NP_663753.3"
                     /db_xref="CCDS:CCDS20838.1"
                     /db_xref="GeneID:246791"
                     /db_xref="MGI:MGI:2149032"
                     /translation="

MAEGPSLHPKLQVASNIPIELSSQIPQDPARNLAFQMCQNPLMTPGSTMQSRLSVPERNLLQQESQGPTRQSGRMPLSDRYVNKQTGPMALRKFRKERTVYSKEQQCLLQKHFDEFQYPNEKKIVELALSVGVTKREIKIWFKNNRAKYRRMKLQNIKQALPETNESSKAVSESTHFPGSIPVVDSDNGESMCSGTFGEDSIPKLNCSQESSLHCFQACDGDMCCPQEYQEYQEYLLHGHAPVTAWNSGQSAAFESQTDLAVAEVPVGLAYAAQAPEDAHNSGPCEDELWQRILEDLDTSDDWLTLRNLSTPVYTTEVLDQSKPYSHEEVCYTHL"

     misc_feature    347..409
                     /gene="Obox3"
                     /gene_synonym="Ohx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UT54.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    449..625
                     /gene="Obox3"
                     /gene_synonym="Ohx"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(449..463,467..469,518..520,536..538,575..577,
                     581..586,593..598,602..610,614..619)
                     /gene="Obox3"
                     /gene_synonym="Ohx"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(455..457,464..466,584..586,593..598,605..607)
                     /gene="Obox3"
                     /gene_synonym="Ohx"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            384..583
                     /gene="Obox3"
                     /gene_synonym="Ohx"
                     /inference="alignment:Splign:2.1.0"
     exon            584..1603
                     /gene="Obox3"
                     /gene_synonym="Ohx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1579..1584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Obox3"
                     /gene_synonym="Ohx"
                     /note="putative"
     polyA_site      1603
                     /gene="Obox3"
                     /gene_synonym="Ohx"
                     /note="putative"
ORIGIN      

aaaacagccagaggatttagcaagttacagcaaccgtctggattcctggcagaggtccaagtcctggattgtatagagaacccgacatcaaccaatggagaggcctgcttctaggacgaaggttctccagtacaggaacatactccaataagttctgaacacacacatggccgaaggcccctccttgcatccaaaactccaagtggcttcgaatatacccatagaactcagttcccaaatacctcaagaccctgcaaggaacttagcttttcaaatgtgtcagaatcccctaatgactccaggaagtacaatgcaatcaagactttcagtccctgaaaggaacctacttcagcaagagtctcaaggaccaacaagacaatcaggtcgtatgccactgtcagatagatatgttaacaaacaaactggccctatggctttaagaaagtttcgaaaagaacgcactgtgtactccaaagaacagcagtgcctgctgcaaaaacattttgatgagttccagtacccaaacgagaagaaaattgtggagctggcactatcagttggtgttacaaagagggagatcaagatctggttcaagaacaaccgagctaagtacaggcggatgaagctccagaatataaaacaagcactgccagagacaaatgaaagctctaaagcggtttctgagtcaacccattttcctggttccatacctgttgttgactcggacaatggagagtccatgtgttcaggcacatttggtgaggattccattcccaaactcaactgcagccaggaatcttccctgcattgttttcaggcctgtgatggggacatgtgttgtccgcaagaataccaagaataccaagaatacctgcttcatggccatgcccctgttacagcttggaactctggtcaatcagcagcatttgaatctcaaactgacttagcagtagctgaagttccagtcggcctggcatatgccgcccaagccccagaggatgctcacaattcaggtccatgtgaagatgagctctggcaaaggatccttgaagacttggacacatcagatgactggcttactctgagaaacctctccactccagtttacaccactgaggtccttgaccagtccaagccttacagccatgaagaagtgtgttatacacacctttagtgtcagtatttggagaaaattttattttacttttttattgggtatttatttcatttacatttccaatgctatcccaaaagacccccctaccctccccccttcccttcccacttcttggccctggcattcccctgtactgaggcagataaagtttgcacgaccaatgagtgtaatcactttgagagcacataattcggagtccattggtagaaaatgatactttgtttagtatatatttggggtggctgtggattcatgcaatatagggactcgctatcaagtctaactccagttatatgattacctacgccctctccttgcttcagaggtcactacatgcaacaggaaccctcatatacatgcagaacttgcaatcatatgatagaaaagcaatacatctgataaataaatactgtgagccaactcccc

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