LOCUS       NM_130869               1893 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus NOBOX oogenesis homeobox (Nobox), mRNA.
ACCESSION   NM_130869
VERSION     NM_130869.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1893)
  AUTHORS   Song,C., Qin,Y., Li,Y., Yang,B., Guo,T., Ma,W., Xu,D., Xu,K.,
            Fu,F., Jin,L., Wu,Y., Tang,S., Chen,X. and Zhang,F.
  TITLE     Deleterious variants in RNF111 impair female fertility and induce
            premature ovarian insufficiency in humans and mice
  JOURNAL   Sci China Life Sci 67 (7), 1325-1337 (2024)
   PUBMED   38874713
REFERENCE   2  (bases 1 to 1893)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1893)
  AUTHORS   Cincotta,S.A., Richardson,N., Foecke,M.H. and Laird,D.J.
  TITLE     Differential susceptibility of male and female germ cells to
            glucocorticoid-mediated signaling
  JOURNAL   Elife 12, 90164 (2024)
   PUBMED   38226689
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1893)
  AUTHORS   Meng,T.G., Guo,J.N., Zhu,L., Yin,Y., Wang,F., Han,Z.M., Lei,L.,
            Ma,X.S., Xue,Y., Yue,W., Nie,X.Q., Zhao,Z.H., Zhang,H.Y., Sun,S.M.,
            Ouyang,Y.C., Hou,Y., Schatten,H., Ju,Z., Ou,X.H., Wang,Z.B.,
            Wong,C.C.L., Li,Z. and Sun,Q.Y.
  TITLE     NLRP14 Safeguards Calcium Homeostasis via Regulating the K27
            Ubiquitination of Nclx in Oocyte-to-Embryo Transition
  JOURNAL   Adv Sci (Weinh) 10 (27), e2301940 (2023)
   PUBMED   37493331
REFERENCE   5  (bases 1 to 1893)
  AUTHORS   Hughes,C.H.K., Smith,O.E., Meinsohn,M.C., Brunelle,M., Gevry,N. and
            Murphy,B.D.
  TITLE     Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the
            ovarian reserve
  JOURNAL   Proc Natl Acad Sci U S A 120 (32), e2220849120 (2023)
   PUBMED   37494420
REFERENCE   6  (bases 1 to 1893)
  AUTHORS   Pangas,S.A., Choi,Y., Ballow,D.J., Zhao,Y., Westphal,H.,
            Matzuk,M.M. and Rajkovic,A.
  TITLE     Oogenesis requires germ cell-specific transcriptional regulators
            Sohlh1 and Lhx8
  JOURNAL   Proc Natl Acad Sci U S A 103 (21), 8090-8095 (2006)
   PUBMED   16690745
REFERENCE   7  (bases 1 to 1893)
  AUTHORS   Choi,Y. and Rajkovic,A.
  TITLE     Genetics of early mammalian folliculogenesis
  JOURNAL   Cell Mol Life Sci 63 (5), 579-590 (2006)
   PUBMED   16416028
  REMARK    Review article
REFERENCE   8  (bases 1 to 1893)
  AUTHORS   Rajkovic,A., Pangas,S.A., Ballow,D., Suzumori,N. and Matzuk,M.M.
  TITLE     NOBOX deficiency disrupts early folliculogenesis and
            oocyte-specific gene expression
  JOURNAL   Science 305 (5687), 1157-1159 (2004)
   PUBMED   15326356
  REMARK    GeneRIF: Nobox is critical for specifying an oocyte-restricted gene
            expression pattern essential for postnatal follicle development
REFERENCE   9  (bases 1 to 1893)
  AUTHORS   Suzumori,N., Yan,C., Matzuk,M.M. and Rajkovic,A.
  TITLE     Nobox is a homeobox-encoding gene preferentially expressed in
            primordial and growing oocytes
  JOURNAL   Mech Dev 111 (1-2), 137-141 (2002)
   PUBMED   11804785
REFERENCE   10 (bases 1 to 1893)
  AUTHORS   Rovescalli,A.C., Asoh,S. and Nirenberg,M.
  TITLE     Cloning and characterization of four murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 10691-10696 (1996)
   PUBMED   8855241
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1996 Dec 24;93(26):15522]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153885.2.
            
            On May 1, 2007 this sequence version replaced NM_130869.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY061761.1, BC125282.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC153885.2         39171-39235
            66-356              AC153885.2         41052-41342
            357-464             AC153885.2         41443-41550
            465-571             AC153885.2         41904-42010
            572-678             AC153885.2         42316-42422
            679-764             AC153885.2         42676-42761
            765-996             AC153885.2         42990-43221
            997-1301            AC153885.2         43556-43860
            1302-1893           AC153885.2         44460-45051
FEATURES             Location/Qualifiers
     source          1..1893
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 21.17 cM"
     gene            1..1893
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /note="NOBOX oogenesis homeobox"
                     /db_xref="GeneID:18291"
                     /db_xref="MGI:MGI:108011"
     exon            1..65
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1612
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /note="newborn ovary homeobox protein; oocyte-specific
                     homeobox protein; homeodomain-containing protein OG-2; OG2
                     homeobox"
                     /codon_start=1
                     /product="homeobox protein NOBOX"
                     /protein_id="NP_570939.1"
                     /db_xref="CCDS:CCDS20093.1"
                     /db_xref="GeneID:18291"
                     /db_xref="MGI:MGI:108011"
                     /translation="

MEPTEKLCKKMQGQEAGDKPRTAALETEGPLQDSALPIQDDQDKQSSLPRASLGKRPLSKTSEELMDAGTCRVHKAPTAAACGPQSEEEGCSPPERKAESLKPSISAVPGQATAGSLNSHEGDLKKESLEVTCQFRKKTRTLYRSDQLEELERIFQEDHYPDSDKRHEISQMVGVTPQRIMVWFQNRRAKWRKVEKLNEKETKNGPAAPSADSSQHRSAPELLDPMPTDLEPGPVPPENILDVFPEPPMLLTSEQTLTPFQNNEGAERVAVTPPLLSPPPIRRANLPLPLGPVQTPQVLPPMRDVPGSDSIYKDKAYVSWGTSIASPPTYSNLEDLGSQDYQASSQLGSFQLSQAPHLPLFPSLQSQFPYLPPFPYPIPSSMPFLPPEDSLFSFPFGFSGDSSQDYCPGPPPGQILLQPPAENMGTGPWSGHCLPEPPFPRPHYPQALGQPLGAEGYFPNLLPTPYALTMSKQSSLGLNGLLEGTRVETGSSLSKMSDEQTSSSLEQPALEEVRDKNKNSHAAGAKE"

     misc_feature    29..406
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VIH1.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    308..667
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]; Region: COG5576"
                     /db_xref="CDD:227863"
     misc_feature    437..607
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    608..763
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VIH1.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    <644..1390
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    839..946
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VIH1.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1490..1609
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VIH1.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            66..356
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /inference="alignment:Splign:2.1.0"
     exon            357..464
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /inference="alignment:Splign:2.1.0"
     exon            465..571
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /inference="alignment:Splign:2.1.0"
     exon            572..678
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /inference="alignment:Splign:2.1.0"
     exon            679..764
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /inference="alignment:Splign:2.1.0"
     exon            765..996
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1301
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1893
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1853..1858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /note="hexamer: AATAAA"
     polyA_site      1893
                     /gene="Nobox"
                     /gene_synonym="OG2; Og2x"
                     /note="major polyA site"
ORIGIN      

ggcgagctcaggagagggagcctgggccatggaacctacggagaagctctgcaagaaaatgcagggccaggaagctggtgacaagcccaggactgctgcactggagacagagggaccactgcaggattctgccctgcccatccaggatgatcaagacaagcagtcctcactccccagggctagcttggggaagaggccactgtcgaagacctctgaggagttaatggatgctggcacgtgcagagtgcacaaagcccccacagcagccgcatgtggtccccaatccgaggaagaaggttgttctcccccagagagaaaggcagaatcgctgaagccatccatttctgcagtccctggccaagccaccgccggttccctcaactctcatgaaggggacctgaagaaagaatccctagaagtgacctgtcaatttcggaaaaagacccgaaccctgtaccgctcagaccagctggaagaactggagaggatatttcaggaagaccactatcctgacagtgacaaacgccatgagatttcccagatggtgggggtaaccccccaaagaatcatggtgtggtttcagaaccgcagggcaaagtggagaaaagtggagaaactgaacgagaaggaaactaagaatggtcctgcagcccccagtgctgacagcagccagcacagatctgctcctgagctcctagaccctatgcctacagacctagaacctggccctgttcctccagagaacatcctggatgtctttcctgagccccccatgctgctgacttctgaacagactctgaccccctttcagaataatgagggtgctgagagggtggcagtgactccaccactcctcagtcccccacctattcgaagggccaaccttcctcttcctctgggtcctgttcaaactcctcaagtactgcctccaatgagggacgttcctggcagtgacagcatatacaaggacaaggcctatgtgtcctggggcactagtatcgcctcaccacccacctactcaaatttggaagacctggggtctcaggactaccaagcaagcagccagttgggttcattccagctctcccaggctccacatttaccccttttcccatcccttcagtcacagtttccgtatctgccccccttcccttaccccatcccaagctcaatgccatttctaccaccagaagactctctgttttcatttccttttggcttcagtggagactcatcacaggattattgcccaggacccccaccaggtcagatcttgctgcagccacctgctgaaaacatgggtacaggaccctggagtggccattgcttgccagaacctcccttccctcgtccacactacccacaggctctgggacaacccctaggggcagagggttactttcctaacctattgccaactccatatgctctgactatgagtaagcagtcttcattaggcctcaatgggcttctcgaaggcactagagtagagaccgggtcctcactaagcaaaatgtcagatgagcagacttcctcttccctcgagcagcccgcactagaggaggtcagagacaaaaataagaatagccatgccgctggagctaaagagtaaagagaaggaagtccttatgggaggcctgggaagggggaagaataaccctgaagaatgtgagaggctatggactggcctgctatgttggtccaaggtctttccagcctgggcttagagaaggaagagagctgccatctcatttccccctttaccctttaggaattcaaaagaatagaagggtcatgttaactctaaacgttaaatgtggtattactgccatcctaggcagtgcatgcaataaataaaacagtaactactgggtgtttggttttgtgaatgaa

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