LOCUS       NM_026435               4887 bp    mRNA    linear   ROD 27-NOV-2023
DEFINITION  Mus musculus ubiquitin-fold modifier 1 (Ufm1), mRNA.
ACCESSION   NM_026435 XM_003084556 XM_003086295
VERSION     NM_026435.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4887)
  AUTHORS   Jiajia H, Ziyao Y, Jiaqi Z, Yanli C, Xiaotao Z and Ming S.
  TITLE     Screening UFMylation-associated genes in heart tissues of
            Ufm1-transgenic mice
  JOURNAL   BMC Cardiovasc Disord 23 (1), 567 (2023)
   PUBMED   37980507
  REMARK    GeneRIF: Screening UFMylation-associated genes in heart tissues of
            Ufm1-transgenic mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4887)
  AUTHORS   Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y,
            Shindo M, Hatta T, Abe M, Uemura T, Lee-Okada HC, Mohamed TM,
            Yokomizo T, Ueno T, Sakimura K, Natsume T, Sorimachi H, Inada T,
            Waguri S, Noda NN and Komatsu M.
  TITLE     The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3
  JOURNAL   Nat Commun 13 (1), 7857 (2022)
   PUBMED   36543799
  REMARK    GeneRIF: The UFM1 system regulates ER-phagy through the ufmylation
            of CYB5R3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4887)
  AUTHORS   Zhang J, Zhu H, Liu S, Quintero M, Zhu T, Xu R, Cai Y, Han Y and Li
            H.
  TITLE     Deficiency of Murine UFM1-Specific E3 Ligase Causes Microcephaly
            and Inflammation
  JOURNAL   Mol Neurobiol 59 (10), 6363-6372 (2022)
   PUBMED   35931931
  REMARK    GeneRIF: Deficiency of Murine UFM1-Specific E3 Ligase Causes
            Microcephaly and Inflammation.
REFERENCE   4  (bases 1 to 4887)
  AUTHORS   Balce DR, Wang YT, McAllaster MR, Dunlap BF, Orvedahl A, Hykes BL
            Jr, Droit L, Handley SA, Wilen CB, Doench JG, Orchard RC, Stallings
            CL and Virgin HW.
  TITLE     UFMylation inhibits the proinflammatory capacity of
            interferon-gamma-activated macrophages
  JOURNAL   Proc Natl Acad Sci U S A 118 (1) (2021)
   PUBMED   33372156
  REMARK    GeneRIF: UFMylation inhibits the proinflammatory capacity of
            interferon-gamma-activated macrophages.
REFERENCE   5  (bases 1 to 4887)
  AUTHORS   Hu X, Zhang H, Song Y, Zhuang L, Yang Q, Pan M and Chen F.
  TITLE     Ubiquitin fold modifier 1 activates NF-kappaB pathway by
            down-regulating LZAP expression in the macrophage of diabetic mouse
            model
  JOURNAL   Biosci Rep 40 (1) (2020)
   PUBMED   31829413
  REMARK    GeneRIF: Ubiquitin fold modifier 1 activates NF-kappaB pathway by
            down-regulating LZAP expression in the macrophage of diabetic mouse
            model.
REFERENCE   6  (bases 1 to 4887)
  AUTHORS   Ha BH, Ahn HC, Kang SH, Tanaka K, Chung CH and Kim EE.
  TITLE     Structural basis for Ufm1 processing by UfSP1
  JOURNAL   J Biol Chem 283 (21), 14893-14900 (2008)
   PUBMED   18321862
  REMARK    GeneRIF: loop between beta3 and alpha2 in addition to the
            C-terminal region of Ufm1 plays a role in binding to UfSP1
REFERENCE   7  (bases 1 to 4887)
  AUTHORS   Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M,
            Hoodless PA, Jones SJ, Marra MA and Helgason CD.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 4887)
  AUTHORS   Azfer A, Niu J, Rogers LM, Adamski FM and Kolattukudy PE.
  TITLE     Activation of endoplasmic reticulum stress response during the
            development of ischemic heart disease
  JOURNAL   Am J Physiol Heart Circ Physiol 291 (3), H1411-H1420 (2006)
   PUBMED   16617122
  REMARK    GeneRIF: A novel ubiquitin fold modifier (Ufm1) not been previously
            associated with ER stress and not found to be induced under any
            condition was found to be upregulated in the hearts of MCP mice
            (transgenic mice that express MCP-1 specifically in the heart).
REFERENCE   9  (bases 1 to 4887)
  AUTHORS   Kiyozumi D, Sugimoto N and Sekiguchi K.
  TITLE     Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1,
            and Frem2 at the basement membrane provokes Fraser syndrome-like
            defects
  JOURNAL   Proc Natl Acad Sci U S A 103 (32), 11981-11986 (2006)
   PUBMED   16880404
REFERENCE   10 (bases 1 to 4887)
  AUTHORS   Nishimura M, Yokoi N, Miki T, Horikawa Y, Yoshioka H, Takeda J,
            Ohara O and Seino S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ075089.1, AK167301.1, AC147262.4 and BP754244.1.
            
            On or before Dec 2, 2010 this sequence version replaced
            XM_003084556.1, XM_003086295.1, NM_026435.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148146.1, AK167301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                CJ075089.1         27-58
            33-3029             AK167301.1         2-2998
            3030-4855           AC147262.4         122912-124737       c
            4856-4887           BP754244.1         1-32                c
FEATURES             Location/Qualifiers
     source          1..4887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 25.43 cM"
     gene            1..4887
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /note="ubiquitin-fold modifier 1"
                     /db_xref="GeneID:67890"
                     /db_xref="MGI:MGI:1915140"
     exon            1..59
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..315
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /codon_start=1
                     /product="ubiquitin-fold modifier 1"
                     /protein_id="NP_080711.1"
                     /db_xref="CCDS:CCDS38430.1"
                     /db_xref="GeneID:67890"
                     /db_xref="MGI:MGI:1915140"
                     /translation="

MSKVSFKITLTSDPRLPYKVLSVPESTPFTAVLKFAAEEFKVPAATSAIITNDGIGINPAQTAGNVFLKHGSELRIIPRDRVGSC"

     mat_peptide     58..306
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /product="Ubiquitin-fold modifier 1. /id=PRO_0000042126"
                     /note="propagated from UniProtKB/Swiss-Prot (P61961.1)"
     misc_feature    67..291
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /note="ubiquitin-like (Ubl) domain found in ubiquitin fold
                     modifier 1 (UFM1); Region: Ubl_UFM1; cd01766"
                     /db_xref="CDD:340465"
     misc_feature    order(112..129,139..141,148..153,160..162)
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:340465"
     exon            60..116
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /inference="alignment:Splign:2.1.0"
     exon            117..174
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /inference="alignment:Splign:2.1.0"
     exon            175..214
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /inference="alignment:Splign:2.1.0"
     exon            215..247
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /inference="alignment:Splign:2.1.0"
     exon            248..4867
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggccatcaaggaagcgcggcgggcggctgggcgcggtgtgtgtcaggcggttccaccatgtcgaaggtgtcctttaaaatcacgttgacgtcggacccgcggctgccgtacaaagttctcagtgttcctgaaagtacgccgttcacagcagtgctaaagtttgcagcagaagaatttaaagttcctgcagctacaagtgcgattattactaatgatggaataggaataaatcctgcacagactgctgggaatgttttcctgaagcacggctcagaactgagaatcattcctagagaccgagttggaagctgctaatatatgcttgttggaacacacagcctttcagaataaatactggtatttgttgttgctgtacaattgaaatcaggcattcaccatacaatgaaagcaccaagaatcaacagaacagggaaagcggccgcttgtcccttcctgttcatttttttcatggaaagagagaatgcctttgagtggagggtacgacaccacaggtcacactgtggtgactgctgcctcaccgggagaagagagtacctctgagacaaatggactgtgctttaaaacaaaaacagcaaaatgggaggatgagtgctaactcttttcaggagcatttggaaattcaaattcacagaattggatgtagtttttaattttgaaatttaaaaggataattgatcatagaggtatttgacttgacagcatctcctagttagatttttaaattatataatttgtgatgaacttaataggtatttgaatgaacagttaaatttatacaaagccaaacattaaattataggatctaaccattatgagtataagttgctattgtacgtcaaatagtttcgatagtagagatcttgtgaatccagtatgtcatggtgggaactgacagtaccacagaagcacccttaggtatattatgaattccttgataaataataaagcattaggacagaaatccttaaaccagtctttttgaggattctatttttgagcagcatccaaaattattgttgcagagatgatctgaagcattggtgggtgtccttaatgaagagggaactttaaagaagctgttaatatagtcacagtggataaggaaccagggatgcaaagatagccaggcccttcccagaagagcagaggaagtgaggaggaacaggaggctggcagtgtccaaaggcagaggtcagagaacgaagccgcagcaggggtgggaaagtgtgaaagggaggagagtactgggcacagggtcagaaagcaatgcacaggcatcaaaactcaccgtagcaatctacaaggatttacataagatttcagggctggcaccctgtgcccggtactcttcttcttcagaatgaaggagattaccaactccccagagtcatcctctaaccttactcagacacccagatgtgagccagtcccctcccaccatgactatttgcctttacacagaaagtccatgtctggcacatgtttcaggatgaattaaatgctgacagtgactgagtgagagccaggcagctctgctttagtgggttagctctttggaggtaaggggtctgtcacatgctccttagagttagagatacgagttctcaataaatatttactgaattcataaataatgtcttcaggaacagtttttatcttgtgtctcatagtccctattacagggccttacttgatttggagatggggcacttgtaagagaattagggattggcatctgaagggctgtcttaatagatgaaggaattgtcattgtccacaggtttgtggagcacattctggggttcagaattatgtagcaatacacacctcatgtttgctgggtttttatgtttctgtctagtgcccagagaccttattccatatactattaggcttctgttagccagacatttgaaaatatttgctacctaattttgcttactattaaatttcttccattctgcctttgcacaaaattctcttgtcagtaatgtttatacagttctacaatatgaaatgatttacctaatcatttgaaaatacatagtcttcaaaatactttactcaaaaactagataacttgttagtaaataaatatgatctataagttctttgtggagaacgttttaggcatggtatttaatttaaatgtctataattaataccttaggaaaatacattttgttacactgtaaatcatggctacctttattttacaataagacatactagccagcatacctattgagccagattattaatactatttttgtaaatgcagagataaaaggtaagtcatgaaaaataaatgtatatttctaaatgtcaatcctttatacagaagaggagaacctttggtggtctcagccctgggtggtgtccagaatgaagttgggaaattagaactactgacttccgaagtcattcctcgggttctcgctcctgcatgaggacctctgtaagcaggtctgggggctgcatgtgctgcttgggtgttagcaccatgacaacctttccacccttgagagcaggattacaggtgaaggtcaaagtaccctggaatcttgggcgttcctttatgctgcttgattctggagtcatctgatggagcacagagataaaagatactgacatttggtcacttctatctttacaacccaagtcagtgggttttggatgctttaattcttaggtttggatgctatttgaagaagatgtatataaataagtccaaagcggttggtgcagccaataaaggtgttcccttacaaaaacctgagttccgtccctgggacctgcatggtggaaggagagaagtgacctccacattcacactgtgacatacacatttatacacacacacaaatgtaagaacatttgagctactatatgtcttagccctggagacatttgggcaaacatttgtagattggaagcatcaatatactgtaaaggagcaatcctaggtccttactgtacccaaggctatttataaagctcggtaaaattctgtgtgtagttgtcattacaatctgttgaacgagggctgtgcagatggctcagtggttaagagtgcctcctgatcttgcagaagaccaaggttttgtccccaaaacccacatagtggctcacaaccatctgtaactgcagttccatgggacccattacccttctggcctctgtaaatgctgcactcatgttcacacacttgcagacaacatgtacacacatgtaaattttggaaaaaaaaaaggtaaatgtctgctgaacttcaagtgtgaagaatagtataacttggtgaatgggtgctaagtggttttcactcactggaaggattagtaagaatgtgccttggcttttgagccaggctttgccttcgaggctccatataatctggagaaatctttgtgtccactttctgcaaagtactaatttgtattgaattatacatttaaaaggtgaaacaagttcctcagcatgctggaaatgtatagtaataaatgacacccctttgaatacatcgtgtagtacggatggaaggtatagagtccagaggcttagggcacacatatataatcccggcagtagggctgcaagatcaaggggagcctgggctgtgcagcaagactgcctctaaacacaaagtacaagaacagtgacagtacctgtctggagttttactacacaggctccgctcactcagaatctaccatgtgtacaagaggccttcctggactggtgtttgtgcatgggcagccatgactgctatggtcatggtttaattctgcagctgtacctagcatcagaggccatttagccctctggtgtggcatacttagtcttacacgttcctaccttcacttccccatctgtgagtccgggaaccccatgtcctgagaatgggaaacctctgcttccaagccaaattaggacttcttagtcacctctctttttgcagagcagttattaaacacaggattatttgtctcaaactatgagttttataagtccaatattatggtttgataaagaatggcccccataggctcagagagtcaaatgcttagtcaccaggtactgtttaaggacaaggaggtgtgaccctgtggtcattagggttgtgctgtgcggtcaggcctagtctctctcatctctctctccactttctcatgctctcaccctttcactctcctgcctgtggatcaggatgtagctctcagctactcaacagtaccatgcctgcctgcttaccaccatgtttcccaccatgatgatggatcaaacctttaaaactgtaagcaacccctaattaaatgctttctcctttaagagttggtttagtcatggtgtcagttcacagcaatagaacagtgactgagataaatatggccaaaacttggtttcaaaatttaactgctgataacaactactttgtaaagcaaagaaacagatgaaaactttgaaaattgcaactatttgtgcttcatcatcagtatttgatttgggtatccatagttcccacacttaccagctacttgccttgaaaatgttattgtctgcattctccatttcagtgacaatattcatttatgtaacagtcatttgaaaaggtttgtggccccgttgtctgatttttttgcagagagttacgattttgttgttgaatacaaaataacagacaaggttgacagacaaatggagagccagtttggggcataaatctctggttctctggcaaaactcatttgaaatgtaaaagctgttactgagagcatatcgtgatgatacatcatgtcaatatttgtttggctgcctagcaggtttaataaatcaattcttaaacataaaaaaaaaaaaaaaaaaaaa

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