2024-05-03 09:40:36, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_026270 1610 bp mRNA linear ROD 11-NOV-2023 DEFINITION Mus musculus AKT1 substrate 1 (Akt1s1), transcript variant 2, mRNA. ACCESSION NM_026270 VERSION NM_026270.4 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 1610) AUTHORS Cai S, Yang Q, Cao Y, Li Y, Liu J, Wang J, Zhang X, Liu L, Li X and Zhang Y. TITLE PF4 antagonizes retinal neovascularization via inhibiting PRAS40 phosphorylation in a mouse model of oxygen-induced retinopathy JOURNAL Biochim Biophys Acta Mol Basis Dis 1866 (3), 165604 (2020) PUBMED 31740404 REMARK GeneRIF: This study, for the first time, links PF4's anti-RNV function to an intracellular signaling molecule PRAS40 and its phosphorylation. REFERENCE 2 (bases 1 to 1610) AUTHORS Figlia G, Norrmen C, Pereira JA, Gerber D and Suter U. TITLE Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system JOURNAL Elife 6, e29241 (2017) PUBMED 28880149 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 1610) AUTHORS Yang W, Yang LF, Song ZQ, Shah SZA, Cui YY, Li CS, Zhao HF, Gao HL, Zhou XM and Zhao DM. TITLE PRAS40 alleviates neurotoxic prion peptide-induced apoptosis via mTOR-AKT signaling JOURNAL CNS Neurosci Ther 23 (5), 416-427 (2017) PUBMED 28294542 REMARK GeneRIF: PRAS40 inhibits mTORC1 hyperactivation and plays a key role in protecting cells against neurotoxic prion peptide-induced apoptosis. Thus, PRAS40 is a potential therapeutic target for prion disease. REFERENCE 4 (bases 1 to 1610) AUTHORS Cordon-Barris L, Pascual-Guiral S, Yang S, Gimenez-Llort L, Lope-Piedrafita S, Niemeyer C, Claro E, Lizcano JM and Bayascas JR. TITLE Mutation of the 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Substrate-Docking Site in the Developing Brain Causes Microcephaly with Abnormal Brain Morphogenesis Independently of Akt, Leading to Impaired Cognition and Disruptive Behaviors JOURNAL Mol Cell Biol 36 (23), 2967-2982 (2016) PUBMED 27644329 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 1610) AUTHORS Rho O, Srivastava J, Cho J and DiGiovanni J. TITLE Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development JOURNAL J Invest Dermatol 136 (10), 2070-2079 (2016) PUBMED 27349859 REMARK GeneRIF: Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development REFERENCE 6 (bases 1 to 1610) AUTHORS Saito A, Hayashi T, Okuno S, Nishi T and Chan PH. TITLE Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia JOURNAL Stroke 37 (2), 513-517 (2006) PUBMED 16397181 REMARK GeneRIF: overexpression of SOD1 may affect the PRAS pathway after transient focal cerebral ischemia by reducing the direct oxidative reaction to pPRAS after reperfusion injury REFERENCE 7 (bases 1 to 1610) AUTHORS Ballif BA, Villen J, Beausoleil SA, Schwartz D and Gygi SP. TITLE Phosphoproteomic analysis of the developing mouse brain JOURNAL Mol Cell Proteomics 3 (11), 1093-1101 (2004) PUBMED 15345747 REFERENCE 8 (bases 1 to 1610) AUTHORS Saito A, Narasimhan P, Hayashi T, Okuno S, Ferrand-Drake M and Chan PH. TITLE Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor JOURNAL J Neurosci 24 (7), 1584-1593 (2004) PUBMED 14973226 REMARK GeneRIF: PRAS phosphorylation and its interaction with pAkt and 14-3-3 might play an important role in neuroprotection mediated by NGF in apoptotic neuronal cell death after transient focal cerebral ischemia REFERENCE 9 (bases 1 to 1610) AUTHORS Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ and Roth RA. TITLE Identification of a proline-rich Akt substrate as a 14-3-3 binding partner JOURNAL J Biol Chem 278 (12), 10189-10194 (2003) PUBMED 12524439 REMARK GeneRIF: The protein product encoded by 1110012J22 gene is proline-rich substrate of Akt which also binds to 14-3-3. A proposed name for this protein is thus PRAS40, for proline-rich substrate of Akt of 40 kDa. REFERENCE 10 (bases 1 to 1610) AUTHORS Chern JJ and Choi KW. TITLE Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc JOURNAL Development 129 (17), 4005-4013 (2002) PUBMED 12163404 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY103589.1, AK141771.1 and BE847693.1. On Dec 10, 2011 this sequence version replaced NM_026270.3. Transcript Variant: This variant (2) contains an alternate first exon compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1 and 2 both encode the same isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK141771.1, AK003638.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-5 BY103589.1 1-5 6-1584 AK141771.1 2-1580 1585-1610 BE847693.1 4-29 c FEATURES Location/Qualifiers source 1..1610 /organism="Mus musculus" /mol_type="mRNA" /db_xref="taxon:10090" /chromosome="7" /map="7" gene 1..1610 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="AKT1 substrate 1" /db_xref="GeneID:67605" /db_xref="MGI:MGI:1914855" exon 1..125 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /inference="alignment:Splign:2.1.0" exon 126..514 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /inference="alignment:Splign:2.1.0" CDS 133..906 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="isoform b is encoded by transcript variant 2; proline-rich AKT1 substrate 1; proline-rich AKT substrate; AKT1 substrate 1 (proline-rich)" /codon_start=1 /product="proline-rich AKT1 substrate 1 isoform b" /protein_id="NP_080546.1" /db_xref="CCDS:CCDS21218.1" /db_xref="GeneID:67605" /db_xref="MGI:MGI:1914855" /translation="
MASGRPEELWEAVVGAAERFQARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIAQAHRAATATRPPGPPPAPQPPSPAPSPPPRPALAREDEEEDEDEPTETETSGERLGGSDNGGLFMMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPTACPQPPATALPTQQYAKSLPVSVPVWAFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPRLNTSDFQKLKRKY"
misc_feature 283..285 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="Omega-N-methylarginine. /evidence=ECO:0007744|PubMed:24129315; propagated from UniProtKB/Swiss-Prot (Q9D1F4.1); methylation site" misc_feature 322..675 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="propagated from UniProtKB/Swiss-Prot (Q9D1F4.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 394..396 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9D1F4.1); phosphorylation site" misc_feature 406..408 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9D1F4.1); phosphorylation site" misc_feature 481..483 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9D1F4.1); phosphorylation site" misc_feature 514..888 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="Proline-rich AKT1 substrate 1; Region: PRAS; pfam15798" /db_xref="CDD:406279" misc_feature 520..534 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="propagated from UniProtKB/Swiss-Prot (Q9D1F4.1); Region: TOS motif. /evidence=ECO:0000250|UniProtKB:Q96B36" misc_feature 682..684 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9D1F4.1); phosphorylation site" misc_feature 721..783 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="propagated from UniProtKB/Swiss-Prot (Q9D1F4.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 739..741 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9D1F4.1); phosphorylation site" misc_feature 742..744 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9D1F4.1); phosphorylation site" misc_feature 766..768 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9D1F4.1); phosphorylation site" misc_feature 769..771 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9D1F4.1); phosphorylation site" misc_feature 796..798 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q96B36; propagated from UniProtKB/Swiss-Prot (Q9D1F4.1); phosphorylation site" misc_feature 871..873 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /note="Phosphothreonine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9D1F4.1); phosphorylation site" exon 515..592 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /inference="alignment:Splign:2.1.0" exon 593..762 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /inference="alignment:Splign:2.1.0" exon 763..1592 /gene="Akt1s1" /gene_synonym="1110012J22Rik; Lobe; Lobel; PRAS40" /inference="alignment:Splign:2.1.0" ORIGIN
tgtgccgtttttctcgaggacaaaccagagcggcttggtggaagccatgttaatgcggggcactaccatctctttgcggggcacgacggcggggtgctggaaaagcgaaacggagagaggaaaagggctcggatggcgtctgggcggccagaggaactgtgggaagccgtcgtgggggccgccgagcgctttcaggcccgcactggcacagagctggtattactgactgcagcgccaccgccgccgccccgccctggaccctgtgcctatgccgcccatggccgcggagccctggcagaggcggcccgacgctgcctccacgacatcgcacaggcgcacagggctgccactgccacccgacctcctggtcccccaccagcaccacagccgcccagccctgctcctagtccaccacctcggccagccctggccagggaggatgaggaggaagatgaggacgagcccactgaaacagagacatctggggagcggctgggcggtagcgataatggaggtctcttcatgatggatgaggatgccaccctccaggacctgccccccttctgcgagtcagacccggagagcacagacgacggcagcctgagcgaggagacgcccgccggtcccacagcctgtccccagcccccggccacagccctgcctacccagcagtatgccaagtctctgcccgtgtcggtgccagtgtgggccttcaaggagaagaggacagaagcccgatcgtcagatgaggagaatggcccgccctcctcgcccgacctagaccgaatagcggccagcatgcgcgcgctggtgctgcgggaggctgaggacacccaggtcttcggggatcttccgcggccgcggctcaataccagcgacttccagaagctgaagcggaaatattaagcgaacagaaagccttggcctgcgagaggccactgcctctcggcccagcaagagaacaattctttccgggattggctggctcaggttgggcggggccggttctaaacgctccaagggtcaactctgtttcttgcctagcaaacgaagctttgcccgcacagccttgactcgcggccccagggcggagcccagctgcgggagctgccgctgctcagccagtgtcgggaagagttgcccgccagccttccagagttcccctacccgattggtcccggcctcctgggagtgtggccaagccctccctaacccagaattggcccgaggcctttaatttcttacactactagggctgttaatcaattgtttttgtttttgttgttttctttgcctgagtcctgacaattgtatcccggttccccaggggacagtctgggtccctctctggtctgacgctccctataggttccaccgcacgacagcctgtccatcaaaacttgtcctgtacccaggacagtaccagcttcctgtcccccgaccctaacaggtgccttaaaaggccctctcccacccaaggtgggggggccaggggggcctcactttccggccctagacttgggtgcgggagagtgggatgggggtagggaggggcgctctgagattaaagttttacctctgactagtgagttaaaaaaaaaaaaaaaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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