LOCUS       NM_022023               4171 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus glia maturation factor, beta (Gmfb), mRNA.
ACCESSION   NM_022023
VERSION     NM_022023.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4171)
  AUTHORS   Bellver-Sanchis,A., Geng,Q., Navarro,G., Avila-Lopez,P.A.,
            Companys-Alemany,J., Marsal-Garcia,L., Larramona-Arcas,R., Miro,L.,
            Perez-Bosque,A., Ortuno-Sahagun,D., Banerjee,D.R., Choudhary,B.S.,
            Soriano,F.X., Poulard,C., Pallas,M., Du,H.N. and Grinan-Ferre,C.
  TITLE     G9a Inhibition Promotes Neuroprotection through GMFB Regulation in
            Alzheimer's Disease
  JOURNAL   Aging Dis 15 (1), 311-337 (2024)
   PUBMED   37307824
  REMARK    GeneRIF: G9a Inhibition Promotes Neuroprotection through GMFB
            Regulation in Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4171)
  AUTHORS   Yin,G., Zeng,W., Li,R., Zeng,M., Chen,R., Liu,Y., Jiang,R. and
            Wang,Y.
  TITLE     Glia Maturation Factor-beta Supports Liver Regeneration by
            Remodeling Actin Network to Enhance STAT3 Proliferative Signals
  JOURNAL   Cell Mol Gastroenterol Hepatol 14 (5), 1123-1145 (2022)
   PUBMED   35953024
  REMARK    GeneRIF: Glia Maturation Factor-beta Supports Liver Regeneration by
            Remodeling Actin Network to Enhance STAT3 Proliferative Signals.
REFERENCE   3  (bases 1 to 4171)
  AUTHORS   Tan,L., Yu,M., Li,Y., Xue,S., Chen,J., Zhai,Y., Fang,X., Liu,J.,
            Liu,J., Wu,X., Xu,H. and Shen,Q.
  TITLE     Overexpression of Long Non-coding RNA 4933425B07Rik Causes Urinary
            Malformations in Mice
  JOURNAL   Front Cell Dev Biol 9, 594640 (2021)
   PUBMED   33681192
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4171)
  AUTHORS   Ahmed,M.E., Selvakumar,G.P., Kempuraj,D., Raikwar,S.P.,
            Thangavel,R., Bazley,K., Wu,K., Khan,O., Khan,A., Zaheer,S.,
            Iyer,S., Burton,C., James,D. and Zaheer,A.
  TITLE     Glia Maturation Factor (GMF) Regulates Microglial Expression
            Phenotypes and the Associated Neurological Deficits in a Mouse
            Model of Traumatic Brain Injury
  JOURNAL   Mol Neurobiol 57 (11), 4438-4450 (2020)
   PUBMED   32737763
  REMARK    GeneRIF: Glia Maturation Factor (GMF) Regulates Microglial
            Expression Phenotypes and the Associated Neurological Deficits in a
            Mouse Model of Traumatic Brain Injury.
REFERENCE   5  (bases 1 to 4171)
  AUTHORS   Ahmed,M.E., Selvakumar,G.P., Kempuraj,D., Raikwar,S.P.,
            Thangavel,R., Bazley,K., Wu,K., Khan,O., Kukulka,K., Bussinger,B.,
            Dubova,I., Zaheer,S., Govindarajan,R., Iyer,S., Burton,C., James,D.
            and Zaheer,A.
  TITLE     Neuroinflammation Mediated by Glia Maturation Factor Exacerbates
            Neuronal Injury in an in vitro Model of Traumatic Brain Injury
  JOURNAL   J Neurotrauma 37 (14), 1645-1655 (2020)
   PUBMED   32200671
  REMARK    GeneRIF: Neuroinflammation Mediated by Glia Maturation Factor
            Exacerbates Neuronal Injury in an in vitro Model of Traumatic Brain
            Injury.
REFERENCE   6  (bases 1 to 4171)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 4171)
  AUTHORS   Zaheer,A., Yang,B., Cao,X. and Lim,R.
  TITLE     Decreased copper-zinc superoxide dismutase activity and increased
            resistance to oxidative stress in glia maturation factor-null
            astrocytes
  JOURNAL   Neurochem Res 29 (8), 1473-1480 (2004)
   PUBMED   15260123
REFERENCE   8  (bases 1 to 4171)
  AUTHORS   Kaimori,J.Y., Takenaka,M., Nakajima,H., Hamano,T., Horio,M.,
            Sugaya,T., Ito,T., Hori,M., Okubo,K. and Imai,E.
  TITLE     Induction of glia maturation factor-beta in proximal tubular cells
            leads to vulnerability to oxidative injury through the p38 pathway
            and changes in antioxidant enzyme activities
  JOURNAL   J Biol Chem 278 (35), 33519-33527 (2003)
   PUBMED   12791701
  REMARK    GeneRIF: proteinuria induction of GMF-beta in renal proximal
            tubular cells may play a critical role in the progression of renal
            diseases by enhancing oxidative injuries
REFERENCE   9  (bases 1 to 4171)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4171)
  AUTHORS   Bourgeois,F., Guimiot,F., Mas,C., Bulfone,A., Levacher,B.,
            Moalic,J.M. and Simonneau,M.
  TITLE     Identification and isolation of a full-length clone of mouse GMFB
            (Gmfb), a putative intracellular kinase regulator, differentially
            expressed in telencephalon
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 304-309 (2001)
   PUBMED   11435704
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093043.6.
            
            On May 17, 2008 this sequence version replaced NM_022023.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF297220.1, SRR1660811.162469.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC093043.6         9778-9919
            143-239             AC093043.6         14538-14634
            240-289             AC093043.6         15793-15842
            290-339             AC093043.6         16372-16421
            340-422             AC093043.6         17033-17115
            423-496             AC093043.6         17703-17776
            497-4171            AC093043.6         20197-23871
FEATURES             Location/Qualifiers
     source          1..4171
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 24.32 cM"
     gene            1..4171
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /note="glia maturation factor, beta"
                     /db_xref="GeneID:63985"
                     /db_xref="MGI:MGI:1927133"
     exon            1..142
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..568
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /note="GMF-beta"
                     /codon_start=1
                     /product="glia maturation factor beta"
                     /protein_id="NP_071306.2"
                     /db_xref="CCDS:CCDS36898.1"
                     /db_xref="GeneID:63985"
                     /db_xref="MGI:MGI:1927133"
                     /translation="

MSESLVVCDVAEDLVEKLRKFRFRKETHNAAIIMKIDKDERLVVLDEELEGVSPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEWLREKLGFFH"

     misc_feature    143..145
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P60984; propagated from
                     UniProtKB/Swiss-Prot (Q9CQI3.3); acetylation site"
     misc_feature    164..529
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /note="ADF-homology domain of glia maturation factor beta
                     and related proteins; Region: ADF_GMF-beta_like; cd11283"
                     /db_xref="CDD:200439"
     exon            143..239
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /inference="alignment:Splign:2.1.0"
     exon            240..289
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /inference="alignment:Splign:2.1.0"
     exon            290..339
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /inference="alignment:Splign:2.1.0"
     exon            340..422
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /inference="alignment:Splign:2.1.0"
     exon            423..496
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /inference="alignment:Splign:2.1.0"
     exon            497..4171
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      627..632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /note="hexamer: CATAAA"
     polyA_site      652
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
     regulatory      4149..4154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /note="hexamer: AATAAA"
     polyA_site      4171
                     /gene="Gmfb"
                     /gene_synonym="3110001H22Rik; 3110001O16Rik; D14Ertd630e"
                     /note="major polyA site"
ORIGIN      

gggccacggcggccgcgtccttaggtgggggaggctgagcggtgcgccagccgaaacaggaagggagttggctgccgagccattcttaaaggggcccaagagatcgcacggcaacgggccgctgacgaccggaaggaaaatgagtgagtctttggtggtttgtgatgttgctgaagatttagtggaaaagctgagaaagtttcgttttcgaaaagaaacccacaatgctgctattataatgaagattgacaaggatgaacgcctggtggtgctggatgaggagctcgagggtgtctctccagatgaacttaaagacgaactacccgagcggcagcctcgcttcattgtgtatagttataaataccaacatgatgatggcagagtctcgtacccgctctgctttattttctccagtcctgtcgggtgtaagcctgagcagcagatgatgtacgctgggagtaagaacaagctagtccagactgccgagctaaccaaggtatttgaaataagaaacactgaagatctaactgaagaatggttacgtgagaaacttggatttttccactaatgtgaacttctgtgtttctaaagtatttatgtattaacctgaccatactggaaccagacataaatagttatttatgcctaaaaatgcactgttacttacagtttgtttcctgcagtaaagaaaaattcttcatttgtgcagtttgaacaaaggggaaatcatcttcatagtaatgagacgttgtgaagtgttcctgcatctgtcattgttagggggactacttttctccagggatgctttgcacccttttgactaatttctataatttatgattcagaatttgtaactgtttgcagacactataggaaggtgggtattagactgtgatagacaacagttcctcctctgaccactcctgggtactggcagtttataagtgcaagtagcattttatcacctgtcacatcattgcggttcatttgggactgaagcgtaagtgaccgattctgagccttgagtagagatgtagtgggacctctgttgaactctccgccagttttcctcctctcttgggttcctgtatctttgcaatcaagtgtagaatcttcatcaatcactcctccttaaggtccggaagttgatttttatggtagagttaggattgttaggttttcttcttatggagaatagcatctgaatcttagaaactgggagctctataatcaagggcttcgttcttggttatgtcactggcagggagcttagactgtagcttggtaacactgcaaagcacctcctaatatgttaatactgtgcctttgattggtcagctttaccattagcttaagactgctacactgccagtgttctagatttggtgaaattaatacttttttaaagggttcaaataaaacaattttctaatatatataattaaaatttgtaataaaccaacttgttacttttaaaattccaactatctgcccaaagttatgatagtaggtgagagttataatttggggtatatttgctattagttttgtgccatatgtaagcattatttaaacattggccacaattaataacaacacatcaatagatgtcataccttttatcctaaatgtcagaagaaattctaatatgaactaagccagtcacagtttgatgacaccatcatcaggaagcaagatttctaatctacttggaattcttaagtttcacttaagaaaacaatgtaagaaatgctgaatagtaatttgacttaaagagacaagttaagagactgtagagacgaccaaattcttatattaagaaggtagtgattttgattgggcattggtggcacataacatttaatcctggcatttgggaggcagagacaggcagatctctgagttcaagaccagcctggtctgcagaagcaagttccagggtaaccaaggctaaacagatgaacaccctgctcccctaaaaagaaaaaaatagcaaaacatctttatgttggcatgtgttcattgcatagtatttgtctcatttagggctttgtgccggttttactggagggaagatagctggaactgtcacagtagagtggagtgtgttgtattcccaactgtgtgctcactagcctgtatgtcaggaagcaattgcaagtgctagaggaggtgatcatattggttcatgaatggaaaagtccctttatttcagtgtccagagagcaagaaaacttcatctaagaagtttaggacttcattatacaggtattttggtatgagctagagaataacttgcttataatcccacaggaatgcagatgagacccaagtaaagggggactttgatgtctctgactgatgcacataagggttcgtttcacctggttatagaagcacgctttcagaagcagtgctacaagtctacgttttaaattcagttctttattttggcttgcatatttaaatcagtttttgaaatttccaagtctttcatagagtgaatggccctgacctgccacacacaggactcttagtctctagttcaagcagcaacaccagtggtgagcagctttccttttcaagcttgtctgactcttacctgtagatgggtcgtttgtaaggtagcacactgagttggggcattaatagaacatggttattctgtctgtccttagacaagtttgtaagtcctgtgccctgcagtgttcatgaaatatttatgtaagtttccctttagctaaaatttacagtatttttcttattctttttctgctgttccgtaaagagtatgtccagatttcataattccaggttttttacactccatgtctttcagcaacaaccattcccactcagccttaatcttaatctttcctttttggaagccactcttcccgggaaccttttaagcaagcattgctttggaaatttctgatcttactaagttgtgcatagcatctaatgtcagaaccgactaggaatcacaatgtatatgtcatgtggttttggtgacaacatgagtgacacatgaagaggggtattctcaggttaccgtgctgcaattccaaaaggtctgagttttaaacagtgatttgttctggtattgacacaattatgttaggaaaaaagctggttgactgttttgtttaattgacttctaaactatgtttgaattgtctgaggagtttactggatgcttagcgcagttaaacattctcgtcctgtgagagaaacattctcttgtaggagaggtgttgcagattgtgattataaaataatttgtagcaaaaatatgtgttagcattttccctccctttttgtctcctattttcaggagacaaacttagccataaactgaatcctggtctgacacttccacaaatggtttccagttagaggagtttattgccaaattaaacttggctcttttcccacttagatagaaactaagaaagctgcacataagaaatgtttggacacttgtaaaactcaagtgactacattaatctgtatgtaaactagtgagcagacacatccataagaattgaaatgccaatatttgggaagtagagagtaacttatatcctatcagatctattgagtgttaatatggtagcactctgtatttgttctgtagactgataatactggaatccataaagtttgagcctttacaacttatgtaaagaaatgttgcaaacatttctggatgagtcttactttgtatctccagaagaatgtagatgtctcctaggcctcctcgtgctgatggttctgagctgaatatttcttggtaggccatgtgacacttcagatcagtgatcctactcctgtaatgttaggacaattatattacgcttatgatagaaacagtttcttgcttttcggaatattattacttgaataccacttgagatcattagcatgccaggaaaagtccattgattttgatggtccaatgtaatctcattcaggaggcttgaaacattggtggtttagtcttgtgaattttaacagttctctgtcattgtttaagaaaaccaacaactggcactacttcttaagctgtggtttcagtctctgctagttcataccgcatgtttattttggagtcttttggtaagcatggtgcttgtactggtttaaataaaatgctaacatgaaagaa

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