LOCUS       NM_009757               3116 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus bone morphogenetic protein 15 (Bmp15), mRNA.
ACCESSION   NM_009757
VERSION     NM_009757.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3116)
  AUTHORS   Liu,Y., Fan,H., Kang,X., Hao,Y., Wang,N., Zheng,H., Li,Y. and
            Kang,S.
  TITLE     A rare germline BMP15 missense mutation causes hereditary ovarian
            immature teratoma in human
  JOURNAL   Proc Natl Acad Sci U S A 121 (10), e2310409121 (2024)
   PUBMED   38427603
REFERENCE   2  (bases 1 to 3116)
  AUTHORS   Ito,H., Emori,C., Kobayashi,M., Maruyama,N., Fujii,W., Naito,K. and
            Sugiura,K.
  TITLE     Cooperative effects of oocytes and estrogen on the forkhead box L2
            expression in mural granulosa cells in mice
  JOURNAL   Sci Rep 12 (1), 20158 (2022)
   PUBMED   36424497
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3116)
  AUTHORS   Gindi,N., Grossman,H., Bar-Joseph,H., Miller,I., Nemerovsky,L.,
            Hadas,R., Nevo,N., Galiani,D., Dekel,N. and Shalgi,R.
  TITLE     Fyn and argonaute 2 participate in maternal-mRNA degradation during
            mouse oocyte maturation
  JOURNAL   Cell Cycle 21 (8), 792-804 (2022)
   PUBMED   35104175
REFERENCE   4  (bases 1 to 3116)
  AUTHORS   Tanaka,K., Hayashi,Y., Takehara,A., Ito-Matsuoka,Y., Tachibana,M.,
            Yaegashi,N. and Matsui,Y.
  TITLE     Abnormal early folliculogenesis due to impeded pyruvate metabolism
            in mouse oocytesdagger
  JOURNAL   Biol Reprod 105 (1), 64-75 (2021)
   PUBMED   33824958
  REMARK    GeneRIF: Abnormal early folliculogenesis due to impeded pyruvate
            metabolism in mouse oocytesdagger.
            Erratum:[Biol Reprod. 2021 Oct 11;105(4):1069. doi:
            10.1093/biolre/ioab154. PMID: 34390336]
REFERENCE   5  (bases 1 to 3116)
  AUTHORS   Ge,W., Tan,S.J., Wang,S.H., Li,L., Sun,X.F., Shen,W. and Wang,X.
  TITLE     Single-cell Transcriptome Profiling reveals Dermal and Epithelial
            cell fate decisions during Embryonic Hair Follicle Development
  JOURNAL   Theranostics 10 (17), 7581-7598 (2020)
   PUBMED   32685006
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3116)
  AUTHORS   Yan,C., Wang,P., DeMayo,J., DeMayo,F.J., Elvin,J.A., Carino,C.,
            Prasad,S.V., Skinner,S.S., Dunbar,B.S., Dube,J.L., Celeste,A.J. and
            Matzuk,M.M.
  TITLE     Synergistic roles of bone morphogenetic protein 15 and growth
            differentiation factor 9 in ovarian function
  JOURNAL   Mol Endocrinol 15 (6), 854-866 (2001)
   PUBMED   11376106
REFERENCE   7  (bases 1 to 3116)
  AUTHORS   Galloway,S.M., McNatty,K.P., Cambridge,L.M., Laitinen,M.P.,
            Juengel,J.L., Jokiranta,T.S., McLaren,R.J., Luiro,K., Dodds,K.G.,
            Montgomery,G.W., Beattie,A.E., Davis,G.H. and Ritvos,O.
  TITLE     Mutations in an oocyte-derived growth factor gene (BMP15) cause
            increased ovulation rate and infertility in a dosage-sensitive
            manner
  JOURNAL   Nat Genet 25 (3), 279-283 (2000)
   PUBMED   10888873
REFERENCE   8  (bases 1 to 3116)
  AUTHORS   Jaatinen,R., Laitinen,M.P., Vuojolainen,K., Aaltonen,J., Louhio,H.,
            Heikinheimo,K., Lehtonen,E. and Ritvos,O.
  TITLE     Localization of growth differentiation factor-9 (GDF-9) mRNA and
            protein in rat ovaries and cDNA cloning of rat GDF-9 and its novel
            homolog GDF-9B
  JOURNAL   Mol Cell Endocrinol 156 (1-2), 189-193 (1999)
   PUBMED   10612437
REFERENCE   9  (bases 1 to 3116)
  AUTHORS   Dube,J.L., Wang,P., Elvin,J., Lyons,K.M., Celeste,A.J. and
            Matzuk,M.M.
  TITLE     The bone morphogenetic protein 15 gene is X-linked and expressed in
            oocytes
  JOURNAL   Mol Endocrinol 12 (12), 1809-1817 (1998)
   PUBMED   9849956
REFERENCE   10 (bases 1 to 3116)
  AUTHORS   Laitinen,M., Vuojolainen,K., Jaatinen,R., Ketola,I., Aaltonen,J.,
            Lehtonen,E., Heikinheimo,M. and Ritvos,O.
  TITLE     A novel growth differentiation factor-9 (GDF-9) related factor is
            co-expressed with GDF-9 in mouse oocytes during folliculogenesis
  JOURNAL   Mech Dev 78 (1-2), 135-140 (1998)
   PUBMED   9858711
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK135882.1, AK139773.1 and
            AU019682.1.
            
            On Aug 30, 2016 this sequence version replaced NM_009757.4.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate subunits of a
            disulfide-linked homodimer, or alternatively, a heterodimer, with
            the related protein, growth differentiation factor 9 (GDF9). This
            protein plays a role in oocyte maturation and follicular
            development, through activation of granulosa cells. Female mice
            lacking a functional copy of this gene exhibit impaired fertility.
            [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139847.1, BC055363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AK135882.1         2-2
            2-3035              AK139773.1         2-3035
            3036-3116           AU019682.1         1-81                c
FEATURES             Location/Qualifiers
     source          1..3116
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 2.81 cM"
     gene            1..3116
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="bone morphogenetic protein 15"
                     /db_xref="GeneID:12155"
                     /db_xref="MGI:MGI:1316745"
     exon            1..683
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    308..310
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="upstream in-frame stop codon"
     CDS             362..1540
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="growth/differentiation factor 9B"
                     /codon_start=1
                     /product="bone morphogenetic protein 15 preproprotein"
                     /protein_id="NP_033887.1"
                     /db_xref="CCDS:CCDS29958.1"
                     /db_xref="GeneID:12155"
                     /db_xref="MGI:MGI:1316745"
                     /translation="

MALLTILRILLWGVVLFMEQRVQMAKPGWPSTALLADDPTLPSILDLAKEAPGKEMKQWPQGYPLRYMLKLYHRSADPHGHPRENRTIGAKMVRLVKPSANTVRPPRGSWHVQTLDFPLASNQVAYELIRATVVYRHQLHLVNYHLSCHVETWVPKCRTKHLPSSKSGSSKPSPMSKAWTEIDITHCIQQKLWNRKGRSVLRLRFMCQQQKGNETREFRWHGMTSLDVAFLLLYFNDTDDRVQGKLLARGQEELTDRESSFLMRSVRQACSIESDASCPSQEHDGSVNNQCSLHPYKVSFHQLGWDHWIIAPRLYTPNYCKGICTRVLPYGLNSPNHAIIQSLVNELVNHSVPQPSCVPYNFLPMSILLIETNGSILYKEYEGMIAQSCTCR"

     sig_peptide     362..436
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z0L4.1)"
     misc_feature    614..616
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z0L4.1); glycosylation site"
     misc_feature    998..1000
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z0L4.1); glycosylation site"
     misc_feature    1067..1069
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z0L4.1); glycosylation site"
     mat_peptide     1163..1537
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /product="Bone morphogenetic protein 15.
                     /id=PRO_0000033895"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0L4.1)"
     misc_feature    1226..1537
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="transforming growth factor beta (TGF-beta) like
                     domain found in TGF-beta superfamily; Region: TGF_beta_SF;
                     cl40434"
                     /db_xref="CDD:477357"
     misc_feature    order(1247..1249,1253..1255,1310..1324,1424..1438,
                     1445..1447,1505..1513)
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="homodimer interface 1 [polypeptide binding]; other
                     site"
                     /db_xref="CDD:381672"
     misc_feature    1406..1408
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z0L4.1); glycosylation site"
     misc_feature    order(1424..1429,1433..1435,1496..1498,1505..1510)
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="homodimer interface 2 [polypeptide binding]; other
                     site"
                     /db_xref="CDD:381672"
     misc_feature    1478..1480
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z0L4.1); glycosylation site"
     exon            684..3116
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3036..3041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="hexamer: AATAAA"
     polyA_site      3064
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="major polyA site"
ORIGIN      

tgcttccttttaacctattagattgggtgcaggccaggttcctggaatgggcctcttctcctcggttactttagcctgtctgagaactgctgtgtacttcccaccagtggggagtgggaagggcatgctgccttgtcccacttgctttttctgtttgttttcatgccaagaagcctagtcaggagactcgctttggcccagaagattctcccacaggaagtaagatagggtctgccagtcggcgtttctttttatttcttgccccgtctttggtatttgttaaaccaggatgtggaagaggtcagactgatgttctttggacttggttaggaatctgctgaaaagcaccaagctttgcaagatggcccttctcacaattcttagaattcttttgtggggagtggtgctttttatggaacagagggtccaaatggcaaagccagggtggccctccaccgccctccttgctgacgaccctacattgccctcaattttggatctggccaaagaagcccctggcaaggagatgaagcaatggccccaaggctatcccctgaggtacatgctcaagttataccatcgttcggctgacccgcatggccatccaagggagaaccgcacgattggagcgaaaatggtgaggctggtaaagccgtcggccaacacagtaaggcctcccagaggttcctggcatgtacagaccctggactttcctctagcatcaaaccaggtagcatacgaactaatcagagccactgtggtttaccgccatcaacttcatctagttaattaccatctctcctgccatgtggaaacttgggttcctaaatgccggaccaagcacttaccttcttctaaatcgggttcctcaaagccttctcccatgtctaaagcctggacagagatagatattacacattgtattcagcagaagctctggaatcgcaagggacggagtgttcttcgcctccgcttcatgtgtcagcagcaaaaaggcaatgagactcgtgagttccggtggcatggcatgacatccttggatgttgccttcttgctactctatttcaatgacaccgatgacagagttcagggtaaacttcttgcaagaggccaagaggagttaactgatagggaatcttcttttctcatgcggagtgtccggcaagcatgcagcattgaatctgatgcctcttgtccttctcaggaacatgatgggtctgtaaataaccagtgttccctccatccttacaaggtcagcttccaccaactaggctgggatcactggatcattgctcctcgtctctataccccaaattactgtaaaggaatctgtactcgggtattaccctatggtctcaattcacccaaccatgccatcattcagagccttgtcaatgaactagtgaatcacagtgtacctcagccttcctgtgtcccttataattttcttcctatgagcatcctcctgattgagaccaacgggagtatcttgtacaaggagtatgagggtatgattgcccagtcctgtacatgtagataatagtgaagttgttgctatctcaggtttcccaagaagctatagatgtttaaagaaaactgtgttaaagctggcagtgatctacccaacctacagattctgttccttatctttaaaaaatatattgtgcttatgcttaaaatataagagccctttgtactctataaacaaaatgctaggatcccatcttaatattttttaaaagtaatttaaaataccatgaaatggttatcttaagcattgtttaaatctctcaccccatttttgagctcctcagcttgtaaaaatgtttctggtgctggtatcctagcatggatcagtagaacttaactagcccccaatactgagataagatgctttctggagatacattattacatcatttttattgtgactttgggaaaaaaaatcaagaaaatactggtccatggtagaagaacatatggagtcctggaggtgacttcattctgggctcacttgattgatgtgtccagttgggctcttctgggcttaggtctctgggagacaaccttgctgtttgggaggaagtatagagctctttcttgaactaaattatgttcacaggatgatttcttgtttttttccctgttttttttgttttggattattattattattattattttgtgctgagaataagcaagtgttctaccactgtgctgtatccccagcccagtttatcttctctataattctatactatatttaagtgttgggacaatattgcaaatgaatgatgcttttttttttgttaaagatcttgaatgctttggagattaggagagagtgaaaagaaagaatttatatcttttattctctatggctataatctagagctctactttaatccctgagggatggggccagaggctcctctgagttctgtctcagacagcactactaataaacagctcttactaaggtactagttaaagaagcccagcatgtctcagtacctgcctagctattgactagttttatcacattctctctgggatggaacctgatttagggcatgggcatgtgctcatcattgttcattcctatctgttccttacatttcccatacattaactcagttatttctttctcaacagttgatgctcacaggactgaatatatgtggatctattccttagcatcattttgctcacatatctacttagaaatcaattcaggctttactgttcttctcttcagtattctcatgacaaccagtttcaagtcgctgtctctcctcccatctcaaagcacagcatggtttcccttaaaatgctctagtattactgtcttcactgagaaaagatggagctccctttgaacgctttacttggctcattgtcttctgaatagccagaactgaaaacctaggaagtcctttgatgaatacaaaaagttgacttttttgtgtgtgtgagacatggaatacccccctatttatatatttgtatgtttatgtattttcttaatcttaaagaataaattttcatttatgtgtgctttgcatataaagttagtaatttcaaaactgtacaaattataagagatgatgaaagct

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