LOCUS       NM_008584               2360 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Mus musculus mesenchyme homeobox 2 (Meox2), mRNA.
ACCESSION   NM_008584
VERSION     NM_008584.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2360)
  AUTHORS   Pizzamiglio,L., Capitano,F., Rusina,E., Fossati,G., Menna,E.,
            Lena,I., Antonucci,F. and Mantegazza,M.
  TITLE     Neurodevelopmental defects in Dravet syndrome Scn1a+/- mice:
            Targeting GABA-switch rescues behavioral dysfunctions but not
            seizures and mortality
  JOURNAL   Neurobiol Dis 207, 106853 (2025)
   PUBMED   40021096
REFERENCE   2  (bases 1 to 2360)
  AUTHORS   Pelaez,M.C., Fiore,F., Larochelle,N., Dabbaghizadeh,A.,
            Comaduran,M.F., Arbour,D., Minotti,S., Marcadet,L., Semaan,M.,
            Robitaille,R., Nalbantoglu,J.N., Sephton,C.F. and Durham,H.D.
  TITLE     Reversal of cognitive deficits in FUSR521G amyotrophic lateral
            sclerosis mice by arimoclomol and a class I histone deacetylase
            inhibitor independent of heat shock protein induction
  JOURNAL   Neurotherapeutics 21 (5), e00388 (2024)
   PUBMED   38972779
REFERENCE   3  (bases 1 to 2360)
  AUTHORS   Sandovici,I., Knee,O., Lopez-Tello,J., Shreeve,N., Fowden,A.L.,
            Sferruzzi-Perri,A.N. and Constancia,M.
  TITLE     A genetically small fetus impairs placental adaptations near term
  JOURNAL   Dis Model Mech 17 (8) (2024)
   PUBMED   39207227
REFERENCE   4  (bases 1 to 2360)
  AUTHORS   Sasner,M., Preuss,C., Pandey,R.S., Uyar,A., Garceau,D.,
            Kotredes,K.P., Williams,H., Oblak,A.L., Lin,P.B., Perkins,B.,
            Soni,D., Ingraham,C., Lee-Gosselin,A., Lamb,B.T., Howell,G.R. and
            Carter,G.W.
  TITLE     In vivo validation of late-onset Alzheimer's disease genetic risk
            factors
  JOURNAL   Alzheimers Dement 20 (7), 4970-4984 (2024)
   PUBMED   38687251
REFERENCE   5  (bases 1 to 2360)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2360)
  AUTHORS   Andres,V., Fisher,S., Wearsch,P. and Walsh,K.
  TITLE     Regulation of Gax homeobox gene transcription by a combination of
            positive factors including myocyte-specific enhancer factor 2
  JOURNAL   Mol Cell Biol 15 (8), 4272-4281 (1995)
   PUBMED   7623821
REFERENCE   7  (bases 1 to 2360)
  AUTHORS   Grigoriou,M., Kastrinaki,M.C., Modi,W.S., Theodorakis,K.,
            Mankoo,B., Pachnis,V. and Karagogeos,D.
  TITLE     Isolation of the human MOX2 homeobox gene and localization to
            chromosome 7p22.1-p21.3
  JOURNAL   Genomics 26 (3), 550-555 (1995)
   PUBMED   7607679
REFERENCE   8  (bases 1 to 2360)
  AUTHORS   Weiss,K.M., Ruddle,F.H. and Bollekens,J.
  TITLE     Dlx and other homeobox genes in the morphological development of
            the dentition
  JOURNAL   Connect Tissue Res 32 (1-4), 35-40 (1995)
   PUBMED   7554933
REFERENCE   9  (bases 1 to 2360)
  AUTHORS   Candia,A.F., Kovalik,J.P. and Wright,C.V.
  TITLE     Amino acid sequence of Mox-2 and comparison to its Xenopus and rat
            homologs
  JOURNAL   Nucleic Acids Res 21 (21), 4982 (1993)
   PUBMED   7909944
REFERENCE   10 (bases 1 to 2360)
  AUTHORS   Candia,A.F., Hu,J., Crosby,J., Lalley,P.A., Noden,D., Nadeau,J.H.
            and Wright,C.V.
  TITLE     Mox-1 and Mox-2 define a novel homeobox gene subfamily and are
            differentially expressed during early mesodermal patterning in
            mouse embryos
  JOURNAL   Development 116 (4), 1123-1136 (1992)
   PUBMED   1363541
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010456.8 and AC159640.2.
            
            On Apr 11, 2018 this sequence version replaced NM_008584.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028352.1, AK031152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-805               CT010456.8         188163-188967
            806-978             AC159640.2         97514-97686         c
            979-2360            AC159640.2         85468-86849         c
FEATURES             Location/Qualifiers
     source          1..2360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 16.84 cM"
     gene            1..2360
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /note="mesenchyme homeobox 2"
                     /db_xref="GeneID:17286"
                     /db_xref="MGI:MGI:103219"
     exon            1..805
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    256..258
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /note="upstream in-frame stop codon"
     CDS             292..1203
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /note="growth arrest-specific homeobox"
                     /codon_start=1
                     /product="homeobox protein MOX-2"
                     /protein_id="NP_032610.1"
                     /db_xref="CCDS:CCDS25888.1"
                     /db_xref="GeneID:17286"
                     /db_xref="MGI:MGI:103219"
                     /translation="

MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHQQQQHQALQSNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPADVEKRSGSKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSLANEDSRDSDHSSEHAHL"

     misc_feature    478..864
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /note="propagated from UniProtKB/Swiss-Prot (P32443.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    850..1020
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1123..1200
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /note="propagated from UniProtKB/Swiss-Prot (P32443.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            806..978
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..2360
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /note="hexamer: AATAAA"
     polyA_site      2360
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /note="major polyA site"
ORIGIN      

gaaagcagttctctgggaccaccttcttttggcttccacctctcccacacttgacatctgagcagctgcgaaggaagctcctccaggtcctagtgtttatacgtgcaggagactggccgctaaggctcaggactgggattagccggctctgctcaaatgcaaacgcgcgcggcttttacttttggagtgagtgggggaaagtcttaggatttccagtgaaaagtgacagcgcttggtggacattcggaccgtccgtgaagtcttctgcttggaagccgaaacttgcatgccatggaacaccccctctttggctgcctgcgcagcccccacgccacagcgcaaggcttgcaccccttctcccagtcttctctggccctccatggaagatctgaccacatgtcctaccccgaactctccacatcttcctcgtcttgcataatcgcgggataccccaacgaggagggcatgtttgccagccagcatcacagggggcaccaccaccaccaccaccatcaccatcaccaccaccagcagcagcagcaccaggctctgcaaagcaactggcacctcccgcagatgtcctctccaccaagcgcggcccggcacagcctgtgcctgcagcctgattcgggagggcccccggagctgggaagcagccctccggtcctgtgttccaactcatctagcctgggctccagcacccctaccggggccgcgtgcgcaccaggggattatggccgtcaagcgctgtcacccgcagacgtagagaagagaagtggcagcaaaaggaaaagcgacagctcagattcccaggaaggaaactacaagtcagaagtgaacagcaaacctaggaaggaaagaacagcttttaccaaagagcaaatcagagaactagaggcagaatttgcccatcataattatctgaccagactgagaagatatgagatagcagtgaatctagacctcactgaaagacaggtgaaagtgtggttccagaacaggagaatgaagtggaagcgggtcaaagggggacagcaaggagctgctgcccgagaaaaggaactggtgaatgtgaaaaagggaacgcttcttccgtcagagctgtcaggaatcggtgcagccaccctccagcagacaggggactcactagcaaacgaggacagccgcgatagtgaccacagctctgagcacgcacacttatgatacctacaaagaccagctccattctcaggaaagcaccattgtgatggcaaaccttaccgaacatcgtttacatggcagatgtctgtggcagtgtggcttagtataattaaatgcaggcatctcgagtctgtgtctcatgatggatagacggtttacactaagtgccttttattgaagatgcttccacagtgaaattggagaaagcgaacgtattccaaatacacttgttcctatatatgacagagagggagatggatgtttgctttggcttgcactgaaaattaaatttgctaccaagagcaaacttgataagacgtttttactcaagatgtctccagagtgaagatgttaaaaataaaaaatgctttgaacattccagttgtgccaggtcatgtgtgtgacactaggcaggtatttgcttttgcttgcactgaaaattaaactgctatcaagttaatccatgaaatagtttatcttgaacagccacagtgcctgaaatcaccaagtggatataaaatgtactgaaactctgtatatattacccctaagtcatttttcctgtcttcactaattttagcaaatgcattcatattagctgattaaaaataggcttttccattgacaaacacagccagcttcttgtatttttatacatttgtgtcagacagagaaaatcagtatgtgcttacttgtgttcaagtagataaaatgcagtagagtctgataggacatatccttgtaccacagacaaagcaaatcttctgttgcattgactatcaactgctgcagatacattagagaacatacctagctcccctccagccttcttctcttatatcttgaaagacattaggatcataggcaaatcagttaccttgcagaacgagtcttgtgcggcaaatgtctgattttacatctttaagttgttaatgtttatgggtctgattcaattaacagggaaaagctttcttcctccttgtttatgatataaaaccaagtgccaaacaaagctaattcttcaagagaatagttgagaaactgaatgtctgacaattagactctgaaagtgcattatttttcatatgctctatattcatgcagaacaagttcttgtattttgtaaaaaaaaaaagataaataaatgatccttgaaataa

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