LOCUS       NM_001417719            1082 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus succinate dehydrogenase complex assembly factor 3
            (Sdhaf3), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001417719 XM_030255595
VERSION     NM_001417719.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1082)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1082)
  AUTHORS   Dennis,R.A. and McCammon,M.T.
  TITLE     Acn9 is a novel protein of gluconeogenesis that is located in the
            mitochondrial intermembrane space
  JOURNAL   Eur J Biochem 261 (1), 236-243 (1999)
   PUBMED   10103055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122240.4 and AC146599.3.
            
            On Mar 9, 2023 this sequence version replaced XM_030255595.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.5169072.1,
                                           SRR13422590.148961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC122240.4         199239-199435
            198-274             AC122240.4         200239-200315
            275-1082            AC146599.3         132361-133168
FEATURES             Location/Qualifiers
     source          1..1082
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 2.83 cM"
     gene            1..1082
                     /gene="Sdhaf3"
                     /gene_synonym="0610005M07Rik; 4933430A16Rik; Acn9"
                     /note="succinate dehydrogenase complex assembly factor 3"
                     /db_xref="GeneID:71238"
                     /db_xref="MGI:MGI:1913288"
     exon            1..197
                     /gene="Sdhaf3"
                     /gene_synonym="0610005M07Rik; 4933430A16Rik; Acn9"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..413
                     /gene="Sdhaf3"
                     /gene_synonym="0610005M07Rik; 4933430A16Rik; Acn9"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; protein ACN9 homolog, mitochondrial; SDH
                     assembly factor 3; succinate dehydrogenase assembly factor
                     3, mitochondrial"
                     /codon_start=1
                     /product="succinate dehydrogenase assembly factor 3,
                     mitochondrial isoform a precursor"
                     /protein_id="NP_001404648.1"
                     /db_xref="GeneID:71238"
                     /db_xref="MGI:MGI:1913288"
                     /translation="

MPGKHVSRVRALYRRILLLHRALPPDLKALGDQYVKDEFRRHKTVGPGEAQRFLKEWENEGGERVLHDAEESCRISSHLENIRRRTQQCCGNKLRTADKAQLEKRVLAPLSQKKNSMTFVMSKLDSCKS"

     misc_feature    48..200
                     /gene="Sdhaf3"
                     /gene_synonym="0610005M07Rik; 4933430A16Rik; Acn9"
                     /note="LYR (leucine-tyrosine-arginine) motif found in
                     mitochondrial succinate dehydrogenase assembly factor 3
                     (SDHAF3) and similar proteins; Region:
                     Complex1_LYR_SDHAF3_LYRM10; cd20270"
                     /db_xref="CDD:380765"
     exon            198..274
                     /gene="Sdhaf3"
                     /gene_synonym="0610005M07Rik; 4933430A16Rik; Acn9"
                     /inference="alignment:Splign:2.1.0"
     exon            275..1082
                     /gene="Sdhaf3"
                     /gene_synonym="0610005M07Rik; 4933430A16Rik; Acn9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      543..548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdhaf3"
                     /gene_synonym="0610005M07Rik; 4933430A16Rik; Acn9"
                     /note="hexamer: AATATA"
     polyA_site      562
                     /gene="Sdhaf3"
                     /gene_synonym="0610005M07Rik; 4933430A16Rik; Acn9"
     regulatory      818..823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdhaf3"
                     /gene_synonym="0610005M07Rik; 4933430A16Rik; Acn9"
                     /note="hexamer: AATAAA"
     polyA_site      841
                     /gene="Sdhaf3"
                     /gene_synonym="0610005M07Rik; 4933430A16Rik; Acn9"
                     /note="major polyA site"
     regulatory      1060..1065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdhaf3"
                     /gene_synonym="0610005M07Rik; 4933430A16Rik; Acn9"
                     /note="hexamer: AATAAA"
     polyA_site      1082
                     /gene="Sdhaf3"
                     /gene_synonym="0610005M07Rik; 4933430A16Rik; Acn9"
ORIGIN      

accttctgcgcaggcgcggcgcgatgccggggaagcatgtctcgagagtccgggctttatataggcgaatcttgctgctacatcgggctctgcccccggacctcaaagccctgggtgaccagtacgtgaaggacgaatttaggagacataagactgttggtcctggcgaggcccagcgattcttgaaggaatgggagaatgaagggggagaaagagtattgcatgatgctgaagagtcttgcaggatctcctcccatcttgaaaatatcaggagacgtacgcagcagtgctgtggcaacaagctgaggacagcagacaaagctcaactggaaaagcgtgttttggcacctctctcccagaagaaaaactcaatgactttcgtgatgagcaaattggacagttgcaagagctgatgcaagaggctactaaacccaataggcagtttagtatcactgagtctacaaaaccacagttgtgatacatgatcttaacaaagtggctacatttataacctgttacctcatctaccattgactctctaaaatatattctttcagctacagaatagtctcttatttttggacagtatgaacaatgcatgatcaaaatcataaatgacgcacttgtcatcattgcaatgacatatttatttgctgtgtggaatgtagttttatggaatttaatttctggactaaagaaaggtgttaaaaaagatatactttgggattatgctgaaatttttttgtatatgaatttgttttaaattctatccccatcaagtgttagcctcctgatttgtctctagcttcatcagttaaataaacatatcataataatggaagatgtagaattccaataagtttgctattagacatattgtgattctgaaagtcccaccatttctcctttagtagtacacacctggctatcactcagaatttcatctatgagtcacgttgaaagttttaagaaaagccttaagattcaattgttaagaatttcagttattgtctaaaggttggggagatgaaaaatactaagttggctcatacatttaaaaataaattatctatcaaaacctg

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