LOCUS       NM_001410589            3676 bp    mRNA    linear   ROD 08-AUG-2023
DEFINITION  Mus musculus exo/endonuclease G (Exog), transcript variant 5, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001410589
VERSION     NM_001410589.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3676)
  AUTHORS   Man JCK, Mohan RA, Boogaard MVD, Hilvering CRE, Jenkins C, Wakker
            V, Bianchi V, Laat W, Barnett P, Boukens BJ and Christoffels VM.
  TITLE     An enhancer cluster controls gene activity and topology of the
            SCN5A-SCN10A locus in vivo
  JOURNAL   Nat Commun 10 (1), 4943 (2019)
   PUBMED   31666509
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3676)
  AUTHORS   Szczesny B, Brunyanszki A, Olah G, Mitra S and Szabo C.
  TITLE     Opposing roles of mitochondrial and nuclear PARP1 in the regulation
            of mitochondrial and nuclear DNA integrity: implications for the
            regulation of mitochondrial function
  JOURNAL   Nucleic Acids Res 42 (21), 13161-13173 (2014)
   PUBMED   25378300
REFERENCE   3  (bases 1 to 3676)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166052.5 and AC121922.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052171.1, SRR7345562.1560795.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC166052.5         3278-3468           c
            192-341             AC166052.5         1330-1479           c
            342-418             AC121922.3         123636-123712       c
            419-533             AC121922.3         121148-121262       c
            534-3676            AC121922.3         107972-111114       c
FEATURES             Location/Qualifiers
     source          1..3676
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.33 cM"
     gene            1..3676
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /note="exo/endonuclease G"
                     /db_xref="GeneID:208194"
                     /db_xref="MGI:MGI:2143333"
     exon            1..191
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /inference="alignment:Splign:2.1.0"
     exon            192..341
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    234..236
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /note="upstream in-frame stop codon"
     exon            342..418
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..995
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /EC_number="3.1.30.-"
                     /note="isoform 2 is encoded by transcript variant 5;
                     endonuclease G-like 1; nuclease EXOG, mitochondrial; endo
                     G-like 1; endo/exonuclease (5'-3'), endonuclease G-like"
                     /codon_start=1
                     /product="nuclease EXOG, mitochondrial isoform 2"
                     /protein_id="NP_001397518.1"
                     /db_xref="GeneID:208194"
                     /db_xref="MGI:MGI:2143333"
                     /translation="

MAETFYLSNIVPQNFDNNSGYWNRIEMYCRELTERFEDVWIVSGPLTLPHTRNDGTKTVSYQVIGEDNVAVPSHLYKVILARRSPESTEPLALGAFVVPNKAIGFQSQLSEFQVSLHDLEKMSGLVFFPRLDRSRDIRNICSVDTCKLLGFQEFTLYLSTRKIDGARSVARLEKVLEALKSSGVEPDDYFLSRYEKKLEELKAKEQKDAQLEKQS"

     misc_feature    <348..749
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /note="DNA/RNA non-specific endonuclease; prokaryotic and
                     eukaryotic double- and single-stranded DNA and RNA
                     endonucleases also present in phosphodiesterases. They
                     exists as monomers and homodimers; Region: NUC; cl00089"
                     /db_xref="CDD:444690"
     misc_feature    399..401
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /note="Mg2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238043"
     misc_feature    792..938
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /note="Endo/exonuclease (EXOG) C-terminal domain; Region:
                     Exog_C; pfam18026"
                     /db_xref="CDD:436219"
     exon            419..533
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /inference="alignment:Splign:2.1.0"
     exon            534..3676
                     /gene="Exog"
                     /gene_synonym="Endogl1; Endogl2; Engl; ENGL-a; ENGL-B;
                     Engla; Englb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agagacaaagtgctggcgcccgcgagtcatggctgcaaagagcttcgcttcccgtctcagggactcgcggcgatttctgaatggcttcttggccggggctgtagtgggcgccgcgggagcggggctgacggcgctgcagtttttccggcgtccggacgcggaatccgcgaagctggcgaggcagccacacgaatctgcagaagaagctgtcttggaacagtttgggtttcctttagctggaacagagacgaggcgttacactaaccacgccctgtcttacgatcaggcaaaacgggtgcccagatgggttcttgagcatatatccaaggacaagatcatcggaagccatggcagaaaccttttacctttctaatatcgtgcctcagaattttgataataactccggctactggaacagaatagaaatgtattgtcgtgagctgacggagagatttgaagatgtttggatagtatcaggacctttaaccttacctcatactaggaatgatggaacgaaaacagttagttaccaggtgattggtgaggacaacgtggccgtcccctcgcacctttacaaggtgatcctggctcgcagaagcccggaatctacggagccgctggcgctgggggcctttgtggtgccaaataaagccattgggttccagtcccagttatccgagttccaggtgagcctccatgacctggagaagatgtcaggtctggtgtttttcccccgtctggatagaagcagggacatccggaatatttgctctgtggacacctgcaagctcctgggtttccaggaattcactctgtacctgagcacgaggaagattgatggagcccggtctgtggccagactggagaaggttctggaagctttgaagagctcaggggtggaacctgacgattacttcctgagtcgctatgagaaaaagctggaggaactgaaggctaaggagcaaaaggacgcccagctggaaaagcagtcctagtgtctgtctcggtgtgcactgagcacctgtgaccaacaggtttattttcaagaaatgatggaattctgaccaaaatcctccaaagactcggggctcaaaactcagtgtcgtccttctctgggatccgaggtggctgagatggttttaaaactctgctctcacgtgctccttccctcatgaccctgaagtcctcccatctgtctgtgttggagaatccagtgactgttcttcctctgtgcaaaccctgctgtcccatcttacctgtgggcaagatgaggctcagagaactctgtatctttaccattggtattcaacagaagtcatccagggtgcctcagagtcaagacagagttagatggatgtaactcagtccgtacctgcatccacggctgtttctggcactacagccctcctggtgagaagggtgtgtctcttctcgcatcatttctgtgggaaaaaacagtgggtcttggaaagatggagatgttttgtgggtttaaccagagactgtggttccctccagggatcacatggtgccagataagtatgtttcttgcctcattggggcctttctaaaggagcccaagaaaggtgtttgccaagagtcgccgggtacctctggtcctgctgtctgctggaccagcacaccacaggtaggtatagcctgggcccaaggtccgaaccagctcattgcctggggaaagagcagctgctgtctgtgctgacctccagactggtttatacagatcttgagctgtcctgagtccatgcgcacagcccagaagcttctgggcaaaaggactcgtctgaatctgccactctgccactgtcctccaagcaatacgagagtgatctttgtggcattgtgtttgcctccgatagaaatgcatgactttacaataaagacaagaaggctctggctgaccctcttctgctccttcatttggagaaaaagaaactgtcaggtgtaggacacagtgacggattagctccgttctgcggtaccttcctcttccccattaacttgtgccagtccttctgaggatagaaagccaaaatgtcaccatgaccgaaaaaaaaatctgttactttctctcctcagaaaagaggtgatggcggggcctgagtgtttctccagcagccctgggaaggaggctgaggctcctcctgcctgtgccccaggttcccaccatgtgtttatgcagccgagctcctcctcctgttgccgtgctctcctctgctggcctggcttgctgctggctttggagttgcttcccacactctccctactcaggaagaatcttgtctgtatcagaaagtttctgtagcctgggattttatttcttatggcagatgctacctggccattgtaagacagaaataagagcaaaccaaaaagacagcacgcctgactgcatatttatttatttatttattgaatctgtatttcttatgagtgttttgcctgtttgcatctgtgcataccacacgagtgcctgttgcccacagaggttagaagagctcattggataccctggaaatggaatcccagatggttctgagccaccgtgtgaatgctggattctctgcagttgaatcggggttctctgcaagagcagccagtgctcttgagccccgatctcagattttatgtgtgaaatatctattgacatataacactgatccttgaattgtcctgtgaacatttgcattaagaggacccaaaacaaacacttaaaatggcccctcagtgtgactgtccgtttttctggattgcagtgcagcagattcctgggccatacttgagtatcaaatgtgtcagaggcagacgttgtagccagtcaaacctgagtggggtcactgtctgttcgtcacctcagtgggctccctcaggttcttgggctgagccttctgggccattcacccttccagttcctggtctgaagaaatgaccaggctgggttggctctgctgtgggaagtccctgtctcggggagggagatttaattcttaatctttcatcatttctagtgatgtcttcaagttctttggtctttggactaaggctgttggccaaagctgaatacagcaaaagccttactggaagttagagaggttagggagagggatgcgagcccctgaactgcgctgccatttctgctcttacatcttaaccagcagagacctctacccttctcttcggcctttgacgagtgcccagcaggagaggcagtctgctcttgagggaatggcttcctgcagagctgtgctcagtttgcagcctgacactggcatgatcctgtgtgcctccatgtcacctgtgcgccctgcctcatctgagagggtattgttgagctcactccgtttgtggcagacttcctgttaacggcttgtgaggggtaggatgtgccctgccaactgcacccacagcctgtgcacctgtgaaagccctgcagttcttgggagaggaggcctgactggtggaagtgggtcagtagaagcaggctttgaaggttaaccccctctcgcttcgggcctgtgtgctttgctttctgtctgccgccatagaaacatataaacctctggagactgctgttcctgttgccctgcctcccataccatagtggactggaatcccagcgctgtcggatcaaataaatccttcccgaagttgcttctga

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