LOCUS       NM_001370857            1501 bp    mRNA    linear   ROD 08-AUG-2023
DEFINITION  Mus musculus alcohol dehydrogenase 6B (class V) (Adh6b), transcript
            variant 1, mRNA.
ACCESSION   NM_001370857 XM_006502557
VERSION     NM_001370857.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1501)
  AUTHORS   Szalai G, Veres M, Duester G, Lawther R, Lockhart M and Felder MR.
  TITLE     Tissue expression pattern of class II and class V genes found in
            the Adh complex on mouse chromosome 3
  JOURNAL   Biochem Genet 46 (11-12), 685-695 (2008)
   PUBMED   18802746
  REMARK    GeneRIF: Adh6b gene expression patterns.
REFERENCE   2  (bases 1 to 1501)
  AUTHORS   Gonzalez-Duarte R and Albalat R.
  TITLE     Merging protein, gene and genomic data: the evolution of the
            MDR-ADH family
  JOURNAL   Heredity (Edinb) 95 (3), 184-197 (2005)
   PUBMED   16121213
  REMARK    Review article
REFERENCE   3  (bases 1 to 1501)
  AUTHORS   Szalai G, Duester G, Friedman R, Jia H, Lin S, Roe BA and Felder
            MR.
  TITLE     Organization of six functional mouse alcohol dehydrogenase genes on
            two overlapping bacterial artificial chromosomes
  JOURNAL   Eur J Biochem 269 (1), 224-232 (2002)
   PUBMED   11784316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079845.31.
            
            On Aug 26, 2022 this sequence version replaced NM_001370857.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189679.104632.1,
                                           SRR5189676.128126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC079845.31        58011-58036
            27-130              AC079845.31        58200-58303
            131-229             AC079845.31        58836-58934
            230-331             AC079845.31        60106-60207
            332-470             AC079845.31        65669-65807
            471-558             AC079845.31        68205-68292
            559-778             AC079845.31        68417-68636
            779-1039            AC079845.31        68818-69078
            1040-1175           AC079845.31        70039-70174
            1176-1314           AC079845.31        73684-73822
            1315-1501           AC079845.31        74711-74897
FEATURES             Location/Qualifiers
     source          1..1501
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 64.21 cM"
     gene            1..1501
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /note="alcohol dehydrogenase 6B (class V)"
                     /db_xref="GeneID:100417514"
                     /db_xref="MGI:MGI:2446626"
     exon            1..26
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /inference="alignment:Splign:2.1.0"
     exon            27..130
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /inference="alignment:Splign:2.1.0"
     exon            131..229
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    140..142
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /note="upstream in-frame stop codon"
     CDS             191..1345
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /EC_number="1.1.1.1"
                     /codon_start=1
                     /product="alcohol dehydrogenase 6B (class V)"
                     /protein_id="NP_001357786.1"
                     /db_xref="CCDS:CCDS89693.1"
                     /db_xref="GeneID:100417514"
                     /db_xref="MGI:MGI:2446626"
                     /translation="

MEQASLATKTSSNVIRCRAAVAWTTNAPLSIEEVEVDPPKAGEVRVKIIASGICGTDNHTLEGKMKTPFPVILGHEGAGVVESVGPGVTTVKPGDKVLMFPLPECRECFYCLYPKGNFCEKENILSPTGLMLDGTSRFTCRGKKIYNIMGTSTFTEYTVVHEIAVAKIEAAAPMDTVCIMSCAVPTGFGAVFNTAQVTPGSSCVVFGLGGIGSAIVMACKASGACRIIGVDINEEKFPRARALGVTDCLNPNKLKKPVQEVVKEMTGVGVDFAFEAIGLIETMVAALKSCNRSYGVCVIMGVAPTGSQLSFDPLVLLPGRTLKSSVLGGYKTRDDIPKLVTDYVQKKINIDPLITHRLPFPKINEGFRLLQEGKCIRCVLSMRP"

     misc_feature    218..1336
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /note="Medium chain reductase/dehydrogenase
                     (MDR)/zinc-dependent alcohol dehydrogenase-like family;
                     Region: MDR; cl16912"
                     /db_xref="CDD:450120"
     misc_feature    order(350..358,365..367,734..736,746..748,809..826,
                     881..886,896..898,941..943,1016..1021,1088..1093,
                     1163..1171)
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /note="NAD(P) binding site [chemical binding]; other site"
                     /db_xref="CDD:176178"
     exon            230..331
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /inference="alignment:Splign:2.1.0"
     exon            332..470
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /inference="alignment:Splign:2.1.0"
     exon            471..558
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /inference="alignment:Splign:2.1.0"
     exon            559..778
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /inference="alignment:Splign:2.1.0"
     exon            779..1039
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1175
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1314
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1501
                     /gene="Adh6b"
                     /gene_synonym="Adh5b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agtccgccctgcatttactctctgaggtgttaaatgtgcagagcttgatgtgtttttctttcaaggtgttaaatgtgcagagcttggtaggacactcccgtatacgtggcacttcggcaggtagaggcagtccagcaggtaaccgcttgagacagaagagccctccagtctaaaccttccagaagcaaagatggaacaagccagcctcgccacaaaaacatccagcaatgtcatcagatgccgggcagctgttgcctggaccactaatgccccgctgtccattgaggaggttgaagttgatccaccaaaggctggtgaggttcgagttaagattatagcctctgggatctgtggcactgataatcataccttagaagggaaaatgaaaacgccatttcctgtcatcctgggccacgagggagctggagttgtggagagtgttggaccaggtgtaaccactgtaaagccaggagataaagtcttaatgttccctcttccggaatgtcgagaatgcttctactgcctctaccctaagggcaacttctgtgagaaagaaaatattctctctccaactggattaatgttggatggaaccagcagatttacctgcagagggaagaaaatctataatataatggggaccagcacgttcacggaatatactgtggtgcatgagattgcagtggcgaagatcgaggctgctgcccctatggatacagtctgcatcatgagctgcgcggtgccgacaggctttggagctgtgtttaacacagctcaggtcacccctggctcttcctgtgtggtgtttggactcggaggaattggctctgccatcgtcatggcctgcaaagcctctggagcatgtagaatcatcggggttgacatcaatgaggagaaatttcctcgggcaagagccttgggggtcaccgactgtctcaaccctaacaagctgaagaagcctgtgcaggaggtggtgaaggaaatgacaggggttggtgttgactttgcctttgaggccatcggactcattgaaaccatggttgcggctttgaagtcatgcaataggagctacggagtgtgtgtgattatgggagtagctccgaccggttcccagctctcttttgacccattggtacttctccctggaagaaccctaaaatcttctgttttgggagggtataaaaccagagatgacatccctaaactagtaactgactacgttcaaaagaaaattaatatagatcctcttataacccatagactgcctttcccaaaaatcaatgaaggattcagattgttgcaagagggaaaatgcatccgttgtgtcctctctatgagaccctgatggtgaccggcacacgggcatctcagcagtgctcttctatgcttctttacctccttggagattaaactgcaaactatggagatcagaacaggaaacacacacacacaattttaacgaattaaactgttaaagaaaataaactatctcaaaactctt

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