LOCUS       NM_001357973            2207 bp    mRNA    linear   ROD 27-APR-2025
DEFINITION  Mus musculus trafficking protein, kinesin binding 1 (Trak1),
            transcript variant 6, mRNA.
ACCESSION   NM_001357973
VERSION     NM_001357973.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2207)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2207)
  AUTHORS   van Spronsen,M., Mikhaylova,M., Lipka,J., Schlager,M.A., van den
            Heuvel,D.J., Kuijpers,M., Wulf,P.S., Keijzer,N., Demmers,J.,
            Kapitein,L.C., Jaarsma,D., Gerritsen,H.C., Akhmanova,A. and
            Hoogenraad,C.C.
  TITLE     TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking
            to axons and dendrites
  JOURNAL   Neuron 77 (3), 485-502 (2013)
   PUBMED   23395375
REFERENCE   3  (bases 1 to 2207)
  AUTHORS   Webber,E., Li,L. and Chin,L.S.
  TITLE     Hypertonia-associated protein Trak1 is a novel regulator of
            endosome-to-lysosome trafficking
  JOURNAL   J Mol Biol 382 (3), 638-651 (2008)
   PUBMED   18675823
REFERENCE   4  (bases 1 to 2207)
  AUTHORS   Gilbert,S.L., Zhang,L., Forster,M.L., Anderson,J.R., Iwase,T.,
            Soliven,B., Donahue,L.R., Sweet,H.O., Bronson,R.T., Davisson,M.T.,
            Wollmann,R.L. and Lahn,B.T.
  TITLE     Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic
            mice
  JOURNAL   Nat Genet 38 (2), 245-250 (2006)
   PUBMED   16380713
  REMARK    GeneRIF: Our data implicate Trak1 as a crucial regulator of GABA(A)
            receptor homeostasis and underscore the importance of hyrt mice as
            a model for studying the molecular etiology of hypertonia
            associated with human neurological diseases.
            Erratum:[Nat Genet. 2006 Mar;38(3):389. Anderson, Jeffrey R
            [added]]
REFERENCE   5  (bases 1 to 2207)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   6  (bases 1 to 2207)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (bases 1 to 2207)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2207)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115863.17.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046285.1, CB244115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC115863.17        86377-86610         c
            235-429             AC115863.17        61517-61711         c
            430-506             AC115863.17        22013-22089         c
            507-623             AC115863.17        12782-12898         c
            624-724             AC115863.17        10776-10876         c
            725-2207            AC115863.17        8460-9942           c
FEATURES             Location/Qualifiers
     source          1..2207
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 72.41 cM"
     gene            1..2207
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /note="trafficking protein, kinesin binding 1"
                     /db_xref="GeneID:67095"
                     /db_xref="MGI:MGI:1914345"
     exon            1..234
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    66..68
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /note="upstream in-frame stop codon"
     CDS             147..917
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /note="isoform 6 is encoded by transcript variant 6;
                     trafficking kinesin-binding protein 1; protein Milton"
                     /codon_start=1
                     /product="trafficking kinesin-binding protein 1 isoform 6"
                     /protein_id="NP_001344902.1"
                     /db_xref="CCDS:CCDS90684.1"
                     /db_xref="GeneID:67095"
                     /db_xref="MGI:MGI:1914345"
                     /translation="

MALAIQLRQPSRAQPLPGLSHTLAGTDSCDVCNSTNLPEVEIISLLEEQLPHYKLRADTIYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEVTSVPRSRPLGGGVPLAATASVTVPSA"

     misc_feature    285..>839
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /note="HAP1 N-terminal conserved region; Region: HAP1_N;
                     pfam04849"
                     /db_xref="CDD:461455"
     exon            235..429
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            430..506
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            507..623
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            624..724
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            725..2207
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1375..1380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /note="hexamer: AATAAA"
     polyA_site      1400
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /note="major polyA site"
ORIGIN      

tgtgcgtcccggggcagcgtggggatcttcagctctgccccaacaagcaagcttgggaaaactgctgaggaaggctcagagctgtggccaagcttgcatggaggaccgctctctctccaagtcctctttggagtttgtgtctgcccatggcattggcaattcagctcaggcagccctccagggcccaacctctgccaggactcagccacacactggctgggacagactcatgtgacgtgtgcaacagcaccaaccttccagaagttgagatcattagcctgctggaggaacagctgccccattacaagctaagagcggacaccatctatggttacgaccacgatgactggctgcatacgcccctcatctccccagatgccaacatcgacctcacaactgagcagatcgaagagacgctgaaatacttccttctatgtgccgaaagagttggccagatgactaagacatacaatgacattgatgctgtcacgaggcttcttgaggagaaagagcgggatttggagctggctgcgaggatcggtcagtcattgttgaagaagaacaagaccctaactgagaggaatgaactgctggaagagcaggtggagcacatccgggaggaggtgtctcagctccgacatgagctgtccatgaaagacgagctgcttcaattctacaccagtgccgctgaggagagcgagcctgagtccgtctgctcaaccccgctgaagaggaacgagtcctcctcctccgtccagaattacttccacctggactctcttcagaagaagctcaaggacctcgaagaggagaacgttgtacttcgatccgaggtgacaagtgtaccccgctctcgccccttgggtgggggtgtccctctggcagcgacagcttcagtgacagtgccatctgcttagcgcccatctgaagacatcctgattgagcttgcactctccagtcagggtgctcggctgcaggctccgccttgtgtgggcgtggcttccggggcggggcggctgtcgcagtgggtggagactgagtcgggtacaggcacgcgagccgagcgctggcccgaaggctagggtgattgttaaggagtagagatgcaccaagaggacgacgtaccaggtctcagtaccaggtctcagagacaggtctgccatggtgaacttggaaaggctgggccgaggcagcctgggaacctggaaggcactgtactaggcgccttcccgacgttgttaacgattgttacattactgttattagcatcactgctgttagtcttcacagcggggcctacagctgcttactttgagtctcatttgcagtgagactcaggtgccaggctgttgggtgtttgaagatgtcagagttaataaatgacaaaggccggatccgcagcctctggctctaaacccaagctttttcccccctcacccaccaccactctctaaaacctctgattcgagtagatttagtgttttttttttttttttgtctttattagcattgagcttgtctgtaggcaaagggatggcccttgtctatcagatttgggctgtgagcctaccttagctggctctagacttccagagacaccccaggagggcagaccatctgtcactttgaatttgccacacactggaaagagcctcctgtcaaggcacaaggaactctttcccacggcctatctttgcagaccccacactagtcagcgatttagggtgactgacaatgtcacccaggcttggtcttacagacccatggctgaagaagggcaagcccatgcttcctagctgcagtctcctggcatctggcgcaggtgactgcctcagtcccaggcacccagcccctccatcccaagatagaacacaagggctctgatccaggtgtggtttcttggtggccccatgtgtgccctcagaattttcatctctgcctgtggtcagggcctaccacactcttggagccagctgtctcattcttctctcttcttttcagccagagcaagctgtctaaagtcctacaaatagctatgtgtgccttctctcttttccagttttgttttgggagcaggtctcactatatagctctggctgtcctggaactcactctgtagaccaggctagttttgaactctcagagatatgctttccttcacctcctaagtgctgggattaaaggtgtgcaccatcacttccagacta

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