LOCUS       NM_001331180            5020 bp    mRNA    linear   ROD 08-NOV-2023
DEFINITION  Mus musculus geranylgeranyl diphosphate synthase 1 (Ggps1),
            transcript variant 6, mRNA.
ACCESSION   NM_001331180
VERSION     NM_001331180.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5020)
  AUTHORS   Wang L, Lin Q, Wei B, Guo Y, Li Q, Wang Z, Wu L, Zhang Y, Yin J and
            Wan B.
  TITLE     CircUBR1 knockdown relieves ventilator-induced lung injury through
            regulating miR-20a-5p/GGPPS1 pathway
  JOURNAL   Cell Signal 112, 110920 (2023)
   PUBMED   37827345
  REMARK    GeneRIF: CircUBR1 knockdown relieves ventilator-induced lung injury
            through regulating miR-20a-5p/GGPPS1 pathway.
REFERENCE   2  (bases 1 to 5020)
  AUTHORS   Edwards W, Greco TM, Miner GE, Barker NK, Herring L, Cohen S,
            Cristea IM and Conlon FL.
  TITLE     Quantitative proteomic profiling identifies global protein network
            dynamics in murine embryonic heart development
  JOURNAL   Dev Cell 58 (12), 1087-1105 (2023)
   PUBMED   37148880
REFERENCE   3  (bases 1 to 5020)
  AUTHORS   Cheng Q, Wu J, Xia Y, Cheng Q, Zhao Y, Zhu P, Zhang W, Zhang S,
            Zhang L, Yuan Y, Li C, Chen G and Xue B.
  TITLE     Disruption of protein geranylgeranylation in the cerebellum causes
            cerebellar hypoplasia and ataxia via blocking granule cell
            progenitor proliferation
  JOURNAL   Mol Brain 16 (1), 24 (2023)
   PUBMED   36782228
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5020)
  AUTHORS   Li D, Li C, Wang T, Zhang C, Zhu Z, Zhang G and Fang B.
  TITLE     Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3
            inflammasome activity via promoting autophagy in sepsis-induced
            acute lung injury
  JOURNAL   Int Immunopharmacol 100, 108106 (2021)
   PUBMED   34530204
  REMARK    GeneRIF: Geranylgeranyl diphosphate synthase 1 knockdown suppresses
            NLRP3 inflammasome activity via promoting autophagy in
            sepsis-induced acute lung injury.
REFERENCE   5  (bases 1 to 5020)
  AUTHORS   Shen N, Gong T, Wang JD, Meng FL, Qiao L, Yang RL, Xue B, Pan FY,
            Zhou XJ, Chen HQ, Ning W and Li CJ.
  TITLE     Cigarette smoke-induced pulmonary inflammatory responses are
            mediated by EGR-1/GGPPS/MAPK signaling
  JOURNAL   Am J Pathol 178 (1), 110-118 (2011)
   PUBMED   21224049
  REMARK    GeneRIF: these results reveal a new EGR-1/GGPPS/MAPK signaling
            pathway that controls cigarette smoke-induced pulmonary
            inflammation.
REFERENCE   6  (bases 1 to 5020)
  AUTHORS   Yoshida T, Asanuma M, Grossmann L, Fuse M, Shibata T, Yonekawa T,
            Tanaka T, Ueno K, Yasuda T, Saito Y and Tatsuno I.
  TITLE     Geranylgeranyl-pyrophosphate (GGPP) synthase is down-regulated
            during differentiation of osteoblastic cell line MC3T3-E1
  JOURNAL   FEBS Lett 580 (22), 5203-5207 (2006)
   PUBMED   16978613
  REMARK    GeneRIF: GGPP is critical for the cell-to-cell contact-induced
            differentiation, in which the down-regulation of GGPPS might be
            involved.
REFERENCE   7  (bases 1 to 5020)
  AUTHORS   Bommel H, Xie G, Rossoll W, Wiese S, Jablonka S, Boehm T and
            Sendtner M.
  TITLE     Missense mutation in the tubulin-specific chaperone E (Tbce) gene
            in the mouse mutant progressive motor neuronopathy, a model of
            human motoneuron disease
  JOURNAL   J Cell Biol 159 (4), 563-569 (2002)
   PUBMED   12446740
REFERENCE   8  (bases 1 to 5020)
  AUTHORS   Martin N, Jaubert J, Glaser P, Szatanik M and Guenet JL.
  TITLE     Genetic and physical delineation of the region overlapping the
            progressive motor neuropathy (pmn) locus on mouse chromosome 13
  JOURNAL   Genomics 75 (1-3), 9-16 (2001)
   PUBMED   11472062
REFERENCE   9  (bases 1 to 5020)
  AUTHORS   Vicent D, Maratos-Flier E and Kahn CR.
  TITLE     The branch point enzyme of the mevalonate pathway for protein
            prenylation is overexpressed in the ob/ob mouse and induced by
            adipogenesis
  JOURNAL   Mol Cell Biol 20 (6), 2158-2166 (2000)
   PUBMED   10688662
REFERENCE   10 (bases 1 to 5020)
  AUTHORS   Kainou T, Kawamura K, Tanaka K, Matsuda H and Kawamukai M.
  TITLE     Identification of the GGPS1 genes encoding geranylgeranyl
            diphosphate synthases from mouse and human
  JOURNAL   Biochim Biophys Acta 1437 (3), 333-340 (1999)
   PUBMED   10101267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY273432.1, CD352882.1, BC069913.1 and CT025604.10.
            
            Transcript Variant: This variant (6) differs in the 5' UTR and
            lacks an in-frame portion of the 5' coding region, compared to
            variant 1. The resulting isoform (2) has a shorter N-terminus,
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.88683.1,
                                           SRR7345562.3993448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                BY273432.1         1-92
            93-284              CD352882.1         1-192
            285-2365            BC069913.1         291-2371
            2366-5020           CT025604.10        6394-9048           c
FEATURES             Location/Qualifiers
     source          1..5020
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 5.29 cM"
     gene            1..5020
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik"
                     /note="geranylgeranyl diphosphate synthase 1"
                     /db_xref="GeneID:14593"
                     /db_xref="MGI:MGI:1341724"
     exon            1..283
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    214..216
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik"
                     /note="upstream in-frame stop codon"
     exon            284..354
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            355..5020
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..1116
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik"
                     /EC_number="2.5.1.1"
                     /EC_number="2.5.1.10"
                     /EC_number="2.5.1.29"
                     /note="isoform 2 is encoded by transcript variant 6;
                     geranylgeranyl pyrophosphate synthetase; geranylgeranyl
                     pyrophosphate synthase; GGPPSase; GGPP synthetase;
                     geranyltranstransferase; farnesyltranstransferase;
                     dimethylallyltranstransferase; farnesyl diphosphate
                     synthase; (2E,6E)-farnesyl diphosphate synthase; GGPP
                     synthase"
                     /codon_start=1
                     /product="geranylgeranyl pyrophosphate synthase isoform 2"
                     /protein_id="NP_001318109.1"
                     /db_xref="GeneID:14593"
                     /db_xref="MGI:MGI:1341724"
                     /translation="

MLHNASLLIDDIEDSSKLRRGFPVAHSIYGVPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDTYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLDTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVQYLEDVGSFAYTRHTLRELEAKAYKQIEACGGNPSLVALVKHLSKMFTEENK"

     misc_feature    376..963
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik"
                     /note="Polyprenyl synthetase; Region: polyprenyl_synt;
                     pfam00348"
                     /db_xref="CDD:425626"
     misc_feature    order(379..381,388..396,400..408,412..417,430..435,
                     589..591,598..600,664..669,676..678,775..780,787..789,
                     817..819,832..834,847..849)
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik"
                     /note="substrate binding pocket [chemical binding]; other
                     site"
                     /db_xref="CDD:173833"
     misc_feature    388..417
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik"
                     /note="chain length determination region [active]"
                     /db_xref="CDD:173833"
     misc_feature    order(403..408,415..417,430..435,598..600,664..666,
                     775..780,787..789,817..819,832..834,847..849)
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik"
                     /note="substrate-Mg2+ binding site [active]"
                     /db_xref="CDD:173833"
     misc_feature    order(403..408,415..417,430..435,664..666,775..780)
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:173833"
     misc_feature    order(403..408,415..417,430..435,598..600,664..666)
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik"
                     /note="aspartate-rich region 1; other site"
                     /db_xref="CDD:173833"
     misc_feature    order(421..465,796..801,817..834,841..855)
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik"
                     /note="active site lid residues [active]"
                     /db_xref="CDD:173833"
     misc_feature    order(775..780,787..789,817..819,832..834,847..849)
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik"
                     /note="aspartate-rich region 2; other site"
                     /db_xref="CDD:173833"
ORIGIN      

tgcgttcgacgagagaggggaggggaaggaggcgcggccatgaggcagaggggaggtggcatacgacgcctgcgcagtgtgatagggatggcgtattttcttgcactgagtgctgcggcgtcgctggccgctgaggagggcagagatttctgtgtgaaatagtgggagggctccaaggaagcctcttgaagagccgcagtcagaacaataaattgagaagtcgatgtgggcactgctagtctcgtaccggcggcggcttcaagtctgagatcatcgtggaaccgtaaacaggtgagaagcaaactttcacaggcatttaatcactggctgaaagttccagaagacaagctacagattatcattgaagtgactgaaatgttgcataatgccagtttactcattgatgatattgaagacagttcaaagctccgacgtggtttcccagtggctcacagcatctatggtgtcccatctgtcattaattctgccaattacgtctacttccttggactggaaaaagtcttaacccttgatcacccggatgcggtgaagcttttcacacgccagcttctggaacttcatcagggacaaggcctcgatatttactggagggacacctacacttgtccaactgaagaagaatataaagccatggtgttgcagaagacaggtggtttgtttggattagcagtaggtcttatgcagctgttctctgattacaaagaagatctaaagccactgcttgacacacttgggctctttttccagattagagatgattatgccaatctacactccaaagaatacagtgaaaacaaaagtttctgtgaagacttgacagaagggaagttctcattccccactatccatgccatttggtcaaggccagaaagcacccaggtacagaacatcctgcgccagagaacagagaatatagatattaaaaagtattgtgtgcagtacctggaggatgtaggttcttttgcatacactcgacacactcttagagagcttgaagctaaagcctacaaacaaattgaggcctgtggtgggaacccttcactagtggctttagtcaagcacttaagtaagatgttcacagaagaaaataaataatactatcctttctggattagactcagtagcttctttcagttgaaaatgaggagtggcttcatcccatttatcttttcttttttttttttttaagatttatttattatatgtaagtgtagctgtcttcagacactccagaagatggagtcagatctcattacggatggttgtgagccaccatgtggttgctgggatttgaactccagaccttcagaaagccaccatcagaagagcagttgggtgctcttacctactgagccatctcaccagccccaccatttatcttttcaagtactagactccaataattgagtaaatgagggtgacgtgtgtaaaagtgttatgttatcaaaatccctttgcataaaaatacaaaattgagggctggagagatggcttagcagttaaaaagctgcttttccagagaaccccggttcaatttccagggcccacagtgaagttcaccaacacctgtaactccatttccagatcatcttctggacttttcaggcaccaggcacacacataggtatacaaacatgcacaatattcagacacataagatatttaatttttatttttttaaaaacaaagttgaaactatcaggaatcacataacgtaggtcataaatgtcagacactaagtgtgacagctcttcctacgaccccacgtgctctgggcttgtcaataaaaaagactgatcttccaagaaactatctgctttctaactatatgacatggagggttctcagtccatagatgacaattcaaaacaagtctctttagctaactgactaaaaagaccaaagaactgctgtttttccctaaatgataatgccaagagtacctcagttttgtctctgaagacctgtgtcaaagtctgaaaagacagaaagaatgcacaggcactcttccacccaacttgtttgtttcaatgcttgacaccccacaaattgtcctttttaacaaaagaggctccacttagtgaagttcaattcacaacctggttccattgtttttttctggtttgtttgtgttttttcttgtaacatttttctaccccaaactgattagtatctgtgattaatgtttctttgaaggaagaaaataatagaaaaggtgtttgtggagtacatgagtaatgccagcattccattggtagagtcaggaagatcagaagctcaaggttatactcagctatatataagtttgtgaccagtctgaactacaggggacattgcatcaaaagaaaagaaaaagaaaaaactgatatatattttttttaatttcttgagacaggtttcactcactatgcagttctagctggcctagaactcaagggtccatcagcttggcttctgcctctttgagagctaggatcaaatgtgtgtcctaccatgcctggcaaagactctgtaagtcaatttatttccttgcctaattaaattaattttggcctggtacttaatagtgaattaaggacctttttagagtcattttgtctatccaataatcaaaatctcgttctttatttggtctatggttcccaaatgttaattcagaagagacccaggaagctggagagatggctcagaggttaagaacactggctgctcttccagaggaccctggttcagttcccagcacccacatggcagttcacaactgtctgtaacttcagttccagaagatctaataccatctcacagacatacatgtaagcaaaatacaaatacacattaaaaaaaaattatctgaagagacccagaacatgagtagctgagttcatttaataaaatgactttatttgcttagatttgtgctacaataatgcttttcctgcctaagaaagtcttgagatatcctcttcgagaaatgttggattttgctgtgtcaaagacatactttttgtttgtttgttttgttttgttttttgagacagagacatactttttaaacaatataaattttctaatttatgcagcttcagaaaaacattaagtttttatatcaaatctgcaagaataaaggtcagttgtattgccataatgtttttttctttcctttgatgtctaaactattgttgacctcactattttccttcagccttttccttcctgggccagccagtgctgctagggaatggattcctgtctgctcttgtagccactgctgccttgttgagcaactcctgtcctgggtagcctgtatcattggctcttcttcctttcctagcagaaaaggagattcctcaactagcaatggaatgtcccttattatctttttctgttctccacctatcaaatgtggaatctcctacctttctttcttcaaattttttacttcaaatctgcctttaagtagtcagccttttatttccaaaaatgtaaaccagatgagatggcacatgcctgtagtattagttcttaggggaaatagagattaaaagttgagggtcctgattggctacatagtgggctagaactagcctggattttgttagaatttgccctgcagccttaggcgaaaggagctcttgagctctagaggccttgtaacatcccaggctgtaattctcaggcatcctaaagctcattttaagctatgtgataagaaacaggggaaagacacgtatatttatacaactttaatcccagcactcaagtggcagaagccggcagatctcttatcatctggtatacagagaaagttccagacagagcagcatagtggactgactgtctgtgtgtgtgtgtctctctctctcaaaaaaaaagcttcaaatacaaaaaaaaaagggctcaaaataatgaaccctacagtagtatgagttcatgtataatagagttagcattttgcttcctcaaccctaacaccccacttggctaaacacaatcactctgcttatcttaattcatctttttatatttacattcaatatgttgagaatgagctataatgtgaaggcattgtttgaccatgtactacttggttaaaaaaaaatacaaaaataaaataaaatcactgatataaatttcaatgttaatttgctcaactccgctccgtacagtatttcctaacacttaattggcactgacacagaagtggctagttgtttgtcattcttttttttttatgtatgtatgtatgtatgtatgtatgtatgtatgtatgtatgtatgttgtttgtttgtttaatgtagcccttgttgggctagaacctgatttgtagatctgagctcaactcagagatctttgtcagagtgcagggattaaacacatgtgccatcactcccagcaaaggctattctatgcaacactactttagaagaatcaccaactttgtattgtttatcactgtacttaaaaagaaggctgtgtttgaagaaataatctatgaaacaaggtcgttgaacctcttttgggtgaaggtcttagtcactgttctattgttgtgaagagataccatggccaaagcaattcttataaatgaaagcatttaatttggggatctgcttacagtttcagtcagtctgttatcagctagtaggaacatagtgtcactcatggccctggagtagtggcttagaactgtgtcctgatctgtaggcagcagattcggtctggcatgaggttctaaaacctcaaagtccactccagtgacacacttcctccaacaaggccacacctccaaattctaattttgtcaaagaattgcactccctggtgactaaggattcagatatatgagcctagagggtcattcttatttaaaccaccacagtgaggtagttcagtactaatggtaagctgttagatggtgtggaaatttttttgaaacttgccagttgcttaatagaaattgtaaattgggaataaacatttcagcagtgttttaaagag

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