LOCUS       NM_001291104            3098 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus fibroblast growth factor 11 (Fgf11), transcript
            variant 2, mRNA.
ACCESSION   NM_001291104 XM_006532189
VERSION     NM_001291104.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3098)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3098)
  AUTHORS   Cho,J.H., Kim,K., Cho,H.C., Lee,J. and Kim,E.K.
  TITLE     Silencing of hypothalamic FGF11 prevents diet-induced obesity
  JOURNAL   Mol Brain 15 (1), 75 (2022)
   PUBMED   36064426
  REMARK    GeneRIF: Silencing of hypothalamic FGF11 prevents diet-induced
            obesity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3098)
  AUTHORS   Meuser,M., Deuper,L., Rudat,C., Aydogdu,N., Thiesler,H.,
            Zarnovican,P., Hildebrandt,H., Trowe,M.O. and Kispert,A.
  TITLE     FGFR2 signaling enhances the SHH-BMP4 signaling axis in early
            ureter development
  JOURNAL   Development 149 (1) (2022)
   PUBMED   35020897
REFERENCE   4  (bases 1 to 3098)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3098)
  AUTHORS   Tejedor,G., Laplace-Builhe,B., Luz-Crawford,P., Assou,S.,
            Barthelaix,A., Mathieu,M., Kissa,K., Jorgensen,C., Collignon,J.,
            Chuchana,P. and Djouad,F.
  TITLE     Whole embryo culture, transcriptomics and RNA interference identify
            TBX1 and FGF11 as novel regulators of limb development in the mouse
  JOURNAL   Sci Rep 10 (1), 3597 (2020)
   PUBMED   32107392
  REMARK    GeneRIF: Whole embryo culture, transcriptomics and RNA interference
            identify TBX1 and FGF11 as novel regulators of limb development in
            the mouse.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3098)
  AUTHORS   Dichmann,D.S., Miller,C.P., Jensen,J., Scott Heller,R. and Serup,P.
  TITLE     Expression and misexpression of members of the FGF and TGFbeta
            families of growth factors in the developing mouse pancreas
  JOURNAL   Dev Dyn 226 (4), 663-674 (2003)
   PUBMED   12666204
REFERENCE   7  (bases 1 to 3098)
  AUTHORS   Hajihosseini,M.K. and Heath,J.K.
  TITLE     Expression patterns of fibroblast growth factors-18 and -20 in
            mouse embryos is suggestive of novel roles in calvarial and limb
            development
  JOURNAL   Mech Dev 113 (1), 79-83 (2002)
   PUBMED   11900978
REFERENCE   8  (bases 1 to 3098)
  AUTHORS   Bachler,M. and Neubuser,A.
  TITLE     Expression of members of the Fgf family and their receptors during
            midfacial development
  JOURNAL   Mech Dev 100 (2), 313-316 (2001)
   PUBMED   11165488
REFERENCE   9  (bases 1 to 3098)
  AUTHORS   Munoz-Sanjuan,I., Smallwood,P.M. and Nathans,J.
  TITLE     Isoform diversity among fibroblast growth factor homologous factors
            is generated by alternative promoter usage and differential
            splicing
  JOURNAL   J Biol Chem 275 (4), 2589-2597 (2000)
   PUBMED   10644718
REFERENCE   10 (bases 1 to 3098)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603707.5 and U66203.1.
            
            On Apr 21, 2018 this sequence version replaced NM_001291104.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066859.1, SRR7652917.1100071.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-655               AL603707.5         180855-181509       c
            656-1063            U66203.1           1-408
            1064-1249           U66203.1           493-678
            1250-1286           AL603707.5         177394-177430       c
            1287-3098           AL603707.5         175297-177108       c
FEATURES             Location/Qualifiers
     source          1..3098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.88 cM"
     gene            1..3098
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="fibroblast growth factor 11"
                     /db_xref="GeneID:14166"
                     /db_xref="MGI:MGI:109167"
     exon            1..848
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    581..583
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="upstream in-frame stop codon"
     CDS             656..1249
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     fibroblast growth factor homologous factor 3; fibroblast
                     growth factor 1d"
                     /codon_start=1
                     /product="fibroblast growth factor 11 isoform 2"
                     /protein_id="NP_001278033.1"
                     /db_xref="CCDS:CCDS70218.1"
                     /db_xref="GeneID:14166"
                     /db_xref="MGI:MGI:109167"
                     /translation="

MAALASSLIRQKREVREPGGSRPVSAQRRVCPRGTKSLCQKQLLILLSKVRLCGGRPTRQDRGPEPQLKGIVTKLFCRQGFYLQANPDGSIQGTPEDTSSFTHFNLIPVGLRVVTIQSAKLGHYMAMNAEGLLYSSRRSGRAWYLGLDKEGRVMKGNRVKKTKAAAHFVPKLLEVAMYREPSLHSVPETSPSSPPAH"

     misc_feature    863..1168
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="FGF domain, beta-trefoil fold, found in acidic and
                     basic fibroblast growth factor (FGF) superfamily; Region:
                     beta-trefoil_FGF; cl00060"
                     /db_xref="CDD:469595"
     exon            849..959
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1063
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1178
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1286
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..3098
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3074..3079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="hexamer: ATTAAA"
     polyA_site      3093
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="major polyA site"
ORIGIN      

gggggtgacaatgagaaaaagcattatccagccagggggcctgggaaccccttttcactgaacctaaacagcctgaattttgagtcatatttgctggcagaggggggatttgaagaaagtgggagacccactccatttagagtatagaaaaggaaaaaagaaaacagagctgggctcctcttgacattgacagcagcctagggtgagctaatgtccacaaagcttaggacccacaccctgtgtaagagtaggctgggcaggagcggccccaaaatagggtagaaagaagcctcggggtattgagaacacatcttagaaatataggagggtcttgactgtgggatagaggaggtatcttctatctggtacagaggccagagaggagggaaggggaaagctttcattaggggacagaattcatgggtgaggtcagctgaggagtgcataggctgctggagccgctggagctagtcagggcccaagggtgggagccggtggtgttggggaacgtactggggtctggggtttctcttcagatcctgtgggtggggcggtgggttgggtcctgagcatgccctggtgagagggctcctcttggggagcccagggcgctccgggagcctgctggtttgggggtgtctcctcccggggcgcgatggcggcgttggccagtagcctgatccgacagaagcgggaggtccgcgagcccgggggcagccggcccgtgtcggcgcagcggcgcgtgtgtccccgcggtaccaagtcactttgccagaaacagctcctcatcctgctgtccaaggtgcgactgtgcggggggcgtcccacgcgacaggaccgcggcccagagcctcagctcaaaggcatcgtcaccaaactgttctgccgccagggtttctacctccaggcgaatcccgatgggagtatccagggcaccccagaggacaccagctccttcacccacttcaatctgattcctgtgggactccgtgtggtcaccatccagagtgccaagctgggtcactacatggccatgaacgctgaggggctattgtacagctcgcgtcgttctggccgggcctggtacctaggcctggacaaggaaggccgggtcatgaagggaaaccgagtcaagaagaccaaggcagctgcccactttgtgcccaagctcctggaggtggccatgtaccgggagccttctctccacagtgttcctgagacctccccttccagtccccctgcccactgagatatagtccctggactggaggctccctgctcttccagcaccggggttccaacactcaaggcaggaaggtaatactcttcaccctggctgagccagtctctgaagccatgtccttctttgcatcgtctcgaagccatagctttctaggtcggtccactggcactcagaatgcatctccttctctctctgctctaccttctgacttggtctggacaggttctgatagagctggtcaccccagccaggcagggccatccctatgttctgtgttggaacccaagtatgtatcctttccacgtctatccttgtcctagatggacacctcccacccctggctttaaaaaagaggccccctactgtagcaattggccttggtctgaattgggaccagtctcaggtcaccactgattaaaccttcttatcccagagacacccaattctagaacgtggtattctagacctttctggagccatacttcctcctgaatctcagttctaggacatagcccatgactctcagccctttcttcccggatggagctagggcctgtatagccatattattgtactagagtaagttctagacctacccttccactttctctagcaattaaaggatgagctatgggtagaactcagctatgattaattaaaaactgattggctctgagctgtgcttggtggcacacacctgtaattcagcacccgggaggctgaatcagacagatcctgagttggaggccatcctgggctacaatagcaaaaccctgtctcaaaagccaatacacacacacacatacacacacacacacacacacacacacagagagagagagagagaaagagagagagagagagagagagagagagaactaatcagtactgaacggatcaagaaccacttcttgcttttcctaaataattttctaaaaatagtccctccagaatactaaccttacttttacatggtttctagtttcagcattccaactagggttctgccagggagacaagagtctggggaaagatacaggaattctggaagaatatacctggctcctagaagggaagctgagagggagaaaatgccatggtatgattgaacctgtgtctgaacacttagctacctcagcaggaattccttccagatcccttttaaagctgaggactttcgttctgatatggtatgctgcatctgtgaggtaaaggagaggaggagaatcaggaaataaaaggctagcctgggctacctagtgaggtcagggccagcctaggctatgtgagaccctgtctcaaacaacaggaagctaaggtctacaatgagaataactctagaattaaaaaggacaaatagggacacagccttgactccccctcacagcagagagacccccaactcagcaataagttcaacttctccgagccctctacaggtcaggcttaggaaacgaggagcctcttgggctcccagacctcatatgtatccccagagcttctaactaaatagaatttactttactttacagcttttaaacctcaggtgggttctaagtacccaaaaaggacctgaaaaacggagaaagccatggggaacctctagtaaaataggaggtagattctgagtctagcagatgtaggtggaaacgtctattgaggtcctaagggaggggctagtgctcaaagacaggtcacttttcctcaggcccttttacttctggcttgttgcaagagatgcccccctccctcatacaaaccccgctcaggctccgcccatctcctggcactgctctcaggggacggggtctccacttcatgctttctgtaattaaagatgatttatacaaccgga

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