LOCUS       NM_001285895            1896 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus calreticulin 4 (Calr4), transcript variant 1, mRNA.
ACCESSION   NM_001285895
VERSION     NM_001285895.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1896)
  AUTHORS   Diaz Del Moral S, Barrena S, Hernandez-Torres F, Aranega A,
            Villaescusa JM, Gomez Doblas JJ, Franco D, Jimenez-Navarro M,
            Munoz-Chapuli R and Carmona R.
  TITLE     Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac
            Troponin-T Lineage Reveals Novel Functions of WT1 in Heart
            Development
  JOURNAL   Front Cell Dev Biol 9, 683861 (2021)
   PUBMED   34368133
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1896)
  AUTHORS   Ansarullah, Jain C, Far FF, Homberg S, Wissmiller K, von Hahn FG,
            Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J,
            Oppenlander L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M,
            Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R,
            Plettenburg O, Muller TD, Meier M, Tschop MH, Coskun U and Lickert
            H.
  TITLE     Inceptor counteracts insulin signalling in beta-cells to control
            glycaemia
  JOURNAL   Nature 590 (7845), 326-331 (2021)
   PUBMED   33505018
  REMARK    Erratum:[Nature. 2021 Apr;592(7852):E1. PMID: 33712809]
REFERENCE   3  (bases 1 to 1896)
  AUTHORS   Dey S and Matsunami H.
  TITLE     Calreticulin chaperones regulate functional expression of
            vomeronasal type 2 pheromone receptors
  JOURNAL   Proc Natl Acad Sci U S A 108 (40), 16651-16656 (2011)
   PUBMED   21933956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JN255799.1, AL627103.13, AK139540.1 and BG083829.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: JN255799.1, SRR15390196.211590.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                JN255799.1         1-32
            33-106              AL627103.13        71060-71133
            107-1320            JN255799.1         107-1320
            1321-1876           AK139540.1         1336-1891
            1877-1896           BG083829.2         516-535
FEATURES             Location/Qualifiers
     source          1..1896
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.1 cM"
     gene            1..1896
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /note="calreticulin 4"
                     /db_xref="GeneID:108802"
                     /db_xref="MGI:MGI:2140435"
     CDS             1..1320
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="calreticulin 4 isoform a precursor"
                     /protein_id="NP_001272824.1"
                     /db_xref="GeneID:108802"
                     /db_xref="MGI:MGI:2140435"
                     /translation="

MRSLSLLPLLLLTSCTFRTQGKRRQVYFREEFEDGDGWTKRWVQSKHQSDYGQFQLASGKFYQDKERDKGLQTTEDAKFYALSTRFKPFSNENETLVVQFSVKHEQGIDCGGGYVKLFPAALNQEDMHSESQYYIMFGPDICGFGNNRLQVILSHKGKYHENNKTLKCRINKDTHLYTLILRPNATYEVKIDNQKVTSGGLEDDWDFLPPKKIKDPYARKPRKWDERQQIEDPDDKKPEDWEDSEFIPDPDAKKPDDWNEAMDGVWEGPLIPNVKYMGEWKPRIIDNPNYQGEWIHPEIDNPKYRPDPTIGHYHNISVLGLDLWQVKSGSIFDNFLLTNDEEFAEEVGNMTWGLRKDVEQQWRELYEEMEKQKEAEETKKKREKERARQEDVWGLDEEDEEDAEEDDEEEAEERLKQEGSAARASLDQKEAHLDQKDEL"

     sig_peptide     1..63
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    82..1011
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /note="Calreticulin family; Region: Calreticulin;
                     pfam00262"
                     /db_xref="CDD:459737"
     exon            1..106
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            107..208
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            209..412
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            413..507
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            508..717
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            718..831
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            832..975
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1068
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1896
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgaggagcctgtcgctgctgcctctgctgctgctgacctcctgcaccttcaggacgcaggggaagagacggcaagtctacttccgggaggagttcgaagatggggatggatggacaaaacggtgggtacaatctaaacatcagtcagattacggccaattccagctagcctcgggaaaattttatcaagataaagagagagataaaggtctccagaccacagaagatgccaagttctacgccctttccaccaggtttaagccattcagcaatgagaatgagaccttggtggttcagttttcagtaaaacacgagcaaggcatcgattgcggcggtggctacgtgaaactctttcctgccgcactgaaccaggaggacatgcactcagaatcccagtattacatcatgttcggcccggacatctgtggctttggcaacaacagactacaggtcatcctttctcacaaagggaaataccatgagaacaacaagaccctcaagtgcaggattaataaagacactcacctgtacactctgatccttcgccctaatgctacttatgaggttaaaattgacaaccagaaggtgacaagtggaggactggaagatgactgggacttcttgcctcccaagaaaataaaagacccctacgccaggaaaccaaggaaatgggatgaacgacaacagatagaggatcctgacgataagaaacctgaggactgggaggactctgaattcatcccagacccggatgccaagaagccagatgactggaatgaggcgatggatggagtgtgggaagggcccttgataccaaacgtcaagtacatgggagaatggaaacctcggatcattgacaaccccaattaccagggcgagtggattcacccagagatagacaaccccaaatacaggcctgaccccaccattggtcactatcacaacattagtgtccttggtctggatctttggcaggtgaaatcaggcagcatctttgacaatttccttctaacaaatgatgaagagtttgctgaagaggttggaaatatgacctggggattaagaaaggatgtggagcagcagtggagagagctgtatgaggaaatggagaaacagaaggaggcggaggagaccaagaagaagagggaaaaggagagagccaggcaagaggacgtctggggactagatgaggaggatgaggaggacgctgaagaggacgacgaggaggaagcagaggaaaggctcaagcaggaaggcagtgcagcgagggcgtctctggaccagaaggaagcccacttggatcagaaggatgaactgtaactgcacagacactgggtgtggccgaagtcagagacggtgcttagagagggaaatgggccctcgcttagcaaattatgggaagtaaaacgactcattctttttagataaactttggatttatagttctactccccttccctgctctatttgctcattggtagaaagggaatgataattttatctcatgaaatggcccttgggactgaatgaggcaatgcctgtaacatgcccaaagtaaatacttgtaaaaaaaatgtagtagttaaaactactatcattatcatggtgtttatgaaattaattgttggtaaataagcttctatataaacttggttcttactttcaactggggtttttcttttgtttaaatatatgcaattcttagtatttatggagcagtgctaacagttgaacccaatgtttccttttttttttttttttttaaatgtattgagcacctaaagccaaaagcagaacatcctttggacgtttggaaaaatacttcatgaaagtcaccttgtttgcctgctgctcttgccttatgtttaaacaattgttacttgtttgcaagtttgc

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