LOCUS       NM_001025570            4098 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Mus musculus paired related homeobox 1 (Prrx1), transcript variant
            3, mRNA.
ACCESSION   NM_001025570
VERSION     NM_001025570.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4098)
  AUTHORS   Hossain,M.N., Gao,Y., Li,X., Zhao,L., Liu,X., Marie de Avila,J.,
            Zhu,M.J. and Du,M.
  TITLE     Single-cell RNA transcriptomics in mice reveals embryonic origin of
            fibrosis due to maternal obesity
  JOURNAL   EBioMedicine 109, 105421 (2024)
   PUBMED   39476533
  REMARK    Erratum:[EBioMedicine. 2025 Feb;112:105573. doi:
            10.1016/j.ebiom.2025.105573. PMID: 39874704]
REFERENCE   2  (bases 1 to 4098)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   3  (bases 1 to 4098)
  AUTHORS   Ning,Y., Duo,S., Lin,X., Zhang,H., Fei,J., Zhang,B., Zeng,Y.,
            Xie,D., Chen,J., Liu,X. and Han,C.
  TITLE     Transcription factor PBX4 regulates limb development and
            haematopoiesis in mice
  JOURNAL   Cell Prolif 57 (5), e13580 (2024)
   PUBMED   38230761
REFERENCE   4  (bases 1 to 4098)
  AUTHORS   Qiu,C., Martin,B.K., Welsh,I.C., Daza,R.M., Le,T.M., Huang,X.,
            Nichols,E.K., Taylor,M.L., Fulton,O., O'Day,D.R., Gomes,A.R.,
            Ilcisin,S., Srivatsan,S., Deng,X., Disteche,C.M., Noble,W.S.,
            Hamazaki,N., Moens,C.B., Kimelman,D., Cao,J., Schier,A.F.,
            Spielmann,M., Murray,S.A., Trapnell,C. and Shendure,J.
  TITLE     A single-cell time-lapse of mouse prenatal development from
            gastrula to birth
  JOURNAL   Nature 626 (8001), 1084-1093 (2024)
   PUBMED   38355799
REFERENCE   5  (bases 1 to 4098)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4098)
  AUTHORS   Uelmen,P.J., Oka,K., Sullivan,M., Chang,C.C., Chang,T.Y. and
            Chan,L.
  TITLE     Tissue-specific expression and cholesterol regulation of
            acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice.
            Molecular cloning of mouse ACAT cDNA, chromosomal localization, and
            regulation of ACAT in vivo and in vitro
  JOURNAL   J Biol Chem 270 (44), 26192-26201 (1995)
   PUBMED   7592824
REFERENCE   7  (bases 1 to 4098)
  AUTHORS   Leussink,B., Brouwer,A., el Khattabi,M., Poelmann,R.E.,
            Gittenberger-de Groot,A.C. and Meijlink,F.
  TITLE     Expression patterns of the paired-related homeobox genes MHox/Prx1
            and S8/Prx2 suggest roles in development of the heart and the
            forebrain
  JOURNAL   Mech Dev 52 (1), 51-64 (1995)
   PUBMED   7577675
REFERENCE   8  (bases 1 to 4098)
  AUTHORS   Weiss,K.M., Ruddle,F.H. and Bollekens,J.
  TITLE     Dlx and other homeobox genes in the morphological development of
            the dentition
  JOURNAL   Connect Tissue Res 32 (1-4), 35-40 (1995)
   PUBMED   7554933
REFERENCE   9  (bases 1 to 4098)
  AUTHORS   Kern,M.J., Witte,D.P., Valerius,M.T., Aronow,B.J. and Potter,S.S.
  TITLE     A novel murine homeobox gene isolated by a tissue specific PCR
            cloning strategy
  JOURNAL   Nucleic Acids Res 20 (19), 5189-5195 (1992)
   PUBMED   1383943
REFERENCE   10 (bases 1 to 4098)
  AUTHORS   Cserjesi,P., Lilly,B., Bryson,L., Wang,Y., Sassoon,D.A. and
            Olson,E.N.
  TITLE     MHox: a mesodermally restricted homeodomain protein that binds an
            essential site in the muscle creatine kinase enhancer
  JOURNAL   Development 115 (4), 1087-1101 (1992)
   PUBMED   1360403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK084387.1 and AC120173.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089006.1, AK032773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1767              AK084387.1         19-1785
            1768-4098           AC120173.9         80517-82847
FEATURES             Location/Qualifiers
     source          1..4098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 70.53 cM"
     gene            1..4098
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="paired related homeobox 1"
                     /db_xref="GeneID:18933"
                     /db_xref="MGI:MGI:97712"
     exon            1..1256
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    785..787
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="upstream in-frame stop codon"
     CDS             1016..1618
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="isoform c is encoded by transcript variant 3;
                     paired mesoderm homeobox protein 1; homeobox protein K-2;
                     homeobox protein mHox; paired-related homeobox protein 1;
                     muscle homeobox protein"
                     /codon_start=1
                     /product="paired mesoderm homeobox protein 1 isoform c"
                     /protein_id="NP_001020741.1"
                     /db_xref="CCDS:CCDS56651.1"
                     /db_xref="GeneID:18933"
                     /db_xref="MGI:MGI:97712"
                     /translation="

MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADESVGEAGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYR"

     misc_feature    1016..1087
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="propagated from UniProtKB/Swiss-Prot (P63013.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1076..1078
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P63014; propagated from
                     UniProtKB/Swiss-Prot (P63013.1); phosphorylation site"
     misc_feature    1175..1324
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="propagated from UniProtKB/Swiss-Prot (P63013.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1310..1468
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1493..1495
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P63013.1); acetylation site"
     misc_feature    1604..1606
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="Phosphoserine. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (P63013.1); phosphorylation
                     site"
     exon            1257..1432
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..4098
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3730..3735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="hexamer: AATAAA"
     polyA_site      3761
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="major polyA site"
ORIGIN      

gaggaaaaggaggtaggagattgtgatggagaaagggggtctgtaaaacgtcaggcgccgcacaaaggctttgccacgtaattacaggctcctattaagtggagatctgccctcccaggggtctccaattttcttgtattccctacaaagcctcctctccatgccagcctgtgccttttgaagtgccagagagcttcttgatccaactgagaagggaaaaggagctccgcacggagaagggggagagagcggagggaagggggaccgccacccttctgcagactcttgaagccccgcttctttatttcttatttttttttcctccttacgaagagtaaagtgagaatcctgctctctaatacatctgcaagacatcactctcctgaaattctagtcactcccgagaatccacaggagtgcagagagggggaacgcgctttcttgaagacattttaaagctggaacaagccttcttctgttggcgcttgaactcttgccgggggaataactttttttaacctctttctctaatttttttaaagccactttgattcttctctccaccccttcttctctcttctgtttgcctaactcccccgccccgctggcctcccctttcctcgctcccccttattattatttttagtgtctgcgagtggacgctttttaagagttgaaagggatattttttttctttttgatctaagcataggttgtttgttttgtttttatttttgaactttttggtgtggattatctctctggaccgcgctggacttggctttagcgaagtaaccgaggctgcagggaaagttacttgtcccgaaagttctacacttcagaaggggtcccaccctctgtttctctctctctctctctctctctctctctctctctctctctctccactcccccctctttcttccccactcggctcctctcccccctcacgcccacagcgtttggtgttgattcgagcgggaagaggggggtgggtgggattggaggggagaccatgacctccagctacgggcacgttctggagcggcaaccggcgctgggcggccgcttggacagcccgggcaacctcgacaccctgcaggcgaaaaagaacttctccgtcagtcacctgctagacctggaggaggccggggacatggtggcggcacaagcagacgaaagtgtgggcgaggcgggccggagcctgctggagtcaccgggactgaccagtggcagcgacacccctcagcaggacaatgaccagttgaactctgaggagaagaagaagagaaagcagcggagaaacaggacaacattcaacagcagccaactgcaggccttggagcgtgtctttgagcggacacattacccggatgcttttgttcgagaagatctcgcacgtcgggtgaacctcactgaggccagagtgcaggtgtggtttcagaaccgaagagccaagttccgcaggaatgagcgagccatgctggccaataaaaacgcttctctcctcaagtcctactcaggagacgtgactgctgtggagcaacccatcgtacctcgtcctgctcccagaccaaccgattatctctcctgggggacagcctctccgtacaggtgaatgactggcccactctctcttgctccacttccacacgctccccagccatccaccactctcaaggctgcttttgcagctggctgacattccttactgggtttacctcttcagagacattcaacttgctggcatccacacacttttttttttccaggagatttctagttgccccaggagcagggcttggggcagaagagagaggggcagccaccagcagtctccttctggactcaggaattcttgccaaggttgcaagactgggaaagaatataaatgaacagatcctttgtaaactgtgcccgatggccctcttggaaccattctggaacaaaagtatcccatttaagacacatttgctgtgttatggccaagtagggaatcaacgtgtaattactccaagtgtaggactaaaggcactcttcacaataaatctgattttgaatgaaaaggaaaggaggaaggctggaagggaggaggggtgaggcaaggatggagggaggaggaggaggaggagagaaaggagtgagacaggagggaaagaggaaaagtcagcaacagagaagctcattttaatcactttcatgaccctagaactttgttagggagaaggttttctttagattcccagtacttcctactccgtttgtacttcttatgtatcccaatctctctctctctctctctctctctctctctctctctctctctctctctctctctctcctgtgatatgctttaaatagaaaagaagaatacactaaacttttatattaagaaggaatcatttacagctggaaataatagatgactatttcaatccctatctggacactttcgccctccattcatggtgcctttcagaaatcacaggttgacataaacgcacctaggattcctggactgaacccgatcaggctagtatgcctttctttaaaccttggagaaacccaagtcaaggctattatatatcctgcccagaagaactatgttcacattcatttttctattgaatgacatctgtgtatctttttaaagttaatgcttgacccatggagggatttaaaactggttacagggaattgggcccagataaagatgagaaatgccacatttgtgaaacacaagtgctttgacacacttgataggtgccactaaatcccaaagcctcatctaaatgctctctcaggtccaagtaagttcttcagagaaacgtcgtagatgcatttggaagttttctacacaccccttgtgaacttagcctgaagcagctctgatctcaacgataggtatctgtgtctgtaagaatgagagaaacccatgtatgttctgggtcttcattggcccaacccttgtggccatgtctatgttacctacttgatatttagatgcttctcctgtagaacttactaaaaacacattttggagactgtttgtgtatagcatattctataatattttaagtaagagaaggactgttttccctacaactattggtagtccatagagtcagtgaacaggaatatgggtatagttcagaggtggtgcattaagctctctggtttgaatttgcgtctacccgggaagtattgctcctttttctccttatgtcttctttgggatttttaccccaagcaattaaccatccagatggctgccatgtggtccctactcatggagctgaacacagcatactgcacaaatggaaatgagatccttcctgaactagcatcaagttaggcaatctgaaccaaagagacatgccccagtgtgggcatctagcagaaactagtaacatgggggtttggtgtgccttttggggaaatattctattttaattgaaaaaaatatagaaattctattttgaaaatccactcataatctcaccatcttgacattagttagctcattttatgattagagtccattagtttatatagggatagtcttagtgtatatattattttgtattatgctcttttatcgtttaaaactgtgtaacttagtactttatactaatttcgtggtatgcatttatttctcttatacacaatgtttgtaaaaaaagccaattgaagcaatatagaagctaattgttcatattttgtatgaagaataaaactaatatccaatataagtaaaaaaagcaaaagtttaaggccacaatttaatcaatggtatgtttctttgacctattgttaactgaagtgtttttaatctcattaatttccaaaagtgtcaaagactattctgttacttggggatgtttctgctatgtttagaatcaaatatattatggttttacagtttgaagctttctaggaaacataactgttattgaggaaatatatatatataaaagcaagaaataatgaaaagcaaaggcgatgacaaaccttgttgtttctgtcagtaccatcatgtcaagctagtacctcacatgagatattcattaaaagatctttctcttggtcaacctttag

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