2024-11-01 08:07:58, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS XM_054372781 7256 bp mRNA linear PRI 26-AUG-2024 DEFINITION PREDICTED: Homo sapiens RAB5B, member RAS oncogene family (RAB5B), transcript variant X1, mRNA. ACCESSION XM_054372781 VERSION XM_054372781.1 DBLINK BioProject: PRJNA807723 KEYWORDS RefSeq; includes ab initio. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_060936) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Updated annotation Annotation Name :: GCF_009914755.1-RS_2024_08 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; RefSeqFE; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 08/23/2024 ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..7256 /organism="Homo sapiens" /mol_type="mRNA" /isolate="CHM13" /db_xref="taxon:9606" /chromosome="12" /sex="female" /cell_line="CHM13htert" /tissue_type="hydatidiform mole" /note="haploid cell line" gene 1..7256 /gene="RAB5B" /note="RAB5B, member RAS oncogene family; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 6 mRNAs, 9 ESTs, 2043 long SRA reads, 14 Proteins, and 65% coverage of the annotated genomic feature by RNAseq alignments, including 13 samples with support for all annotated introns" /db_xref="GeneID:5869" /db_xref="HGNC:HGNC:9784" /db_xref="MIM:179514" CDS 2033..2785 /gene="RAB5B" /codon_start=1 /product="ras-related protein Rab-5B isoform X1" /protein_id="XP_054228756.1" /db_xref="GeneID:5869" /db_xref="HGNC:HGNC:9784" /db_xref="MIM:179514" /translation="
MSLEGVLKPGNPLPFPLPPLQYPPPSTLSHSDNLAMTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNLGGAAGRSRGVDLHEQSQQNKSQCCSN"
misc_feature 2195..2683 /gene="RAB5B" /note="Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion; Region: Rab5_related; cd01860" /db_xref="CDD:206653" misc_feature 2195..2203 /gene="RAB5B" /note="Rab subfamily motif 1 (RabSF1); other site" /db_xref="CDD:206653" misc_feature 2216..2239 /gene="RAB5B" /note="G1 box; other site" /db_xref="CDD:206653" misc_feature order(2222..2242,2270..2275,2288..2293,2369..2371, 2534..2539,2543..2545,2624..2632) /gene="RAB5B" /note="GTP/Mg2+ binding site [chemical binding]; other site" /db_xref="CDD:206653" misc_feature order(2240..2275,2285..2290) /gene="RAB5B" /note="Rab subfamily motif 2 (RabSF2); other site" /db_xref="CDD:206653" misc_feature order(2270..2272,2285..2311) /gene="RAB5B" /note="Switch I region; other site" /db_xref="CDD:206653" misc_feature order(2285..2287,2297..2320,2339..2341,2345..2347) /gene="RAB5B" /note="putative GEF interaction site [polypeptide binding]; other site" /db_xref="CDD:206653" misc_feature 2291..2293 /gene="RAB5B" /note="G2 box; other site" /db_xref="CDD:206653" misc_feature order(2294..2299,2303..2305,2357..2362,2381..2383, 2387..2389,2393..2401) /gene="RAB5B" /note="putative GDI interaction site [polypeptide binding]; other site" /db_xref="CDD:206653" misc_feature 2294..2308 /gene="RAB5B" /note="Rab family motif 1 (RabF1); other site" /db_xref="CDD:206653" misc_feature order(2300..2308,2312..2314,2378..2380,2399..2404) /gene="RAB5B" /note="effector interaction site [active]" /db_xref="CDD:206653" misc_feature 2345..2359 /gene="RAB5B" /note="Rab family motif 2 (RabF2); other site" /db_xref="CDD:206653" misc_feature 2360..2371 /gene="RAB5B" /note="G3 box; other site" /db_xref="CDD:206653" misc_feature order(2369..2371,2375..2407) /gene="RAB5B" /note="Switch II region; other site" /db_xref="CDD:206653" misc_feature 2378..2395 /gene="RAB5B" /note="Rab family motif 3 (RabF3); other site" /db_xref="CDD:206653" misc_feature 2402..2407 /gene="RAB5B" /note="Rab family motif 4 (RabF4); other site" /db_xref="CDD:206653" misc_feature 2429..2446 /gene="RAB5B" /note="Rab family motif 5 (RabF5); other site" /db_xref="CDD:206653" misc_feature 2510..2527 /gene="RAB5B" /note="Rab subfamily motif 3 (RabSF3); other site" /db_xref="CDD:206653" misc_feature 2534..2545 /gene="RAB5B" /note="G4 box; other site" /db_xref="CDD:206653" misc_feature 2624..2632 /gene="RAB5B" /note="G5 box; other site" /db_xref="CDD:206653" misc_feature 2672..2680 /gene="RAB5B" /note="Rab subfamily motif 4 (RabSF4); other site" /db_xref="CDD:206653" polyA_site 7256 /gene="RAB5B" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN
agatagcgtcttgttctgtcgcccaggctggagtgcagtggtgtaatcagctcactacaaccttcaactcctgggctccagtgattctcccaccacagcctctggagtagctgggattacaggcacataccaccatgcccagctaatttttttaaatgttttctagagactcagtctcgctatgttgcctaggctggtctcaaactcctcacctcaagcaaggcttccccttttatctcccaaacccctgggattacaggcatgggccgctctgccaggcctgttttttctctttttctttctctgtaccactttcatattgtggcttcttccctgcccccgatctcccccctacccaccccaggtggagtcttgctctgttacccaggctggagtgtggtggcacgatctcggctcactgcaacctccgcctcccgggtttaagcagttctgcctcagcctcccgagtaggattacaaatgccggccaccaaccacacccggctaattttttttttttttttttagactgagtctcgctgttgctctgtcgccaggctggagtacagtggtgcaatctcagctcactgcaacctccacctcacaagttcaagcagttcacctgcctcaacctcccaagtagctgggactacaggcacgcgccaccacgcccagctaatttttgtatttttagtagagacggggtttcaccatgtttgccaggcttgtctcaaactcctgacctcctgatctgcctgcctttgcctcccaaagtgctgggattacaggcgtgagccactgtgcccgccttttattttttgagacggagtctcgctctgtcacccaggctggagcacagtggcgcatcagctcagtgcaccctctaccttctgggtttaagcgattctcctgcctcagcctctggagtagctgggattacaggtatgcaccaccacacccagctaattttttttgtatttttagtggagacggggtttcaccatgttggccaggcagggctcgaacttctgacctcaggtgatccacctcagcctcccaaagtgctgggattataggtatgagctactgcacccaggctgtggctgctttttaggaatatattgataacaactaatattgagatatattttaatagctattagcactatgctaaacacatctttcacttattatttgtagctatgaggatggtattttttccattttacaaaggtagaaggtaaggcttagagaggtagagaaattctctttatatcatattagtaatgattagtagcttaatatttatttagcacttagtatctatcaaatacttaaaatactttagttatttatatgcattatctcatttaatccttacaacacccttatgaagtaggtgcttataaggctattatctcattttacagatgaggaaatgaatgcacacatatatttagtgacttgctcaaggttcatagctagtaagtagagctgaaaaacaaacgtggagaattggactccagagcctttattcctctgaattgcctcctgtatgattttctgtctttacgatctagtaagtggggttactgaaaatttttaaccccagtttaactccagtcccactaattgtggtgacaaaataatgatgtttccccacatatgccatagagtatgatgtctgtgaagtcactaggatctgctttggaaaagcgaaagagtaatttgaacaagcaaagtacaactctcaagcaatgcttaggtttgggagagaggtttttgcatgctctgcctatgctaacttccctttgaatttcatagttcctttccgctcagagtcaggatgatgaaatgtattcagatttagacgattagaatctcaaagtcccaactcttctctctgttccctgccccaccagcagctttcttagccctcttagaagatagaggagctgattcagtgtattctttcatcaaatactgattgcttgcagacttaacgccctataccatcctctggagacttctgcatgtctttagaaggagtgttgaagcctggaaatcccctccccttccccctcccccctttacagtatccccctccctccaccctttcccattctgataatctggccatgactagcagaagcacagctaggcccaatgggcaaccccaggccagcaaaatttgccagttcaaattggtcctgctgggagaatctgcagtgggaaagtcaagcctggtattacgttttgtcaaagggcagttccatgagtaccaggagagcaccattggagcggccttcctcacccagtccgtttgtctagatgacacaacagtgaagtttgagatctgggacacagctgggcaggagcgatatcacagcttagcccccatgtactacaggggtgcccaagctgcaatcgtggtttacgacattactaatcaggaaacctttgcccgagcaaagacatgggtgaaggaactacagcgacaggccagtcctagcatcgttattgccctggcagggaacaaagctgacctggccaacaaacgtatggtggagtatgaagaggcccaggcatatgcagatgacaacagcttattgttcatggagacttcagccaagacagctatgaacgtgaatgatctcttcctggcaatagctaagaagttgccaaagagtgaaccccagaatctgggaggtgcagcaggccgaagccggggtgtggatctccatgaacagtcccagcagaacaagagccagtgttgtagcaactgagggggtggctagcagcaaacaagtatggagctagcacaagagctaagaaataacctccatccctacccctcagcacacaacccctacggtaacagcacactgagccctggctcccaagggctgcctcctgacagctccgtcatggcactttttaacgcttcagcaacaaacaccaggcagctgttgccactggcctcctaccccctactctggggcttgggggtcaactccccccaggacttaccttccaaaacaaactttcttcactttgtattataggtacaagacagcgacttacgtatcttttctcctcctccctagtgttcctccccattttttcagaaaacacttctgactcctgtcccttccccttctgcttttggtcagtccctgttcttgagcctcttttctcctctccccaggatgcagaaagtggtgaacccaggaactgaggaaggaggtttccagttcatttacattaagggccctgggggagaataaagctcagagcaggagggagtaaggaaacatttcctttttgtttttatttggttggagtttctcatatttgaaaacattgcggtatccatgatttggccttgtggagggtgttcctaggtagaggtgagaatggggaggcaagatctcaggcaccaggcaggaggtgccttgtaagctaactgggcggaggtggaggtgcagtgtcaactgtggctctgtaactcttcaaaggcccagtttcccctcacgcagcctcttaggtagcgtttcccctaatcgtgggggttggaccccagagtcttccaaagaattttcactggttgcctgcatctttggctctgctgtgatctgattggaggagggacagtttctggtacccatcctctgatttatacatatgcattttttcccctctggcctttagatggcctcagccccagccaccatatacccctgcagtttgcactttaattgatggtagttcagttggggtacttgttttatggaagttttgattgatttacttgccctcccaccttctttttaattcaatgaaatctgaggttaatgcgaggttcgaggagaggttatagataaaactaccagtggcagctactcaagtcctatctccactgttagcttcctccaactctaattattaacctatattcttgccaagctaactattgactataggtttgcctttcctggagaattaattgagcaattgaggagtgtctcaggatagcacaggccaaggtaggggagtaaaaaggaggtcaggcaaaagggaggagttttctgtcctttcccaggtttcacactcaatttgatatccattaccatgtcttttctacttccttgtaaataggtatgatctttattcccactgtacagtctgttctatcctctgcctcccatcaggccctgtttctttgttcctttgttaatatcttgaatttagtccctccatccttaatccccccatccctccccatcatgcaaccagtggtttaatccatgtaccaataggggctagtaccacagaggcctcctgtggtgccctcgtatcataccacctgttcctgtggagagggaatgaccggcactgaaggtaccttacaactggctcatattatcagaggaccttggtcctttctaaatctctagtctctcttcatatccttcatcaggtgttttaagatgtctctgagaagccatcaaggcaaaagagaactttaagttccttgttccagcccggagttttgggaaagaaagaaaggaaaggtcacagtgacctaggattggaaccttcctgcccttttggcttgcagactgccttctatcccagaacagctgagaaatctatgaagctgagattctgaaggacccagcttaggttcttccacttaggcctcaattcccttccttttccaggggcagccttagttcccatggccctgaaacacacacatttcccccttcctttcccagaagccactggccccccatagcacccagtgcatcctttttacaagtggaagaactaggatggctttccaaagtcttctagaaatgaagttctttctctgtgcagctttcccccttggagcaggagtgaagatgtttcattatcttgggcctgggaaaccacttccccaggcttctccctccccccacccccataggaacaggatttggccttagcttctgggcctatcggctgccttccctctacttcctaccacctcttctgccttcctttgagctctgttgggcttggggatcttagttttcttttgtttatttcccagctcatttttttcttctggtcagtttttttaagggggggtgttgtggttttttgtttttgttttgcttctgagaaagcatttgcctttcttcctctcccaacataacaatcgtggtaacagaatgcgactgctgatttaccgatgtatttaatgtaagtaaaaaaaggaaaaaaagaaaagggcattggagtgttgcttttttttattttattgttattattattattatttttgctatttgtcaggtactaggaatttggaagaaaggatacccagtaatgttctactgaatcagaaacacacctttccctgcatcttgatacatctttattccctttaatcttttcttaaacatctagtttagaaaatagcccttctattgctatttaatcacccctcttctaaggccactagattgttcatcaaatcaaaccctattatatctttttaggccctcttaacagaatgtatatgtgtagggtatggtctgtggatctttgggcccactgatcagattagagagaggggtgctatttgaagtagtatacaaaaatgtatgtgcatatttctttttttttttttaattgagacggagtctctgtcgctagcctggagtacagtggcacgatcttggctcacagcaatctccgcctcctgagttcaagtgattctcctgcctcagcctcctgagtagctaggattacaggcacgcaccaacacacccagctaatttttgtatttttagtagagacggggtttcaccatgttggtcaggctggtcttgaactcctgacctcgtgatccacccaccttggcctcccaaagtgctgggattacgggcgtgagccactgcgcccggccgtatgtgcatatttctaggatccatttctatatgtttctcaaaggggtccatgacccaaaggttgaaaaacatcactgagttagttttcttgtagcttccacctcaacgggaaaatttcctctggatctgctcttgactcctagtgtacttcaaacccttcagtccaccacagtctaaaggtcgagggaagggaaatgaaataggattatgtgtggttgcagtaggctttaaattccaaagaatctgaaggtggataggaaagaggactggtgccagacaaatctgacattctaggcctgtctctgtcaacttaaccagctgtggccttgatcaagttagttagtgccttccgcctcgtttcttcatctgtaaagtaaaagctgaagattaaggtcaattatgtaaagtatgtgtgtcacacaaaagtagatgacactattaggaaggaggcttttagatagtccctaactgacttctctgtatcttcctttggctgagacttttttttttttaggttgaagctcgctttctctctctctccctctttctccctctctctctctctctcactctctctctctccatatatatatacatatatatatatatatatattttttttttaacaactggtaggataggttgggcattagccttcttcagtgatttgattgtatacagattgaaatcctttccatttccaaacacttaagagccaaagccaacttgccaacttttcactgtcggttcccttaccttatatctcttggtaataccccccacccccgttccctgattcctggtaaaagctctagttggagagccgaaaggaaaggaaatgatctttcaaaattaaaggtgaacaccttcacttaaactgattaaaattgcagctccaccgtccggcctctagagggcagtgtatggatacatttgtccagattgggggactaggtttgataaattttgtcctgcatcaaatgacaaaagggtaataggaaatgtattatatttatgccccttactttgagataagagactacaaccttcatacttcggggtgttaagctgccattgctcttgttaaggggcagtttgttttttaagagatggggtcttgctctgttgtccaggctggagtgcagtgccgcgatcttggctcagtgcaacctcgaactcctgggcttaagcgatcctcccgcctcagcctcccgagtactgggactacaggcgtgtgccaccaaggggcgattattattttttttttctacgcaaaataaaagacggctattca
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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