2024-05-03 02:12:10, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NR_039687 70 bp RNA linear PRI 04-SEP-2020 DEFINITION Homo sapiens microRNA 4476 (MIR4476), microRNA. ACCESSION NR_039687 VERSION NR_039687.1 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 70) AUTHORS Enomoto Y, Takagi R, Naito Y, Kiniwa T, Tanaka Y, Hamada-Tsutsumi S, Kawano M, Matsushita S, Ochiya T and Miyajima A. TITLE Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs JOURNAL Sci Rep 7 (1), 7780 (2017) PUBMED 28798470 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 70) AUTHORS Kozomara A and Griffiths-Jones S. TITLE miRBase: integrating microRNA annotation and deep-sequencing data JOURNAL Nucleic Acids Res. 39 (Database issue), D152-D157 (2011) PUBMED 21037258 REFERENCE 3 (bases 1 to 70) AUTHORS Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI, Liu Q, How T, Grubor V, Gao Y, Patel A, Wu H, Zhu J, Blobe GC, Lipsky PE, Chadburn A and Dave SS. CONSRTM Hematologic Malignancies Research Consortium TITLE Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs JOURNAL Blood 116 (23), e118-e127 (2010) PUBMED 20733160 REFERENCE 4 (bases 1 to 70) AUTHORS Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright AJ. TITLE miRBase: microRNA sequences, targets and gene nomenclature JOURNAL Nucleic Acids Res. 34 (Database issue), D140-D144 (2006) PUBMED 16381832 COMMENT PROVISIONAL REFSEQ: This record is based on preliminary annotation provided by NCBI staff in collaboration with miRBase. The reference sequence was derived from AL450267.10. Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611317.1 [ECO:0000345] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-70 AL450267.10 111154-111223 c FEATURES Location/Qualifiers source 1..70 /organism="Homo sapiens" /mol_type="transcribed RNA" /db_xref="taxon:9606" /chromosome="9" /map="9p13.2" gene 1..70 /gene="MIR4476" /gene_synonym="mir-4476" /note="microRNA 4476" /db_xref="GeneID:100616456" /db_xref="HGNC:HGNC:41793" /db_xref="miRBase:MI0016828" precursor_RNA 1..70 /gene="MIR4476" /gene_synonym="mir-4476" /product="microRNA 4476" /db_xref="GeneID:100616456" /db_xref="HGNC:HGNC:41793" /db_xref="miRBase:MI0016828" exon 1..70 /gene="MIR4476" /gene_synonym="mir-4476" /inference="alignment:Splign:2.1.0" variation 5 /gene="MIR4476" /gene_synonym="mir-4476" /replace="a" /replace="g" /db_xref="dbSNP:2131825174" variation 8 /gene="MIR4476" /gene_synonym="mir-4476" /replace="c" /replace="t" /db_xref="dbSNP:1461511671" variation 9 /gene="MIR4476" /gene_synonym="mir-4476" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:1827583158" variation 22 /gene="MIR4476" /gene_synonym="mir-4476" /replace="c" /replace="t" /db_xref="dbSNP:1827582664" variation 25 /gene="MIR4476" /gene_synonym="mir-4476" /replace="c" /replace="t" /db_xref="dbSNP:188233723" variation 27 /gene="MIR4476" /gene_synonym="mir-4476" /replace="g" /replace="t" /db_xref="dbSNP:1827582278" variation 28 /gene="MIR4476" /gene_synonym="mir-4476" /replace="c" /replace="t" /db_xref="dbSNP:1563939607" variation 29 /gene="MIR4476" /gene_synonym="mir-4476" /replace="c" /replace="g" /db_xref="dbSNP:1392800732" variation 35 /gene="MIR4476" /gene_synonym="mir-4476" /replace="c" /replace="g" /db_xref="dbSNP:1326452833" variation 41 /gene="MIR4476" /gene_synonym="mir-4476" /replace="c" /replace="g" /db_xref="dbSNP:1464670807" ncRNA 45..66 /ncRNA_class="miRNA" /gene="MIR4476" /gene_synonym="mir-4476" /product="hsa-miR-4476" /db_xref="miRBase:MIMAT0019003" /db_xref="GeneID:100616456" /db_xref="HGNC:HGNC:41793" /db_xref="miRBase:MI0016828" variation 47 /gene="MIR4476" /gene_synonym="mir-4476" /replace="a" /replace="g" /db_xref="dbSNP:978640498" variation 48 /gene="MIR4476" /gene_synonym="mir-4476" /replace="a" /replace="g" /db_xref="dbSNP:1827580567" variation 50 /gene="MIR4476" /gene_synonym="mir-4476" /replace="a" /replace="g" /db_xref="dbSNP:1019792440" variation 51 /gene="MIR4476" /gene_synonym="mir-4476" /replace="a" /replace="g" /db_xref="dbSNP:1827579972" variation 54 /gene="MIR4476" /gene_synonym="mir-4476" /replace="c" /replace="t" /db_xref="dbSNP:2131824984" variation 58 /gene="MIR4476" /gene_synonym="mir-4476" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:1587893061" variation 60 /gene="MIR4476" /gene_synonym="mir-4476" /replace="g" /replace="t" /db_xref="dbSNP:1563939578" variation 66 /gene="MIR4476" /gene_synonym="mir-4476" /replace="c" /replace="t" /db_xref="dbSNP:1008364367" variation 67 /gene="MIR4476" /gene_synonym="mir-4476" /replace="c" /replace="t" /db_xref="dbSNP:1563939566" ORIGIN
aaaagcctgtccctaagtccctcccagccttccagagttggtgccaggaaggatttagggacaggctttg
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]