2024-05-03 04:40:06, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NR_031579 91 bp RNA linear PRI 26-SEP-2021 DEFINITION Homo sapiens microRNA 2113 (MIR2113), microRNA. ACCESSION NR_031579 VERSION NR_031579.1 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 91) AUTHORS Zhang L, Chen Y, Bao C, Zhang X and Li H. TITLE Eukaryotic initiation Factor 4AIII facilitates hepatocellular carcinoma cell proliferation, migration, and epithelial-mesenchymal transition process via antagonistically binding to WD repeat domain 66 with miRNA-2113 JOURNAL J Cell Physiol 235 (11), 8199-8209 (2020) PUBMED 31975383 REMARK GeneRIF: Eukaryotic initiation Factor 4AIII facilitates hepatocellular carcinoma cell proliferation, migration, and epithelial-mesenchymal transition process via antagonistically binding to WD repeat domain 66 with miRNA-2113. REFERENCE 2 (bases 1 to 91) AUTHORS Jing J, Xu D, Li Z, Jiang M, Wang J and Zhang J. TITLE Genetic variants in MIR2113 and MIR129-LEP are associated with the susceptibility of COPD in the Chinese Han population JOURNAL Pulm Pharmacol Ther 64, 101945 (2020) PUBMED 32931917 REMARK GeneRIF: Genetic variants in MIR2113 and MIR129-LEP are associated with the susceptibility of COPD in the Chinese Han population. REFERENCE 3 (bases 1 to 91) AUTHORS Enomoto Y, Takagi R, Naito Y, Kiniwa T, Tanaka Y, Hamada-Tsutsumi S, Kawano M, Matsushita S, Ochiya T and Miyajima A. TITLE Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs JOURNAL Sci Rep 7 (1), 7780 (2017) PUBMED 28798470 REMARK Publication Status: Online-Only REFERENCE 4 (bases 1 to 91) AUTHORS Andrews SJ, Das D, Anstey KJ and Easteal S. TITLE Association of AKAP6 and MIR2113 with cognitive performance in a population-based sample of older adults JOURNAL Genes Brain Behav 16 (4), 472-478 (2017) PUBMED 28067462 REMARK GeneRIF: Two single nucleotide polymorphisms (SNPs), MIR211-rs10457441 and AKAP6-rs17522122 were genotyped in 1570 non-demented older Australians of European ancestry. MIR2113-rs10457441*T was associated with accelerated decline in episodic memory. No other associations with baseline cognitive performance or with linear or quadratic rate or cognitive changes were observed for this SNP. REFERENCE 5 (bases 1 to 91) AUTHORS Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, Hofer E, Ibrahim-Verbaas CA, Kirin M, Lahti J, van der Lee SJ, Le Hellard S, Liu T, Marioni RE, Oldmeadow C, Postmus I, Smith AV, Smith JA, Thalamuthu A, Thomson R, Vitart V, Wang J, Yu L, Zgaga L, Zhao W, Boxall R, Harris SE, Hill WD, Liewald DC, Luciano M, Adams H, Ames D, Amin N, Amouyel P, Assareh AA, Au R, Becker JT, Beiser A, Berr C, Bertram L, Boerwinkle E, Buckley BM, Campbell H, Corley J, De Jager PL, Dufouil C, Eriksson JG, Espeseth T, Faul JD, Ford I, Gottesman RF, Griswold ME, Gudnason V, Harris TB, Heiss G, Hofman A, Holliday EG, Huffman J, Kardia SL, Kochan N, Knopman DS, Kwok JB, Lambert JC, Lee T, Li G, Li SC, Loitfelder M, Lopez OL, Lundervold AJ, Lundqvist A, Mather KA, Mirza SS, Nyberg L, Oostra BA, Palotie A, Papenberg G, Pattie A, Petrovic K, Polasek O, Psaty BM, Redmond P, Reppermund S, Rotter JI, Schmidt H, Schuur M, Schofield PW, Scott RJ, Steen VM, Stott DJ, van Swieten JC, Taylor KD, Trollor J, Trompet S, Uitterlinden AG, Weinstein G, Widen E, Windham BG, Jukema JW, Wright AF, Wright MJ, Yang Q, Amieva H, Attia JR, Bennett DA, Brodaty H, de Craen AJ, Hayward C, Ikram MA, Lindenberger U, Nilsson LG, Porteous DJ, Raikkonen K, Reinvang I, Rudan I, Sachdev PS, Schmidt R, Schofield PR, Srikanth V, Starr JM, Turner ST, Weir DR, Wilson JF, van Duijn C, Launer L, Fitzpatrick AL, Seshadri S, Mosley TH Jr and Deary IJ. CONSRTM Generation Scotland TITLE Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949) JOURNAL Mol Psychiatry 20 (2), 183-192 (2015) PUBMED 25644384 REMARK GeneRIF: This study showed that genome-wide significant SNP-based associations within three genomic regions 6q16.1 (MIR2113), 14q12 (AKAP6/NPAS3 region) and 19q13.32 (TOMM40/APOE region) with cognition. REFERENCE 6 (bases 1 to 91) AUTHORS Muhleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F, Treutlein J, Mattheisen M, Forstner AJ, Schumacher J, Breuer R, Meier S, Herms S, Hoffmann P, Lacour A, Witt SH, Reif A, Muller-Myhsok B, Lucae S, Maier W, Schwarz M, Vedder H, Kammerer-Ciernioch J, Pfennig A, Bauer M, Hautzinger M, Moebus S, Priebe L, Czerski PM, Hauser J, Lissowska J, Szeszenia-Dabrowska N, Brennan P, McKay JD, Wright A, Mitchell PB, Fullerton JM, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Krasnow V, Chuchalin A, Babadjanova G, Pantelejeva G, Abramova LI, Tiganov AS, Polonikov A, Khusnutdinova E, Alda M, Grof P, Rouleau GA, Turecki G, Laprise C, Rivas F, Mayoral F, Kogevinas M, Grigoroiu-Serbanescu M, Propping P, Becker T, Rietschel M, Nothen MM and Cichon S. TITLE Genome-wide association study reveals two new risk loci for bipolar disorder JOURNAL Nat Commun 5, 3339 (2014) PUBMED 24618891 REMARK Publication Status: Online-Only REFERENCE 7 (bases 1 to 91) AUTHORS Low SK, Chung S, Takahashi A, Zembutsu H, Mushiroda T, Kubo M and Nakamura Y. TITLE Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan JOURNAL Cancer Sci 104 (8), 1074-1082 (2013) PUBMED 23648065 REFERENCE 8 (bases 1 to 91) AUTHORS Tzur G, Levy A, Meiri E, Barad O, Spector Y, Bentwich Z, Mizrahi L, Katzenellenbogen M, Ben-Shushan E, Reubinoff BE and Galun E. TITLE MicroRNA expression patterns and function in endodermal differentiation of human embryonic stem cells JOURNAL PLoS One 3 (11), e3726 (2008) PUBMED 19015728 REFERENCE 9 (bases 1 to 91) AUTHORS Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R and Cuppen E. TITLE Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis JOURNAL Genome Res 16 (10), 1289-1298 (2006) PUBMED 16954537 REFERENCE 10 (bases 1 to 91) AUTHORS Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright AJ. TITLE miRBase: microRNA sequences, targets and gene nomenclature JOURNAL Nucleic Acids Res 34 (Database issue), D140-D144 (2006) PUBMED 16381832 COMMENT PROVISIONAL REFSEQ: This record is based on preliminary annotation provided by NCBI staff in collaboration with miRBase. The reference sequence was derived from AL590239.7. Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-91 AL590239.7 104098-104188 FEATURES Location/Qualifiers source 1..91 /organism="Homo sapiens" /mol_type="transcribed RNA" /db_xref="taxon:9606" /chromosome="6" /map="6q16.1" gene 1..91 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /note="microRNA 2113" /db_xref="GeneID:100302164" /db_xref="HGNC:HGNC:37058" /db_xref="miRBase:MI0003939" precursor_RNA 1..91 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /product="microRNA 2113" /db_xref="GeneID:100302164" /db_xref="HGNC:HGNC:37058" /db_xref="miRBase:MI0003939" exon 1..91 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /inference="alignment:Splign:2.1.0" variation 1 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="t" /db_xref="dbSNP:750819020" variation 5 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="c" /db_xref="dbSNP:1006033587" variation 9 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="g" /db_xref="dbSNP:1772260374" variation 14 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="g" /replace="t" /db_xref="dbSNP:2127970574" variation 15 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="g" /replace="t" /db_xref="dbSNP:917485215" variation 20 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="c" /db_xref="dbSNP:567387838" variation 22 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="c" /replace="g" /db_xref="dbSNP:375206435" variation 23 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="g" /replace="t" /db_xref="dbSNP:1772260503" variation 24 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="c" /replace="t" /db_xref="dbSNP:949102376" variation 26 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="c" /replace="t" /db_xref="dbSNP:1410202872" variation 29 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:753328121" variation 32 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="c" /db_xref="dbSNP:780303302" variation 38 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:1772260666" variation 39 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="c" /replace="t" /db_xref="dbSNP:117428639" variation 40 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:142927919" variation 44 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="c" /db_xref="dbSNP:1253750932" variation 45 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="c" /replace="t" /db_xref="dbSNP:796275267" variation 47 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="g" /db_xref="dbSNP:980377341" variation 48 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="g" /db_xref="dbSNP:1772260801" variation 52 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="g" /db_xref="dbSNP:1360211362" ncRNA 56..76 /ncRNA_class="miRNA" /gene="MIR2113" /gene_synonym="hsa-mir-2113" /product="hsa-miR-2113" /db_xref="miRBase:MIMAT0009206" /db_xref="GeneID:100302164" /db_xref="HGNC:HGNC:37058" /db_xref="miRBase:MI0003939" variation 63 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="c" /replace="g" /db_xref="dbSNP:1772260863" variation 66 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:1205511802" variation 67 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="g" /db_xref="dbSNP:1772260927" variation 73 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="g" /replace="t" /db_xref="dbSNP:899034165" variation 74 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="c" /replace="g" /db_xref="dbSNP:1772260979" variation 77 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="g" /db_xref="dbSNP:1772261008" variation 79 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="g" /replace="t" /db_xref="dbSNP:1772261027" variation 80 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="c" /replace="t" /db_xref="dbSNP:1772261060" variation 83 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:1325246236" variation 86 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="t" /db_xref="dbSNP:1772261113" variation 91 /gene="MIR2113" /gene_synonym="hsa-mir-2113" /replace="a" /replace="g" /db_xref="dbSNP:926262506" ORIGIN
ttttcaaagcaatgtgtgacaggtacagggacaaatcccgttaataagtaagaggatttgtgcttggctctgtcacatgccactttgaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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