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Previous release (v1)
2026-10-05 17:50:29, GGRNA.v2 : RefSeq release 233 (Jan, 2026)
LOCUS NR_029856 111 bp RNA linear PRI 03-MAR-2024
DEFINITION Homo sapiens microRNA 365b (MIR365B), microRNA.
ACCESSION NR_029856
VERSION NR_029856.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 111)
AUTHORS Wang,Y., Lv,S., Zhou,X., Niu,X., Chen,L., Yang,Z. and Peng,D.
TITLE Identification of hsa-miR-365b-5p's role in Alzheimer's disease: A
combined analysis of miRNA and mRNA microarrays
JOURNAL Neurosci Lett 790, 136892 (2022)
PUBMED 36181964
REMARK GeneRIF: Identification of hsa-miR-365b-5p's role in Alzheimer's
disease: A combined analysis of miRNA and mRNA microarrays.
REFERENCE 2 (bases 1 to 111)
AUTHORS Gao,Y., Miao,Y., Zhang,W., Ru,X. and Hou,L.
TITLE MicroRNA-365 induces apoptosis and inhibits invasion of human
myeloma cells by targeting homeobox A9 (HOXA9)
JOURNAL Environ Toxicol Pharmacol 85, 103627 (2021)
PUBMED 33621688
REMARK GeneRIF: MicroRNA-365 induces apoptosis and inhibits invasion of
human myeloma cells by targeting homeobox A9 (HOXA9).
REFERENCE 3 (bases 1 to 111)
AUTHORS Liu,Y., Jia,J., Song,B., Qiu,H., Liang,G., Zhang,B. and Wang,K.
TITLE Serum microRNA-365 suppresses non-small-cell lung cancer metastasis
and invasion in patients with bone metastasis of lung cancer
JOURNAL J Int Med Res 48 (10), 300060520939718 (2020)
PUBMED 33121309
REMARK GeneRIF: Serum microRNA-365 suppresses non-small-cell lung cancer
metastasis and invasion in patients with bone metastasis of lung
cancer.
REFERENCE 4 (bases 1 to 111)
AUTHORS Tian,Q., Sun,H.F., Wang,W.J., Li,Q., Ding,J. and Di,W.
TITLE miRNA-365b promotes hepatocellular carcinoma cell migration and
invasion by downregulating SGTB
JOURNAL Future Oncol 15 (17), 2019-2028 (2019)
PUBMED 30943053
REMARK GeneRIF: miR-365b promoted hepatocellular carcinoma (HCC) cell
motility and spreading. Furthermore, SGTB was found to be a
downstream target of miR-365b, and knockdown of the SGTB gene could
mimic the effect of miR-365b in hastening HCC cell migration and
invasion. These results imply that miR-365b plays a tumor-promoting
role in HCC by suppressing SGTB expression.
REFERENCE 5 (bases 1 to 111)
AUTHORS Guo,Y., Ma,D., Jia,S.F., Liu,J., Fan,S.B., Zhang,M., Shi,L.R.,
Jiang,L.L., Shi,J.X., Wang,H.Q., Zheng,H.Y. and Li,O.
TITLE [Proliferation of MicroRNA-365 and E74-like Factor 4 in Cervical
Cancer Cells and Its Clinical Significance]
JOURNAL Zhongguo Yi Xue Ke Xue Yuan Xue Bao 41 (2), 220-227 (2019)
PUBMED 31060678
REMARK GeneRIF: The decreased expression of miR-365 in human cervical
cancer cells relieves its inhibitory effect on ELF4, which promotes
the proliferation of cervical cancer cells and the formation of
tumor.
REFERENCE 6 (bases 1 to 111)
AUTHORS Lui,W.O., Pourmand,N., Patterson,B.K. and Fire,A.
TITLE Patterns of known and novel small RNAs in human cervical cancer
JOURNAL Cancer Res 67 (13), 6031-6043 (2007)
PUBMED 17616659
REFERENCE 7 (bases 1 to 111)
AUTHORS Landgraf,P., Rusu,M., Sheridan,R., Sewer,A., Iovino,N., Aravin,A.,
Pfeffer,S., Rice,A., Kamphorst,A.O., Landthaler,M., Lin,C.,
Socci,N.D., Hermida,L., Fulci,V., Chiaretti,S., Foa,R.,
Schliwka,J., Fuchs,U., Novosel,A., Muller,R.U., Schermer,B.,
Bissels,U., Inman,J., Phan,Q., Chien,M., Weir,D.B., Choksi,R., De
Vita,G., Frezzetti,D., Trompeter,H.I., Hornung,V., Teng,G.,
Hartmann,G., Palkovits,M., Di Lauro,R., Wernet,P., Macino,G.,
Rogler,C.E., Nagle,J.W., Ju,J., Papavasiliou,F.N., Benzing,T.,
Lichter,P., Tam,W., Brownstein,M.J., Bosio,A., Borkhardt,A.,
Russo,J.J., Sander,C., Zavolan,M. and Tuschl,T.
TITLE A mammalian microRNA expression atlas based on small RNA library
sequencing
JOURNAL Cell 129 (7), 1401-1414 (2007)
PUBMED 17604727
REFERENCE 8 (bases 1 to 111)
AUTHORS Griffiths-Jones,S., Grocock,R.J., van Dongen,S., Bateman,A. and
Enright,A.J.
TITLE miRBase: microRNA sequences, targets and gene nomenclature
JOURNAL Nucleic Acids Res 34 (Database issue), D140-D144 (2006)
PUBMED 16381832
REFERENCE 9 (bases 1 to 111)
AUTHORS Bentwich,I., Avniel,A., Karov,Y., Aharonov,R., Gilad,S., Barad,O.,
Barzilai,A., Einat,P., Einav,U., Meiri,E., Sharon,E., Spector,Y.
and Bentwich,Z.
TITLE Identification of hundreds of conserved and nonconserved human
microRNAs
JOURNAL Nat Genet 37 (7), 766-770 (2005)
PUBMED 15965474
REFERENCE 10 (bases 1 to 111)
AUTHORS Xie,X., Lu,J., Kulbokas,E.J., Golub,T.R., Mootha,V.,
Lindblad-Toh,K., Lander,E.S. and Kellis,M.
TITLE Systematic discovery of regulatory motifs in human promoters and 3'
UTRs by comparison of several mammals
JOURNAL Nature 434 (7031), 338-345 (2005)
PUBMED 15735639
COMMENT PROVISIONAL REFSEQ: This record is based on preliminary annotation
provided by NCBI staff in collaboration with miRBase. The reference
sequence was derived from AC003101.2.
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs
that are involved in post-transcriptional regulation of gene
expression in multicellular organisms by affecting both the
stability and translation of mRNAs. miRNAs are transcribed by RNA
polymerase II as part of capped and polyadenylated primary
transcripts (pri-miRNAs) that can be either protein-coding or
non-coding. The primary transcript is cleaved by the Drosha
ribonuclease III enzyme to produce an approximately 70-nt stem-loop
precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and
antisense miRNA star (miRNA*) products. The mature miRNA is
incorporated into a RNA-induced silencing complex (RISC), which
recognizes target mRNAs through imperfect base pairing with the
miRNA and most commonly results in translational inhibition or
destabilization of the target mRNA. The RefSeq represents the
predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Sequence Note: This record represents a predicted microRNA
stem-loop as defined by miRBase. Some sequence at the 5' and 3'
ends may not be included in the intermediate precursor miRNA
produced by Drosha cleavage.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript is intronless :: LM608692.1 [ECO:0000345]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-111 AC003101.2 165450-165560
FEATURES Location/Qualifiers
source 1..111
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q11.2"
gene 1..111
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/note="microRNA 365b"
/db_xref="GeneID:100126356"
/db_xref="HGNC:HGNC:33693"
/db_xref="miRBase:MI0000769"
precursor_RNA 1..111
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/product="microRNA 365b"
/db_xref="GeneID:100126356"
/db_xref="HGNC:HGNC:33693"
/db_xref="miRBase:MI0000769"
exon 1..111
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/inference="alignment:Splign:2.1.0"
variation 4
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:2073202594"
variation 5
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2508441328"
variation 6
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="g"
/replace="t"
/db_xref="dbSNP:1344842646"
variation 7
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1330489469"
variation 9
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="c"
/replace="g"
/db_xref="dbSNP:900121303"
variation 12
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1567710000"
variation 13
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="c"
/replace="g"
/db_xref="dbSNP:766837638"
variation 14
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2508441342"
variation 15
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2142867677"
variation 21
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2508441346"
variation 28
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:753933844"
ncRNA 29..50
/ncRNA_class="miRNA"
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/product="hsa-miR-365b-5p"
/db_xref="miRBase:MIMAT0022833"
/db_xref="GeneID:100126356"
/db_xref="HGNC:HGNC:33693"
/db_xref="miRBase:MI0000769"
variation 29
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2073202711"
variation 30..32
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="gg"
/replace="ggg"
/db_xref="dbSNP:759650574"
variation 30
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1245222811"
variation 32
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1315675828"
variation 35..37
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="ttt"
/replace="tttt"
/db_xref="dbSNP:2073202773"
variation 37
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:367566254"
variation 38
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:755134697"
variation 39
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace=""
/replace="a"
/db_xref="dbSNP:2508441383"
variation 39
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:2142867690"
variation 40
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:889256848"
variation 46
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:374487127"
variation 48..52
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="tgt"
/replace="tgtgt"
/db_xref="dbSNP:767877480"
variation 48
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="t"
/db_xref="dbSNP:2508441388"
variation 49
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:752977263"
variation 51
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:757063619"
variation 56
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="c"
/db_xref="dbSNP:2073202946"
variation 61
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="g"
/replace="t"
/db_xref="dbSNP:1235293289"
variation 62
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:2073202972"
variation 64
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2508441401"
variation 67
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:1197663564"
ncRNA 68..89
/ncRNA_class="miRNA"
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/product="hsa-miR-365b-3p"
/db_xref="miRBase:MIMAT0022834"
/db_xref="GeneID:100126356"
/db_xref="HGNC:HGNC:33693"
/db_xref="miRBase:MI0000769"
variation 74
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:781117282"
variation 82
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1183474028"
variation 84
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:1411099672"
variation 89..90
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="t"
/replace="tt"
/db_xref="dbSNP:35143473"
variation 89
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:745712604"
variation 90
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2508441418"
variation 96
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2508441423"
variation 97
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="g"
/replace="t"
/db_xref="dbSNP:2508441427"
variation 98
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="c"
/db_xref="dbSNP:1446760787"
variation 99..101
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace=""
/replace="agt"
/db_xref="dbSNP:2508441438"
variation 99
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:868649161"
variation 100
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:769737289"
variation 101
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:779901692"
variation 102
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:748781270"
variation 104
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:1161355910"
variation 106
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:768183902"
variation 107
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="g"
/replace="t"
/db_xref="dbSNP:531981415"
variation 108
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:761466924"
variation 109
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:771780110"
variation 111
/gene="MIR365B"
/gene_synonym="hsa-mir-365b; mir-365b; MIR365-2;
MIRN365-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1444292098"
ORIGIN
agagtgttcaaggacagcaagaaaaatgagggactttcaggggcagctgtgttttctgactcagtcataatgcccctaaaaatccttattgttcttgcagtgtgcatcggg
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]