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Previous release (v1)
2025-08-30 15:05:13, GGRNA.v2 : RefSeq release 231 (Jul, 2025)
LOCUS NM_001441339 12771 bp mRNA linear PRI 07-JUN-2025
DEFINITION Homo sapiens bromodomain and WD repeat domain containing 3 (BRWD3),
transcript variant 2, mRNA.
ACCESSION NM_001441339 XM_005262113 XM_054326752
VERSION NM_001441339.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 12771)
AUTHORS Tian,M.Q., Liu,X.R., Lin,S.M., Wang,J., Luo,S., Gao,L.D.,
Chen,X.B., Liang,X.Y., Liu,Z.G., He,N., Yi,Y.H. and Liao,W.P.
CONSRTM China Epilepsy Gene 1.0 Project
TITLE Variants in BRWD3 associated with X-linked partial epilepsy without
intellectual disability
JOURNAL CNS Neurosci Ther 29 (2), 727-735 (2023)
PUBMED 36514184
REMARK GeneRIF: Variants in BRWD3 associated with X-linked partial
epilepsy without intellectual disability.
REFERENCE 2 (bases 1 to 12771)
AUTHORS Delanne,J., Lecat,M., Blackburn,P.R., Klee,E.W., Stumpel,C.T.R.M.,
Stegmann,S., Stevens,S.J.C., Nava,C., Heron,D., Keren,B.,
Mahida,S., Naidu,S., Babovic-Vuksanovic,D., Herkert,J.C.,
Torring,P.M., Kibaek,M., De Bie,I., Pfundt,R., Hendriks,Y.M.C.,
Ousager,L.B., Bend,R., Warren,H., Skinner,S.A., Lyons,M.J., Poe,C.,
Chevarin,M., Jouan,T., Garde,A., Thomas,Q., Kuentz,P.,
Tisserant,E., Duffourd,Y., Philippe,C., Faivre,L. and
Thauvin-Robinet,C.
TITLE Further clinical and molecular characterization of an XLID syndrome
associated with BRWD3 variants, a gene implicated in the
leukemia-related JAK-STAT pathway
JOURNAL Eur J Med Genet 66 (1), 104670 (2023)
PUBMED 36414205
REMARK GeneRIF: Further clinical and molecular characterization of an XLID
syndrome associated with BRWD3 variants, a gene implicated in the
leukemia-related JAK-STAT pathway.
Review article
REFERENCE 3 (bases 1 to 12771)
AUTHORS Manojlovic,Z., Christofferson,A., Liang,W.S., Aldrich,J.,
Washington,M., Wong,S., Rohrer,D., Jewell,S., Kittles,R.A.,
Derome,M., Auclair,D., Craig,D.W., Keats,J. and Carpten,J.D.
TITLE Comprehensive molecular profiling of 718 Multiple Myelomas reveals
significant differences in mutation frequencies between African and
European descent cases
JOURNAL PLoS Genet 13 (11), e1007087 (2017)
PUBMED 29166413
REMARK GeneRIF: BCL7A, BRWD3, and AUTS2 demonstrate significantly higher
mutation frequencies among AA cases. These genes are all involved
in translocations in B-cell malignancies. Moreover, we detected a
significant difference in mutation frequency of TP53 and IRF4 with
frequencies higher among CA cases. Our study provides rationale for
interrogating diverse tumor cohorts to best understand tumor
genomics across populations.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 12771)
AUTHORS Grotto,S., Drouin-Garraud,V., Ounap,K., Puusepp-Benazzouz,H.,
Schuurs-Hoeijmakers,J., Le Meur,N., Chambon,P., Fehrenbach,S., van
Bokhoven,H., Frebourg,T., de Brouwer,A.P. and Saugier-Veber,P.
TITLE Clinical assessment of five patients with BRWD3 mutation at Xq21.1
gives further evidence for mild to moderate intellectual disability
and macrocephaly
JOURNAL Eur J Med Genet 57 (5), 200-206 (2014)
PUBMED 24462886
REMARK GeneRIF: A nonsense mutation in BRWD3 in a family with X-linked
intellectual disability associated with macrocephaly.
REFERENCE 5 (bases 1 to 12771)
AUTHORS Suh,E.J., Kabir,M.H., Kang,U.B., Lee,J.W., Yu,J., Noh,D.Y. and
Lee,C.
TITLE Comparative profiling of plasma proteome from breast cancer
patients reveals thrombospondin-1 and BRWD3 as serological
biomarkers
JOURNAL Exp Mol Med 44 (1), 36-44 (2012)
PUBMED 22024541
REMARK GeneRIF: potential serological biomarker of breast cancer
REFERENCE 6 (bases 1 to 12771)
AUTHORS Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
TITLE Identification and characterization of a set of conserved and new
regulators of cytoskeletal organization, cell morphology and
migration
JOURNAL BMC Biol 9, 54 (2011)
PUBMED 21834987
REMARK Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
10.1186/s12915-024-02036-3. PMID: 39390519]
Publication Status: Online-Only
REFERENCE 7 (bases 1 to 12771)
AUTHORS Tarpey,P.S., Smith,R., Pleasance,E., Whibley,A., Edkins,S.,
Hardy,C., O'Meara,S., Latimer,C., Dicks,E., Menzies,A.,
Stephens,P., Blow,M., Greenman,C., Xue,Y., Tyler-Smith,C.,
Thompson,D., Gray,K., Andrews,J., Barthorpe,S., Buck,G., Cole,J.,
Dunmore,R., Jones,D., Maddison,M., Mironenko,T., Turner,R.,
Turrell,K., Varian,J., West,S., Widaa,S., Wray,P., Teague,J.,
Butler,A., Jenkinson,A., Jia,M., Richardson,D., Shepherd,R.,
Wooster,R., Tejada,M.I., Martinez,F., Carvill,G., Goliath,R., de
Brouwer,A.P., van Bokhoven,H., Van Esch,H., Chelly,J., Raynaud,M.,
Ropers,H.H., Abidi,F.E., Srivastava,A.K., Cox,J., Luo,Y.,
Mallya,U., Moon,J., Parnau,J., Mohammed,S., Tolmie,J.L.,
Shoubridge,C., Corbett,M., Gardner,A., Haan,E., Rujirabanjerd,S.,
Shaw,M., Vandeleur,L., Fullston,T., Easton,D.F., Boyle,J.,
Partington,M., Hackett,A., Field,M., Skinner,C., Stevenson,R.E.,
Bobrow,M., Turner,G., Schwartz,C.E., Gecz,J., Raymond,F.L.,
Futreal,P.A. and Stratton,M.R.
TITLE A systematic, large-scale resequencing screen of X-chromosome
coding exons in mental retardation
JOURNAL Nat Genet 41 (5), 535-543 (2009)
PUBMED 19377476
REMARK GeneRIF: Includes the identification of truncating mutations in
this gene that segregated with mental retardation in the families
tested.
REFERENCE 8 (bases 1 to 12771)
AUTHORS Field,M., Tarpey,P.S., Smith,R., Edkins,S., O'Meara,S., Stevens,C.,
Tofts,C., Teague,J., Butler,A., Dicks,E., Barthorpe,S., Buck,G.,
Cole,J., Gray,K., Halliday,K., Hills,K., Jenkinson,A., Jones,D.,
Menzies,A., Mironenko,T., Perry,J., Raine,K., Richardson,D.,
Shepherd,R., Small,A., Varian,J., West,S., Widaa,S., Mallya,U.,
Wooster,R., Moon,J., Luo,Y., Hughes,H., Shaw,M., Friend,K.L.,
Corbett,M., Turner,G., Partington,M., Mulley,J., Bobrow,M.,
Schwartz,C., Stevenson,R., Gecz,J., Stratton,M.R., Futreal,P.A. and
Raymond,F.L.
TITLE Mutations in the BRWD3 gene cause X-linked mental retardation
associated with macrocephaly
JOURNAL Am J Hum Genet 81 (2), 367-374 (2007)
PUBMED 17668385
REMARK GeneRIF: BRWD3 is therefore a new gene implicated in the etiology
of XLMR associated with macrocephaly and may cause disease by
altering intracellular signaling pathways affecting cellular
proliferation.
REFERENCE 9 (bases 1 to 12771)
AUTHORS Muller,P., Kuttenkeuler,D., Gesellchen,V., Zeidler,M.P. and
Boutros,M.
TITLE Identification of JAK/STAT signalling components by genome-wide RNA
interference
JOURNAL Nature 436 (7052), 871-875 (2005)
PUBMED 16094372
REFERENCE 10 (bases 1 to 12771)
AUTHORS Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
Dohner,H., Stilgenbauer,S. and Lichter,P.
TITLE Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
leukemia disrupts two novel genes
JOURNAL Genes Chromosomes Cancer 42 (2), 128-143 (2005)
PUBMED 15543602
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL590031.6, AL669934.6 and
AL512504.9.
On or before Jun 7, 2025 this sequence version replaced
XM_005262113.4, XM_054326752.1.
Summary: The protein encoded by this gene contains a bromodomain
and several WD repeats. It is thought to have a chromatin-modifying
function, and may thus play a role in transcription. Mutations in
this gene are associated with a spectrum of cognitive disabilities
and X-linked macrocephaly. This gene is also associated with
translocations in patients with B-cell chronic lymphocytic
leukemia. [provided by RefSeq, Jul 2017].
##Evidence-Data-START##
Transcript exon combination :: SRR14038197.1628590.1,
SRR14038196.1694055.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-437 AL590031.6 60951-61387 c
438-496 AL590031.6 60756-60814 c
497-526 AL590031.6 60523-60552 c
527-586 AL590031.6 60049-60108 c
587-737 AL590031.6 45132-45282 c
738-836 AL590031.6 43364-43462 c
837-997 AL669934.6 25333-25493 c
998-1219 AL669934.6 23796-24017 c
1220-1320 AL669934.6 15752-15852 c
1321-1391 AL669934.6 14891-14961 c
1392-1492 AL669934.6 13882-13982 c
1493-1533 AL669934.6 13220-13260 c
1534-1638 AL669934.6 9680-9784 c
1639-1792 AL669934.6 8516-8669 c
1793-1927 AL669934.6 4697-4831 c
1928-2056 AL669934.6 3512-3640 c
2057-2282 AL669934.6 2326-2551 c
2283-2450 AL512504.9 220331-220498 c
2451-2637 AL512504.9 218415-218601 c
2638-2731 AL512504.9 216999-217092 c
2732-2808 AL512504.9 208269-208345 c
2809-2977 AL512504.9 205520-205688 c
2978-3091 AL512504.9 204322-204435 c
3092-3199 AL512504.9 200799-200906 c
3200-3324 AL512504.9 197581-197705 c
3325-3407 AL512504.9 196750-196832 c
3408-3519 AL512504.9 193782-193893 c
3520-3581 AL512504.9 192931-192992 c
3582-3737 AL512504.9 192665-192820 c
3738-3858 AL512504.9 191895-192015 c
3859-3984 AL512504.9 190809-190934 c
3985-4063 AL512504.9 190610-190688 c
4064-4120 AL512504.9 188911-188967 c
4121-4261 AL512504.9 187705-187845 c
4262-4336 AL512504.9 186304-186378 c
4337-4489 AL512504.9 184852-185004 c
4490-4653 AL512504.9 183307-183470 c
4654-4751 AL512504.9 182839-182936 c
4752-4910 AL512504.9 182183-182341 c
4911-12771 AL512504.9 170345-178205 c
FEATURES Location/Qualifiers
source 1..12771
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq21.1"
gene 1..12771
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/note="bromodomain and WD repeat domain containing 3"
/db_xref="GeneID:254065"
/db_xref="HGNC:HGNC:17342"
/db_xref="MIM:300553"
exon 1..437
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
misc_feature 278..280
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/note="upstream in-frame stop codon"
CDS 407..5665
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/note="isoform 2 is encoded by transcript variant 2; novel
WD repeat domain protein; bromo domain-containing protein
disrupted in leukemia"
/codon_start=1
/product="bromodomain and WD repeat-containing protein 3
isoform 2"
/protein_id="NP_001428268.1"
/db_xref="GeneID:254065"
/db_xref="HGNC:HGNC:17342"
/db_xref="MIM:300553"
/translation="
MAAAPTQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQREDETVGTSDASVEDPVVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKKPKQTRKKKGGLVSIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEERNSTDAEEDTEIVDLDSDGPGTSSGRKVKCRGRRQSLKCNPDAWKKQCKELLSLIYEREDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTSSPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLPVKQDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELGSSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRAKRARIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY"
exon 438..496
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 497..526
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 527..586
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 587..737
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 738..836
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 837..997
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 998..1219
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 1220..1320
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 1321..1391
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 1392..1492
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 1493..1533
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 1534..1638
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 1639..1792
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 1793..1927
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 1928..2056
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 2057..2282
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 2283..2450
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 2451..2637
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 2638..2731
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 2732..2808
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 2809..2977
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 2978..3091
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 3092..3199
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 3200..3324
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 3325..3407
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 3408..3519
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 3520..3581
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 3582..3737
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 3738..3858
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 3859..3984
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 3985..4063
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 4064..4120
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 4121..4261
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 4262..4336
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 4337..4489
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 4490..4653
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 4654..4751
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 4752..4910
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
exon 4911..12771
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/inference="alignment:Splign:2.1.0"
polyA_site 6457
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/note="major polyA site"
regulatory 10702..10707
/regulatory_class="polyA_signal_sequence"
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/note="hexamer: AATAAA"
polyA_site 10734
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/note="major polyA site"
regulatory 10989..10994
/regulatory_class="polyA_signal_sequence"
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/note="hexamer: AATAAA"
polyA_site 11014
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/note="major polyA site"
regulatory 11394..11399
/regulatory_class="polyA_signal_sequence"
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/note="hexamer: AATAAA"
polyA_site 11420
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
regulatory 12704..12709
/regulatory_class="polyA_signal_sequence"
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
/note="hexamer: AATAGA"
polyA_site 12723
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
polyA_site 12771
/gene="BRWD3"
/gene_synonym="BRODL; DCAF20; MRX93; XLID93"
ORIGIN
acttcggctcctccctcttctcgctccgtctatctctctctctctctctctctccgcccccccaccccccgcgtctctctctctctctctctctctctctctctctctctctctctctttttcctctctctctctctctcttctctctctctctctcactcactcactctctctctccctctccctctcctctccttcctcctccgcctcctcagctcttgggctagaatatctatgggtcgaaacgtgatgcgatgaattcgagagagagcgaaactaggacgaggagtgcggcggaagcggcgggactcccgggcatgggggcttcaccacaatagaggcagcgcccccacccgcccccgccagcccctccggagcgaagcccccaaaccccctcgggaaaaggatggcggcagcacctacccagatcgaagccgagctgtattacctgatcgctaggttcttgcagtctggaccctgcaacaaatccgctcaggtgctagtgcaggagctcgaggagcatcagctgattccgcgccgcttagattgggaggggaaagagcaccgaagaagcttcgaggatctggtggcagcaaatgcacacattcctccagactacctccttaaaatttgtgagagaattggtcctttactagataaagagatccctcagagtgttcctggggtacagacattattaggtgttggtcggcagtctctgctacgggatgccaaagactgtaagagtacactatggaatgggtctgcttttgcggctctgcatagaggcagacctccagaactacctgtaaattatgtgaaacctccaaatgtggtgaatatcacctctgccaggcaattaaccggctgtagtcgctttggtcatattttcccttcatctgcttaccagcacattaagatgcataagagaattctggggcacttgtcatctgtctactgtgtagcatttgaccgaagcgggagaagaatttttacaggttcagatgactgtttagtaaaaatttgggctacagatgatggacgccttcttgctacacttcgtggacactctgctgaaatttctgacatggctgttaactatgaaaacactcttattgctgcaggcagctgtgataaggtagtaagagtatggtgtcttcgaacttgtgcacccgttgcagtccttcagggccattcagcttctattacttccatacagttttgtccatcaactaaaggcacaaacagatacctcacttctactggtgctgatggaacaatctgtttctggcaatggcatgtaaaaacaatgaagtttagagatcgcccggtgaaatttactgagagatccagacctggagtccagatatcttgttcatctttcagttctggtggtatgttcattacaactggtagtactgaccatgtgattagaatatattatttgggttctgaggttcctgagaaaattgctgaattagagtcacatacggataaagttgttgctgttcagttctgtaacaatggagacagtttaagatttgttagtggaagtcgagatggaacggcaagaatttggcagtatcagcaacaagaatggaagagtatagtgctagacatggctactaaaatgactggcaataatttgccatctggagaagacaagatcactaaacttaaggtgactatggtggcctgggatcgctatgataccacagttattactgcagtgaacaattttcttttgaaagtgtggaattctatcacaggacagcttcttcatacattatctggacatgatgatgaagtattcgttctagaagcccatccatttgatcaaaggatcatactttcagcaggtcatgatgggaacatttttatttgggaccttgaccgggggaccaaaattcggaattactttaacatgattgaaggccaaggccatggtgcggtgtttgattgtaaattttcaccagatggaaaccattttgcctgcacagattctcatggacatttgctgctttttggttttggatgcagtaaatactacgaaaagattccagatcagatgttcttccacacggattatcgtcctcttattcgtgatgccaataactatgtattggatgaacaaacccaacaagctcctcacctcatgcctcctccatttttggtggatgttgatggaaatcctcatcccacaaaattccaacggttggtaccaggacgggaaaattgtaaagatgaacagcttataccacagctgggatatgtggctaatggtgatggtgaggtagtagaacaggtaattgggcagcaaaccaatgaccaagatgagagcattcttgatggaataatcagggagctgcagagagaacaagacctgagactaattaatgaaggagatgttccacatttaccagttaatagagcatactctgttaatggtgctctgagaagtccaaacatggacatatcttcttccccaaacatcaggcttcgaagacatagtagtcaaattgaaggtgttagacaaatgcataacaatgctcctcggagccagatggccactgaaagagatctcatggcgtggagcagaagagtggtggtcaatgaactaaataatggggttagtagggtacaggaagaatgtcgaactgcaaaaggtgacatagaaatcagtctttatacagttgaaaagaagaaaaagccatcttacactactcaaagggaagatgaaactgttggcacaagtgacgcttcggtagaggatcctgttgttgaatggcaaagtgaaagttcttccagtgactcatcaagtgaatattctgattggacagcagatgctggaataaatttacaacccccaaaaagacaaaccagacagacaacacgtaaaatatgcagcagctctgatgaggaaaatttgaagtccctagaagaaaggcagaagaaacctaagcagactagaaagaagaaaggaggactggtttctatagcaggtgagcctaatgaagaatggtttgcccctcagtggatcttggatactataccccgacgttccccatttgtcccacaaatgggagatgagcttatctattttaggcaaggacatgaagcttatgttcgggctgtaaggaaatcgaaaatatacagtgttaatttacaaaaacagccatggaacaaaatggatctcagggagcaagagtttgttaagattgtaggaatcaaatatgaggttggcccacccacactgtgctgcttgaagcttgcatttctggacccaatttcaggcaaaatgactggagaatctttttccattaagtatcatgacatgccggatgtcattgacttccttgtgctacatcagttttataatgaagccaaagaaaggaactggcagattggtgatagattccgcagtataatagatgacgcctggtggtttgggactgtggagagtcagcagccttttcaaccagagtatcctgatagttctttccagtgttacagtgttcactgggacaataatgagagagaaaagatgagcccatgggatatggagccaattccagaaggaactgcctttccagatgaagttggtgctggtgttcctgtctcccaggaagaattgactgctttgctatacaaaccccaggaaggagagtggggggctcattccagagacgaagaatgtgaacgggttattcagggcatcaaccaccttctttccctggattttgccagcccttttgctgttccagtggatctcagtgcctaccccttgtattgtactgtagttgcttatccaactgacctcaataccatcaggcggagacttgaaaatcgcttttacaggagaatatcagcattaatgtgggaggtacgctatattgaacataatgccaggactttcaatgagccagacagtcctatagttaaagcagctaaaattgtaactgatgtcttacttcgatttattggggatcagagctgtactgatatactggatacttataataaaattaaagcagaagaacgaaacagtactgatgcagaggaggatacagaaattgttgatttagattcagacggtcctggtacttcatctggaagaaaggtcaaatgccgaggcagaagacagtctttaaagtgtaatcctgatgcttggaaaaaacaatgcaaggaactattgagcctcatttatgaacgtgaagactcggagccatttcgacagccagctgatcttctttcttacccaggtcatcaggagcaagagggagaatcctcagagtctgttgttccagaaagacaacaagattcatctctttctgaggattatcaagatgttatagatactcctgtggacttcagcactgtgaaagaaactttggaagcaggaaactatggtagtcctctggaattttataaggatgttcgccaaatattcaacaactccaaagcttatacctctaataaaaagtcaaggatctatagcatgatgctgcgattatctgccttatttgaaagtcatatcaaaaatatcatctctgaatataagtcagcaatccagagtcagaagaggagaaggccacggtacagaaaacgtctaagaagcagcagcagttcattatctagtagtggagcacctagtccaaaagggaagcagaaacaaatgaagttgcagcctaaaaatgaccagaatacctcagtatctcatgccaggactagctctcctttctcatctcctgtttcagatgctgctgaagggctttcactatatctacttgatgatgagccagatgggccattttcttcatcgagcttcggtggatatagccgaagtggaaatagccatgacccagggaaagccaaatcatttcggaatagagttttgccagttaaacaagatcactcccttgatggaccccttacaaatggtgatggcagagagccccggacaggaatcaagagaaaactacttagtgcatcagaagaagatgaaaacatgggaggagaagataaagagaaaaaagaaacaaaagagaaatctcatttatccacctcagagagtggagagttaggatccagtttaagttctgaaagtacctgtggttctgactctgactctgaatcaacttccagaacagatcaagattacgtagatggagaccatgattatagcaaattcatacaaaccagacctaaaagaaaactcagaaagcaacatggcaatggaaaaagaaattggaagaccagaggcacaggaggaagaggcagatggggaagatggggtagatggagtagaggaggcagaggaagaggaggcaggggacgagggagtcgaggaagaggtggaggtggcactagggggaggggaagagggagaggaggaagaggtgcttctagaggagctaccagagccaaacgagcacgtattgcagatgatgaatttgataccatgttttcaggacgtttcagtagactgcctcgaattaaaacaagaaaccaaggcaggaggactgttttatataatgatgattctgataatgacaattttgtgtccactgaggatcctctgaatcttggtacatccagatcaggcagagtgcgtaaaatgacagaaaaagccagggttagccatctcatgggatggaattattaacagttaataaatttagaataacttaaaaaattcaatggccttctactgcagggaatttaccaggaaatctacaaagcaagttgtgtggggacttctgcttcctttcacattggtgcttttccatttatgccagtatacatttgtttcaagacttttgatctccacacttcatttgttcaaataagccttactcattaggccttaaattaaaagaaattctgcccacacacacacaaacacatacacacacatacacacacacagacacacacacacgaaacacaacacagacactacagatttactacattaaaggagcattcagcttcttaagagtagcatgacatttttatctcaatagaatagccctcttttgcttttgtatcacagaagtatagcaccttcttacagagttttatatagtttgtttttgccattttgattcctatacccagtaataataacttttgcacaatacaccaatcctaaaggcagctattaaatgtttacagtttctatattgtaagagcgatctggattattttactcttcccaggccaaactttcatgacttgtactgaactgaagtatatatttatactacagttttttggggggtggggggatcttgatatgcttttcattgatttgcataattcacgttaaaggtgagaaagggttggtgccttgtaaatatgtagcagatcttcgtggtgtgttctgatgtgtgcattaactttattaaaaaagaatacttgaggtatcaatctagacaaggtgccaaatgcaaaagtttcccgcatcaatttttttcctatcacattttattgcattaatagaatttgtgtagcttaaataacttaaacatttgaaaaatcctcatccacaaagaacaacttctttgaacagtagctcagctacctcttaactacaactactggaaacattaaggaaaatagatgctgttattccttactgactaaggagaaatagaacaagcttagtaggaatgaataccccataagttataagctgagaggttgttaataattgtattggctctcaaattaataattgtaattaacaaagtttcataaatatagtatgctctaccaccttaggctttcttagaacatatttgtgtaagtagacttgggctactgcttatatatttctgctccacttaccatttaacagctgtgagttgctggttttcatttgaatcttaaaatttaacaaagcacctggtttgatttggaatgttttggctagctagtattatgaatcaacttatagattctgctcatatcattccaaagggttcttctgttctagtctttcaggaaagaaccttattgcactgcacactcatgttgtgaatcattattttatagataaaaaacatctttaaaaacccttattgtcttgtttacagcagtagagtgcacatggttccataagtgagcttgagttccaaggtcagttttactccccaaatttaatattacagatttgttcatttgttagatacttacatttctgaggtaagagggataatagcaatttctgtttctgtaacagcaaatttgttgcacttagatcaggctcatgggataaaacagacttcttagtatatacctagctatcccaggatatttcttaagctaatgtgtttgtctcatgctttcaatcatttcatgcatctgaaaacccttaagtgcagaggaaggcgtacacacataaaactttgcttttttggtagggtcggcagtagggttattcttggactaacatctttaagcagttttcacttgcagtggaaatgatgttcaggctttaagagaaagtattgtgaattgttaatggcactaacttctgttactagacagcagaccaagctatttttttgttgtagtctttttttcactaaaccaaaactacttctggttgtaactcagctgccactttaaaccatagtagagattcaaaacgttcctatttgaaactacatttgatttttgctaaaatgtgctgtttcggttatttatctcttgggcatttagactaaattgtgcctgtattcctgaaatcaataatactttggcttatcctgatctaagtaacatagttacttaaattcctggatatacccaaatatggatcacatgtatcattttagtttgaaattttttgttgacattcttctatgaagagctgacctcttgaaatgtagaagaattgacatttgtgtgattttggctatctggagctttatttataatttattttgaaaaataaaaatgccacatttatttcccaaatgtcaagattttctagaattagataattagaataataaggctgaagacattttaaagcatattttatatgtagtgaaatactgtgaaaatattagtgaacagcattttgctgtaatgtttatttcagttattaagatttaaagagttagtcatcagggtatgttagataaacatagttatcatttattaaacaaacagataattttctgtttgcatgcaaattattttaataagtgtgaaaataaaagtttggaagatagtatttttacttttatatctggacttttttttcccccaatttacactttgctttcttgtaataccacctcctgtgaatgtgttgtaattagtatcacattgattactttatcattttaatttctttgaggccctttaaacctacgtaaaatctgggtccagccatagcaaagcaagtacaaaatgaacaaagaattttgaagaaaagcctaaatcttaaattgctaagaaaaaacactgttatatttaggcccgtgagagcatatacatgtataaacctaatcctatgctagatatgaatagtcagtgagctgtaatatttctcataaatgctaataatgtttaaattcccagctttaagatcttagtgtgtgtatatatttataaaatctgaattgtgtgtttcttctatggcttactgtgtgtttctctttcagcaataggatgctctctaaaacattcactagcctactagcctacttactaaatttttgtatatgtgtgtttgtgcacttgtatgtgtgtaaagttttttccccaacttgacacaccttatctcagacattcaaaaaaagagaacattttgtatggaggacagtctgccaactttttgcctctctacagctcttagcctgtatatttactgcttgatcattcattatgccttctagataaccagtccaggttttgtcatatacctgtgtccctctattctttttatttccctttttaattttttttcttttttttccctccccagaaatcaggcttgtgttggaattcttctctataatactttgtttcccgcagatgcaaagtaacaaagtaactgagtaaaattagaaatctcattctgcacaactgtgcgctcagatatttaactcagccttctaatacttttaagtacgtttctgttatttatctttttgttgtttttgttttaatcccatagattgtcatcagacaataatagagtgattgagagagaaagatataaatgccacttctaactttttgataaaacttttttgagcatttttcaaaaatttgtatgtttgtggtaatggggaattaaacaccttttacagctgatgtatgttggaaatcattttatgtacatttaccaactggtacttatcttcaagttggaattttcacatccataaaagggagacttgcatcatatataattttcagtatactttgctgtccagccttttaaacaattacagtaacattttgagttctgtgatgaatagttctaggggaagggatggaactttcgacatgtaaagtccattgttttaaatgctaaccccatccccaatatttttgtggaacgtgaggctttatgaaaggtttatcagaaatagaatattctaaagtcacttttatggcttatttcaaaaactagtgtgaaagtattttcatgcttttttgtttctcatcttttagcaaagcttctttaccaagttttgattaaattgcaatataaaattaagttttttcacggtgctatattttgtggaatatgggtagcactcaggtttctttcttttttcttttctccttccttcttccttcattccttcattcctccctcccccctccctccctccctctcttccttccctccttccttccttcctcacctcggcctcccaaagtgctgggattacaggcatgagccaccgtgcccggcctatatacccttattcttgattatttcttttttcatcttttcaatcctgcttacttttatcctcacttttctttctgccatgaaaactgcacctaatttaccacacttaagattggcaatttttgattcattgatgggagaagtacagtagaaaggccctgcagtttagaattaagttgtgtttgtttatttacatgtatgcccatttcttctaaattaaatctagaatgtgagactttgacatataaaagcatgataagtattttcttaaaaaataagactattgatacataatgaaaccaccattggtaattgaattttaaaatgatatgcaaaaatatttagaaatccagttgggaaatgtgtttttgcatatgtcaccagatacacattaggcagtactacaaatgttaattcttaaacaatactgtggtgatggcaatcagtaatttatttctttgtcctgtaacttatcattcttgtcttttgtaatgtcttacacagtattaacataactgtaccttttttttgttcttggtatccatacattttaagatggaaaatcagttcatagttgatatgatattgtatatgggcaaaatgtccgttaaactaaaattcagtaaaaaaggtaatataaactggcttgatttataaaagatgttttgtttggcagttatcagtcattataagcaattatcttcaaagacaaaaaaactggactaatttgttgccattctttatgggatgtttacaataaaattccaagttgtttggaatcaattgcactcttgctgctttatgccttaatttatgtaccagagaaaaattaaccagaagaaagaaatatggagttacctattcagctttagagattgtaacatgtaactcttaggtctttcttgtttctttgtcatagaatattttattactattactttttaatctgagaaactaggatgcttcttcctatcaaagaaaaggttttgttttttgttttcatcttagacattgcaaatattctttgggtcacttttaggataataaatatgatgtttacactttaaatgtgggctgcttggtgcattcaataacagcctgcaaagcatttgtcaacattttgttttgcagagcttttcaaaatgaatagatctctaacatatttatgacttacaacttttaacagctgagttatatgtacctgacattttaaaatgtatagtaagattacctacattgtaaatggtgctttaattcagtgtaagtgtaggagagagagaagtgaggtgagatgatctgaatgctctaacaggaacattcataactatatagttacccagaatttgtctcccagtggcaaacattccactaggttcaagataaataagctggccaaagactggactgtatctttgatatatatatactgtgtattttgtgtatttagaataaaaaaaatgcatttaggaaaaaagtagactgattttttacaatattcagagattgaagtggagataagttgtttggtatttttgtttagttgcttaattggttagagatagccctctttaaggatataaaaatcttacattaaaaatttttggttaaggccaggcacagtgactcacgtttataatctcagcattttgggaagccatggtgggaggattatttgagcccaggagttcaagaccagcctgggcagcatagtgagacaccgtatctacaaaacaattttttttttaattagctgggcatggttgtgtgtgcctgtaagtcccaggtacttgggagacaggtgggaggatcactcgagcctgggaggtcaaggctgcagtgagctgtgatcatgccactgcactccagcctggggatccattttttttccaagttgagaaggtcaagaaaaaggtgctctccatcctctctcaattatatgttcttgacaatttaaagctactttaccaaaatgtgcaaaataaaaccaatatattgagcctgtgagttgatcttttgaatgagatttttggtgggatagttaagcctatacgcttacagttgctttctcaggtcatttatataaatacttaagggctttttaatgctacaaaacacaggtagatcaaacaataatattaaatgaagtaaactttttacggtatcgatttttcccccaaagttctagggaaacattttcctttcctttctatgtaactttaatagatttttctttgccatctgtgacaattgccttaatgaagttcttatctacagattataaacatctaattataattataaaatcttataattttaattattctagacatctagttttaacagttattaattaacaaattgatatttaatttgatgttggagacctaaaagtctttctgaatctagtattaattttgaattgccaccttgcctggtcagcatctttgcagttctcttcaattttataagttttgtaagtaaatatatgaagaaataaaaacattttaaattctttaatttaggtgactaatattaattgatggagcttattcatttttaaggatttttgtggttgatttttgtcatgttgcaattctagttagaatttgtataacaacatgttaatttgtattggcaattttgtatagtctgttaagtaatttaagtcaaggaaactgctaacgtgttccctcctcccttggcttttaaaaaaaagcttacaatatgtttaaatgaaatttgcataacaaattgtgtaatagatcatttgaaaagtactgttttgttacccttgagtattattcatctaaaatattaataatgaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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