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Previous release (v1)
2026-06-24 23:06:49, GGRNA.v2 : RefSeq release 233 (Jan, 2026)
LOCUS NM_001441107 3562 bp mRNA linear PRI 07-JUN-2025
DEFINITION Homo sapiens formin binding protein 4 (FNBP4), transcript variant
10, mRNA.
ACCESSION NM_001441107
VERSION NM_001441107.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3562)
AUTHORS Das,A., Bhattacharya,S., Bhattacharjee,S., Bagchi,A. and
Dasgupta,R.
TITLE Computational analyses of the length and compositional variations
of the FNBP4 gene across 10 different species
JOURNAL Gene 575 (2 Pt 3), 765-777 (2016)
PUBMED 26456197
REFERENCE 2 (bases 1 to 3562)
AUTHORS Nourashrafeddin,S., Aarabi,M., Modarressi,M.H., Rahmati,M. and
Nouri,M.
TITLE The Evaluation of WBP2NL-Related Genes Expression in Breast Cancer
JOURNAL Pathol Oncol Res 21 (2), 293-300 (2015)
PUBMED 25417742
REFERENCE 3 (bases 1 to 3562)
AUTHORS Das,A., Bhattacharya,S., Bagchi,A. and Dasgupta,R.
TITLE In-silico characterization of Formin Binding Protein 4 Family of
proteins
JOURNAL Interdiscip Sci 7 (1), 43-64 (2015)
PUBMED 25183348
REFERENCE 4 (bases 1 to 3562)
AUTHORS Kondo,Y., Koshimizu,E., Megarbane,A., Hamanoue,H., Okada,I.,
Nishiyama,K., Kodera,H., Miyatake,S., Tsurusaki,Y., Nakashima,M.,
Doi,H., Miyake,N., Saitsu,H. and Matsumoto,N.
TITLE Whole-exome sequencing identified a homozygous FNBP4 mutation in a
family with a condition similar to microphthalmia with limb
anomalies
JOURNAL Am J Med Genet A 161A (7), 1543-1546 (2013)
PUBMED 23703728
REMARK GeneRIF: A c.683C>T (p.Thr228Met) mutation in FNBP4 was found as a
primary candidate to microphthalmia with limb anomalies
REFERENCE 5 (bases 1 to 3562)
AUTHORS Aspenstrom,P.
TITLE Formin-binding proteins: modulators of formin-dependent actin
polymerization
JOURNAL Biochim Biophys Acta 1803 (2), 174-182 (2010)
PUBMED 19589360
REMARK Review article
REFERENCE 6 (bases 1 to 3562)
AUTHORS Zucconi,A., Dente,L., Santonico,E., Castagnoli,L. and Cesareni,G.
TITLE Selection of ligands by panning of domain libraries displayed on
phage lambda reveals new potential partners of synaptojanin 1
JOURNAL J Mol Biol 307 (5), 1329-1339 (2001)
PUBMED 11292345
REFERENCE 7 (bases 1 to 3562)
AUTHORS Bedford,M.T., Sarbassova,D., Xu,J., Leder,P. and Yaffe,M.B.
TITLE A novel pro-Arg motif recognized by WW domains
JOURNAL J Biol Chem 275 (14), 10359-10369 (2000)
PUBMED 10744724
REFERENCE 8 (bases 1 to 3562)
AUTHORS Depraetere,V. and Golstein,P.
TITLE WW domain-containing FBP-30 is regulated by p53
JOURNAL Cell Death Differ 6 (9), 883-889 (1999)
PUBMED 10510470
REFERENCE 9 (bases 1 to 3562)
AUTHORS Chan,D.C. and Leder,P.
TITLE Genetic evidence that formins function within the nucleus
JOURNAL J Biol Chem 271 (38), 23472-23477 (1996)
PUBMED 8798555
REFERENCE 10 (bases 1 to 3562)
AUTHORS Chan,D.C., Bedford,M.T. and Leder,P.
TITLE Formin binding proteins bear WWP/WW domains that bind proline-rich
peptides and functionally resemble SH3 domains
JOURNAL EMBO J 15 (5), 1045-1054 (1996)
PUBMED 8605874
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC021443.27.
Summary: This gene encodes a protein containing two tryptophan-rich
WW domains that binds the proline-rich formin homology 1 domains of
formin family proteins, suggesting a role in the regulation of
cytoskeletal dynamics during cell division and migration. It also
binds intersectin family proteins suggesting a role in the
maintenance of membrane curvature at sites of nascent vesicle
formation. Naturally occurring mutations in this gene are
associated with Waardenburg anophthalmia syndrome. [provided by
RefSeq, Apr 2017].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR14038191.3456177.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-279 AC021443.27 119550-119828 c
280-372 AC021443.27 117757-117849 c
373-509 AC021443.27 107015-107151 c
510-848 AC021443.27 98543-98881 c
849-1059 AC021443.27 96440-96650 c
1060-1184 AC021443.27 89103-89227 c
1185-1289 AC021443.27 86512-86616 c
1290-1423 AC021443.27 85024-85157 c
1424-1611 AC021443.27 83861-84048 c
1612-1922 AC021443.27 76955-77265 c
1923-2067 AC021443.27 76515-76659 c
2068-2408 AC021443.27 75463-75803 c
2409-2566 AC021443.27 72416-72573 c
2567-3562 AC021443.27 69004-69999 c
FEATURES Location/Qualifiers
source 1..3562
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p11.2"
gene 1..3562
/gene="FNBP4"
/gene_synonym="FBP30"
/note="formin binding protein 4"
/db_xref="GeneID:23360"
/db_xref="HGNC:HGNC:19752"
/db_xref="MIM:615265"
exon 1..279
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
CDS 54..2657
/gene="FNBP4"
/gene_synonym="FBP30"
/note="isoform 10 is encoded by transcript variant 10;
formin-binding protein 30"
/codon_start=1
/product="formin-binding protein 4 isoform 10"
/protein_id="NP_001428036.1"
/db_xref="GeneID:23360"
/db_xref="HGNC:HGNC:19752"
/db_xref="MIM:615265"
/translation="
MGKKSRAVPGRRPILQLSPPGPRGSTPGRDPEPEPDTEPDSTAAVPSQPAPSAATTTTTAVTAAAASDDSPSEGKDEQEAVQEVPRVVQNPPKPVMTTRPTAVKATGGLCLLGAYADSDDDDNDVSEKLAQSKETNGNQSTDIDSTLANFLAEVNEGIQALSNSEEEKKGVAASLLAPLLPEGIKEEEERWRRKVICKEEPVSEVKETSTTVEEATTIVKPQEIMLDNIEDPSQEDLCSVVQSGESEEEEEQDTLELELVLERKKAELRALEEGDGSVSGSSPRSDISQPASQDGMRRLMSKRGKWKMFVRATSPESTSRSSSKTGRDTPENGETAIGAENSEKIDENSDKEMEVEESPEKIKVQTTPKVEEEQDLKFQIGELANTLTSKFEFLGINRQSISNFHVLLLQTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATPKGWSCHWDRDHRRYFYVNEQSGESQWEFPDGEEEEEESQAQENRDETLAKQTLKDKTGTDSNSTESSETSTGSLCKESFSGQVSSSSLMPLTPFWTLLQSNVPVLQPPLPLEMPPPPPPPPESPPPPPPPPPPAEDGEIQEVEMEDEGSEEPPAPGTEEDTPLKPSAQTTVVTSQSSVDSTISSSSSTKGIKRKATEISTAVVQRSATIGSSPVLYSQSAIATGHQAAGIGNQATGIGHQTIPVSLPAAGMGHQARGMSLQSNYLGLAAAPAIMSYAECSVPIGVTAPSLQPVQARGAVPTATIIEPPPPPPPPPPPPPPAPKMPPPEKTKKGRKDKAKKSKTKMPSLVKKWQSIQRELDEEDNSSSSEEDRESTAQKRIEEWKQQQLVSGMAERNANFEALPEDWRARLKRRKMAPNT"
misc_feature 1395..1490
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Two conserved tryptophans domain; also known as the
WWP or rsp5 domain; around 40 amino acids; functions as an
interaction module in a diverse set of signalling
proteins; binds specific proline-rich sequences but at low
affinities compared to other...; Region: WW; cd00201"
/db_xref="CDD:238122"
misc_feature order(1437..1439,1473..1475)
/gene="FNBP4"
/gene_synonym="FBP30"
/note="binding pocket [active]"
/db_xref="CDD:238122"
exon 280..372
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 373..509
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 510..848
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 849..1059
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 1060..1184
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 1185..1289
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 1290..1423
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 1424..1611
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 1612..1922
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 1923..2067
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 2068..2408
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 2409..2566
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 2567..3562
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
regulatory 3538..3543
/regulatory_class="polyA_signal_sequence"
/gene="FNBP4"
/gene_synonym="FBP30"
/note="hexamer: AATAAA"
polyA_site 3562
/gene="FNBP4"
/gene_synonym="FBP30"
/note="major polyA site"
ORIGIN
agtgcccgcccctctcggccgcccgacgctctctgctcgcgcttgggctcgcgatggggaagaagtcccgggcggtacccggccgtaggcccatcctgcaactctctccgccgggtcctcggggcagcacgccgggccgggacccggagccggaacccgacactgagccggactcaaccgcggcggtccccagccagcccgccccgtcggcggcgacgaccaccaccaccgcggtgactgccgccgcggcctcggacgactcgccttcagaaggcaaggatgaacaggaagcggtgcaggaggttcctagagttgttcagaatcctccaaaaccagtcatgaccactagacccacagctgttaaagcaacaggcggtctatgcttgcttggtgcttatgctgacagtgatgacgatgacaatgatgtttccgaaaaactagcacaatccaaagagacaaatggaaaccagtcaactgatattgatagtacattggccaacttcctagcggaagtaaatgaaggaattcaggctctctcaaatagtgaggaggagaagaaaggggtggcagcatcgctgcttgctcctttattgcctgagggaataaaagaagaagaagagagatggagaagaaaagtaatttgtaaagaggagccagtttcagaagtaaaagaaacaagtacaacagtagaagaagcaacaacaatagtaaagccacaggaaattatgttggacaatatagaagacccttctcaggaggatctttgcagtgttgtccaatctggagaaagtgaggaggaagaggaacaagatacccttgaactggagctagttttggaaaggaaaaaagcagagttgcgagccttggaggaaggagatggtagtgtgtcagggtctagtccacgttctgatatcagccagccagcatctcaagatggaatgcgtaggcttatgtctaaaagaggaaaatggaagatgtttgttcgagctaccagtccagaatctaccagtaggagttctagtaaaactggacgagatactccagaaaatggagaaactgcaattggtgctgaaaattcagaaaaaatagatgagaattcagataaagagatggaagtagaagaatctccagagaaaataaaagtacagacaacaccaaaagtagaagaagaacaggatttgaaatttcagattggagaactggcaaataccctgacaagtaaattcgagtttctaggcattaatagacaatccatctccaactttcatgtgctgctcttacagactgagactcgaattgcagactggcgggaaggggctcttaatggaaactaccttaaacgaaaacttcaggatgcagcagaacaactaaaacagtatgaaataaacgccactcctaaaggctggtcctgccactgggacagggatcatagacggtatttctatgtaaacgaacagtcgggcgagtctcagtgggagtttccagatggtgaagaggaagaagaagaaagccaagcacaagaaaatagagatgagactcttgccaaacagaccttgaaagacaaaactggcactgattcaaattcaacagaatcctctgaaacttccacaggttctctttgtaaagaatccttttctggtcaagtttcttcttcatcactcatgccacttactccattctggaccctccttcagtcaaatgttcctgtgcttcaacctccattacccttggaaatgccaccacccccacctccacctccagaatcacctccaccccctcctccaccacctcctcctgcggaagatggtgagatccaggaggtagagatggaggatgagggaagtgaggagccccctgccccaggaacagaggaagatacccctttgaaaccttcagcacaaaccacagttgtaactagccagagttcagttgattccaccatctctagttcttcttccactaaaggaataaagaggaaagctacagaaattagcactgcagtggttcagaggtcagctaccattggcagttctccagttctctatagccagtcagctatagctacaggtcaccaggcagcagggattggaaaccaggcaacaggaattggacatcagacaataccagttagccttccagcagcaggaatgggtcatcaggccagaggaatgagcctgcagtcaaattaccttggactagcggcagcacctgcaattatgagttatgcagaatgttctgtcccaattggagtgactgctccctcattgcagccagttcaggcccgaggtgctgtgcctaccgctaccattatagaaccaccaccaccacctcctcctcctcctcctccaccaccaccagctcccaaaatgccaccacctgaaaagacaaaaaaaggaaggaaagacaaggcaaagaagagtaagaccaaaatgccatctttggtaaaaaagtggcagagtatccagcgtgagttagatgaagaggacaattctagttccagtgaagaggatcgggaatcaactgcacagaagcgaattgaagagtggaaacagcagcagctggttagtggcatggcagagagaaatgctaattttgaagcccttcctgaggattggagagcaaggctgaagagaaggaaaatggctccaaacacatagtttttaagtttttaaaacttttttgtattattgtttgttttgtgttcagttcaaagtcttaaccagttttattgtcaaataaactataaatgttatgggggagatcttataaatttcctgggcaagagtgtatgcatacaaagttttcacttttgtgaaatgtaatttttctgtttttgcaaagggatgaggtgattggaattgctttgaccatgctgcctttattctcaaactggcaaacttagcatgttaggtgtattaacctcatcagtcttgaagaacatgtggctcatgagtataacacttctgtagaggactccctgacaaaagtgaagaattaacttctcctccagaacaagtgcaattcagaaggcagctctgcattctaccttgcttgactggaattgtctgaagctttttctggcctcttttctctagtcggccacccctgaagtgctgaggtctaagtggtttacctcgtgctgatagatggccacactctttagagtagttctcataagttctagaactggtagctcggtcgtttcgcacactaggtggcatacaggcagcagcaggtgttcatatccttgattttgagaatttcccctcaagtatgtggcagtaaatacaacaagacactctatgtattaatgtctccattgtcttaaccctgttccaaaacaaaattcacctcctttctttatgtgaatgtattctccataaaattccagtatttaaaaagcagtttactgttctgtactttctgttgtatcacaatcaggtaaaagtcactttaaactgaggaaacggcaaattgtgttttaaagctctttgtatttctccagtttctgaccttgtaaatttgtatatatgcactaataaagctttttttataatcctga
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]